Nature Search

Exosomal microRNA-4800-3p in portal vein blood promotes liver metastasis in pancreatic cancer by targeting PLAA

Satoru Miyahara
Hidenori Takahashi
Hidetoshi Eguchi
ResearchOpen Access19 Apr 2026
Scientific Reports

P: 1-16
Host control of persistent Epstein–Barr virus infection

Using blood-based genome sequence data, non-genetic and genetic factors associated with control of Epstein–Barr virus during persistent infection are reported.

Axel Schmidt
T. Madhusankha Alawathurage
Kerstin U. Ludwig
ResearchOpen Access19 Feb 2026
Nature

P: 1-13
Ultrafast plasma dynamics in laser-irradiated nanowire arrays probed with an X-ray free-electron laser

Daisuke Tanaka
Hiroshi Sawada
Keisuke Shigemori
ResearchOpen Access01 Apr 2026
Scientific Reports

P: 1-12
Rough Mutants of Salmonella Typhimurium (3) Enzymatic Synthesis of Nucleotide-Sugar Compounds

HIROSHI NIKAIDO
KISHIKO NIKAIDO
B. A. D. STOCKER
Research28 Mar 1964
Nature

Volume: 201, P: 1301-1302
Acid hydrolysis and α-hydroxy acids in meteorites

HIROSHI MLZUTANI
Research14 Dec 1978
Nature

Volume: 276, P: 738
The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force

Genetic mechanisms influencing COVID-19 susceptibility are not well understood. Here, the authors analyzed whole blood RNA-seq data of 465 Japanese individuals with COVID-19, highlighting thousands of fine-mapped variants affecting expression and splicing of genes, as well as the presence of COVID-19 severity-interaction eQTLs.

Qingbo S. Wang
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access22 Aug 2022
Nature Communications

Volume: 13, P: 1-19
DOCK2 is involved in the host genetics and biology of severe COVID-19

A genome-wide association study highlights a variant in DOCK2, which is common in East Asian populations but rare in Europeans, as a host genetic risk factor for severe COVID-19.

Ho Namkoong
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access08 Aug 2022
Nature

Volume: 609, P: 754-760
Blood DNA virome associates with autoimmune diseases and COVID-19

Analysis of the blood DNA virome in patients with COVID-19 and autoimmune disease associates endogenous HHV-6 (eHHV-6) and high anellovirus load with increased disease risk, most notably for systemic lupus erythematosus. eHHV-6 carriers show a distinct immune response.

Noah Sasa
Shohei Kojima
Yukinori Okada
ResearchOpen Access03 Jan 2025
Nature Genetics

Volume: 57, P: 65-79
BH4-domain peptide from Bcl-x_L exerts anti-apoptotic activity in vivo

Rie Sugioka
Shigeomi Shimizu
Yoshihide Tsujimoto
Research20 Nov 2003
Oncogene

Volume: 22, P: 8432-8440
MS-DIAL 5 multimodal mass spectrometry data mining unveils lipidome complexities

Lipids are complex molecules crucial for life. The authors developed MS-DIAL 5, a tool that enhances in-depth structure elucidations and the spatial mapping of lipidome. Using advanced techniques, they uncovered new insights into the biosynthetic pathway of eye-specific phosphatidylcholines.

Hiroaki Takeda
Yuki Matsuzawa
Hiroshi Tsugawa
ResearchOpen Access28 Nov 2024
Nature Communications

Volume: 15, P: 1-18
Transported into fuel cells

Proton-conducting solids are crucial components in a variety of electrochemical and energy-conversion devices. A porous metal–organic framework loaded with guest molecules displays both proton-conducting and gas-tight properties, affirming its potential as a fuel cell membrane.

