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This study provides evidence of a cascading positive tipping point towards electric vehicles, which has occurred or lies within the next few years in lead markets of the EU and China, and potentially the US, and it could spill out into peripheral vehicle marketss across the rest of the world.

Detecting tipping points and predicting extreme events from data remains a challenging problem in complex systems related to climate, ecology and finance. The authors propose a data-driven approach to estimate probabilities of rare events in complex systems, and detect tipping points/catastrophic shifts.

Single-species antibiotic dose response is a poor predictor of multi-species community dynamics because it cannot foresee the tipping points that cause irreversible changes in resistance that persist even when treatment stops.

The tipping points framing is widely used in climate discussions but receives mixed feedback. This Perspective critiques it for oversimplifying the complexities of natural and social systems and failing to drive effective action, and offers recommendations for future improvements.

Biomarkers of the tipping point before metastasis in hepatocellular carcinoma (HCC) could help stratify patient treatment. Here, the authors study dynamic network biomarkers to identify CALM3 as a potential suppressor of metastasis, the level of which can predict overall survival and relapse-free survival in postoperative HCC.

Integrated assessment modelling backed by expert judgement indicates that the existence of future multiple interacting climate tipping points, with irreversible economic damages, greatly increases the social cost of carbon.

Climate change could drive critical parts of the Earth system past tipping points, causing large-scale, abrupt and/or irreversible changes that harm societies. Here, the authors suggest that satellite remote sensing can play a unique role in helping manage these profound risks, by providing improved early warning of tipping points across scales.

The electronic transport properties of charge-ordered kagome metals are controversial. Now careful measurements on unperturbed samples show that previously measured anisotropy in the transport occurs only when external perturbations are present.

Most chemotherapeutic agents, including gemcitabine, do not elicit immunogenic cell death, a phenomenon associated with the release of damage-associated molecule patterns (DAMPs). Here, the authors show that gemcitabine-treated dying cancer cells express hallmark DAMPs but their immunogenic properties are hindered by the concomitant release of the inhibitory DAMP PGE₂.

Analysis of the uncertainty associated with the timing of climate tipping points suggests that carbon taxes need to be increased by a minimum of 50%. If considering a rapid, high-impact tipping event, these taxes should be more than 200% higher. This implies that the discount rate to delay stochastic tipping points is much lower than that for deterministic climate damages.

It has been postulated that there is a threshold temperature above which permafrost will reach a global tipping point, causing accelerated thaw and global collapse. Here it is argued that permafrost-thaw feedbacks are dominated by local- to regional-scale processes, but this also means there is no safety margin.

A tipping point occurs when an external forcing causes a qualitative change in a system. Human-induced climate change could push several large elements of the climate system, such as the Greenland ice sheet, past a tipping point. Given the severity of the potential impacts, early warning of these changes would be advantageous. This Review discusses the most promising approaches to early warning of tipping points.

International climate policy needs to induce a socioeconomic tipping to a low or no-carbon economy if we are to avoid climate change tipping points.

Measurements of the composition-dependent viscosity of rhyolitic magma reveal a tipping point that changes the physical properties of the melt and controls the transition between effusive and explosive eruptions.

Riera and Dillin review how longevity is affected by metabolic changes and mitochondrial function.

Spin manipulation for quantum information processing often requires cost-intensive sample design and cryogenic temperatures. Now, surface functionalization of CsPbBr₃ quantum dots enables coherent optical manipulation of hole spins under ambient conditions.

Indonesian Throughflow has nonlinear response to CO2, with a rapid decline after crossing a tipping point. The first tipping point may be approaching, signaling a potential climate tipping element with implications for global climate.

The end of the green Sahara in the mid-Holocene was gradual, but punctuated by rapidly changing episodes of extreme drought and wetness, to which human societies were exposed and had to adapt to, as a lake record from southern Ethiopia suggests.

This study highlights the role Polar regions as a limiting factor in global sustainability due to teleconnection effects, and then propose a SDG target, key indicators, and emphasize Indigenous inclusion and global action.

In this study, the authors use a combination of experimental and modeling approaches to show that a human gut bacterial community can exist in different states under the same conditions. The mechanism behind these alternative states is likely based on metabolic change in response to nutrient depletion.

