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Showing 1–50 of 63 results

Advanced filters: Author: J Kuball Clear advanced filters

De novo H3.3K27M-altered diffuse midline glioma in human brainstem organoids to dissect GD2 CAR T cell function

Bessler et al. developed a human organoid model for H3.3K27M-altered diffuse midline glioma that recapitulates key tumor features and demonstrated its utility for modeling CAR T cell and microglia functions.

Nils Bessler
Amber K. L. Wezenaar
Anne C. Rios
ResearchOpen Access05 Jan 2026
Nature Cancer

P: 1-18
Dual targeting of cancer metabolome and stress antigens affects transcriptomic heterogeneity and efficacy of engineered T cells

Here, the authors show that combining γ9δ2 TCR-mediated metabolic and co-stimulatory stress targeting by chimeric NKG2D or anti-CD277 co-receptors shapes transcriptomic heterogeneity of engineered T cells and is associated with improved control of solid tumors.

Patricia Hernández-López
Eline van Diest
Jürgen Kuball
Research27 Nov 2023
Nature Immunology

Volume: 25, P: 88-101
Gallium nitride multichannel devices with latch-induced sub-60-mV-per-decade subthreshold slopes for radiofrequency applications

A distribution in fin widths, due to variability in the fabrication process, can be used to study a latching condition in gallium nitride transistors in which drain current sharply transits from an off-state value to a high on-state value with a slope of less than 60 mV per decade.

Akhil S. Kumar
Stefano Dalcanale
Martin Kuball
ResearchOpen Access22 May 2025
Nature Electronics

Volume: 8, P: 510-517
CCR5-targeted allogeneic gamma–delta CD19 chimeric antigen receptor T cells for HIV-associated B cell-malignancy immunotherapy

CCR5-deficient gamma–delta CD19 CAR T cells show resistance to HIV-mediated depletion and antitumour efficacy in B cell malignancies.

Ángel Ramírez-Fernández
Alexander J. Dimitri
Joseph A. Fraietta
Research21 Oct 2025
Nature Biomedical Engineering

P: 1-15
Cis- and trans-binding chimeric costimulatory receptors enhance T-cell fitness and tumor control

Patricia Hernández-López
Caterina Riillo
Dennis X. Beringer
Research10 Dec 2025
Cellular & Molecular Immunology

Volume: 23, P: 79-93
Uncovering the mode of action of engineered T cells in patient cancer organoids

The dynamics and molecular mechanisms of T cell therapies are probed in cancer organoids.

Johanna F. Dekkers
Maria Alieva
Anne C. Rios
ResearchOpen Access25 Jul 2022
Nature Biotechnology

Volume: 41, P: 60-69
Electric field mapping of wide-bandgap semiconductor devices at a submicrometre resolution

Electric-field-induced second harmonic generation can be used to measure the in-plane electric field in gallium nitride high-electron-mobility transistors and probe how dopants influence the electric field distribution.

Yuke Cao
James W. Pomeroy
Martin Kuball
Research21 Jun 2021
Nature Electronics

Volume: 4, P: 478-485
Current capacity and gaps in viral vector manufacturing: a survey of centers associated with CTIWP of EBMT, NXTGEN-hightech, DARE-NL, T2EVOLVE, and GoCART coalition

Ganesh Ramesh
Zsolt Sebestyen
Jurgen Kuball
Correspondence17 Dec 2025
Bone Marrow Transplantation

P: 1-4
CRISPR screens decode cancer cell pathways that trigger γδ T cell detection

A combination of genome-wide CRISPR screens in target cancer cells identifies pathways that regulate γδ T cell killing and BTN3A cell surface expression.

Murad R. Mamedov
Shane Vedova
Alexander Marson
Research30 Aug 2023
Nature

Volume: 621, P: 188-195
Usage of rabbit anti-thymocyte / anti-T-lymphocyte globulins (ATG / ATLG) for hematological malignancies in allogeneic hematopoietic cell transplantation: Best practice recommendations from the EBMT Practice Harmonisation and Guidelines Committee

Giorgia Battipaglia
Claudia Wehr
Jürgen Kuball
Reviews26 Nov 2025
Bone Marrow Transplantation

P: 1-14
Disrupting the balance between activating and inhibitory receptors of γδT cells for effective cancer immunotherapy

In this Review, Beringer and colleagues highlight how future strategies for developing immunotherapies using γδT cells and their receptors will depend on creating intentional imbalances between activating and inhibitory receptors through the genetic engineering of γδT cell-inspired biologics and cellular therapies.

