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N-desethyl-fluornitrazene is a µ-opioid receptor agonist derived from nitazenes that has supramaximal intrinsic efficacy that produces analgesia with minimal adverse effects in rodent models.

Encoding polarization information using multiplexed off-axis holography yields a scheme for performing ultrafast chiroptical microscopy.

Oversimplified synthetic wastewater misjudges fouling drivers and distorts economics. This study reveals that organic synergies counterintuitively mitigate membrane fouling, advocating for compositional fidelity to bridge lab-industry gaps.

Schiller and colleagues present a systematic comparison of methods that quantify whether pairs of cell types preferentially co-occur in tissues, highlighting their strengths and limitations. This study also introduces COZI for sensitive detection of directional spatial relationships.

Kancharla, Kelly et al. identify an acridone antimalarial potent across all major parasite life stages. Lead candidate T111 shows oral efficacy, low toxicity, and synergy with tafenoquine, providing a unique mechanism to overcome resistance.

Femtosecond laser pulse-induced coherent helicity switching of magnetic vortices in permalloy disks on picosecond timescales is reported.

Fabricating coloured radiative cooling coatings that are easy to produce and do not compromise cooling performance is challenging. Ying Liu et al. develop a one-step fabrication method that yields coloured ethyl cellulose coatings while preserving high solar reflectance.

High entropy spinel oxides host multiple metals in one crystal structure with tunable catalytic properties, but controlling coordination site occupancy of metal cations is difficult. Here, the authors exploit site preference energy differences to direct metal occupancy, boosting conductivity and oxygen evolution activity.

Nanoscale bandgap tuning in van der Waals heterobilayers using an electro-plasmonic nanocavity provides electrical control of exciton dynamics, producing localized interlayer exciton density gradients and enhanced diffusion currents in the nanoscale.

Spatial transcriptomics and immunofluorescence microscopy of human samples and mouse models reveal that infection-driven cholesterol overload in granulomas impairs macrophage–CD4⁺ T cell interactions and anti-tuberculosis immunity.

Wide-field quantum sensing shows μm-scale inhomogeneous superconductivity in high-pressure La₃Ni₂O₇, linking local diamagnetic response to stress and stoichiometry and clarifying mechanisms that suppress or enhance superconductivity.

Here authors define a detailed ontology of point defects in Ti3C2 MXenes through STEM imaging, computer vision and statistical analysis, and MC-MD simulations, providing a framework to understand the 3D structure of MXenes that is applicable to a wide class of 2D materials.

The introduction of liquid metals to refractory metals weakens metal bonding, which enables rapid, low-temperature fabrication of refractory metal bulk materials with ultrafine grains, high strength and tunable composition.

ROS-mediated sulfenylation or ‘oxidative activation’ of p-GSK-3β can terminate glycogenesis and initiate gluconeogenesis by modulating Gys2 and FoxO1, leading to hepatic insulin resistance.

Drosophila larvae grow a hundredfold within a few days. Lefranc et al. reveal that gut metabolism is transiently reprogrammed to support unbridled juvenile growth but also adult fitness, showing that early-life metabolism shapes lifelong physiology.

Global Burden of Disease analysis found that in 2023, suboptimal diet was estimated to be responsible for 4 million deaths and 97 million morbidity burdens from ischemic heart disease.

Widespread declines in common species raise concerns, but links to extinction risk and climate change remain unclear. Here, the authors show that many small climate change effects can accumulate to drive rapid population extinction in a common iconic bird.

Bimerons are magnetic solitons that are topologically equivalent to skyrmions in in-plane magnetized systems. This study demonstrates the room-temperature creation of bimerons in Co₈Zn₈Mn₄ via femtosecond laser pulse excitation, revealing dynamic topological control and morphological transitions of these solitons.

Atmospheric circulation patterns and mean climate conditions lead to heterogeneity in water isotope–temperature relationships across Antarctica, and accounting for these effects allows for more robust interpretation of temperature proxy records from ice cores.

High hole mobilities in a polarization-induced two-dimensional hole gas at a gallium nitride/aluminium nitride interface can allow Shubnikov–de Haas oscillations of light and heavy holes to be observed in gallium nitride.

CenSpark is a dual-ligand fluorescent probe binding simultaneously inner and outer microtubule sites, a configuration unique to doublet and triplet microtubules, enabling selective live imaging of centrioles and cilia across species.

Catalytic ammoxidation of methylarenes to nitriles is industrially relevant, yet current systems rely on noble metals or harsh conditions. Now an Fe-based single-atom catalyst in B,N-doped carbon enables selective C(sp³)–H ammoxidation and C–C cleavage using molecular oxygen and ammonia.

JWST phase-curve observations reveal that the two innermost TRAPPIST-1 planets emit thermal radiation consistent with bare rocky surfaces, indicating that both lack thick atmospheres.

Exploiting the differences between quantum and classical physics typically requires nonlinear devices. Quantum nonlinear effects have now been demonstrated in a nanomechanical resonator due to strong coupling with an intrinsic two-level defect.

Physical networks can learn to accomplish tasks on the fly by adjusting their internal parameters. Now it is shown that such physical learning can be achieved in metamaterials that can learn to change shape.

