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Analysis combining multiple global tree databases reveals that whether a location is invaded by non-native tree species depends on anthropogenic factors, but the severity of the invasion depends on the native species diversity.

Pre-treatment dual immune checkpoint blockade in cervical cancer remains understudied. In this trial, the authors show that neoadjuvant immune checkpoint blockade enhances immune activation and correlates with improved response to subsequent chemoradiation in patients with cervical carcinoma.

Targeting alterations in both the PI3K-AKT-mTOR and DNA repairs pathways has shown synergy in preclinical studies. Here, the authors a phase I/II clinical trial investigating the combination of Olaparib (PARP inhibitor), metronomic cyclophosphamide (chemotherapy) and metformin (PI3K-AKT-mTOR inhibitor) in patients with recurrent endometrial carcinoma.

Boué et al. longitudinally assess cognition in patients aged ≥70 years receiving hormone therapy for metastatic prostate cancer. Poorer objective and subjective cognition occurs in patients receiving hormone therapy, particularly when androgen receptor pathway inhibitors (ARPI) are added to androgen deprivation therapy (ADT).

Single-agent maintenance PARP inhibition may represent an effective strategy for advanced/metastatic endometrial cancer treatment. Here this randomized phase IIb UTOLA trial evaluates the efficacy and safety of orally administered olaparib in female patients (n = 145) without progression following front-line platinum-based chemotherapy for advanced/metastatic endometrial cancer.

Species’ traits and environmental conditions determine the abundance of tree species across the globe. Here, the authors find that dominant tree species are taller and have softer wood compared to rare species and that these trait differences are more strongly associated with temperature than water availability.

Pluripotent stem cells can integrate into embryos and contribute to all tissues, including the germline, when in a naïve state. Here, authors identify factors that reprogram rabbit iPSCs into a naïve-like state capable of generating viable germline chimeras.

Wood density is an important plant trait. Data from 1.1 million forest inventory plots and 10,703 tree species show a latitudinal gradient in wood density, with temperature and soil moisture explaining variation at the global scale and disturbance also having a role at the local level.

A superconducting transition is used to switch a single molecule magnet from a blocked magnetization state to a resonant quantum tunnelling regime

Immune checkpoint blockade could improve the complete cytoreduction rate with standard-of-care neoadjuvant chemotherapy (NACT) in patients with ovarian cancer. Here the authors report the results of a randomized phase II trial of NACT alone or in combination with pembrolizumab (anti-PD1) in patients with advanced high-grade serous carcinoma.

Analysis of ground-sourced and satellite-derived models reveals a global forest carbon potential of 226 Gt outside agricultural and urban lands, with a difference of only 12% across these modelling approaches.

Magnetic molecules have long been seen to hold promise in magnetic sensing applications. In this paper, Serrano et al show that a single layer of a magnetic molecule, a terbium based complex, is sensitive to the local magnetic field variation of a superconducting surface on which it is deposited.

Alternative stable states in forests have implications for the biosphere. Here, the authors combine forest biodiversity observations and simulations revealing that leaf types across temperate regions of the NH follow a bimodal distribution suggesting signatures of alternative forest states.

In patients with newly diagnosed, transplant-ineligible multiple myeloma, addition of weekly bortzomib to isatuximab, lenalidomide and dexamethasone leads to increased minimal residual disease negativity compared with isatuximab, lenalidomide and dexamethasone.

The adaptive, biomarker-driven BISCAY trial evaluating durvalumab with targeted agents in patients with metastatic urothelial carcinoma based on tumor genomic alterations finds no added clinical benefit over durvalumab monotherapy.

Examining drivers of the latitudinal biodiversity gradient in a global database of local tree species richness, the authors show that co-limitation by multiple environmental and anthropogenic factors causes steeper increases in richness with latitude in tropical versus temperate and boreal zones.

Current cell segmentation methods for Saccharomyces cerevisiae face challenges under a variety of standard experimental and imaging conditions. Here the authors develop a convolutional neural network for accurate, label-free cell segmentation.

Integrating inventory data with machine learning models reveals the global composition of tree types—needle-leaved evergreen individuals dominate, followed by broadleaved evergreen and deciduous trees—and climate change risks.

A spatially explicit global map of tree symbioses with nitrogen-fixing bacteria and mycorrhizal fungi reveals that climate variables are the primary drivers of the distribution of different types of symbiosis.

Weak magneto-chiral dichroic effects may explain why biomolecules all have the same chirality, but they are notoriously difficult to observe. Using hard X-rays, strong magneto-chiral dichroism has now been observed in a paramagnetic molecular helix.

Single-molecule magnets are molecular complexes with magnetic bistability, and recently it was shown that such a magnetic memory effect is retained for Fe₄ clusters when they are wired to a gold surface. These authors have tailored the clusters to have a preferential orientation and form a self-assembled monolayer on the surface. It then becomes possible to observe quantum tunnelling of the magnetization, which shows up as steps in the magnetic hysteresis loop.

Molecular magnets are promising for their use as high-density memory devices. However, maintaining the molecules’ magnetic state when bonded to a substrate has been impossible. The discovery, in sophisticated experiments, that single magnetic molecules can indeed show magnetic hysteresis when wired to a gold surface opens the door to individually address magnetic molecules.