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Extreme thermal transport in 2D materials challenges classical models. Here the authors combine microheater-based thermal control and Raman thermometry to reveal high in-plane thermal conductivity and non-diffusive phonon transport in suspended monoisotopic hBN.

Certifiably random bits can be generated using the 56-qubit Quantinuum H2-1 trapped-ion quantum computer accessed over the Internet.

Barcoding microbial ribosomal RNA creates a recording of gene transfer events without requiring translation.

Large biospecimen banks are limited by a lack of fast, flexible, database-like retrieval. Here, authors encode metadata as DNA barcodes on silica-encapsulated samples and demonstrate numerical range, categorical, and Boolean queries, enabling rapid, precise recall from pooled DNA/RNA archives.

Data from 12,608 pregnancies across 7 African countries and a simulation model suggest that the total number of malaria-exposed pregnancies across sub-Saharan Africa exceeded 13 million in 2023, and that current prevention measures avoided more than 2 million malaria-related anaemia cases.

A scheme to prepare a magic state, an important ingredient for quantum computers, on a superconducting qubit array using error correction is proposed that produces better magic states than those that can be prepared using the individual qubits of the device.

Using commercial 0.8-μm metal-oxide thin-film transistor technology, a flexible processor chip can be built that has hardwired parameters for machine learning and is capable of smart applications such as odour recognition.

Two programmable riboregulator systems, based on toehold and three-way junction RNA motifs, were designed and validated as robust translational repressors in cells and applied for the construction of logic gates.

Genome-wide analyses of blood cell phenotypes derived from perturbations coupled with flow cytometry-based functional readouts identify loci associated with latent cellular traits, yielding insights into biological mechanisms underlying common diseases.

Attosecond spectroscopy enables the study and manipulation of electron dynamics in solid state samples, enabling the potential realisation of ultrafast optoelectronics. Here, the authors report the generation and control of light-induced quantum tunnelling currents in graphene phototransistors with sub-femtosecond switching times under ambient conditions.

Mast cells are immune cells that release membraneless mast cell extracellular granules (MCEGs) in response to allergic inflammation and pathogen infection. MCEGs are found to be condensates formed through sugar–metabolite interactions with elevated pH and higher metal concentration that enrich and enhance the activity of immune modulators, such as cytokines and proteases.

Phase velocity of graphene plasmons is electrically controlled in a set-up enabling tuning of the phase between 0 and 2π.

Ferroelectric ordering of moiré excitons and collective photon emission emerge in WSe₂/WS₂ heterobilayers near the Mott state driven by strong dipolar interactions and a transition to symmetry-broken ferroelectric phases.

In type II CRISPR systems, the guide RNA (gRNA) comprises a CRISPR RNA (crRNA) and a hybridized trans-acting CRISPR RNA (tracrRNA), both being essential in guided DNA targeting functions. Here the authors investigate the programmability of crRNA-tracrRNA hybridization for Cas9 and apply this to biosensing.

Endocrinologists have traditionally focused on studying one hormone or organ system at a time. Here the authors use transcriptomic data from the mouse lemur to globally characterize primate hormonal signaling, describing hormone sources and targets, identifying conserved and primate specific regulation, and elucidating principles of the network.

A patient with newly diagnosed glioblastoma was safely treated with neoadjuvant nivolumab, relatlimab and ipilimumab before maximal resection, with comprehensive immune profiling showing the induction of overall immune activation early during treatment. The patient had no definitive evidence of recurrence at 17 months after treatment.

In a significant step forward in complexity and capability for bottom-up assembly of nanoelectronic circuits, this study demonstrates scalable and programmable logic tiles based on semiconductor nanowire transistor arrays. The same logic tile, consisting 496 configurable transistor nodes in an area of about 960 μm², could be programmed and operated as, among other functions, a full-adder, full-subtractor and multiplexer. The promise is that these logic tiles can be cascaded to realize fully integrated nanoprocessors with computing, memory and addressing capabilities.

Flexible electronic platforms would enable the integration of functional electronic circuitry with many everyday objects; here, a low-cost and fully flexible 32-bit microprocessor is produced.

RNA has been used in a variety of synthetic biology circuits but never as a transcriptional activator. Two design strategies using synthetic and natural sequences now lead to RNA activators, enabling RNA-only logic gates.

The mitochondrial β-barrel assembly machinery exhibits conformational dynamics in the absence of substrate. The antibiotic darobactin A stabilizes the open confirmation of the Sam50 lateral gate and inhibits SAM complex function in vitro.

The development of electronic flying qubits requires the ability to generate and control single-electron excitations. Here the authors demonstrate quantum coherence of ultrashort single-electron plasmonic pulses in an electronic Mach-Zehnder interferometer, revealing a non-adiabatic regime at high frequencies.

Silica beads encapsulating DNA information and functionalized with DNA labels create an alternative DNA data storage system, where direct random access and data retrieval are enabled by complementary fluorescent strands that identify beads for separation in fluorescence-activated sorting.