Dennis X. Beringer
Trudy Straetemans
Jürgen Kuball
Reviews02 Jun 2025
Nature Reviews Cancer

Volume: 25, P: 590-612
Engineered allogeneic T cells decoupling T-cell-receptor and CD3 signalling enhance the antitumour activity of bispecific antibodies

The antitumour activity of bispecific antibodies in immunocompromised hosts can be potentiated via allogeneic T cells engineered with a T-cell receptor that decouples antigen-mediated T-cell activation from T-cell cytotoxicity.

Edo Kapetanovic
Cédric R. Weber
Sai T. Reddy
ResearchOpen Access25 Sept 2024
Nature Biomedical Engineering

Volume: 8, P: 1665-1681
Circumventing tolerance to a human MDM2-derived tumor antigen by TCR gene transfer

Thomas Stanislawski
Ralf-Holger Voss
Matthias Theobald
Research01 Oct 2001
Nature Immunology

Volume: 2, P: 962-970
Hunting for clinical translation with innate-like immune cells and their receptors

W Scheper
C Gründer
J Kuball
Reviews18 Dec 2013
Leukemia

Volume: 28, P: 1181-1190
Carfilzomib, lenalidomide and dexamethasone followed by a second ASCT is an effective strategy in first relapse multiple myeloma: a study on behalf of the Chronic malignancies working party of the EBMT

Rémi Tilmont
Ibrahim Yakoub-Agha
Salomon Manier
ResearchOpen Access05 Aug 2023
Bone Marrow Transplantation

Volume: 58, P: 1182-1188
Anti-thymocyte globulin with CsA and MMF as GVHD prophylaxis in nonmyeloablative HLA-mismatched allogeneic HCT

Walter J. F. M. van der Velden
Goda Choi
Suzanne van Dorp
Research19 Jun 2021
Bone Marrow Transplantation

Volume: 56, P: 2651-2655
Prospective evaluation of sequential treatment of sclerotic chronic graft versus host disease with rituximab and nilotinib

Lotte van der Wagen
Liane te Boome
Jürgen Kuball
Research16 Mar 2018
Bone Marrow Transplantation

Volume: 53, P: 1255-1262
Uniform electroactive fibre-like micelle nanowires for organic electronics

The self-assembly of block copolymers to form micelles has been used in applications such as drug delivery and composite reinforcement. Here the authors explore the use of fibre-like micelles of controlled length in the active layer of field-effect transistor devices.

Xiaoyu Li
Piotr J. Wolanin
Ian Manners
ResearchOpen Access26 Jun 2017
Nature Communications

Volume: 8, P: 1-9
Combination of a fusogenic glycoprotein, pro-drug activation and oncolytic HSV as an intravesical therapy for superficial bladder cancer

G R Simpson
A Horvath
H S Pandha
ResearchOpen Access12 Jan 2012
British Journal of Cancer

Volume: 106, P: 496-507
Improved GVHD-free and relapse-free survival after ex vivo αβTCR and CD19 depleted allogeneic HSCT compared to T cell replete HSCT

A. H. G. Stuut
C. Nijssen
M. A. de Witte
Research15 Mar 2025
Bone Marrow Transplantation

Volume: 60, P: 673-681
Translating gammadelta (γδ) T cells and their receptors into cancer cell therapies

γδT cells display potent cytotoxicity towards a large array of haematological and solid tumours while preserving normal tissues. In this Review, Sebestyen et al. analyse the tumour specificity mechanisms of γδT cells and the challenges and opportunities for the use of such cells and their receptors in cancer immunotherapy.

Zsolt Sebestyen
Immo Prinz
Jurgen Kuball
Reviews06 Sept 2019
Nature Reviews Drug Discovery

Volume: 19, P: 169-184
In-depth virological and immunological characterization of HIV-1 cure after CCR5Δ32/Δ32 allogeneic hematopoietic stem cell transplantation

The recipient of an allogeneic stem cell transplant from a CCR5Δ32/Δ32 donor shows evidence of HIV type 1 cure, including the absence of a viral rebound over 4 years after stopping antiretroviral treatment.

