Search

Global analysis of obesity trends from 1980 to 2024 in 200 countries and territories using data from 4,050 population-based studies reveals that framing obesity as a single global epidemic masks the highly varied dynamics across countries and age groups.

Results from integrative population-based investigations indicate co-occurring types of clonal hematopoiesis are highly enriched and markedly increase blood cancer risk, highlighting new opportunities for early detection and targeted surveillance of high-risk individuals.

Molecular precursors containing V, Bi and Zn are thermally transformed into oxide materials. Detailed studies reveal and characterise the formation of amorphous intermediates, a new kinetic polymorph of BiVO₄, and incorporation of Zn dopants.

Natural silk, mechanically strong and biodegradable, offers great potential for sustainable functional materials. Here the authors present a simple thermomechanical method for fabricating high-performance structural and optically active materials directly from silk fibres.

Lithium sulfides have been previously investigated as 1 V anodes for Li-ion batteries, but suffered from significant performance issues. Here, the authors report on a 1 V lithium sulfide electrode with noteworthy performance, demonstrating that sulfide-based electrodes may merit further exploration.

Ferromagnetic systems produced by the transition metal doping of semiconductors may be used as components of spintronic devices. Here, a new ferromagnet, Li_1+y(Zn_1-xMn_x)As, is prepared in bulk quantities and shown to have a critical temperature approaching 50 K.

PTCHD1-AS, which encodes a long non-coding RNA, is associated with the aetiology of autism spectrum disorder in humans through striatal molecular and circuit-level dysregulation.

A self-powered artificial leaf integrating a perovskite photocathode with a noble-metal-free spinel oxide anode enables simultaneous solar-driven hydrogen production and efficient degradation of toxic hydrazine without any external bias.

Global Burden of Disease analysis found that in 2023, suboptimal diet was estimated to be responsible for 4 million deaths and 97 million morbidity burdens from ischemic heart disease.

MOSAIC is a versatile multimodal microscope that allows seamless transition between various light-sheet, two-photon, label-free and super-resolution modalities. It is demonstrated in various systems ranging from cell culture to mice.

Three-body low-energy s-wave states play an important role in few-body physics and associated universal phenomena, yet their experimental observation in nuclear system has been elusive. Here, the authors identify the three-body s-wave properties in neutron-rich ¹⁰He nuclei with improved statistics and sensitivities.

Selective iodoplumbate cold casting enables kinetically stabilized hybrid perovskites through control of precursor chemistry and crystallization kinetics. This strategy produces uniform 2D layers that enhance out-of-plane charge transport in 3D:2D bilayer devices, achieving power conversion efficiencies of 25.14% in small-area devices and 22.36% in mini-modules.

Autophagic activity has a protective role in Alzheimer’s disease in mice. Here the authors investigate the role of autophagy-initiating protein ULK1 and report that its overexpression stimulates autophagic flux, reduces amyloid and tau pathology and delays cognitive decline.

This study reports a paralog-selective p300 degrader with potent anti-cancer activity in hematological malignancies, demonstrating a strategy to selectively target transcriptional coactivators through protein degradation.

LHAASO has detected γ-ray emission with a spectrum extending to 2 PeV from the pulsar wind nebula (PWN) powered by PSR J1849-0001, indicating an extreme particle acceleration efficiency and challenging the current particle acceleration theories.

Communication between distant brain regions is mediated by plastic networks of gap junction-coupled astrocytes.

Thermally activated ion migration in van der Waals heterostructures delivers precise, energy-efficient on-chip thermometry.

In this work, authors show that O-redox in 4d and 5d transition metal oxides involves the formation of molecular oxygen trapped in the particles. These results are in accord with observations in 3d oxides and show that the greater covalency of the 4d and 5d oxides does not stabilise peroxo-like species.

Integration of data representing 35,120 brain scans from diverse global studies enables construction of reference charts that define normative microstructural and macrostructural properties across the human lifespan for research and clinical diagnosis.

Although rechargeable lithium–air batteries are receiving significant attention because of their high theoretical specific energy, carbon cathodes that are currently used decompose during oxidation and promote electrolyte decomposition on cycling. A titanium carbide-based cathode is now shown to reduce side-reactions, and exhibits enhanced reversible formation and decomposition of Li₂O₂.

The study shows that global gross primary productivity is more limited by air dryness than by soil moisture. This influence strengthens with temperatures and more severe, prolonged droughts, suggesting rising air dryness may accelerate declines in land carbon storage.

The carbon sink of tropical forests is in part constrained by biomass turnover. This study assesses aboveground biomass turnover in the Amazon and finds that convective storms are the main driver of spatial variation in turnover and future climate impacts will lead to accelerated biomass turnover.

The limited tunability of threshold voltage is a major obstacle for applying two-dimensional transistors in post-silicon electronics. Here, the authors show that bimetallic thiophosphates, such as LiInP₂S₆, enable programmable threshold voltages in both n-type and p-type 2D transistors, leading to low-power, high-speed complementary logic inverters.

Discharge in lithium–air batteries can be triggered by using solvents or salts that dissolve LiO₂ intermediate. Adding DBBQ to a weakly solvating electrolyte solution can help O₂ reduction to Li₂O₂ in solution and enhance electrochemical performance.

Materials with variable and reversible thermal conductivities are important in technologies, and yet such materials are rare. Here, Cho et al. report in situmeasurements of thermal conductivity of lithium cobalt oxide, and show how to reversibly modulate thermal conductivities over a considerable range.

