Nature Search

EvoMDT: a self-evolving multi-agent system for structured clinical decision-making in multi-cancer

Qicai Liu
Zhichao Hu
Guangliang Qiang
ResearchOpen Access07 Jan 2026
npj Digital Medicine

P: 1-15
Direct deaminative functionalization with N-nitroamines

A safe, versatile deaminative method converts aromatic amines into diverse C–X and C–C bonds via N-nitroamine intermediates, enabling broad one-pot cross-couplings without hazardous diazonium salts.

Guangliang Tu
Ke Xiao
Xiaheng Zhang
ResearchOpen Access27 Oct 2025
Nature

Volume: 648, P: 341-348
Genomic heterogeneity of multiple synchronous lung cancer

Some patients present with multiple lung tumours but it is unclear whether these are metastases or individual lesions. Here, the authors use genomics techniques to demonstrate in six patients that multiple tumours have individual genetic profiles and represent separate tumours.

Yu Liu
Jianjun Zhang
Yanning Gao
ResearchOpen Access21 Oct 2016
Nature Communications

Volume: 7, P: 1-8
Ultra-depleted mantle source of basalts from the South Pole–Aitken basin

Extreme Sr–Nd depletion in 2.8-billion-year-old basalt fragments from the lunar farside South Pole–Aitken basin suggests an ultra-depleted mantle source resulting from lunar magma ocean crystallization and/or later impact-related melt extraction.

Qin Zhou
Wei Yang
Fu-Yuan Wu
ResearchOpen Access09 Jul 2025
Nature

Volume: 643, P: 371-375
Urban vitality in the context of shrinkage: spatiotemporal patterns and influencing factors at urban and regional scales

Ling Han
Ye Wei
Guangliang Xi
ResearchOpen Access26 Sept 2025
Humanities and Social Sciences Communications

Volume: 12, P: 1-16
Evaluating the analytical validity of circulating tumor DNA sequencing assays for precision oncology

Reliable detection of mutations below 0.5% variant allele frequency remains a key challenge for circulating tumor DNA sequencing assays.

Ira W. Deveson
Binsheng Gong
Joshua Xu
Research12 Apr 2021
Nature Biotechnology

Volume: 39, P: 1115-1128
Spectral interpretation of late-stage mare basalt mineralogy unveiled by Chang’E-5 samples

Laboratory spectroscopic and X-ray diffraction analyses on the Chang’E-5 lunar soil samples have demonstrated that the spectral features of lunar late-stage mare basalts are representative of iron-rich high-Ca pyroxene rather than olivine.

Dawei Liu
Xing Wang
Chunlai Li
ResearchOpen Access10 Oct 2022
Nature Communications

Volume: 13, P: 1-10
Human activities shape important geographic differences in fish mercury concentration levels

Mercury exposure from fish consumption poses a risk to human health, and effective mercury management is hampered by uncertainty about how human activities affect mercury levels in fish. This study presents global geographic variations in total mercury and methylmercury levels in fish and quantifies the impact of human activities.

Yuping Xiang
Guangliang Liu
Guibin Jiang
Research26 Sept 2024
Nature Food

Volume: 5, P: 836-845
Loss of PHF8 induces a viral mimicry response by activating endogenous retrotransposons

The role of PHD finger protein 8 (PHF8) in anti-tumour immunity remains to be investigated. Here, the authors suggest PHF8 as an epigenetic checkpoint and show that targeting PHF8 induces a viral mimicry response enhancing anti-tumour immunity in colorectal cancer.

Yanan Liu
Longmiao Hu
Xiufeng Pang
ResearchOpen Access15 Jul 2023
Nature Communications

Volume: 14, P: 1-17
An atlas of DNA methylomes in porcine adipose and muscle tissues

Epigenetic and genetic factors have a role in obesity but the role of epigenetics in this disease is unclear. Here, Liet al. investigated global DNA methylation patterns in three breeds of pigs that have different fat contents, providing a resource for the further analysis of differentially methylated gene promoters in obesity.

