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Understanding collective behaviour is an important aspect of managing the pandemic response. Here the authors show in a large global study that participants that reported identifying more strongly with their nation reported greater engagement in public health behaviours and support for public health policies in the context of the pandemic.

Supersolids combine superfluid and crystal order and their response to external driving remains unclear. Now it is shown that, in a dipolar supersolid, rotation induces synchronization of the crystal motion via vortex nucleation.

In a first global analysis, researchers find that sandy shores are severely squeezed between human infrastructure and the rising sea, as on average, the first road or building is currently situated at just 390 meters distance from the shoreline.

Despite frequent AKT/mTOR pathway activation in patient’s rhabdomyosarcoma (RMS), success of AKT inhibitors in the clinical has been limited. Here, using RMS patient-derived models, the authors demonstrate that the efficacy of the AKT inhibitor, ipatasertib, is in part due to its off-target effects on PRKG1, identifying PRKG1 as a potential biomarker for ipatasertib response.

The distribution of consumer food expenditures across value-added activities on farms and in the post-farmgate value chain, although important, has been overlooked. Building on a global food dollar series, this study shows how the farm and post-farmgate shares of consumer food expenditures evolve in response to changing economic, demographic and agricultural conditions in different regions.

Solitons are encountered in a wide range of nonlinear systems, from water channels to optical fibres. They have also been observed in Bose–Einstein condensates, but only now have such ‘ultracold solitons’ been made to live long enough for their dynamical properties to be studied in detail.

Giardini et al. present an imaging method that combines quantitative measurements of cardiac electrophysiology with high-resolution three-dimensional structural reconstructions, enabling the detection of arrhythmogenic electrical coupling between cardiomyocytes and non-myocytes in murine hearts.

The rTg4510 mosue line has a tauopathy-like phenotype which is attributed to overexpression of human tau in the frontal cortex. Here the authors identify potential confounding genetic factors that could contribute to the phenotype.

N-Myc fuels neuroendocrine prostate cancer. Here, the authors describe how targeting HSP70, a major N-Myc partner, coordinates with STUB1 to facilitate the degradation of N-Myc. This process slows neuroendocrine prostate cancer growth, improves the efficacy of Aurora Kinase A inhibitors, and reduces neuroendocrine pathway activity.

The advantage of living in cities compared with rural areas with respect to height and BMI in children and adolescents has generally become smaller globally from 1990 to 2020, except in sub-Saharan Africa.

Photoinhibition of photosystem I and differential damage of FeS clusters under high light levels are natural phenomena in angiosperms that control electron flow to molecular oxygen while maintaining optimal carbon dioxide assimilation.

Magnetostirring is used to rotate the magnetic field and set a dipolar supersolid composed of ultracold atoms spinning, revealing fundamental differences in vortex seeding dynamics between modulated and unmodulated quantum fluids.

The lymphatic vasculature has emerged as a key component of the heart’s response to injury, influencing both regeneration and maladaptive remodeling. Research now highlights the role of lymphatic clearance in shaping the composition of tissue-resident macrophages within the neonatal heart.

One third of all epilepsies are treatment-resistant. Here, the authors show in a genetic model of epilepsy that a repurposed drug can correct cell defects, brain circuits and seizure-like events by accelerating endocytosis.

Recovery of ancient Mycobacterium lepromatosis genomes in 4,000-year-old human remains from Chile demonstrates that this causal agent of Hansen’s disease has a long history in the Americas, predating the colonial period by millennia.

Brain evolution at the cellular level is understudied. Here, the authors compare olfactory circuits from three Drosophila species, finding species-specific connectivity patterns associated with food odours and suggesting that more connectivity may be related to learning performance.

Eva Hoffman, Alan Handyside and colleagues generate genome-wide maps of crossovers and chromosome segregation patterns by recovering all three products of single female human meioses. They detect a reverse chromosome segregation pattern and selection for higher recombination rates in the female germ line and report chromosomal drive against non-recombinant chromatids at meiosis II.

