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Trained and validated on data from 2,344 patients with smoldering multiple myeloma, a new algorithm using longitudinal biomarker dynamics provides accurate prediction of risk of disease progression, outperforming established models.

Global Burden of Disease analysis found that in 2023, suboptimal diet was estimated to be responsible for 4 million deaths and 97 million morbidity burdens from ischemic heart disease.

Atomic-level changes to molecular junctions are found to tune the thermal conductance of the junctions by a factor of two. These observations, performed using high-resolution calorimetric scanning tunnelling probes, show how single atoms can influence and control phonon transport in molecular junctions.

When 100 social and behavioural science claims were examined, 34% of reanalyses closely matched the original results, with 74% reaching the same conclusion, revealing limited robustness of single-path analyses and the need to address analytical uncertainty.

The immunological events that correlate with latent Mycobacterium tuberculosis (Mtb) infection (LTBI) containment in immune suppressed hosts remain to be explored. The authors here show that CD8⁺ T cells are critical for BCG vaccination-induced prevention of Mtb dissemination in the absence of CD4⁺ T cells in a mouse model of contained tuberculosis.

ProtAIDe-Dx is a deep joint-learning model that uses plasma proteomics to provide simultaneous probabilistic diagnoses across six conditions associated with aging.

A prespecified analysis from the SELECT trial showed that semaglutide reduces major adverse cardiovascular events by 20% compared with placebo, particularly in patients at high risk of fibrosis, as indicated by the Fibrosis-4 index.

In the phase 3 EMN24 IsKia trial, transplant-eligible patients with newly diagnosed multiple myeloma who received isatuximab with carfilzomib, lenalidomide and dexamethasone pretransplant induction and post-transplant consolidation showed higher rates of measurable residual disease negativity after consolidation than patients who received carfilzomib, lenalidomide and dexamethasone.

Odd-parity spin-triplet superconductivity remains difficult to establish experimentally. Now, several distinct magnetic-field-tuned superconducting states—including a possible topological helical phase—have been identified in YbRh₂Si₂.

A graphene–hBN heterostructure integrated onto a photonic crystal cavity shows enhanced bolometric response owing to improved light absorption and ultrafast thermal relaxation time.

Quantum fluctuations have been detected in a macroscopic, millimole-scale solid-state spin ensemble without the use of external excitations, enabling non-invasive quantum sensing techniques.

An analysis of whole-exome sequencing data linked to longitudinal electronic health records from 44,028 British South Asians finds new gene–phenotype associations and identifies 2,991 genes with rare biallelic predicted loss-of-function genotypes.

Experimental evolution of fission yeast (Schizosaccharomyces pombe) in the same environment as a previous experiment with budding yeast (Saccharomyces cerevisiae) reveals parallel evolution but distinct molecular mechanisms and targets of adaptation in the two species.

An improved strategy for siting food and energy production is needed to avoid further habitat loss. This paper presents a multi-sector framework that can empower land use planners to find synergies across conservation and development sectors.

A national classification system of wetland hydrologic connectivity to streams, which could be applied globally, demonstrates and advances current understanding of how wetland connectivity affects surface water quality.

Thermal inertia is used to infer physical properties of asteroid surfaces. Here, authors propose that the low thermal inertia of asteroids Bennu and Ryugu is driven by cracks in rocks resulting from geological processes within the parent body – or more recently through micrometeorite impacts

Prediction of tumour recurrence in anal squamous cell carcinoma can be challenging. Here, the authors use a tumour-informed ctDNA assay to show concordance with relapse in patients following failed definitive-intent chemoradiation.

Air purification could avert 60 million disability-adjusted life years (DALYs) from wildfire-related fine particulate matter (PM_2.5) and 2.2 billion DALYs from all-source PM_2.5 globally, according to a global assessment integrating health gains and economic feasibility.