Mingzhou Li
Honglong Wu
Ruiqiang Li
Research22 May 2012
Nature Communications

Volume: 3, P: 1-11
Evidence of water on the lunar surface from Chang’E-5 in-situ spectra and returned samples

Laboratory analysis of returned Chang’E-5 samples from the lunar surface show their hydroxyl contents to be on the weak end of lunar hydration features.

Jianjun Liu
Bin Liu
Ziyuan Ouyang
ResearchOpen Access14 Jun 2022
Nature Communications

Volume: 13, P: 1-10
Interpreting stimulated plasma renin and aldosterone to select physiologically individualized therapy for resistant hypertension: importance of the class of stimulating drugs

Xiao Huang
Junpei Li
J. David Spence
Research27 Sept 2019
Hypertension Research

Volume: 42, P: 1971-1978
Quantum spin Hall insulator in halogenated arsenene films with sizable energy gaps

Dongchao Wang
Li Chen
Yeqing Chen
ResearchOpen Access24 Jun 2016
Scientific Reports

Volume: 6, P: 1-7
Strain induced band inversion and topological phase transition in methyl-decorated stanene film

Dongchao Wang
Li Chen
Yeqing Chen
ResearchOpen Access06 Dec 2017
Scientific Reports

Volume: 7, P: 1-8
Analysis of a four generation family reveals the widespread sequence-dependent maintenance of allelic DNA methylation in somatic and germ cells

Aifa Tang
Yi Huang
Yaoting Gui
ResearchOpen Access13 Jan 2016
Scientific Reports

Volume: 6, P: 1-8
Resonant tunneling modulation in quasi-2D Cu₂O/SnO₂ p-n horizontal-multi-layer heterostructure for room temperature H₂S sensor application

Guangliang Cui
Mingzhe Zhang
Guangtian Zou
ResearchOpen Access13 Feb 2013
Scientific Reports

Volume: 3, P: 1-8
Endoderm Jagged induces liver and pancreas duct lineage in zebrafish

The hepatopancreatic duct cells connect liver hepatocytes and pancreatic acinar cells to the intestine, but the mechanism for their lineage specification is unclear. Here, the authors reveal that Notch ligands Jagged1b and Jagged2b induce duct cell lineage in the liver and pancreas of the zebrafish.

Danhua Zhang
Keith P. Gates
P. Duc Si Dong
ResearchOpen Access03 Oct 2017
Nature Communications

Volume: 8, P: 1-11
Identification of genomic alterations in oesophageal squamous cell cancer

Using whole-genome and whole-exome sequencing, this study identifies eight significantly mutated genes in oesophageal squamous cell cancer, including two genes, ADAM29 and FAM135B, not previously associated with this cancer type.

Yongmei Song
Lin Li
Qimin Zhan
Research16 Mar 2014
Nature

Volume: 509, P: 91-95
Lunar farside to be explored by Chang’e-4

Weiren Wu
Chunlai Li
Ziyuan Ouyang
Correspondence28 Mar 2019
Nature Geoscience

Volume: 12, P: 222-223
Incorporating high-frequency information into edge convolution for link prediction in complex networks

Zhiwei Zhang
Haifeng Xu
Guangliang Zhu
ResearchOpen Access05 Mar 2024
Scientific Reports

Volume: 14, P: 1-12
Correction to: CHD1L prevents lipopolysaccharide-induced hepatocellular carcinomar cell death by activating hnRNP A2/B1-nmMYLK axis

Guangliang Wang
Xiaofeng Zhang
Ning-Fang Ma
Amendments and CorrectionsOpen Access02 Mar 2022
Cell Death & Disease

Volume: 13, P: 1
Bacillus cereus is a key microbial determinant of intractable otitis media with effusion

Fan, Chen, Xu et al. investigate the role of the middle ear microbiota in otitis media with effusion (OME) progression. Bacillus cereus is identified as a key microbial determinant associated with intractable OME, suggesting its potential as a prognostic biomarker.