The Nr4a family of nuclear receptors has been implicated in thymocyte central tolerance via clonal deletion and regulatory T cell induction. Here the authors show, using mouse bone marrow chimeras, that Nr4a1 and Nr4a3 are also redundantly required for Bcl211/BIM induction and contribute to an anergy-like transcriptome in auto-reactive thymocytes.

Polaritons are confined hybrid light-matter excitations holding potential for optoelectronic and sensing applications, but their characterization is usually limited to optical spectroscopy. Here, the authors report the electrical spectroscopy of mid-infrared plasmon-phonon polaritons in Au/hBN/graphene nanoresonators, showing high lateral confinement and quality factors.

Near-field photocurrent nanoscopy is used for imaging strongly confined terahertz graphene plasmons with linear dispersion.

Analysis of a placebo-controlled trial of a BCMA-targeting CAR-T cell therapy in patients with myasthenia gravis shows that CAR-T cell infusion selectively remodels the systemic immune environment, with elimination of BCMA-high plasma cells and activated plasmacytoid dendritic cells and changes in the autoreactive B cell repertoire.

SMC complexes are ring-shaped motors that fold DNA by extruding loops, but how they navigate large DNA obstacles is unclear. Here, Liu et al., show that SMC complexes bypass obstacles by threading obstacle linkers through a selective hinge channel, enabling translocation on crowded chromatin.

Many viral vaccine antigen candidates are transmembrane glycoproteins, and their development requires methods which allow their biophysical characterization. Here authors present an optimized nanodisc assembly platform which provides reproducible, scalable, and accurate replication of the vaccine candidates for detailed analysis.

Global Burden of Disease estimates show that between 1990 and 2023, the prevalence and burden of drug use disorders, inclusive of amphetamine, cannabis, cocaine and opioid use, have been increasing in high-income countries, particularly in the USA.

Dual-rail encodings of quantum information can be used to detect loss errors, allowing these errors to be treated as erasures. The measurement of dual-rail states with error detection has now been demonstrated in superconducting cavities.

Two below-threshold surface code memories on superconducting processors markedly reduce logical error rates, achieving high efficiency and real-time decoding, indicating potential for practical large-scale fault-tolerant quantum algorithms.

Cryo-EM structures of fungal Sec61–Sec62–Sec63 complexes show how Sec63 and Sec62 work together in a hierarchical manner to activate the Sec61 channel for protein translocation into the endoplasmic reticulum.

Individual electrons trapped on the surface of solid neon can operate as charge qubits with very long coherence times.

In this immunological ancillary study of the PREVAC trial, the authors show that approved Ebola virus vaccines induce memory T-cell responses that persist during the five year follow-up after initial vaccination.

Pocock et al. reveal that transient activation of 5′ AMP-activated protein kinase and estrogen-related receptor drives robust maturation of multicellular human cardiac organoids, enabling modeling of desmoplakin cardiomyopathy dysfunction, which could be rescued using the bromodomain and extra-terminal inhibitor INCB054329.

Hutchinson-Gilford Progeria Syndrome is characterized by premature aging with cardiovascular disease being the main cause of death. Here the authors show that inhibition of the NAT10 enzyme enhances cardiac function and fitness, and reduces age-related phenotypes in a mouse model of premature aging.

A cell-sorting method leveraging leucine zippers allows for the generation of T cells displaying multiple chimaeric antigen receptors as well as receptors converting inhibitory signals into stimulatory signals.

The authors report the emergence of quadrupolar excitons in WS₂/WSe₂/WS₂ trilayer heterostructures where the electron is layer-hybridized in WS₂ layers and the hole localizes in WSe₂. Quadrupolar excitons exhibit distinct behaviour under electric fields, enriching exciton–exciton interactions.

Linking proteins secreted from individual cells with other cellular information is challenging. Here, authors report a high-throughput method which uses hydrogel nanovials loaded with single cells to link the secretion profile of individual cells with their surface markers and transcriptomic data.

Spatial transcriptomic studies and lineage tracing reveal that, after brain injury, transient profibrotic fibroblasts develop from existing brain fibroblasts, infiltrate lesions, regulate the local immune response and lead to beneficial scar tissue formation.

Walmsley and colleagues report that systemic hypoxia induces persistent loss of histone H3K4me3 marks and epigenetic reprogramming in neutrophil progenitors, resulting in long-term impairment of subsequent neutrophil effector functions.

HIV epidemic trends among female sex workers in sub-Saharan Africa are rarely known. The authors analyse HIV prevalence trends among female sex workers based in Zimbabwe and report a significant decline between 2016-2017 and 2021-2023, which may be due to increased treatment coverage among the male population.

Bhattacharjee and Schaeffer et al. map exclusive breastfeeding (EBF) in 94 low- and middle-income countries (LMICs), finding increased EBF practice and reduced subnational variation across the majority of LMICs from 2000 to 2018. However, only six LMICs will meet WHO’s target of ≥70% EBF by 2030 nationally, and only three will achieve this in all districts.