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B7H3 is an immune checkpoint overexpressed in many cancers and associated with tumor immune evasion. Here, the authors discover that in colorectal cancer, particularly microsatellite-stable tumors, palmitic acid promotes ZDHHC24- mediated B7H3 palmitoylation, regulating CD8⁺ T cell antitumor activity.

Alternative splicing greatly expands the transcriptomic and proteomic diversity in vertebrates. Here, the authors develop a machine-learning tool to identify functional splicing events during hematopoietic cell differentiation, revealing new regulators of hematopoiesis.

RABV upregulates FBXL18, which stabilizes BST2 via K11-linked ubiquitination at Lys109/110, thereby activating NF-κB. FBXL18 knockdown effectively suppresses inflammation and virulence, highlighting its potential as a therapeutic target for rabies.

Magnesium metal batteries hold great promise for next-generation energy storage but struggle with limited understanding of their deposition mechanisms. Here, authors employ cryogenic electron microscopy to uncover how interfacial chemistry governs magnesium deposition across diverse electrolytes.

Dysregulation of blood vessel size can cause vascular malformations. Here, the authors demonstrate that endothelial cells generate circumferential actomyosin cables to control the size of cells and vessels.

The stabilization of perovskites in both solution and solid phases is critical to the fabrication of solution-processed perovskite solar cells. Here, 4-(trifluoromethyl)phenylhydrazine is introduced to enhance storage stability, achieving consistent high efficiency of 26.0% in stable devices.

Functionalizing unactivated carbon–hydrogen bonds is a powerful and atom efficient method to introduce functionality into a molecule. Here, the authors show activation and intramolecular amination of primary C–H bonds using a silver catalyst.

The interplay between the low-energy carriers in Dirac materials and magnetism is likely to reveal many novel physical phenomena. Here, the authors use two-magnon Raman scattering to determine the exchange energies of two prototypical magnetic Dirac systems, CaMnBi₂ and SrMnBi₂.

Transplanted older livers are prone to injury through unclear mechanisms, precluding effective treatment development. Here, the authors show that decreased FTO expression in older livers inhibits Acsl4 and Tfrc mRNA stability in an m6A-dependent manner, increasing cell death in older donor livers.

A single-cell multi-omics atlas of rice is revealed, providing insight into cell-type functions and molecular programs.

Extracting atmospheric water is a sustainable strategy to enable decentralized access to safely managed water but remains impractical due to its limited daily water output at low relative humidity. Here, the authors demonstrate a hygroscopic polymer composed of renewable biomass which allows high water uptake at low relative humidity

Neoadjuvant cancer therapeutic strategy has been explored in phase I/II clinical studies for head and neck squamous cell carcinoma. Here this group reports a single-arm, phase II clinical trial evaluating the neoadjuvant radiotherapy plus PD-1 inhibitor tislelizumab combined with paclitaxel and cisplatin, followed by radical surgical resection on 28 patients with untreated stage III-IVB head and neck squamous cell carcinoma.

This study shows that Galectin-3 promotes wound healing by binding to and undergoing phase separation with integrin α5β1, a process disrupted by AGEs in pre-clinical models of diabetes. Topical Galectin-3 restored healing in synergy with insulin.

Solar-powered desalination is a sustainable approach to generate clean water for our society. Here, authors report lightweight, flexible, and fluidic-diode membrane-based evaporators to allow directional water transport and optimized heat localization. This Janus evaporator design enables high performance interfacial solar water evaporation, as well as hydrovoltaic applications.

The authors report a dual photothermal-electrocatalysis interface which enables efficient ammonia extraction and purification from air and wastewater, thereby advancing sustainable waste-to-fuel conversion.

Wang and colleagues generate two protein-level mutant p53 reporters and use them to identify precancerous clones in normal tissues in vivo, characterized by increased amino acid metabolism and a transcriptomic signature that includes Ybx3.

Seawater electrolytes provide a sustainable option for aqueous zinc batteries but challenge the stability of zinc metal electrodes. Here, authors elucidate the zinc electrode failure mechanisms and propose a charge gradient interface strategy to stabilize the zinc electrode in seawater electrolytes.

Sorption-based atmospheric water harvesting has the capability of capturing water from air anytime and anywhere. A facile strategy to synthesize bidirectionally aligned and hierarchically structured nanocomposite could realize scalable and efficient sorption-based atmospheric water harvesting.

Both drifter current observations and satellite-based tropical cyclone (TC)-induced sea surface cooling demonstrate that weak TCs have intensified in recent decades.