Yue Fan
Junru Chen
Xingming Chen
ResearchOpen Access03 May 2025
Communications Medicine

Volume: 5, P: 1-8
Mesenchymal stem cell treatment improves outcome of COVID-19 patients via multiple immunomodulatory mechanisms

Rongjia Zhu
Tingdong Yan
Robert Chunhua Zhao
ResearchOpen Access26 Oct 2021
Cell Research

Volume: 31, P: 1244-1262
CHD1L prevents lipopolysaccharide-induced hepatocellular carcinomar cell death by activating hnRNP A2/B1-nmMYLK axis

Guangliang Wang
Xiaofeng Zhang
Ning-Fang Ma
ResearchOpen Access29 Sept 2021
Cell Death & Disease

Volume: 12, P: 1-11
PLK1 inhibition promotes apoptosis and DNA damage in glioma stem cells by regulating the nuclear translocation of YBX1

Xuetao Li
Guangliang Chen
Hao Wang
ResearchOpen Access17 Feb 2023
Cell Death Discovery

Volume: 9, P: 1-12
Focal embolic cerebral ischemia in the rat

In this model, the middle cerebral artery (MCA) is occluded with a fibrin-rich allogeneic clot, producing an embolic model of MCA occlusion in the rat that mimics the key components of neurovascular damage observed in human ischemic stroke.

Li Zhang
Rui Lan Zhang
Zheng Gang Zhang
Protocols05 Mar 2015
Nature Protocols

Volume: 10, P: 539-547
Whole Exome Sequencing Identifies Frequent Somatic Mutations in Cell-Cell Adhesion Genes in Chinese Patients with Lung Squamous Cell Carcinoma

Chenguang Li
Zhibo Gao
Qingyi Wei
ResearchOpen Access27 Oct 2015
Scientific Reports

Volume: 5, P: 1-11
Topological edge states in high-temperature superconductiving FeSe/SrTiO₃ films with Te substitution

Li Chen
Hongmei Liu
Qiandong Zhuang
ResearchOpen Access11 Mar 2019
Scientific Reports

Volume: 9, P: 1-10
Investigating subtypes of lung adenocarcinoma by oxidative stress and immunotherapy related genes

Guangliang Duan
Changxin Huang
Huiping Dai
ResearchOpen Access27 Nov 2023
Scientific Reports

Volume: 13, P: 1-15
Distinct epigenomes in CD4⁺ T cells of newborns, middle-ages and centenarians

Ming Zhao
Jian Qin
Qianjin Lu
ResearchOpen Access05 Dec 2016
Scientific Reports

Volume: 6, P: 1-15
The intrarenal blood pressure modulation system is differentially altered after renal denervation guided by different intensities of blood pressure responses

Yinchuan Lai
Hao Zhou
Yuehui Yin
Research06 Oct 2022
Hypertension Research

Volume: 46, P: 456-467
A phase II study of a modified FOLFOX6 regimen as neoadjuvant chemotherapy for locally advanced gastric cancer

Xiang Wang
Lin Zhao
Xiaoyi Li
ResearchOpen Access12 May 2016
British Journal of Cancer

Volume: 114, P: 1326-1333
CHD1L augments autophagy-mediated migration of hepatocellular carcinoma through targeting ZKSCAN3

Xiaofeng Zhang
Yinshan Bai
Ning-Fang Ma
ResearchOpen Access15 Oct 2021
Cell Death & Disease

Volume: 12, P: 1-11
Organochlorine pesticides (OCPs) in wetland soils under different land uses along a 100-year chronosequence of reclamation in a Chinese estuary

Junhong Bai
Qiongqiong Lu
Guangliang Zhang
ResearchOpen Access03 Dec 2015
Scientific Reports

Volume: 5, P: 1-10
Highly sensitive H₂S sensors based on Cu₂O/Co₃O₄ nano/microstructure heteroarrays at and below room temperature

Guangliang Cui
Pinhua Zhang
Dongchao Wang
ResearchOpen Access02 Mar 2017
Scientific Reports

Volume: 7, P: 1-10
Depth-distribution patterns and control of soil organic carbon in coastal salt marshes with different plant covers