Hiroshi Kitagawa
News & Views01 Dec 2009
Nature Chemistry

Volume: 1, P: 689-690
Cerium in chert as an indication of marine environment of its formation

HIROSHI SHIMIZU
AKIMASA MASUDA
Research24 Mar 1977
Nature

Volume: 266, P: 346-348
A Case of Kawasaki Disease with Re-dilatation of the Coronary Artery Five Years after the Onset

Yasuhiko Mori
Hiroshi Katayama
Hiroshi Tamai
Research01 Jan 2003
Pediatric Research

Volume: 53, P: 186
Optical Absorption and ESR Studies of Poly(p-phenylene sulfide) Doped with Sulfur Trioxide

Hiroshi Shimizu
Hisaaki Kanetsuna
Yoshikazu Tanabe
Research01 Aug 1987
Polymer Journal

Volume: 19, P: 915-922
Deciphering state-dependent immune features from multi-layer omics data at single-cell resolution

A single-cell multiomic immune cell atlas from 235 Japanese, including patients with COVID-19 and healthy individuals, linked with host genetics including germline and somatic mutation, plasma proteomics and metagenomics data reveals that immune cells are dynamically regulated in a cell state-dependent manner.

Ryuya Edahiro
Go Sato
Yukinori Okada
ResearchOpen Access28 Jul 2025
Nature Genetics

Volume: 57, P: 1905-1921
Functional expression and germline atransmission of a human chromosome fragment in chimaeric mice

Kazuma Tomizuka
Hitoshi Yoshida
Isao Ishida
Research01 Jun 1997
Nature Genetics

Volume: 16, P: 133-143
Long-term Outcome of Coronary Abnormalities in Kawasaki Disease

Hiroshi Nishikawa
Masaki Matsushima
Masami Nagashima
Research01 Jan 2003
Pediatric Research

Volume: 53, P: 186
X-Ray Photoelectron Spectroscopy of Electron-Acceptor Doped Poly(p-phenlene sulfide)

Hiroshi Shimizu
Yoshikazu Tanabe
Hisaaki Kanetsuna
Research01 Apr 1986
Polymer Journal

Volume: 18, P: 367-370
Mechanism of Charge-Transfer Polymerization. I. Polymerizations of N-Vinylcarbazole with Some Quinones in a Non-Polar Solvent

Tadao Natsuume
Masahiko Nishimura
Hiroshi Mikawa
Research01 Mar 1970
Polymer Journal

Volume: 1, P: 181-189
Involvement of the hypothalamus–raphe magnus–spinal defecation center axis in stress-induced defecation in rats

The hypothalamic neurons projecting to the raphe magnus nucleus activate descending serotonergic neurons, thereby activating spinal defecation center. The pathway plays a role in transmitting acute psychological stress to the colorectum.

Natsufu Yuki
Tomoya Sawamura
Yasutake Shimizu
ResearchOpen Access01 Apr 2026
Communications Biology

Volume: 9, P: 1-12
CD38 is critical for social behaviour by regulating oxytocin secretion

Duo Jin
Hong-Xiang Liu
Haruhiro Higashida
Research07 Feb 2007
Nature

Volume: 446, P: 41-45
Abrogation of aberrant glycolytic interactions eliminates senescent cells and alleviates aging-related dysfunctions

Takumi Mikawa
Masahiro Kameda
Hiroshi Kondoh
ResearchOpen Access15 Dec 2025
Signal Transduction and Targeted Therapy

Volume: 10, P: 1-18
Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin

Toshio Hirano
Kiyoshi Yasukawa
Tadamitsu Kishimoto
Research06 Nov 1986
Nature

Volume: 324, P: 73-76
Three-dimensional aromaticity in an antiaromatic cyclophane

Little is known about interactions between two antiaromatic molecules. Here, the authors synthesised a cyclophane, in which two antiaromatic porphyrin moieties adopt a stacked face-to-face geometry with a distance shorter than the sum of the van der Waals radii of the atoms involved.

Ryo Nozawa
Jinseok Kim
Hiroshi Shinokubo
ResearchOpen Access08 Aug 2019
Nature Communications

Volume: 10, P: 1-7
High proportion of missense mutations of the BRCA1 and BRCA2 genes in Japanese breast cancer families

Toyomasa Katagiri
Fujio Kasumi
Y. Miki
Research01 Feb 1998
Journal of Human Genetics

Volume: 43, P: 42-48
Cortical parvalbumin neurons are responsible for homeostatic sleep rebound through CaMKII activation

The role of cortical PV neurons in the regulation of sleep architecture and homeostatic sleep rebound is not fully understood. Here, the authors show that CaMKII-mediated control of cortical parvalbumin-neuron activity regulates the homeostatic sleep rebound in mice.