In a phase 2 trial of adults with neurofibromatosis type 1 and inoperable/growing plexiform neurofibromas, treatment with the MEK inhibitor selumetinib resulted in an objective response rate of 63.6% and improvement in other patient outcomes, with additional biopsy-based data providing further information on drug activity.

Surveys from 2,584 sites across the Indo-Pacific identify key climate, socioeconomic and environmental drivers associated with hard coral assemblages. This informs a strategic approach to protect, recover or transform coral reef management.

Here, the authors reveal the emerging replication timing program in mouse zygotes and 2-cell embryos, which differs from embryonic stem cells. They find systematic differences between the replication timing of the two parental genomes at pericentromeric regions and Polycomb target sites.

The authors use fisheries databases and predictive models to understand past and future changes in the availability of iron, calcium omega-3 and protein from seafood. They show disproportional loss of nutrients in tropical low-income countries, which will be exacerbated by higher levels of global warming.

The extent to which the ocean acts as a sink and source of airborne particles to the atmosphere is unresolved. Here, the authors report high microbial loads over the tropical Atlantic, Pacific and Indian oceans and propose islands as stepping stones for the transoceanic transport of terrestrial microbes..

Methods for automated fluorescence imaging allow high-throughput examination of reporter expression patterns in zebrafish embryos. They are applied to mapping promoter-enhancer interactions in this organism.

Cardiac regeneration is hindered by the limited division of cardiomyocytes. Here, the authors show that Arid1a drives maturation and limits proliferation through interaction with Yap. Suppression of Arid1a enhances proliferation after injury.

Assessing microbial water quality is an important approach to monitor potential risks to human and environmental health. The use of two human faecal bacteria as molecular indicators is shown to be more sensitive than conventional measures for detecting contamination on an extensive set of data.

Bohn et al. present and test a model to explain how children combine information during word learning. They conclude that children become more sensitive to individual information sources with age, but the way they integrate information remains stable.

Increased susceptibility to gastrointestinal infections and colitis can be driven by a failure to maintain intestinal homeostasis. Here, using a forward genetic screen, Song et al. identify and characterise the role of TVP23B in Paneth cell and goblet cell function, and its impact on colitis.

Michael Talkowski and colleagues analyze balanced chromosomal abnormalities in 273 individuals by whole-genome sequencing. Their findings suggest that sequence-level resolution improves prediction of clinical outcomes for balanced rearrangements and provides insight into pathogenic mechanisms such as altered gene regulation due to changes in chromosome topology.

ZEB2 transcription factor is increased in a subset of cardiomyocytes during stress to induce cardioprotective effects after injury. Here the authors show that therapeutic delivery of ZEB2 prevents cardiac dysfunction after ischemic damage and promotes the activation of pro-angiogenic signals.

Here, the authors use cryo-EM and biochemical analysis to investigate how the CRISPR-associated protein Cas9 interrogates DNA to locate its RNA-matching target sequence.

SMARCA4 is commonly inactivated in lung and ovarian cancers. Here the authors show that SMARCA4-deficient tumours have significantly reduced levels of the histone demethylases KDM6s and a strong dependency on these demethylases for tumour growth, so that they are vulnerable to KDM6s inhibition.

Trafficking of IgA/commensal complex in the gut has been implicated in inflammatory bowel diseases such as Crohn’s disease, but molecular insights are still lacking. Here the authors show, using mouse model or human cells, that NOD2 mutation increases IgA transport, potentially by altering gut microfold cells from the gut, to impact gut inflammation.

CD39 is an ectonucleotidase associated with immunoregulatory function. Here authors show regulation of CD39 expression by an endogenous antisense RNA moiety transcribed from the 3‘ end of CD39/ENTPD1 which when itself is silenced results in amelioration of pathology in an animal model of colitis.

Here the authors present a SARS-CoV2 seroepidemiological observational study from a random, household-based study population in a small town in Germany, showing the effect of a super-spreading event on infection rate, severity, and potentially infection fatality rate.