Junhong Bai
Guangliang Zhang
Xinhui Liu
ResearchOpen Access06 Oct 2016
Scientific Reports

Volume: 6, P: 1-12
Prevalence of and risk factors for refractive error: a cross-sectional study in Han and Mongolian adults aged 40–80 years in Inner Mongolia, China

M. Wang
J. Ma
G. L. Shan
Research03 Jun 2019
Eye

Volume: 33, P: 1722-1732

Search

EvoMDT: a self-evolving multi-agent system for structured clinical decision-making in multi-cancer

Direct deaminative functionalization with N-nitroamines

Genomic heterogeneity of multiple synchronous lung cancer

Ultra-depleted mantle source of basalts from the South Pole–Aitken basin

Urban vitality in the context of shrinkage: spatiotemporal patterns and influencing factors at urban and regional scales

Evaluating the analytical validity of circulating tumor DNA sequencing assays for precision oncology

Spectral interpretation of late-stage mare basalt mineralogy unveiled by Chang’E-5 samples

Human activities shape important geographic differences in fish mercury concentration levels

Loss of PHF8 induces a viral mimicry response by activating endogenous retrotransposons

An atlas of DNA methylomes in porcine adipose and muscle tissues

Evidence of water on the lunar surface from Chang’E-5 in-situ spectra and returned samples

Interpreting stimulated plasma renin and aldosterone to select physiologically individualized therapy for resistant hypertension: importance of the class of stimulating drugs

Quantum spin Hall insulator in halogenated arsenene films with sizable energy gaps

Strain induced band inversion and topological phase transition in methyl-decorated stanene film

Analysis of a four generation family reveals the widespread sequence-dependent maintenance of allelic DNA methylation in somatic and germ cells

Resonant tunneling modulation in quasi-2D Cu₂O/SnO₂ p-n horizontal-multi-layer heterostructure for room temperature H₂S sensor application

Endoderm Jagged induces liver and pancreas duct lineage in zebrafish

Identification of genomic alterations in oesophageal squamous cell cancer

Lunar farside to be explored by Chang’e-4

Incorporating high-frequency information into edge convolution for link prediction in complex networks

Correction to: CHD1L prevents lipopolysaccharide-induced hepatocellular carcinomar cell death by activating hnRNP A2/B1-nmMYLK axis

Bacillus cereus is a key microbial determinant of intractable otitis media with effusion

Mesenchymal stem cell treatment improves outcome of COVID-19 patients via multiple immunomodulatory mechanisms

CHD1L prevents lipopolysaccharide-induced hepatocellular carcinomar cell death by activating hnRNP A2/B1-nmMYLK axis

PLK1 inhibition promotes apoptosis and DNA damage in glioma stem cells by regulating the nuclear translocation of YBX1

Focal embolic cerebral ischemia in the rat

Whole Exome Sequencing Identifies Frequent Somatic Mutations in Cell-Cell Adhesion Genes in Chinese Patients with Lung Squamous Cell Carcinoma

Topological edge states in high-temperature superconductiving FeSe/SrTiO₃ films with Te substitution

Investigating subtypes of lung adenocarcinoma by oxidative stress and immunotherapy related genes

Distinct epigenomes in CD4⁺ T cells of newborns, middle-ages and centenarians

The intrarenal blood pressure modulation system is differentially altered after renal denervation guided by different intensities of blood pressure responses

A phase II study of a modified FOLFOX6 regimen as neoadjuvant chemotherapy for locally advanced gastric cancer

CHD1L augments autophagy-mediated migration of hepatocellular carcinoma through targeting ZKSCAN3

Organochlorine pesticides (OCPs) in wetland soils under different land uses along a 100-year chronosequence of reclamation in a Chinese estuary

Highly sensitive H₂S sensors based on Cu₂O/Co₃O₄ nano/microstructure heteroarrays at and below room temperature

Depth-distribution patterns and control of soil organic carbon in coastal salt marshes with different plant covers

Prevalence of and risk factors for refractive error: a cross-sectional study in Han and Mongolian adults aged 40–80 years in Inner Mongolia, China

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