Kazuhiro Kon
Koji L. Ode
Hiroki R. Ueda
ResearchOpen Access18 Jul 2024
Nature Communications

Volume: 15, P: 1-19
A pivotal role of cytosolic phospholipase A₂ in bleomycin-induced pulmonary fibrosis

Takahide Nagase
Naonori Uozumi
Takao Shimizu
Research01 May 2002
Nature Medicine

Volume: 8, P: 480-484
High-performance affinity beads for identifying drug receptors

Noriaki Shimizu
Kotaro Sugimoto
Hiroshi Handa
Research01 Aug 2000
Nature Biotechnology

Volume: 18, P: 877-881
Sucrose-preferring gut microbes prevent host obesity by producing exopolysaccharides

While diet is essential for daily nutrient acquisition, excessive intake of sugar-rich foods drives obesity and related health issues like diabetes. Here, the authors show that commensal bacterium S. salivarius curbs obesity by transforming dietary sugars into beneficial compounds.

Hidenori Shimizu
Junki Miyamoto
Ikuo Kimura
ResearchOpen Access29 Jan 2025
Nature Communications

Volume: 16, P: 1-16
Cross-modal deep generative models reveal the cortical representation of dancing

Using fMRI and AI-powered computational models, researchers mapped how the brain choreographs dance—revealing precise, brain-wide patterns and clear differences between expert dancers and novices.

Yu Takagi
Daichi Shimizu
Hiroshi Imamizu
ResearchOpen Access18 Nov 2025
Nature Communications

Volume: 16, P: 1-12
Singular localization of sodium channel β4 subunit in unmyelinated fibres and its role in the striatum

Voltage-gated Na+ channel β-subunits are concentrated in the nodes of Ranvier and axon initial segments of myelinated axons and have a variety of functions. Here the authors show, using genetically modified mice, that this subunit is present in unmyelinated fibres in the striatum and is required for generation of resurgent Na+ current in striatal neurons.

Haruko Miyazaki
Fumitaka Oyama
Nobuyuki Nukina
Research21 Nov 2014
Nature Communications

Volume: 5, P: 1-15
Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity

Peripheral blood mononuclear cells from 73 Japanese patients with coronavirus disease 2019 (COVID-19) and 75 healthy controls were analyzed using single-cell transcriptomics. Combining these data with genotyping data highlights the interplay between host genetics and the immune response in modulating disease severity.

Ryuya Edahiro
Yuya Shirai
Yukinori Okada
ResearchOpen Access24 Apr 2023
Nature Genetics

Volume: 55, P: 753-767
Predicting future kidney function in type 2 diabetes mellitus using machine learning and baseline health information

Hiroyuki Unoki-Kubota
Kentaro Nakajima
Yasushi Kaburagi
ResearchOpen Access27 Mar 2026
Scientific Reports

Volume: 16, P: 1-12
Randomized open-label non-inferiority trial of paracetamol or celecoxib for patients with chronic low back pain

Kazuhiro Hayashi
Kenji Miki
Masao Yukioka
ResearchOpen Access09 Dec 2025
Scientific Reports

Volume: 16, P: 1-8
Mutations in the cardiac troponin I gene associated with hypertrophic cardiomyopathy

Akinori Kimura
Haruhito Harada
Takehiko Sasazuki
Research01 Aug 1997
Nature Genetics

Volume: 16, P: 379-382
Complete sequencing and characterization of 21,243 full-length human cDNAs

Toshio Ota
Yutaka Suzuki
Sumio Sugano
Research21 Dec 2003
Nature Genetics

Volume: 36, P: 40-45
Outcomes of sequential therapy for advanced upper tract urothelial cancer and bladder cancer

Manato Kanesaka
Tomokazu Sazuka
Tomohiko Ichikawa
ResearchOpen Access25 Nov 2025
Scientific Reports

Volume: 15, P: 1-10
Polymerization of N-Phenylmaleimide with Organoaluminum Initiators

Tokio Hagiwara
Yasushi Sekino
Tadashi Narita
Research01 Mar 1994
Polymer Journal

Volume: 26, P: 349-356
Stemphones, Novel Potentiators of Imipenem Activity against Methicillin-resistant Staphylococcus aureus, Produced by Aspergillus sp. FKI-2136

Nobuhiro Koyama
Tomoko Nagahiro
Satoshi Ōmura
Research01 Nov 2005
The Journal of Antibiotics

Volume: 58, P: 695-703
Decreased extra-renal urate excretion is a common cause of hyperuricemia

Hyperuricemia, or gout, is thought to arise either from urate overproduction or from decreased renal excretion of urate. Ichidaet al. show that the extra-renal excretion of urate also has a role in the pathogenesis of hyperuricemia, and propose a new classification for patients with this disease.