Classical understanding of aromaticity has been challenged by its emergence in rings featuring only metal atoms. Now, diuranium and dithorium inverse sandwich complexes featuring a central cyclo-Bi₃³⁻ unit have been synthesized. These tribismuth rings exhibit exalted diamagnetism and are σ-aromatic, in contrast to the π-aromaticity in analogous tricarbon rings, providing benchmark data for comparisons between organic and inorganic aromaticity.

Operando birefringence microscopy measurements of the stresses around growing dendrites in solid electrolytes show that stresses decrease as current densities increase, revealing a linkage between electrochemical and mechanical stability that informs the design of solid-state batteries.

Analysis of neuroimaging datasets across five major psychedelics revealed a shared brain signature and provides a comprehensive insight into how these drugs reorganize brain architecture.

Feng, Alvarenga et al. use cryo-electron microscopy to visualize the activation of the transmembrane protein 16F channel and scramblase in liposomes to show that it adopts a conformation that forms separate pathways for ions and lipids, thereby rationalizing its dual activity.

Global observations show that ecosystems sustain transpiration at temperatures above those that maximize photosynthesis. This thermal gap reveals that carbon uptake declines before water loss under climate warming.

SAGA regulates gene expression through KAT2A‑mediated acetylation, but how KAT2A stability is controlled was unclear. Here, the authors show that SAGA CORE subunits stabilise KAT2A, and that unassembled KAT2A is targeted by UBR5 and OTUD5 for degradation.

Starburst galaxies are seen to host galaxy-scale winds, which are super-fast and could be powered entirely by the thermal pressure of gas heated by supernovae.

The mechanisms driving reversible dedifferentiation events towards a drug-tolerant persister (DTP) state remain to be explored. Here, multi-omics, information-theoretic approaches and dynamic systems modelling highlight the role of the oxidative-stress–mediated NF-κB/RelA axis in driving the transition towards DTP across multiple cancer types.

Scalable fabrication of ordered perovskite quantum dot superlattices enables high-efficiency, ultrahigh-resolution LEDs and active-matrix displays with greatly improved brightness, stability and device lifetime.

This study shows that magnetic fields speed film regeneration on scratched 70/30, Cu-Ni alloys in seawater, yielding the NiO-rich single-layer film with improved, corrosion resistance and offering a new way to extend marine engineering equipment lifespan.

Induction of hypothermia during hibernation/torpor enables certain mammals to survive under extreme conditions. Here, the authors show that the natural product P57 induces hypothermia by targeting pyridoxal kinase and has a potential application in therapeutic hypothermia.

BioMedAgent is a self-evolving LLM multi-agent framework that learns to use various bioinformatics tools and chain them into executable workflows for autonomously carrying out diverse biomedical data tasks initiated by natural-language prompts.

A randomized controlled trial in rural Burkina Faso found no evidence that providing small labelled cash transfers to support healthcare visits for individuals with chronic non-communicable diseases improved their care linkage or treatment uptake.

Exposome analyses across 34 countries showed that social exposures were associated with faster functional brain aging and physical exposures with faster structural brain aging.

BaTa₂S₅, which consists of alternating layers of TaS₂ and Ba₂TaS₄, is shown to host a triplet superconducting phase at high magnetic field. This triplet phase emerges from another—more conventional—superconducting state.

The response of Mars’ ionosphere to major solar energetic events has been known, but such observations are challenging. Here, the authors show mutual radio occultation observations revealing that a solar flare in May 2024 enhanced the lowest ionospheric layer of Mars by 278% of its typical size.

Urban water systems in low-income cities often face contamination risks and unreliable supply, motivating evaluations of infrastructure upgrades. An assessment of the impact of water service line replacements on water quality and access in Beira, Mozambique, reveals reduced source water contamination and improved access.

Light-responsive hydrogels allow the generation of dynamic microstructures, but spatial resolution can be limited and response times slow. Here, the authors report the development of a light-responsive thin film with surface modulation at sub-micron resolution and fast actuation in response to patterned illumination.

Social rewards hold therapeutic potential for alleviating drug relapse, yet the neural substrates remain unclear. Here, authors show that social reward and drug relapse activate distinct dopaminergic populations within the VTA, which dynamically compete to regulate behavioral outcomes.

Kim et al. revealed how taste receptor type 2 member 43, a bitter taste receptor that detects coffee-derived compounds, recognizes bitter tastants through cryo-electron microscopy structures of ligand-bound complexes, supported by biochemical and computational analyses, providing a structural framework for coffee bitter taste signaling.

This study from Wei-Guang Li, Tian-Le Xu and colleagues shows that neuropeptide Y released by specific hippocampal inhibitory neurons can switch fear memories into extinction memories by acting on two distinct receptor-defined neuron populations.

Urea, the most widely used nitrogen fertilizer, has unknown impacts on freshwater ecosystems. This study demonstrates that urea additions in Canadian prairie agricultural reservoirs triple phytoplankton abundance without increasing cyanobacterial toxins, revealing considerable nitrogen loss to the atmosphere and highlighting potential global water quality degradation in phosphorus-rich agricultural regions.

Structured polarization fields drive stress-induced reconfiguration of azopolymer micropillars, enabling vectorial field-guided lithography of programmable complex microstructures, which are quantitatively predicted by the Viscoplastic PhotoAlignment model.