Björn-Erik Ole Jensen
Elena Knops
Guido Kobbe
ResearchOpen Access20 Feb 2023
Nature Medicine

Volume: 29, P: 583-587
Fresh or frozen grafts for allogeneic stem cell transplantation: conceptual considerations and a survey on the practice during the COVID-19 pandemic from the EBMT Infectious Diseases Working Party (IDWP) and Cellular Therapy & Immunobiology Working Party (CTIWP)

N. Worel
P. Ljungman
A. Ruggeri
Research06 Sept 2023
Bone Marrow Transplantation

Volume: 58, P: 1348-1356
Warming Alaskan rivers affect first-year growth in critical northern food fishes

Peyton A. Thomas
Dylan Blaskey
Keith N. Musselman
ResearchOpen Access06 Aug 2025
Scientific Reports

Volume: 15, P: 1-14
Mapping T cell dynamics to molecular profiles through behavior-guided transcriptomics

Behavior-guided transcriptomics is an extension to the BEHAV3D protocol, for the integration of T cell live-imaging data with single-cell transcriptomics, enabling analysis of gene programs linked to dynamic T cell behaviors.

A. K. L. Wezenaar
U. Pandey
A. C. Rios
Protocols10 Feb 2025
Nature Protocols

Volume: 20, P: 2453-2480
Preserved measles immunity after allogeneic hematopoietic stem cell transplantation in a cohort of mainly αβ T-cell-depleted graft recipients

M. J. M. Janssen
M. A. de Witte
A.H.W. Bruns
Correspondence06 Oct 2025
Bone Marrow Transplantation

Volume: 61, P: 92-94
Predictive factors for vaccine failure to guide vaccination in allogeneic hematopoietic stem cell transplant recipients

Michelle J. M. Janssen
Anke H. W. Bruns
Jürgen Kuball
Research20 Aug 2021
Bone Marrow Transplantation

Volume: 56, P: 2922-2928
Pure white cell aplasia following allogeneic hematopoietic stem cell transplantation

Laura A. Michielsen
Moniek A. de Witte
Anna van Rhenen
Correspondence25 Sept 2025
Bone Marrow Transplantation

Volume: 60, P: 1669-1671
BEHAV3D: a 3D live imaging platform for comprehensive analysis of engineered T cell behavior and tumor response

BEHAV3D is a 3D live imaging platform for analyzing engineered T cell behavior and tumor response. This provides insights into the mode of action of cellular immunotherapy, capturing heterogeneity within and between tumors during treatment response.

Maria Alieva
Mario Barrera Román
Anne C. Rios
Protocols19 Mar 2024
Nature Protocols

Volume: 19, P: 2052-2084
Graft engineering: how long can you wait, how low can you go, and pandemic readiness

Klaartje Nijssen
Kasper Westinga
Jürgen Kuball
Correspondence03 Apr 2023
Bone Marrow Transplantation

Volume: 58, P: 820-822
Physiochemical disparity of mismatched HLA class I alloantigens and risk of acute GVHD following HSCT

V Kosmoliaptsis
M M Jöris
F H J Claas
Research26 Jan 2015
Bone Marrow Transplantation

Volume: 50, P: 540-544
Adenovirus-mediated gene therapy for bladder cancer: efficient gene delivery to normal and malignant human urothelial cells in vitro and ex vivo

J D Chester
W Kennedy
M A Knowles
Research14 Jan 2003
Gene Therapy

Volume: 10, P: 172-179
Lenalidomide added to standard intensive treatment for older patients with AML and high-risk MDS

G. J. Ossenkoppele
D. A. Breems
M. Van Marwijk Kooy
Research04 Feb 2020
Leukemia

Volume: 34, P: 1751-1759
Hematopoietic stem cell transplantation in Europe 2014: more than 40 000 transplants annually

J R Passweg
H Baldomero
M Mohty
ResearchOpen Access22 Feb 2016
Bone Marrow Transplantation

Volume: 51, P: 786-792
Gene therapy for bladder cancer using E1B-55 kD-deleted adenovirus in combination with adenoviral vector encoding plasminogen kringles 1–5

J-L Hsieh
C-L Wu
A-L Shiau
ResearchOpen Access29 Apr 2003
British Journal of Cancer