Here the authors compare genetic testing strategies in rare movement disorders, improve diagnostic yield with genome analysis, and establish CD99L2 as an X-linked spastic ataxia gene, showing that CD99L2–CAPN1 signaling disruption likely drives neurodegeneration.

Enhanced future methane emissions from global wetlands under warming could substantially offset the emissions reduction goals of the Global Methane Pledge, according to ensemble simulations from terrestrial biosphere models.

Perovskite solar cells face efficiency losses in ambient air because their precursors are highly moisture- and oxygen-sensitive. Liu et al. use an ionic-liquid additive to stabilize precursor chemistry, enabling robust processing and high-performance devices.

Developing safe, fast-recharging Li-metal batteries is challenging due to the need for stable, non-flammable electrolytes. This study presents an electrolyte design using miniature anion–Li⁺ solvation structures, achieving high conductivity, stable cycling and improved safety.

Interferometric scattering microscopy combined with photoluminescence imaging enables the fast, high-throughput screening of size and quantum yield for thousands of perovskite nanocubes at the single-particle level across their entire life cycle.

The understanding of the reemergence of pressure induced superconductivity in alkali-metal intercalated FeSe is hampered by sample complexities. Here, Sun et al. report the electronic properties of (Li_1–xFe _x )OHFe_1–ySe single crystal not only in the reemerged superconducting state but also in the normal state.

A high-resolution spectroscopic analysis reveals ultralow amounts of heavy elements in the star SDSS J0715−7334. The star originates from the Large Magellanic Cloud and probably formed directly after the first stars through dust cooling.

Conversion electrodes for lithium-ion batteries are capable of high capacity but low energy efficiency and low voltages are problematic. The electrochemical reactivity of MgH₂ with Li shows promise in using metal-hydride electrodes for both lithium-ion-battery and hydrogen storage applications.

Conventional slurry electrodes limit high-energy lithium batteries. This work shows that dry-processed electrodes with molecularly coupled carbon–binder networks enable high mass and active material loading, supporting stable high-voltage operation and enhancing battery energy density.

When senescent cells accumulate during adulthood they negatively influence lifespan and promote age-dependent changes in several organs; clearance of these cells delayed tumorigenesis in mice and attenuated age-related deterioration of several organs without overt side effects, suggesting that the therapeutic removal of senescent cells may be able to extend healthy lifespan.

In a prospective cohort of 166 participants (and in a 63-participant validation cohort), dermal α-synuclein and 4-repeat tau seed amplification, combined with serum neurofilament light chain assays, were able to identify parkinsonian syndromes.

The CMS experiment at CERN reports one of the highest-precision measurements of the W boson mass, finding it in line with standard model predictions and at odds with recent anomalous measurements.

Recharging Li–O₂ batteries requires oxidation of the discharge product solid Li₂O₂. Now a redox-mediating molecule is shown to assist this process by transferring electron–holes between solid Li₂O₂ and the positive electrode in a non-aqueous Li–O₂ cell. This allows the cell to be charged at rates that are otherwise impossible.

Understanding collective behaviour is an important aspect of managing the pandemic response. Here the authors show in a large global study that participants that reported identifying more strongly with their nation reported greater engagement in public health behaviours and support for public health policies in the context of the pandemic.

The development of superior and cost-effective catalysts for the oxygen reduction and evolution reactions is pivotal for the future hydrogen economy. Now a series of Ru-modified Li₂MnO₃ catalysts have been designed to optimize the electronic structure and achieve a high performance in both oxygen reduction and evolution reactions, as demonstrated in practical anion exchange membrane fuel cell and water electrolyser tests.

Using warming microcosms across 100 paired sites, a global meta-analysis and microbiome manipulation experiments, this study shows that agricultural microbiomes confer higher compositional and multifunctionality resistance to warming and can transfer this resistance to natural soils.

Repurposing existing drugs for vascular dementia (VaD) could have clinical impact. Here, using Mendelian randomization, researchers tested whether cholesterol, anti-inflammatory or blood pressure drug targets affect risk of VaD, finding little evidence to support repurposing opportunities. A potential benefit was seen for beta-blocker target ADRB1 while ACE inhibition was observed to potentially increase risk of VaD.

Inflammatory signaling profoundly influences cellular metabolism and stress responses. Here, the authors show that the IKK complex directly controls TFEB stability through β-TrCP2–dependent proteasomal degradation, mechanistically linking inflammation to lysosomal regulation.

A chemoproteomic strategy reveals how posttranslational modifications reshape protein ligandability across the human proteome, uncovering more than 400 state-dependent interactions, including phosphorylation-driven control of KRAS inhibitor activity.

This work provides a mechanistic understanding of how certain prefrontal circuits in the rodent brain permit flexibility to selectively stop learned behaviours through interactions with core subcortical reward systems.

Intercalation-type metal oxides are promising anodes for Li-ion batteries but suffer from low energy and power density together with cycling instability. A nanostructured rock-salt Nb₂O₅ formed via amorphous-to-crystalline transformation during cycling with Li⁺ is shown to exhibit enhanced performance.

Mapping DNA variants that modulate mortality using a starting population of 6,438 young mice defined 29 distinct loci that influence lifespan and mortality with divergent age- and sex-specific effects, as well as 30 loci that specifically couple body mass with longevity.

A single-cell spatial atlas identifies a B cell-predominant microenvironment within the profibrotic tubular niche that marks a subset of patients with diabetic kidney disease with rapid progression.