Nature Search

On the issue of transparency and reproducibility in nanomedicine

Following our call to join in the discussion over the suitability of implementing a reporting checklist for bio–nano papers, the community responds.

Hon S. Leong
Kimberly S. Butler
Chiara Pastore
Correspondence03 Jul 2019
Nature Nanotechnology

Volume: 14, P: 629-635
Publisher Correction: Methionine is a metabolic dependency of tumor-initiating cells

Zhenxun Wang
Lian Yee Yip
Wai Leong Tam
Amendments and Corrections21 May 2019
Nature Medicine

Volume: 25, P: 1022
The landscape of N⁶-methyladenosine in localized primary prostate cancer

Transcriptome-wide m⁶A RNA methylation profile in 162 primary prostate tumors identifies m⁶A association with prognostic clinical features and disease aggression.

Xin Xu
Helen Zhu
Housheng Hansen He
ResearchOpen Access24 Mar 2025
Nature Genetics

Volume: 57, P: 934-948
Analysis of clinically relevant variants from ancestrally diverse Asian genomes

Clinically significant genetic variation in Asian populations is under-characterized. Here, the authors show the diversity in prevalence and spectrum of human disease and pharmacogenetic variants in a multi-ethnic Asian population.

Sock Hoai Chan
Yasmin Bylstra
Weng Khong Lim
ResearchOpen Access05 Nov 2022
Nature Communications

Volume: 13, P: 1-15
Methionine is a metabolic dependency of tumor-initiating cells

Elevated activity of the methionine cycle is essential for cancer stem cell tumorigenesis and represents a therapeutic vulnerability.

Zhenxun Wang
Lian Yee Yip
Wai Leong Tam
Research06 May 2019
Nature Medicine

Volume: 25, P: 825-837
Genomic landscape of lung adenocarcinoma in East Asians

Genomic and transcriptomic analysis of lung adenocarcinoma (LUAD) in Asia indicates that Asian LUADs have fewer mutations, lower driver prevalence and fewer copy number alterations than European LUADs.

Jianbin Chen
Hechuan Yang
Weiwei Zhai
Research03 Feb 2020
Nature Genetics

Volume: 52, P: 177-186
E-cadherin interacts with EGFR resulting in hyper-activation of ERK in multiple models of breast cancer

Gabriella C. Russo
Ashleigh J. Crawford
Denis Wirtz
Research20 Mar 2024
Oncogene

Volume: 43, P: 1445-1462
The spatial organization of intra-tumour heterogeneity and evolutionary trajectories of metastases in hepatocellular carcinoma

Hepatocellular carcinoma has one of the poorest survival rates amongst cancers. Here, the authors highlight the intra-tumour heterogeneity of this disease, finding that spatially closer tumour sectors are genetically more similar and that intra-hepatic metastasis is accompanied by rapid genetic diversification.

Weiwei Zhai
Tony Kiat-Hon Lim
Pierce Kah-Hoe Chow
ResearchOpen Access27 Feb 2017
Nature Communications

Volume: 8, P: 1-9
Perceived stress during labor and its association with depressive symptomatology, anxiety, and pain catastrophizing

Hon Sen Tan
T. Agarthesh
Ban Leong Sng
ResearchOpen Access20 Aug 2021
Scientific Reports

Volume: 11, P: 1-7
Novel Methods of Determining Urinary Calculi Composition: Petrographic Thin Sectioning of Calculi and Nanoscale Flow Cytometry Urinalysis

Carson T Gavin
Sohrab N Ali
Hon S Leong
ResearchOpen Access14 Jan 2016
Scientific Reports

Volume: 6, P: 1-12
Scaffold-free, Human Mesenchymal Stem Cell-Based Tissue Engineered Blood Vessels

Youngmee Jung
HaYeun Ji
Kam W. Leong
ResearchOpen Access12 Oct 2015
Scientific Reports

Volume: 5, P: 1-9
Elucidating the genomic architecture of Asian EGFR-mutant lung adenocarcinoma through multi-region exome sequencing

EGFR mutant lung adenocarcinoma (LUAD) exhibit diverse clinical outcomes in response to targeted therapies. Here the authors show that these LUADs involve a complex genomic landscape with high intratumor heterogeneity, providing insights into the evolutionary trajectory of oncogene-driven LUAD and potential mediators of EGFR TKI resistance.

