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DISC1 attenuates Zika virus infection and congenital Zika syndrome by promoting autophagy via AMPK-mTOR signaling and is implicated in ZIKV-induced long-term neurological deficits.

Bicyclic peptides targeting integrin are promising drug candidates, yet achieving high selectivity for specific integrins remains challenging. Here, the authors design RGD-containing bicyclic peptides with a tryptathionine bridge, demonstrating that peptide 5j selectively targets integrin αvβ3, and induces αvβ3-targeted cytotoxicity by drug-peptide conjugates.

Wang and colleagues show that an AI-assisted designed peptide obstructs GSDMD pores and inhibits IL-1β and IL-18 release and pyroptosis.

Genomic analyses of 2,191 global common wheat accessions and over 47,000 yellow rust (YR) response data points across several environments and pathogen races provide a genome-wide landscape of YR resistance genes and effective alleles.

The majority of adoptive T cell therapy-based clinical studies are based on the ex vivo expansion of neoantigen-specific tumor infiltrating lymphocytes. Here the authors report the results of a pilot study of adoptive cell therapy with personalized neoantigen-specific CD8 + T cells obtained from peripheral blood mononuclear cells in patients with locally advanced or metastatic solid tumors refractory.

While there has been evidence of strong carrier multiplication effects in halide perovskites, studies in actual solar cells are lacking. Here, the authors demonstrate such effects with a low threshold of 2E_g and a high efficiency of 99.4%, realizing unbiased internal quantum efficiency up to 160%.

Organic photovoltaics are promising for indoor applications, yet their voltage losses are large and limit device performance. Here, Cui et al. present a wide-gap non-fullerene acceptor that retains a voltage of 1.1 V at low light intensities enabling an efficiency of 26.1%.

The use of a dimensionally graded 2D perovskite interface and passivation results in perovskite solar cells with very low photovoltage loss.

Polynary perovskite oxides are promising air electrodes for rSOCs, with configuration entropy (S_config) often linked to reactivity. However, high S_config alone does not strongly correlate with performance. This study develops a model identifying key descriptors to guide high-activity oxide discovery.

A reconstruction of the light profile for the Milky Way from an internal perspective provides an estimate of the Galaxy’s size that can be directly compared to other galaxies. This property will help to understand how typical the Milky Way is.

There is growing interest in designing photocatalysts for CO₂ conversion. Here, the authors combine an ionic liquid with Co single atoms as dual-cocatalysts for g-C₃N₄, accelerating electron kinetics and improving CO₂ reduction selectivity.

Non-fullerene acceptors based on non-fused conjugated structures have potential for realizing low-cost organic photovoltaic cells, owing to its synthetic simplicity. Here, the authors develop a non-fused molecule with a three-dimensional interpenetrating network and compact π-π stacking, which is highly suitable for PV applications.

The reliability of memristors has always been a major obstacle in neuromorphic computing. This work reports a negative differential resistance memristor based on quantum well structure for neuron circuit implementation, which shows low performance variation (0.264%), high temperature resistance at 400 °C.

Non-invasive approaches for risk stratification and screening remain crucial for colorectal cancer (CRC). Here, the authors develop a model for CRC risk stratification by integrating plasma proteomics data with polygenic risk score and QCancer-15 risk score, which could guide recommendations for earlier screening of high-risk populations.

Using donor-acceptor bulk heterojunction as sensitiser for efficient charge generation and low charge recombination in triplet-triplet annihilation upconversion, Bi et al report solid-state one-step printed device with upconversion efficiency of 2.2% and threshold excitation intensity of 10 mW cm⁻².

The hot carriers in halide perovskite nanocrystals cool much slower than those in conventional semiconductor nanocrystals due to the phonon bottleneck. Here, Li et al. demonstrate enhanced multiple exciton generation with lower threshold in intermediate-confined perovskite nanocrystals based on this effect.

Bi et al. report eco-friendly green LEDs based on interfacial potential-graded ZnSeTe quantum dots with alleviated lattice mismatch and Auger recombination, resulting in peak efficiency of 21.7% at 520 nm, current efficiency of 75.7 cd A⁻¹, and half-lifetime of 99.4 h at 1000 nits.

Extremely remote alpine lakes may experience ecological shifts due to hemispheric-scale anthropogenic influences, according to diatom ecological analysis of Shuanghu Lake in the Altai Mountains of inland Asia.

The neural mechanisms responsible for cold defense regulation are still unclear. Here, authors show parallel thermogenic pathways from the brain stem to the hypothalamus work together to enable resilience to cold temperature exposure and hypothermia.

The authors compute the gradient of the Milky Way’s heavy elements as though they were viewing our Galaxy from the outside. This will allow astronomers to compare Galactic measurements with those for other galaxies to understand how typical the Milky Way is.

An unusual violation of the Wiedemann-Franz law with enhanced Lorenz number is revealed by thermal Hall measurements in NdAlSi. As its origin, the authors propose the presence of a hidden Kondo-type scattering process between itinerant electrons and localized moments in this magnetic Weyl semimetal.

Organic solar cells based on non-fullerene acceptors have enabled high efficiencies yet their charge dynamics and its impact on the photovoltaic parameters are not fully understood. Now, Chen et al. provide a general description of non-radiative voltage losses in both fullerene and non-fullerene solar cells.

Simultaneously achieving high efficiency and mechanical robustness is challenging for ultraflexible organic solar cells. Here, Qin et al. present a robust interlayer of Zinc-chelated polyethylenimine (PEI-Zn) to facilitate the demonstration of efficient and mechanically robust ultraflexible solar cells.

Nutrient levels in Chinese lakes have rapidly increased since 1950 but future trends in lacustrine nitrogen and phosphorus across China will differentiate, according to projections up to 2100.

Impaired sociability is often interpreted as social avoidance. Here, the authors show that the problem is actually failure to distinguish social from nonsocial stimuli, caused by indistinguishable coactivity patterns in the medial prefrontal cortex.

How the Asian monsoon, earth surface processes and human development interact is not well known. Here, a new record of dust storm intensity shows a relationship between the stability of dynasties and dust storm activity for the last ~2200 years, which argues for a strong human control of dust storms in East Asia over this time.

The WD40 domain of the SCF^Cdc4ubiquitin ligase targets substrates via multiple phosphorylated degron motifs. The authors define a second degron-binding WD40 pocket that imparts a negative allosteric effect on binding to the primary pocket, and thereby enables the dynamic exchange of bound degrons.

NLRC5 is known for its role in inflammation and antigen presentation. Here Luan et al. find that NLRC5 protects mice from intimal hyperplasia following vascular injury, and regulates the response of vascular smooth muscle cells to injury through direct interaction with PPARγ.

Photonics reconfigurable memristor simulate volatile and non-volatile properties to achieve dynamic modulation of neurons and synapses and demonstrate application scenarios.

The development of low-cost and high-performance organic photovoltaic materials is critical for the industrialization of organic photovoltaic technology. This Review discusses the key structural features of high-performance materials, summarizes advancements in low-cost donors and acceptors and outlines future molecular design strategies.

The production and titration of the SARS-CoV-2 S pseudotyped virus using a VSV-based pseudovirus production system in this protocol enable its use under biosafety level 2 conditions as well as in a neutralization assay to assess the level of neutralizing antibodies or molecular inhibitors in a sample.