Jun Wang and colleagues report whole-genome resequencing of 17 wild and 14 cultivated soybean accessions. They characterize population structure, patterns of linkage disequilibrium and selection in soybeans.

Converting nitrate from waste sources into ammonia provides an effective method for both wastewater treatment and ammonia production. Here the authors report a scalable solution-phase synthesis of high-entropy single-atom nanocage catalysts for efficient nitrate-to-ammonia conversion.

The study reveals that the BrJMJ18 gene, encoding an H3K36me2/3 Jumonji demethylase, is a candidate gene for a QTL regulating thermotolerance in a thermotolerant Brassica rapa subspecies, and its allele (BrJMJ18^Par) can modulate flowering time, plant growth, and chlorophyll biosynthesis in a temperature-dependent manner.

High-content screening of a natural diterpenoid library identified a highly potent anti-liver fibrosis lead, 12-deoxyphorbol 13-palmitate (DP), which targets apolipoprotein L2 (APOL2) and impairs APOL2–SERCA2–PERK–HES1 signaling.

In quantum multiparameter estimation, achieving the best precision for each parameter is hindered by the Heisenberg principle. Here, the authors demonstrate how to mitigate this problem by using appropriate probe states.

Systems for automatic detection of a single disease may miss other important conditions. Here, the authors show a deep learning platform can detect 39 common retinal diseases and conditions.

Wang et al. show that Akt methylation by SETDB1 is recognized by demethylase JMJD2A, which then recruits E3 ligases to induce K63-linked Akt ubiquitination, leading to Akt activation and tumorigenesis.

Lithium-ion batteries with fast-charging properties are urgently needed for wide adoption of electric vehicles. Here, the authors show a fast charging/discharging and long-term stable electrode made from a mixed electronic/ionic conductor material enabled by a space charge mechanism.

Tannins in grains prevent sparrow consumption but cause bitterness for people with sensitive taste. A study uncovered genes controlling tannin presence in sorghum and revealed a coevolution among humans, sorghums and birds linked by tannins in African agroecosystems.

Chromosome-level genome assemblies of 11 bamboo species comprising lineages from diploid (herbaceous) to tetraploid and hexaploid (woody) provide insights into dynamic subgenome dominance in bamboos.

Suppression of the competing H₂ evolution reaction in CO₂ electroreduction in strong acids remains a considerable challenge. Here, authors report a silver-based electrode that enables CO₂ conversion to CO exceeding 85% at ampere-level current densities in pH = 1 electrolytes.

IL-6 is an important cytokine in the tumour microenvironment, but its role in regulating autophagy in cancer cells is unclear. Here the authors show that IL-6 activates autophagy in colorectal cancer through the interaction between JAK2 and autophagy regulator, BECN1, which leads to chemotherapeutic resistance.

2D biochemical sensors hold potential for monitoring toxic contaminants in water, but they are usually affected by device-to-device variations. Here, the authors propose a scalable fabrication process and quality control procedure to realize graphene field-effect transistor arrays able to simultaneously detect trace amounts of heavy metal ions and bacteria in flowing water.

An optimized head-mounted fluorescent mesoscope enables large-scale calcium imaging at single-neuron resolution in freely moving mice, facilitating neurobehavioural studies during social interactions and fear-conditioning experiments.

Improving the energy density of lithium-sulfur batteries is necessary for their practical application. Here, the authors report free-standing and low-tortuosity carbon frameworks as host for sulfur and lithium, enabling scalable thickness independent electrochemical performance.

Urea is one the most-used synthetic nitrogen fertilizers that have been key to feeding a growing population. However, its production is energy intensive. Here, the authors show an electrocatalytic approach that allows for selective urea synthesis from nitrate and carbon dioxide at ambient conditions.

A strategy that depends on attenuated brassinosteroid signalling is described for the design of semi-dwarf wheat varieties with improved grain yield compared with that of green revolution varieties.

The development of artificial skins needs ultra-sensitive pressure sensors. Pan and coworkers show a method to impart elasticity to a rigid conducting polymer film by forming hollow-sphere microstructure for piezoresistive sensor applications, which can sense less than 1 Pa at rapid response.

How Akt pathway is activated under stress is poorly understood. Here, the authors demonstrate the crucial role of AMPK for cellular stresses and growth factors- mediated Akt activation through a mechanism involving the E3 ubiquitin ligase Skp2 and Cullin-1.

DeepCAD-RT denoises fluorescence time-lapse images in real time.

The identification of genes that control economically important traits is an essential step towards crop improvement. Here the authors sequence the genome of the wild soybean and, through a combined genetic and functional approach, identify a new gene affecting salt tolerance in soybean.