Rahul Nahar
Weiwei Zhai
Daniel S. W. Tan
ResearchOpen Access15 Jan 2018
Nature Communications

Volume: 9, P: 1-11
STEAP1-targeted strategies in advanced prostate cancer: a review on therapeutic and diagnostic implications

Ja Yoon Heo
Minzhi Sheng
Urban Emmenegger
Reviews23 Oct 2025
Prostate Cancer and Prostatic Diseases

P: 1-7
Publisher Correction: On the issue of transparency and reproducibility in nanomedicine

Hon S. Leong
Kimberly S. Butler
Chiara Pastore
Amendments and Corrections29 Jul 2019
Nature Nanotechnology

Volume: 14, P: 902
Publisher Correction: On the issue of transparency and reproducibility in nanomedicine

Hon S. Leong
Kimberly S. Butler
Chiara Pastore
Amendments and Corrections09 Jul 2019
Nature Nanotechnology

Volume: 14, P: 811
The classification of intestinal polyposis

Peh Yean Cheah
Kiat Hon Lim
Choong Leong Tang
Correspondence26 Dec 2012
Nature Genetics

Volume: 45, P: 2
Cancer cell extravasation requires ⁱplectin-mediated delivery of MT1-MMP at invadopodia

Olivia R. Grafinger
John J. Hayward
Hon S. Leong
Research05 Jul 2024
British Journal of Cancer

Volume: 131, P: 931-943
The Singapore National Precision Medicine Strategy

This Perspective article discusses Singapore’s efforts to implement a National Precision Medicine Strategy through the integration of genomic, clinical and lifestyle data of up to one million Singaporean individuals.

Eleanor Wong
Nicolas Bertin
Patrick Tan
Reviews19 Jan 2023
Nature Genetics

Volume: 55, P: 178-186
Targeting of CCBE1 by miR-330-3p in human breast cancer promotes metastasis

Aruz Mesci
Xiaoyong Huang
Stanley K Liu
ResearchOpen Access18 Apr 2017
British Journal of Cancer

Volume: 116, P: 1350-1357
Translational models of prostate cancer bone metastasis

In this Review, Berish and colleagues outline the development of currently used models of prostate cancer bone metastasis and discuss mechanistic and therapeutic advances made using these models. The authors also suggest future directions to improve the applicability of these models to the metastatic cascade and human disease.

Richard B. Berish
Aymon N. Ali
Hon S. Leong
Reviews16 May 2018
Nature Reviews Urology

Volume: 15, P: 403-421
Clinical significance of STEAP1 extracellular vesicles in prostate cancer

Karan Khanna
Nikki Salmond
Karla C. Williams
ResearchOpen Access15 Feb 2021
Prostate Cancer and Prostatic Diseases

Volume: 24, P: 802-811
Human fetal dendritic cells promote prenatal T-cell immune suppression through arginase-2

Prenatal immune suppression is regulated by fetal arginase-2-expressing dendritic cells which respond normally to toll-like receptor stimulation but, in contrast to adult dendritic cells, induce regulatory T cells and repress TNF-α secretion by effector T cells.

Naomi McGovern
Amanda Shin
Florent Ginhoux
Research14 Jun 2017
Nature

Volume: 546, P: 662-666
Invadopodia are chemosensing protrusions that guide cancer cell extravasation to promote brain tropism in metastasis

Karla C. Williams
Mario A. Cepeda
Hon S. Leong
ResearchOpen Access16 Jan 2019
Oncogene

Volume: 38, P: 3598-3615
Accelerated growth and local progression of radiorecurrent prostate cancer in an orthotopic bioluminescent mouse model

Gavin Frame
Xiaoyong Huang
Stanley K. Liu
ResearchOpen Access28 Dec 2024
Scientific Reports

Volume: 14, P: 1-13
Quantification of cancer cell extravasation in vivo

This protocol describes a rapid (<24 h), reproducible and cheap technique for evaluating cancer cell invasiveness by quantifying in vivo rates of cancer cell extravasation in the chorioallantoic membrane (CAM) of chicken embryos.

Yohan Kim
Karla C Williams
Hon S Leong
Protocols21 Apr 2016
Nature Protocols

Volume: 11, P: 937-948
Factors associated with women’s preferences for labor epidural analgesia in Singapore: a survey approach

Chin Wen Tan
Semra Ozdemir
Ban Leong Sng
ResearchOpen Access29 Jun 2022
Scientific Reports

Volume: 12, P: 1-9
Correction: E-cadherin interacts with EGFR resulting in hyper-activation of ERK in multiple models of breast cancer

Gabriella C. Russo
Ashleigh J. Crawford
Denis Wirtz
Amendments and Corrections05 Apr 2024
Oncogene

Volume: 43, P: 1488
Targeting PLOD2 suppresses invasion and metastatic potential in radiorecurrent prostate cancer

Gavin Frame
Hon Leong
Stanley K. Liu
ResearchOpen Access21 Aug 2024
BJC Reports

Volume: 2, P: 1-11
A set of molecular markers predicts chemosensitivity to Mitomycin-C following cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for colorectal peritoneal metastasis

