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Single-atom catalysts (SACs) offer high atom utilization and efficiency, but their synthesis is challenging. This work realizes the mass production of sustainable SACs and demonstrates their application in vascular healing.

A short peptide derived from a commensal-fungal-secreted protein promotes repair in models of colon epithelial damage when delivered directly or via probiotic microbes.

This study introduces ChemAHNet, a deep learning model that predicts stereoselectivity and absolute configurations in the asymmetric hydrogenation of olefins with two prochiral centers, providing a broadly applicable tool for catalyst and substrate design.

Authors develop a siRNA delivery system, named Ionizable Polymeric Micelles (IPMs) which employs a FAPi modification, enabling IPMs to target activated hepatic stellate cells, silencing target genes and treating liver fibrosis.

Synthetic methods to access unsymmetrical polysulfides are limited despite their high biological relevance. Here, the authors disclose a polysulfurating reagent affording unsymmetrical di- and tri-sulfides under mild conditions, and suitable for late-stage modification of natural products.

Limited therapeutic options are available for pulmonary fibrosis because its molecular pathogenesis remains unclear. Here, the authors show that the CCL20– integrin α5β1–TGF β signaling cascade could be a potential therapeutic target for pulmonary fibrosis.

Dynamic ionic gradients of counterions in films of metal nanoparticles functionalized with charged organic ligands can be used to create transistors that are capable of a 400-fold modulation of the electrical conductivity and can be used to construct logic gates and half-adder circuits.

The host factors that drive adaptive substitutions in the influenza virus remain poorly understood. Here, Zou et al. identify GGCX as a key determinant for the adaption of Eurasian avian-like H1N1 swine influenza virus to receptor binding.

Some thiamine diphosphate-dependent enzymes are powerful biocatalysts, forming carbon–carbon bonds between two α-keto acids, but their catalytic properties have been poorly understood. Now the substrate selectivity and catalytic stereoselectivity of two representative enzymes, CsmA and BbmA, have been fully characterized. Enzymatic total synthesis using these enzymes generates diverse carboligation products.

Cryo-electron and atomic force microscopy shed light on how fibrils of the protein tau, which accumulate in the brain of people with Alzheimer’s disease, can be disassembled by short peptides, providing a possible route towards developing treatments.

A new AI generative model leverages the use of synthetic images to effectively augment existing datasets, boosting performance across multiple medical applications

Interpreting bone metastases (BMs) from computed tomography (CT) images remains challenging. Here, the authors develop an AI-based Bone Lesion Detection System - BLDS - and validate it in a cohort of 2,518 patients across five hospitals, showing highly sensitive and accurate performance for BM detection from CT scans.

The energy disorders in the lateral direction of the junction in large-area photovoltaic modules are largely overlooked. Here, authors employ organic amidinium passivators to suppress the micro-inhomogeneity in the lateral energy landscapes and achieve high performance stable perovskite solar cells.

The partial replacement of the A-site by divalent methylenediammonium cations inhibits ion migration and photoinduced halide segregation in wide-bandgap perovskites. Single-junction devices achieve a certified power conversion efficiency of 22.71%, whereas perovskite/Cu(In,Ga)Se₂ tandem devices exhibit an efficiency of 30.13% in a four-terminal architecture.

Treatments for Alzheimer’s disease (AD) remain limited. Here, the authors show that 40 hertz blue light activates a visual circuit to boost glymphatic drainage, and enhances memory, motivation, and anti-Aβ therapy efficacy in a mouse model of AD.

Preparation of xanthene-containing compounds has been limited due to structural bias existing methods pose. Here, the authors developed a mild, diversity-oriented method for rhodamines synthesis, leading to the finding of compounds with antibacterial potency against a variety of bacterial species.

A portable multiplexed assay allows for the rapid detection, via plasmonic-gold-enhanced near-infrared fluorescence, of SARS-CoV-2 RNA at single-copy sensitivity and single-nucleotide specificity for the discrimination of variants of the virus.

Developing a new technique/method and/or mechanism for separating ionic charges is critical to the fabrication of a high-performance nanogenerator. Here, we demonstrate that the magnetic force can be used to drive the movement and separation of charges within metal nanoparticles film when these nanoparticles are functionalize with charged magnetic ligands. Placing the magnetic field induces the gradient distribution of magnetic counterions which subsequently transforms into the electric potential and outputs electrical energy.

Mapk7 regulates bone mass and bone marrow adiposity by controlling mesenchymal stem cells fate transition through phosphorylation of Ser1490 of LRP6 and promoting nuclear translocation of β-catenin.

Although hydrogels with complex, heterogeneous and reconfigurable structures are promising materials for use in intelligent systems, fabricating such hydrogels is challenging. Now it has been shown that they can be fabricated by reversibly gluing different hydrogel units using a photocontrolled metallopolymer adhesive. This method can be used to design hydrogels with customized functions.

Immune cells produce reactive oxygen species (ROS) to eliminate pathogens, but cell-spontaneous death and ageing may also be induced. Here the authors show that, upon sensing ROS, Mst1/2 kinases modulate the activity of Nrf2 transcription factor and downstream genetic programs to protect mouse macrophages from death and ageing.

Here, the authors show the amyloid formation of a low-complexity domain of NCAP, and its potential for guiding the design of antiviral agents.

A two-leg ladder with tunable gauge fields is achieved by one-dimensional synthetic momentum-state lattice of a noninteracting Bose gas.

Integrating a control interface with a quantum processor as the number of qubits scales is a significant challenge. Here the authors report a cryogenic on-chip microwave pulse generator for superconducting qubits with high degree of controllability, negligible heat load, and a small footprint.

Water based inks used for water-jet rewritable paper (WJRP) are an environmental friendly alternative to conventional printing, but black colour in WJRP could not be realized so far. Here the authors demonstrate black as well as other colour WJRP based on binary systems containing less-sensitive acidochromic dyes and mild proton donors.

Hippo signaling controls cell and tissue growth. Geng et al. show that Hippo signaling is required for T_H17 cell differentiation but inhibits T_reg cell differentiation.