We find that justice considerations constrain the integrated Earth system boundaries more than safety considerations for climate and atmospheric aerosol loading, and our assessment provides a foundation for safeguarding the global commons for all people.

Climate policies based on conventional economic models that assume that citizens are entirely self-interested may trigger negative responses, even among those who support green lifestyles. A more dynamic approach is proposed, accounting for the importance of green values that may be undermined or enhanced by policy.

Zhu et al. find that aging causes region-specific myelin damage in the spinal cord, which is counteracted by enhanced TGFβ signaling in microglia, revealing a protective mechanism for healthy aging.

This study identifies certain “early warning signs” of exploratory decisions in the brain and body, suggesting that exploration may be the result of an arousal-driven tipping point in prefrontal brain states.

Abrupt changes are developing across Antarctica’s ice, ocean and biological systems; some of these changes are intensifying faster than equivalent Arctic changes, potentially irreversibly, and their interactions are expected to worsen other impacts across the Antarctic environment and global climate system.

Incorporating evolutionary dynamics into a population model, the authors show that, even though changing ecological conditions are not enough to induce an immediate regime shift in the system, selection-induced evolutionary responses acting on a phenotypic trait may eventually cause a regime shift by pushing it beyond a tipping point after a substantial delay.

Rooftop photovoltaic systems are often seen as a niche solution for mitigation but could offer large-scale opportunities. Using multi-source geospatial data and artificial intelligence techniques, the authors map their potential for reducing global temperatures and analyse regional differences.

Abrupt regime shifts could in theory be predicted from early warning signals. Here, the authors show that true critical transitions are challenging to classify in lake planktonic systems, due to mismatches between trophic levels, and reveal uneven performance of early warning signal detection methods.

The dramatic loss of Arctic sea ice with climate change has led to the prediction of a tipping point beyond which ice loss is irreversible and polar bear habitat will be catastrophically lost. By contrast, this study shows a linear relationship between temperature and sea-ice coverage that overcomes the albedo effect that would cause a tipping point. As a result, reducing greenhouse gas emissions can have a positive effect on polar bear populations.

Ecosystem Based Management measures developed to prevent overfishing could be particularly important under climate change. Here the authors combine climate and fish stock modelling to show that EBM cap implementation reduces climate-driven fishery declines under RCP 4.5 and 8.5 before midcentury. However, there are thermal tipping points beyond which potential collapses are predicted.

Reactive nitrogen (Nr) contributes strongly to PM_2.5 air pollution in Europe. Here, authors identify diverse Nr control pathways for Europe depending on emission and pollution formation and a priority of NH₃ control when costs are considered.

Detailed understanding of how cancer cells transition from a drug sensitive to a tolerant state is lacking. Here, using single cell proteomic and metabolic data the authors uncover that isogenic BRAF mutant melanoma cells can take two distinct paths to become tolerant to BRAF inhibition.

Semantic arguments about the definition of 'tipping points' are distracting attention away from the causes and impacts of climate change in the Arctic.

The authors assess the risk of overshoot beyond 1.5 °C warming, using three scenarios with minimal overshoot, brief overshoot and sustained overshoot. They show a risk of long-term Amazon dieback, which begins as early as 1.3 °C warming but is largely mitigated by reducing temperature below 1.5 °C.

Plant traits drive ecosystem dynamics yet are challenging to map globally due to sparse measurements. Here, the authors combine crowdsourced biodiversity observations with Earth observation data to accurately map 31 plant traits at 1 km² resolution.

A challenge for testing mechanisms of past climate change is the precise correlation of palaeoclimate records. Here, through climate modelling and the alignment of terrestrial, ice and marine ¹⁴C and ¹⁰Be records, the authors show that Southern Ocean freshwater hosing can trigger global change.

RNF114 is an E3 ligase that can recognize ADP-ribose (ADPr) and ubiquitin with separate domains. Using these domains, Kolvenbach and Palumbieri et al. developed a proteomics approach to map ADP-ribosyl-ubiquitylation sites, revealing that serine ADPr induced by DNA damage is a target for ubiquitylation.