Baseline conditions- Blacks/Males ingesting a “Typical American Diet” exhibited lower urinary tumor necrosis factor-α (TNF-α) levels than Whites/Females, likely contributing to higher Na+ - K+ -2Cl- cotransporter type 2 (NKCC2) activity as previously suggested for Black vs White individuals. Higher urinary TNF-α in Females may be required to suppress inherently higher NKCC2 activity to maintain homeostasis. After randomization- Urinary TNF-α increased only for those on the high sodium & control diet, an effect which appeared to be attenuated for those on the Dietary Approaches to Stop Hypertension (DASH) diet.
- Elizabeth D. Drugge
- Khalid Farhan
- Nicholas R. Ferreri
