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Adipose CoA handling is critical for lipid metabolism and homeostasis. Here, the authors identify TMEM120A as an ER-resident CoA binding protein enriched in adipocytes that promotes fatty acid recycling to support energy metabolism and limit lipotoxic stress, while its loss leads to adipose inflammation and metabolic dysfunction under high-fat diet conditions.

This study reports a metal-encapsulated PbS quantum dot photoanode that delivers high photocurrent and long-term stability for PEC water splitting without sacrificial agents, advancing sustainable clean energy.

Monitoring skin hydration and water loss has diagnostic power. Here, the authors present a wearable skin analyzer that enables long-term monitoring of these parameters.

Kim et al. report the medium n-phase pinning for quasi-2D perovskites by forming strong cation-π interaction complex. The homogeneous phase distribution leads to peak efficiency of 22.5% for sky-blue perovskite LEDs. The phase-pinning strategy also extends to pure- and deep-blue spectral region.

Uninterrupted monitoring of pressure and temperature at skin interfaces can help to minimize the potential for pressure injuries in hospitalized or bedridden patients. Here, the authors introduce a soft, skin-mountable sensor that can continuously provide readings via antennas mounted under bedding, and demonstrate the functionality and robustness of the devices on patients.

Upon cold exposure, two types of thermogenic fat cells, brown and beige adipocytes, are sequentially activated. Here, the authors show that E3 ubiquitin ligase RNF20 coordinates the sequential thermogenic activation through fat depot specific substrates.

The biological mechanisms regulating blood-brain barrier integrity remain unclear. Here, the authors identify microglial NLRP3-gasdermin D signaling as a driver of blood-brain barrier disruption during peripheral inflammation in mice, mediated by CXCL-dependent neutrophil recruitment.

The naïve CD4 T cell compartment is traditionally deemed as homogenous. Here, by leveraging scRNA-seq analysis, the authors reveal the role of naive CD4 T cell heterogeneity in disease states and therapeutic outcomes by characterizing a Th1-poised naive CD4 T cell subpopulation, linked to anti-tumor immunity in mice and responsiveness to anti-PD-1 therapy in humans.

Artificial muscle actuators enabled by responsive functional materials like shape memory alloys are promising candidates for compact e-wearable devices. Here, authors demonstrate augmented reality glasses and two-way communication haptic gloves capable of image depth control and immersive tactile response.

Different types of metabolic rewiring are reported to drive cancer development and as a potential therapeutic target. Here, the authors perform multi-omics analyses in a cohort of human normal and malignant thyroid samples and show association of mitochondrial one-carbon metabolism with undifferentiated thyroid cancer.

Inspired by mechanoreceptors on flying insects, a flapping-wing drone that makes use of strain sensors on the wings and reinforcement-learning-based flight control has been developed. The drone can fly in various unsteady environments, including in windy conditions.

Kim et al. report a strategy to reduce the dynamic disorder of the perovskite lattice by using CMMs that adsorb on the surface of PeNCs via van der Waals interactions and hydrogen bonding. The resulting pure green LEDs satisfying the Rec. 2020 color standard show a high EQE of 26.1%.

Fueled by ATP hydrolysis in N-ethylmaleimide sensitive factor (NSF), the 20S complex disassembles SNARE complexes in a single unravelling step. Here authors use single-molecule methods to show cooperativity between the NSF and SNARE complex, which prevents ATP consumption without productive disassembly.

Brain organoids derived from human pluripotent stem cells can model human brain development and disease, though current culture systems fail to ensure reliable production of high-quality organoids. Here the authors combine human brain extracellular matrix and culture in a microfluidic device to promote structural and functional maturation of human brain organoids.

Dysregulation of plasmalogen metabolism in adipose tissue is associated with metabolic diseases. Here the authors characterize the role of adipocyte TMEM86A as a lysoplasmalogenase and show its deletion is protective against high fat diet induced metabolic disease, an effect that can be recapitulated by plasmenyl lysophosphatidylethanolamine 18:0 supplementation.

The genetic link between placenta function and congenital heart defects has been established, though the cellular mechanisms underlying this connection is less clear. Here they show that PIBF1 regulates syncytiotrophoblast fusion and that loss of PIBF1 also negatively impacts heart development, providing a potential link between the development of these two organs.

Bahn et al explore the role of the lipid raft protein Prominin-1 in liver regeneration. They show that Prominin-1 promotes hepatocyte proliferation after acute liver injury by interacting with the signal transducer GP130, confining it to lipid rafts and activating IL-6 signaling pathway and eventual activation of STAT3.

Inspired by semi-aquatic animals, such as water striders and fisher spiders, that can exhibit a unique locomotion mechanism involving jumping on water, the authors find the scale dependency of water jumping performance and verify it with a theoretical model and robots with improved jumping performance.

To enable the large-area manufacture of solution-processed organic electronics, direct photocrosslinking processes has emerged as a promising technology solution. Here, the authors report an efficient universal crosslinking agent for micropatterning of stacked multi-layered organic electronics.

Topological transition of a bubble to a skyrmion by the controlled magnetic monopoles injection in Fe/Gd magnetic multilayers. The magnetic monopoles injected from the top and bottom surfaces are topologically characterized by Q = −1 and Q = +1, respectively.

AMPK activation has been suggested as treatment for obesity and its complications. Here the authors show that the ubiquitin ligase MKRN1 binds to AMPK and mediates its ubiquitination and degradation. Loss of MKRN1 leads to AMPK activation, increased glucose consumption and decreased lipid accumulation.