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Combined behavioural, circuit-level and cellular approaches are used to demonstrate how hypothalamic neurons integrate hunger and oestrous state to drive a switch in how female mice interact with pups.

Yelland et al. use yeast genetics and cryo-EM to show how 2′-O-methylation on a single rRNA base gates the assembly of the ribosome via regulating interaction with the essential GTPase Nog2.

A dispersive sensing technique, termed the radiofrequency electron cascade, can perform singlet-triplet readout of two exchange-coupled electron spins in a natural silicon planar metal–oxide–semiconductor quantum-dot array.

Typically, Boolean logic gates have to compromise between high speed and low energy consumption which can become limiting at scale. Here, the authors demonstrate architectures for NOT and XNOR gates that enable simultaneous low power and fast operation.

The leakiness of commonly used genetic components can make the construction of complex synthetic circuits difficult. Here the authors construct NOR gate architecture, using dCas9 fused to the chromatin remodeller Mxi1, that can be wired together into complex circuits.

Global Burden of Disease analysis found that in 2023, suboptimal diet was estimated to be responsible for 4 million deaths and 97 million morbidity burdens from ischemic heart disease.

Parallel operation of two exchange-only qubits consisting of six quantum dots arranged linearly is shown to be achievable and maintains qubit control quality compared with sequential operation, with potential for use in scaled quantum computing.

Spin qubits are a platform for quantum computing. There are many advantages for quantum information processing if the spin qubit can move. Here, Helgers et al. use a surface acoustic wave to define a moving quantum dot and demonstrate the magneticfield-free control of the spin precession, bringing “flying” spin qubits a step closer.

Superconductivity in twisted bilayer WSe₂ evolves smoothly with twist angle and emerges near Fermi surface reconstruction, linking previously distinct phase diagrams and clarifying its correlated origin.

Using a cryogenic 300-mm wafer prober, a new approach for the testing of hundreds of industry-manufactured spin qubit devices at 1.6 K provides high-volume data on performance, allowing optimization of the complementary metal–oxide–semiconductor (CMOS)-compatible fabrication process.

Scaling Si spin qubits relies on the uniform control of qubit-host interactions. This work finds correlations in qubit energy levels across a manufactured device arising from placement of Ge in the quantum well, consistent with atomistic modeling.

Cluster states are a key resource in quantum technologies, but generation of large-scale 2D cluster states faces several difficulties. Here, the authors show how to generate a 2 × n ladder-like cluster state via sequential emission of time- and frequency multiplexed photonic qubits from a transmon-based device.

Magic state distillation is achieved with logical qubits on a neutral-atom quantum computer using a dynamically reconfigurable architecture for parallel quantum operations.

The rapid evolution of SARS-CoV-2 challenges antibody therapeutics, but glycan-masked antigens enable isolation of class 3 monoclonal antibodies that potently neutralize diverse Omicron variants and reveal cross-reactive epitopes.

Spin qubits are attractive for scalable quantum information, but integrating different classes of two-qubit logic has remained elusive. Here, the SWAP, CPHASE, and CNOT-class two-qubit gates are implemented in a silicon device operating even at temperatures above 1 K.

Programmable and reversible CRISPRi-based genetic circuits function in a variety of plants.

Coherent control of plasmon wavepackets is essential for quantum information processing using flying electron qubits. Here, the authors demonstrate a method to isolate and select electron channels contributing to a plasmon using a cavity formed by local constrictions, enabling precise control of plasmon eigenstates.

A microfluidic valve that amplifies the pressure in a fluid channel enables the realization of static microfluidic digital control logic. This in turn could enable more versatility and integration in the control of flows in ‘lab-on-a-chip’ systems.

To simulate physical systems on a quantum computer, their degrees of freedom must be encoded into qubits. This Review assesses the different methods that exist to allow quantum calculation of fermionic systems.

Quantum simulations of chemistry and materials are challenging due to the complexity of correlated systems. A framework based on reconfigurable qubit architectures and digital–analogue simulations provides a hardware-efficient path forwards.

Carnitine uptake by OCTN2 supports fatty acid metabolism. Here, authors report cryo-EM structures of human OCTN2, revealing the mechanism of sodium ion-dependent carnitine transport and providing insight into disease-associated variants.

Previous measurements of interferometers based on quantum Hall (QH) edge channels have suggested potential electron pairing effects. Here, the authors investigate the coupling between QH edge channels in graphene Aharonov-Bohm (AB) interferometers, proposing a possible single-particle explanation for the apparent interference phase jumps and AB frequency doubling.

