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Liquid crystal elastomers are promising for actuators in soft robotics, but 3Dprinting methods often restrict responsive properties. Here the authors design by tuning the printing angle, affording a coiled fiber, for programmable actuation.

SUCCEED is a supervised multi-task DNA foundation model pretrained on 6,389 ENCODE tracks. It integrates CNN and Transformer architectures to model local motifs and long-range dependencies, enabling prediction of genomic regulatory features across tasks and cell types.

Soft tactile chips embed in-situ sensing in pneumatic actuators, improving teleoperation via adaptive haptic feedback. Liquid-metal pressure and pectin temperature sensors enable precise manipulation and better human-robot interaction.

This study reports real-space, layer-resolved magnetic imaging of the van der Waals antiferromagnet (Fe,Co)₃GaTe₂ using SPLEEM, revealing A-type interlayer coupling, intrinsic chiral spin textures and enabling controlled writing of antiferromagnetic skyrmions.

Designing efficient high entropy catalysts is highly desired but remains challenging. Here, the authors report the spin state engineering to develop high-entropy Ruddlesden Popper perovskite oxides for efficient seawater splitting, with the strategy applicable to other high entropy catalysts.

Treatment failure exists in Induction chemotherapy followed by concurrent chemoradiotherapy (CCRT) for locoregionally advanced nasopharyngeal carcinoma (LA-NPC) patients. Here this group reports a phase 2 randomized trial evaluating the efficacy and safety of adding nimotuzumab, to CCRT on 246 patients with untreated, non-keratinising, stage II–IVA LA-NPC.

This work introduces Siamese foundation models tailored for crystal structure prediction. The proposed approach achieves superior performance on downstream benchmarks and in superconductor validation tasks.

Epstein-Barr virus (EBV) associated gastric cancer shows uncertain immunochemotherapy benefits. This phase II clinical trial reports efficacy and safety outcomes of neoadjuvant toripalimab plus CapeOX chemotherapy regimen in locally advanced EBV-associated gastric or gastroesophageal junction cancer.

This research reveals that platelet infiltration initiated by the platelet HuR-PSPF regulatory process coordinates systemic aging. Targeting platelet HuR may be a promising strategy for anti-aging interventions

In NIID, toxic polyG from NOTCH2NLC GGC repeats disrupts nucleoli and chromatin, causing DNA damage and senescence. Here, the authors show that ASOs targeting the repeats reduce polyG buildup and reverse damage, suggesting a new treatment.

The authors conducted two trials to evaluate the efficacy and safety of NH600001, an etomidate derivative, in gastrointestinal endoscopy. The results showed NH600001 has a sedative effect while reducing the risk of adrenocortical depression.

Early detection of nasopharyngeal carcinoma through Epstein–Barr virus serology is hindered by a low positive predictive value. Here this group introduces a hierarchical dynamic model for stratification refinement within serologically defined risk individuals thereby yielding cost savings for current serological screening strategy.

Researchers develop a swellable polymer platform that immobilizes photocatalysts into flexible films and enables three-dimensional stacking architectures, boosting solar-driven hydrogen production and increasing energy output per unit area.

Electrosynthesis of H₂O₂ in acidic conditions offers a sustainable alternative to traditional methods but is hindered by low selectivity. Here, the authors report that adding alkali metal cations restructures interfacial water networks to suppress proton transport, boosting H₂O₂ production.

All-inorganic perovskite solar cells promise strong stability but still suffer from moisture-driven surface damage and limited efficiency. Zhang et al. form a one-dimensional/three-dimensional interface using a tailored salt to stabilize the material and boost performance.

Nutrient deficiencies are widespread, but blood tests are often inconvenient. Here, the authors develop a wearable electrochemical platform for noninvasive, real-time detection of multiple low-concentration vitamins in sweat and validate its performance in human studies.

Electric vehicles support decarbonization but raise critical material demand, which is often misestimated due to overlooked real-world and heterogeneous characteristics. Here, the authors use a bottom-up multi-dataset fusion approach to characterize segment mix, battery capacity, and battery chemistry across five passenger vehicle segments covering China’s 31 provinces and 29 EU countries.

This study identifies a Rht-A1–TaLA1-D module controlling wheat tiller angle, elucidates its mechanism, and traces the selection trajectory of TaLA1-D during wheat breeding, providing new insights for developing ideotype wheat varieties.

Cell-type-specific 3D genome maps are hard to generate experimentally. Here, the authors develop Hi-Compass, a deep-learning framework that predicts chromatin interactions from accessibility data across variable sequencing depths, recovering chromatin loops and linking disease variants to target genes.

Inner ear diseases are difficult to treat due to anatomical constraints. Here, the authors present a dual-segment continuum robot integrating navigation, endoscopy, and a force-sensing microneedle for atraumatic transcanal access to the round window membrane.

Global analysis of obesity trends from 1980 to 2024 in 200 countries and territories using data from 4,050 population-based studies reveals that framing obesity as a single global epidemic masks the highly varied dynamics across countries and age groups.