Volume: 88, P: 1492-1499
Activity of ex vivo graft and DLI Engineering within the last decade increases, a survey from the EBMT Cellular Therapy & Immunobiology Working Party

M. A. de Witte
J. E. Mooyaart
J. Kuball
Correspondence18 Mar 2023
Bone Marrow Transplantation

Volume: 58, P: 719-722
Compatibility at amino acid position 98 of MICB reduces the incidence of graft-versus-host disease in conjunction with the CMV status

Raphael Carapito
Ismail Aouadi
Seiamak Bahram
Research14 Apr 2020
Bone Marrow Transplantation

Volume: 55, P: 1367-1378
Comparative therapeutic value of post-remission approaches in patients with acute myeloid leukemia aged 40–60 years

J J Cornelissen
J Versluis
B Löwenberg
Research27 Nov 2014
Leukemia

Volume: 29, P: 1041-1050
Disseminated nontuberculous mycobacterial infections after allogeneic hematopoietic stem cell transplantation: a risk-based strategy for early diagnosis

Laura G. M. Daenen
Jan-Tom van der Bruggen
Jurgen Kuball
Correspondence20 May 2023
Bone Marrow Transplantation

Volume: 58, P: 956-958
Correction to: Predictive factors for vaccine failure to guide vaccination in allogeneic hematopoietic stem cell transplant recipients

Michelle J. M. Janssen
Anke H. W. Bruns
Jürgen Kuball
Amendments and Corrections31 Mar 2022
Bone Marrow Transplantation

Volume: 57, P: 1050
Biomarker profiling of steroid-resistant acute GVHD in patients after infusion of mesenchymal stromal cells

L C J te Boome
C Mansilla
J Kuball
Research03 Apr 2015
Leukemia

Volume: 29, P: 1839-1846
The use of MSCs in steroid-refractory acute GvHD in Europe: a survey from the EBMT cellular therapy & immunobiology working party

L. G. M. Daenen
L. E. van der Wagen
J. Kuball
Correspondence20 Feb 2025
Bone Marrow Transplantation

Volume: 60, P: 708-714
Efficacy of MSC for steroid-refractory acute GVHD associates with MSC donor age and a defined molecular profile

Lotte E. van der Wagen
Alberto Miranda-Bedate
Jürgen Kuball
Correspondence28 Apr 2020
Bone Marrow Transplantation

Volume: 55, P: 2188-2192
Tyrosine kinase inhibitor levels matter in treating chronic GVHD

Lotte van der Wagen
Julie Janssen
Jürgen Kuball
Correspondence16 Jan 2019
Bone Marrow Transplantation

Volume: 54, P: 1141-1144
γδT cells elicited by CMV reactivation after allo-SCT cross-recognize CMV and leukemia

W Scheper
S van Dorp
J Kuball
Research01 Jan 2013
Leukemia

Volume: 27, P: 1328-1338
Trends in allogeneic haematopoietic cell transplantation for myelofibrosis in Europe between 1995 and 2018: a CMWP of EBMT retrospective analysis

D. McLornan
D. J. Eikema
I. Yakoub-Agha
Research28 Apr 2021
Bone Marrow Transplantation

Volume: 56, P: 2160-2172
Severe ICANS after CAR T-cell therapy and assessment of prevention with levetiracetam for seizure prophylaxis following CAR T-cell for DLBCL & PMBCL in Europe: a survey on behalf of the Cellular Therapy & Immunobiology Working Party (CTIWP) of the EBMT

Piera Angelillo
Ana Alarcon Tomas
Annalisa Ruggeri
Correspondence25 Oct 2024
Bone Marrow Transplantation

Volume: 60, P: 100-102
Comparative value of post-remission treatment in cytogenetically normal AML subclassified by NPM1 and FLT3-ITD allelic ratio

J Versluis
F E M in ‘t Hout
J J Cornelissen
Research24 Jun 2016
Leukemia

Volume: 31, P: 26-33
Jon van Rood (1926–2017)

C Mueller
C Bonini
M Mohty
Comments & Opinion06 Dec 2017
Bone Marrow Transplantation

Volume: 52, P: 1587
Ruxolitinib in corticosteroid-refractory graft-versus-host disease after allogeneic stem cell transplantation: a multicenter survey

R Zeiser
A Burchert
N von Bubnoff
Research31 Jul 2015
Leukemia

Volume: 29, P: 2062-2068

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