Measurements of anyons moving through a quantum point contact allow the extraction of their tunnelling exponent. This fully characterizes their topological order and confirms that they are well described by the Luttinger liquid theory.

Transcriptional activity in plants is controlled with a programmable gene circuit.

Longitudinal metatranscriptomics in a prospective cohort of 1,164 adults hospitalized for COVID-19 reveals that azithromycin offered no apparent anti-inflammatory benefit but enriched the respiratory microbiome with potential pathogens and antimicrobial resistance genes.

Experimental observation of flux periodicity ϕ₀/2 for interference of the outermost edge mode of Fabry-Perot interferometers has been attributed to exotic electron pairing mechanisms. Here, the authors demonstrate that the interfering charges of a Fabry-Perot interferometer are single electrons

Integrating an electronic device with a cavity can cause the electrons to couple to photons strongly enough to form hybrid modes. Now, the cavity effects induced by intrinsic graphite gates are shown to modify the low-energy properties of graphene.

A computer based on droplets moving in microfluidic channels requires synchronous manipulation of the droplets. Such synchronous logic is now shown for a system of ferrofluid droplets, with a rotating magnetic field providing the computer clock rate.

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

Silicon spin qubits can be fabricated in a 300 mm semiconductor manufacturing facility using all-optical lithography and fully industrial processing.

Here, the authors use electrostatic gates to trap interlayer excitons (IE) in MoSe₂/WSe₂ heterobilayers. They observe an exponential broadening of the IE emission linewidth that signals the IE ionization threshold.

Bosonic qubits can be engineered to feature intrinsic protection against certain kinds of errors, which makes quantum error correction across many bosonic qubits possible with less overhead.

Nuclear spins in solid-state systems can have very long coherence times, which makes them attractive for use as qubits. Now a nuclear spin qubit device has been developed with all-microwave two-qubit control that has important performance benefits.

Experimental measurements of high-order out-of-time-order correlators on a superconducting quantum processor show that these correlators remain highly sensitive to the quantum many-body dynamics in quantum computers at long timescales.

Estimates from the Global Burden of Disease study reveal declines in chronic respiratory disease mortality between 1990 and 2023—especially during the COVID-19 pandemic—but the burdens on people affected remain substantial.

Whole-genome sequencing of polioviruses in Uganda following nOPV2 use showed high genetic stability and no sustained transmission, even though a rare double recombinant strain regained virulence, but did not spread due to high vaccination coverage.

Data from 12,608 pregnancies across 7 African countries and a simulation model suggest that the total number of malaria-exposed pregnancies across sub-Saharan Africa exceeded 13 million in 2023, and that current prevention measures avoided more than 2 million malaria-related anaemia cases.

Electrons can seem electrically neutral in some devices. Neutral states can be distinguished in real time by a measure of their electron pairing called odd or even parity.

Mechanisms for generating spin-polarized currents may be helpful for applications. Now one such mechanism that uses the unusual Landau-level spectrum of WSe₂ under a strong magnetic field is demonstrated.

Large biospecimen banks are limited by a lack of fast, flexible, database-like retrieval. Here, authors encode metadata as DNA barcodes on silica-encapsulated samples and demonstrate numerical range, categorical, and Boolean queries, enabling rapid, precise recall from pooled DNA/RNA archives.

Immune disease-associated biomarker values are commonly more variable in affected compared to unaffected patient populations, which limits a biomarker’s informative range. Here, the authors formalise a computational solution that splits datasets into informative and uninformative subsets to improve biomarker discovery and performance of multivariate predictive models.

Despite their versatility, superconducting qubits such as transmons still have limited coherence times compared to resonators. Here, the authors show how to use a single transmon to implement universal one-qubit and two-qubit operations among nine qubits encoded in superconducting resonators’ eigenmodes.

Mast cells are immune cells that release membraneless mast cell extracellular granules (MCEGs) in response to allergic inflammation and pathogen infection. MCEGs are found to be condensates formed through sugar–metabolite interactions with elevated pH and higher metal concentration that enrich and enhance the activity of immune modulators, such as cytokines and proteases.

The nature of correlated insulator states commonly observed in moiré superlattices are still under investigation. Here, the authors use pump-probe spectroscopy to study the dynamics of correlated insulator states in a WSe₂/WS₂ moiré heterostructure at two different fillings, elucidating distinct time-domain signatures associated with these states.

Ferroelectric ordering of moiré excitons and collective photon emission emerge in WSe₂/WS₂ heterobilayers near the Mott state driven by strong dipolar interactions and a transition to symmetry-broken ferroelectric phases.

Certifiably random bits can be generated using the 56-qubit Quantinuum H2-1 trapped-ion quantum computer accessed over the Internet.