Hybrid neural networks often underperform compared to conventional neural networks because of their low array utilization. Lu et al. propose a programmable spiking architecture that leverages photonic reconfigurable devices to integrate synaptic and neuronal functions without compromising performance.

Electrochromic windows provide an energy-efficient pathway to manage thermal efficiency. This work describes a glazing design that is scalable, stable over cycling and functional for a wide solar spectrum.

The Hippo pathway relies on TEAD transcription factors, but how TEAD4 dynamically engages DNA was unclear. Here, the authors show that TEAD4 multimerisation stabilizes DNA binding and YAP recruitment, with VGLL4 modulating this process in a stoichiometry‑dependent manner.

Electronic chirality is a fascinating but still poorly understood phenomenon. Here, the authors show that CuPc molecules on bilayer graphene exhibit electronic chirality driven by twisted π–π interactions, which can be reversibly switched using an STM tip.

Emerging evidence suggests that organs age at different rates. This study identifies a mechanism by which the naturally hypoxic intervertebral disc ages relatively slowly, via selective autophagy of HIF-1α, and designs a small molecule to export this mechanism across tissues.

A MoSe₂ piezocatalyst with lattice strain upcycles wastewater pollutants into value-added chemicals, offering an environmental and energy solution by accelerating carbon reduction and lowering reaction energy barriers.

Reduced expression of STING in cancer cells due to ER and Golgi dysfunction enables tumor immune escape and limits STING targeted therapies. The authors here develop a cell membrane derived nanodisc system ND-cGAMP-HP that delivers activated STING directly to tumor cells bypassing ER Golgi translocation which activates the IFN-I signaling pathway and induces potent cellular immune responses.

In nasopharyngeal carcinoma (NPC), cisplatin is known to be associated with poor treatment compliance and notable side effects therefore more effective platinum drugs are expected. Here this group updates the 10-year survival analysis results of a multicenter, randomized, phase 3 trial evaluating the efficacy of lobaplatin and fluorouracil induction chemotherapy plus concurrent chemoradiotherapy on 502 NPC patients.

Scalable fabrication of inverted perovskite solar cells is achieved through crystal-solvate (CSV) pre-seeding. The pre-seeded, nanostructured CSV layer suppresses morphological and electronic defects, allowing a cell efficiency of 26.13% and a 49.91 cm² mini-module efficiency of 23.15%.

Here, in mouse models of GMPPB dystroglycanopathy, the authors show that impaired glycosylation disrupts muscle integrity and triggers broader cellular stress. They identify actionable pathways that improve muscle function, suggesting therapeutic strategies.

Ma et al. report a laser polishing and surface reconstruction strategy to improve the surface quality of micron-thick Pb-Sn narrow-bandgap perovskites, enabling single-junction and all-perovskite tandem solar cells with efficiencies of 23.47% (certified) and 29.80%, respectively, by the antisolvent-free method.

According to a data model analysis, dark brown carbon emitted by wildfires exerts radiative effects that can rival or exceed those of black carbon, extending into mid- and high-latitude regions, including the Arctic.

Fe-based polyanionic cathodes are promising for Na-ion batteries but are limited by inactive Na sites and irreversible Na loss. Here the authors employ targeted V³⁺ substitution to tune the Na⁺ coordination environment, activate inert sites and stabilize high-voltage redox for high-performance Na-ion batteries.

Planetary science is a rapidly growing research field in China. In March 2025, many hundreds of early-career planetary scientists gathered in Huangshan, China, to exchange the latest findings on this topic.

The DAMPE satellite observed a universal charge-dependent spectral softening in primary cosmic rays, and ruled out mass-dependent softening with >99.999% confidence.

A meta-analysis of ~3,000 empirical observations shows that systemic shifts in manure management and technology integration can reduce reactive nitrogen and carbon dioxide emissions from global livestock systems under various mitigation scenarios.

Metainterfaces that have repetitive surface unit structures, and are inspired by the mortise–tenon and finger-joint structures used in traditional woodworking, can be used to create functional interfaces with enhanced electronic and thermal transport.

GSCo is a Generalist–Specialist Collaboration that combines the generalizability of generalist foundation models with the domain-specific benefits of specialist models. GSCo remains efficient and scalable while excelling at diverse medical tasks.

Lin et al. developed a Variational Autoencoder based deep learning model using daytime ambulatory blood pressure monitoring (ABPM) and activity/posture data to predict nocturnal hypertension. The study found that entropy-reduction preprocessing enhanced model performance, offering an effective supplement to ABPM for screening high-risk individuals intolerant to night monitoring.

Selenization is a key step in kesterite solar cell fabrication, but controlling ion migration during this process is challenging. Cui et al. address this issue by introducing a Li₂SnS₃ interphase, achieving a certified power conversion efficiency of 15.0%.

Photonic components fabricated from van der Waals materials and patterned using focused ion beam lithography with aluminium passivation demonstrate quality factors exceeding 10⁶ and an efficient nonlinear optical response.