Kimiyoshi Ichida
Hirotaka Matsuo
Hiroshi Suzuki
ResearchOpen Access03 Apr 2012
Nature Communications

Volume: 3, P: 1-7
Genome-wide association meta-analysis identifies GP2 gene risk variants for pancreatic cancer

Previous genome-wide association studies have identified risk loci for pancreatic cancer but were centered on individuals of European ancestry. Here the authors identify GP2 gene variants associated with pancreatic cancer susceptibility in populations of East Asian ancestry.

Yingsong Lin
Masahiro Nakatochi
Keitaro Matsuo
ResearchOpen Access24 Jun 2020
Nature Communications

Volume: 11, P: 1-12
Seasonal pigment fluctuation in diploid and polyploid Arabidopsis revealed by machine learning-based phenotyping method PlantServation

Long-term monitoring of plants in field fluctuating environments remains challenging. Here, the authors develop PlantServation, a machine learning-based phenotyping method, and estimate environmental and genotypic effects on the pigment anthocyanin content of diploid and polyploid Arabidopsis.

Reiko Akiyama
Takao Goto
Kentaro K. Shimizu
ResearchOpen Access22 Sept 2023
Nature Communications

Volume: 14, P: 1-16
dbTMM: an integrated database of large-scale cohort, genome and clinical data for the Tohoku Medical Megabank Project

Soichi Ogishima
Satoshi Nagaie
Masayuki Yamamoto
ResearchOpen Access10 Dec 2021
Human Genome Variation

Volume: 8, P: 1-8
A mutation in the ceruloplasmin gene is associated with systemic hemosiderosis in humans

Kunihiro Yoshida
Kenichi Furihata
Nobuo Yanagisawa
Research01 Mar 1995
Nature Genetics

Volume: 9, P: 267-272
Adult Patients of Kawasaki Disease with Acute Myocardial Infarction Who had not been Pointed Out Coronary Artery Lesions Previously

Yasuhiko Mori
Hiroshi Katayama
Hiroshi Tamai
Research01 Jan 2003
Pediatric Research

Volume: 53, P: 178
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
Grafting of iPS cell-derived tenocytes promotes motor function recovery after Achilles tendon rupture

Tendon self-renewal occurs rarely and reconstructive surgery comes with significant limitations. Here the authors present an induced pluripotent stem cell-based method to generate tenocytes, analyze their developmental trajectory using scRNA-seq, and demonstrate their contribution to motor function recovery after Achilles tendon injury via engraftment and paracrine effects.

Taiki Nakajima
Akihiro Nakahata
Makoto Ikeya
ResearchOpen Access18 Aug 2021
Nature Communications

Volume: 12, P: 1-12
Cyslabdan, a New Potentiator of Imipenem Activity against Methicillin-resistant Staphylococcus aureus, Produced by Streptomyces sp. K04-0144

Atsushi Fukumoto
Yong-Pil Kim
Satoshi Ōmura
Research01 Jan 2008
The Journal of Antibiotics

Volume: 61, P: 7-10
Pancreatic glycoprotein 2 is a first line of defense for mucosal protection in intestinal inflammation

Glycoprotein-2 (GP-2) can protect the intestinal epithelial barrier from bacteria and is associated with protection against Crohn’s disease. Here, the authors show pancreatic GP-2 is the source of the intestine’s luminal GP-2 that binds bacteria and prevents them from attaching to the epithelium, also limiting pathology in a DSS colitis mouse model.

Yosuke Kurashima
Takaaki Kigoshi
Hiroshi Kiyono
ResearchOpen Access16 Feb 2021
Nature Communications

Volume: 12, P: 1-17
Blood pressure during long-term cilostazol-based dual antiplatelet therapy after stroke: a post hoc analysis of the CSPS.com trial

Kazunori Toyoda
Masatoshi Koga
Hiroaki Tanaka
ResearchOpen Access09 Jul 2024
Hypertension Research

Volume: 47, P: 2238-2249

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