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Approved antibody–drug conjugates (ADCs) remain constrained by a limited repertoire of payloads with restricted modes of action. Here, the authors present phosphoramidate-based self-immolative linker units that facilitate stable attachment in serum and traceless drug release in the target cell from aliphatic and aromatic alcohols with various modes of action.

The study introduces radio interferometric multiplexed spectroscopy (RIMS), a method designed to efficiently monitor the radio emissions of massive samples of stars. Applying it to LOFAR data, the authors identify stellar bursts, offering clues to possible star–planet magnetic interactions.

Understanding collective behaviour is an important aspect of managing the pandemic response. Here the authors show in a large global study that participants that reported identifying more strongly with their nation reported greater engagement in public health behaviours and support for public health policies in the context of the pandemic.

deepmriprep leverages neural networks to enable voxel-based morphometry preprocessing of MRI data that is 37× faster than existing methods while achieving comparable accuracy in segmentation, registration and final statistical maps across large datasets.

DNA methylation and copy number variant analyses across a large number of genetic mouse models of pediatric brain tumors reveal subtype-specific molecular alterations shared with the corresponding human diseases.

This work examines future coastal risks in Europe’s Outermost Regions and Overseas Countries and Territories. By 2150, 3,000 km² could flood yearly, with €5.9 bn in annual damages and 0.5 million people exposed. Mitigation cuts impacts nearly in half, but long-term resilience strategies are needed.

In JAK2V617F mutant myeloproliferative neoplasms (MPN), inflammation impacts clinical outcomes. This study uncovers that the NLRP3 inflammasome drives thrombocytosis, granulocytosis, HSPC expansion, splenomegaly, and bone marrow fibrosis in MPN

We show that FOXF2 maintains cerebrovascular function through Tie2 signaling, and that pharmacological activation of Tie2 with AKB-9778 rescues deficits in cerebral small vessel disease and stroke.

Reducing the embodied carbon emissions of building material stock is essential for mitigation. Using a high-resolution multiyear dataset in China, researchers show the historically massive contributions of these emissions during past decades of rapid urbanization and the potential risks for future climate goals.

High reproduction is often associated by higher mortality in models with well-mixed populations. Here, the authors model spatially-structured populations, finding that variants with proportional increases in birth and death rates become disadvantaged, even when they have a higher lifetime reproductive output.

Optically active spin defects in diamond and hBN are promising solid-state quantum sensors but often fall short for chemical sensing. Here the authors show that BN nanotubes hosting such defects create a nanoporous, omnidirectional quantum “mesh” sensor at room temperature, enhancing chemical detection through high surface area and improved sample accessibility.

DNA repair pathways shape CRISPR editing outcomes. Here, authors identified FDA approved drugs that can be repurposed as repair modulators or to induce synthetic lethality, and uncovered new roles for ESR2 and AOX1 in DNA repair, enhancing editing and offering potential therapeutic applications.

Here the authors show that mitochondrial RNA leaks into the cytosol of senescent cells through sublethal apoptosis, driving inflammation. Blocking this pathway improves outcomes in Metabolic Dysfunction-Associated Steatohepatitis.

The 4D Nucleome Project demonstrates the use of genomic assays and computational methods to measure genome folding and then predict genomic structure from DNA sequence, facilitating the discovery of potential effects of genetic variants, including variants associated with disease, on genome structure and function.

Rare-earth permanent magnets are engineered with a complex microstructure of composition and phase, grains and grain boundaries, and it is this complex structure which leads to the magnetic performance. Here, Giron and coauthors, through thorough microstructural analysis, demonstrate that the grain microstructure, not grain boundaries, are primarily responsible for optimal magnetic properties.

Cancer cells can utilize the lymph node transportation network to disseminate. Here, the authors show that breast cancer can alter the lymphatic endothelial cells (LECs) in the sentinel lymph nodes and that Matrix Gla protein is upregulated in LECs, which in turn promotes cancer cell adhesion.

The asymmetric distribution of lipopolysaccharide (LPS) on the surface of the bacterial outer membrane is essential and crucial for antibiotic resistance. Here, authors characterize the LPS translocon holo-complex, LptDEMY, uncovering conformational translocon state transitions that might explain how LPS is assembled at the outer membrane surface.

Conventional doped spiro-OMeTAD hole transport layer often leads to poor device operational stability. Here, the authors employ light to generate protons from bistriflimide dopants in the precursor solution to increase conductivity, achieving efficiency of 20.95% in perovskite solar modules.