Nicholas Brian Shannon
Joey Wee-Shan Tan
Melissa Ching Ching Teo
ResearchOpen Access22 Jul 2019
Scientific Reports

Volume: 9, P: 1-10
Rapid formation of multicellular spheroids in double-emulsion droplets with controllable microenvironment

Hon Fai Chan
Ying Zhang
Kam W. Leong
ResearchOpen Access10 Dec 2013
Scientific Reports

Volume: 3, P: 1-8
Jerantinine A induces tumor-specific cell death through modulation of splicing factor 3b subunit 1 (SF3B1)

Felicia Fei-Lei Chung
Perry Faith Tze Ming Tan
Chee-Onn Leong
ResearchOpen Access15 Feb 2017
Scientific Reports

Volume: 7, P: 1-13
Female tilapia, Oreochromis sp. mobilised energy differently for growth and reproduction according to living environment

Ros Suhaida Razali
Sharifah Rahmah
Hon Jung Liew
ResearchOpen Access05 Feb 2024
Scientific Reports

Volume: 14, P: 1-10
Correction: Corrigendum: Stage of Breast Cancer Progression Influences Cellular Response to Activation of the WNT/Planar Cell Polarity Pathway

Connor D. MacMillan
Hon S. Leong
Alan B. Tuck
Amendments and Corrections23 Jan 2015
Scientific Reports

Volume: 5, P: 1
At-admission prediction of mortality and pulmonary embolism in an international cohort of hospitalised patients with COVID-19 using statistical and machine learning methods

Munib Mesinovic
Xin Ci Wong
David Zucman
ResearchOpen Access16 Jul 2024
Scientific Reports

Volume: 14, P: 1-43
Kidney injury molecule-1 inhibits metastasis of renal cell carcinoma

Jasper C. Lee
Demitra M. Yotis
Lakshman Gunaratnam
ResearchOpen Access04 Jun 2021
Scientific Reports

Volume: 11, P: 1-12
Stage of Breast Cancer Progression Influences Cellular Response to Activation of the WNT/Planar Cell Polarity Pathway

Connor D. MacMillan
Hon S. Leong
Alan B. Tuck
ResearchOpen Access10 Sept 2014
Scientific Reports

Volume: 4, P: 1-14
Neonicotinoid-induced pathogen susceptibility is mitigated by Lactobacillus plantarum immune stimulation in a Drosophila melanogaster model

Brendan A. Daisley
Mark Trinder
Gregor Reid
ResearchOpen Access02 Jun 2017
Scientific Reports

Volume: 7, P: 1-13
Intravital imaging of embryonic and tumor neovasculature using viral nanoparticles

Hon Sing Leong
Nicole F Steinmetz
John D Lewis
Protocols08 Jul 2010
Nature Protocols

Volume: 5, P: 1406-1417
High-pH reversed-phase fractionated neural retina proteome of normal growing C57BL/6 mouse

Ying Hon Sze
Qian Zhao
Thomas Chuen Lam
ResearchOpen Access26 Jan 2021
Scientific Data

Volume: 8, P: 1-9
Isolation and synthesis of falcitidin, a novel myxobacterial-derived acyltetrapeptide with activity against the malaria target falcipain-2

Brinda Somanadhan
Santosh R Kotturi
Mark S Butler
Research23 Jan 2013
The Journal of Antibiotics

Volume: 66, P: 259-264
Microfluidic enrichment for the single cell analysis of circulating tumor cells

Trifanny Yeo
Swee Jin Tan
Chwee Teck Lim
ResearchOpen Access29 Feb 2016
Scientific Reports

Volume: 6, P: 1-12
Structural basis for the neutralization of hepatitis E virus by a cross-genotype antibody

Ying Gu
Xuhua Tang
J. Sivaraman
Research20 Mar 2015
Cell Research

Volume: 25, P: 604-620
Human 21T breast epithelial cell lines mimic breast cancer progression in vivo and in vitro and show stage-specific gene expression patterns

Lesley H Souter
Joseph D Andrews
Alan B Tuck
Research10 May 2010
Laboratory Investigation

Volume: 90, P: 1247-1258
ISARIC-COVID-19 dataset: A Prospective, Standardized, Global Dataset of Patients Hospitalized with COVID-19

Ali Abbas
Sheryl Ann Abdukahil
Luis Felipe Reyes
ResearchOpen Access30 Jul 2022
Scientific Data

Volume: 9, P: 1-22
Extracellular vesicles such as prostate cancer cell fragments as a fluid biopsy for prostate cancer

S I Brett
Y Kim
H S Leong
Reviews12 May 2015
Prostate Cancer and Prostatic Diseases

Volume: 18, P: 213-220

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