Metal–halide complexes are central to light emission in halide perovskites, but their bottom-up spatial arrangement is difficult to control. Now a crown-ether-assisted supramolecular strategy has been shown to enable the synthesis of one-dimensional metal–halide molecular wires with high photoluminescence efficiency and strong nonlinear optical responses.

The APOE-ε4 allele is the strongest genetic risk factor for late-onset Alzheimer’s disease, but it is not deterministic. Here, the authors show that common genetic variation changes how APOE-ε4 influences cognition.

Over five years, implementation of the NHS England Lung Cancer Screening Programme achieved high early-stage detection rates and demonstrated that the programme is both feasible and scalable for reaching high-risk and underserved populations.

The rapid evolution of SARS-CoV-2 challenges antibody therapeutics, but glycan-masked antigens enable isolation of class 3 monoclonal antibodies that potently neutralize diverse Omicron variants and reveal cross-reactive epitopes.

Using nasal brush biopsies from the olfactory region, single-cell profiling revealed neuroimmune alterations in Alzheimer’s Disease detectable at a pre-clinical stage, offering an accessible window into early neurodegenerative disease in humans.

Children with dyslexia show significant differences in Visual Word Form Area size and specialization compared to typical readers, suggesting enduring neural characteristics exist even after targeted intervention increases reading ability scores.

A pangenome reference for the phenotypically diverse crop sorghum aims to help accelerate future efforts to breed crops that are better adapted to changing environments.

Plasma p-tau217 tests used to develop clocks that predict when cognitively unimpaired individuals would develop symptoms of Alzheimerʼs disease.

Glioblastoma is characterised by high levels of intratumoural heterogeneity and plasticity, hindering treatment. Here, the authors develop an analytical framework, scFOCAL, to predict the sensitivity of glioblastoma cell subpopulations to therapies based on reversal of disease transcriptional signatures to identify synergistic therapeutic combinations.

In a large UK-based primary care randomized trial, immediate artificial intelligence (AI)-driven prioritization of chest X-rays did not significantly shorten time to computed tomography or lung cancer diagnosis versus standard workflow, suggesting that AI-based prioritization alone is unlikely to accelerate the lung cancer diagnostic pathway.

In this Review, Emmert and colleagues provide an overview of the clinically available metallic and polymeric stents used to treat coronary artery disease and valvular heart disease, and discuss the manufacturing techniques used to fabricate these stents, with a focus on the emerging role of 3D-printing technologies.

Stable and cell-specific transgene expression can be achieved through in vivo site-specific integration of large DNA payloads using a two-vector system of enveloped delivery vehicles and adeno-associated viruses.

In this study, the authors examine the potential shared genetic vulnerability across externalizing traits related to substance use and to substance use disorders.

As presented at the 2026 ASCO Genitourinary Cancers Symposium, in the phase 2 INDIBLADE trial, induction therapy with ipilimumab and nivolumab followed by consolidating chemoradiotherapy in stage II/III muscle-invasive bladder cancer led to encouraging bladder-intact event-free survival outcomes that were associated with ctDNA clearance.

Different agricultural management systems, for example, conventional versus organic, can have different benefits and challenges. Authors here examine the biodiversity, crop yield and ecosystem multifunctionality impacts of transitioning from conventional to organic agriculture across 179 global croplands.

Longitudinal metatranscriptomics in a prospective cohort of 1,164 adults hospitalized for COVID-19 reveals that azithromycin offered no apparent anti-inflammatory benefit but enriched the respiratory microbiome with potential pathogens and antimicrobial resistance genes.

Murthy and colleagues discussed recent research on the effect of a tucanitib–trastuzumab–capecitabine regimen in patients with HER2⁺ breast cancer and leptomeningeal metastasis.

R-loops cause genome instability by creating conflicts with transcription and replication. Here the authors show that SFPQ binds R-loops at repetitive elements, recruits DAXX and maintains H3.3 deposition. Loss of SFPQ leads to genome instability and cGAS–STING activation, correlating with improved sarcoma patient survival.