Multi-omics profiling of diverse cancer cachexia models uncovers a multi-tissue metabolite-coordinated response associated with disease progression and links multi-tissue one-carbon metabolism to wasting.

Efficient lead optimization in drug discovery requires improving potency, synthetic accessibility, and physicochemical properties. Here, the authors utilize machine learning to screen large chemical spaces, demonstrating automated selection of optimized molecules to improve cycle times.

Gonzalez-Gallego et al. developed a fully iPS-cell-based human three-dimensional blood–brain barrier (BBB) model and used it to study roles of the stroke risk gene FOXF2 in BBB dysregulation, demonstrating its applicability for mechanistic research and drug development.

RNA-binding proteins play key roles in post-transcriptional gene regulation. Here, Hemm et al. developed RAPDOR, a widely applicable tool based on Jensen-Shannon Distance and the analysis of similarities that identified 165 potential RNA-binding proteins from GradR analysis in a cyanobacterium.

The authors develop an on-chip molecular deposition method to generate large electric fields in bilayer transition metal dichalcogenides, enabling the hybridisation of intralayer and hitherto unobserved interlayer excitons.

The ATPase UAP56 acts as an ATP-gated molecular switch that directs mRNA ribonucleoprotein complexes from TREX to nuclear-pore-complex-anchored TREX-2 complexes for mRNA export from the nucleus.

X-ray study of compressed water shows that superionic ice adopts mixed close-packed structures rather than a single phase - a far more complex behaviour than expected, mirroring solid ice’s rich phases and informing planetary interior models.

Immune genetic and disease surveillance of a wild meerkat population over 20 years shows that tuberculosis imposes strong pathogen-mediated balancing selection on the meerkats’ major histocompatibility complex via rare-allele advantage or fluctuating selection.

Interact-omics, a high-throughput cytometry-based framework, resolves the cellular interaction landscape.

ProDomino is a machine leaning-based method, trained on a semisynthetic domain insertion dataset, to guide the engineering of protein domain recombination.

3D printing can be used to manufacture composite materials, but to modify material properties multiple feedstocks are required. Here the authors modify printing temperature or light intensity to modify the material properties and achieve property differentiation from a single feedstock.

Realizing >5 V batteries is hindered by the instability of electrolytes. Here, a fluoride shielding layer, LiCl-4Li₂TiF₆, enables high-voltage, high-capacity all-solid-state batteries because of its combined oxidative stability and Li⁺ conductivity.

Using data from 100 million Brazilian workers, this study reveals persistent occupational segregation—skills segregate workers by gender, while social status of occupations segregates by race, with Black workers concentrated in lower-status jobs.

H₃O⁺ and OH⁻ mediate electrochemical processes at water/metal electrode interfaces. Here, the authors show that these ions form distinct solvation structures on electrified gold surfaces: OH⁺ remains in close contact with the electrode, while H₃O⁺ resides farther away.

In the phase 3 STAR trial, subretinal administration of the AAV2-based gene therapy timrepigene emparvovec in patients with choroideremia did not lead to a significant difference in the primary endpoint of 15-letter Early Treatment Diabetic Retinopathy Study (ETDRS) improvement in visual acuity from baseline compared to untreated controls.

Herpell et al. use data from Germany to study the short- and medium-term effects of a programme to match Ukrainian refugees with private hosts on integration outcomes. Hosting led to improvements in social, psychological and navigational integration.

Templated synthesis is a valuable method for the preparation of oligomers but requires stoichiometric amounts of the template. Here a catalytic macrocyclic template is reported that promotes the oligomerization of a small-molecule substrate and controls its length. The length of the oligomer correlates with the dimensions of the template.

The synthesis and isolation of a crystalline dication derived from a bis(imino)carbene through a two-electron oxidation/oxide-ion abstraction strategy is reported that bypasses the carbene radical cation, maintaining significant electrophilicity with two accessible vacant orbitals.

This study reveals that an outer membrane protein from the predator Bdellovibrio bacteriovorus forms a pentameric assembly that traps a lipid monolayer within. This allows the discovery of two superfamilies, distributed across a wide range of bacteria, likely to adopt a similar architecture.

An understanding of excess protons in nanoconfined water is highly relevant to technological applications such as fuel cell membranes. Here, ab initiosimulation reveals almost barrier-free proton transfer even in the limit of molecularly thin water films confined by mineral sheets.