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Conventional organic polymeric resists and chemical solutions used in microlithographic techniques can damage sensitive materials. Here, the authors report the application of inorganic selenium molecules as a lithographic mediator and encapsulation layer during the processing of various sensitive materials, such as perovskites and black phosphorus.

T-cell engager (TCE)-based immunotherapy requires further development in solid tumors due to limited T cell penetration, immunosuppressive tumor microenvironment and toxicity. The authors here develop a glypican-3 targeting mRNA TCE (MTS105) which manifests superior T cell activation and tumor regression hepatocellular carcinoma mice model comparing to conventional TCE, and safety with cynomolgus monkey studies.

The key regulators driving intrinsic immune responses and neuropathic pain remain elusive. Here, the authors elucidate that ZFP612-mediated epigenetic disinhibition of Il1rl1 within the 3D genome in dorsal root ganglion neurons causes neuropathic pain.

The authors report a Fe–N₄ single-atom catalyst decorated with SiO₂ nanoparticles acting as radical scavengers, which reduce harmful byproducts and stabilize active sites, improving durability and activity for oxygen reduction.

Liu and colleagues examine how severe acute respiratory syndrome coronavirus 2 variants evade CD8⁺ T cell epitope recognition.

Li, Platt et al. examine cross-reactivity of antibodies induced by the adult-specific pneumococcal conjugate vaccine V116 within serogroups 6 and 15. Antibodies demonstrated cross-reactivity to non-vaccine serotypes 6 C and 15B, suggesting broader coverage may be available beyond the 21 V116 serotypes following vaccination.

High-pressure diamond anvil cell experiments reveal that compression strengthening of nanocrystalline nickel increases as its grain sizes decrease to 3 nanometres, owing to dislocation hardening and suppression of grain boundary plasticity.

A manually operated portable water disinfection system can rapidly inactivate pathogens in water, offering a promising approach for safe water treatment in low-resource settings.

Tight junctions are crucial for maintaining intestinal barrier homeostasis. Here the authors show that PEAK1 sustains Src activity at tight junctions and facilitates its interaction with ZO-1 to preserve tight junction integrity.

Piwi-interacting RNAs (piRNAs) are vital for genome integrity and fertility. Here the authors reveal that spatial clustering of piRNA genes in Caenorhabditis elegans promotes transcription through phase separation and deSUMOylation, uncovering a SUMOylation-regulated mechanism for piRNA production in heterochromatic genomes.

The authors demonstrate non-collinear harmonic spectroscopy to observe the crossover of various strong-field effects on electron dynamics at femtosecond timescales. This provides insights into many-body effects at the carrier level and enables advancements in ultrafast optoelectronic and nanophotonics.

Li₅FeO₄ is a high-capacity prelithiation agent but suffers from poor air stability. Here, authors apply a carbon coating strategy to significantly improve its resistance to moisture, enabling over 92% capacity retention after 72 h exposure to ambient air.

Here the authors engineer a bispecific antibody (Ab) for HIV-1 by combining a gp41 N-heptad repeat targeting Ab with a CD4 binding Ab. Prepositioning via CD4 binding results in high neutralization breadth and potency, and experiments in HIV infected humanized male mice show reduction of viral load.

This study reports a fully integrated 128 × 8 optoelectronic memristor array with Si complementary metal–oxide–semiconductor circuits, featuring configurable multi-mode functionality. It demonstrates diversified in-sensor computing tasks and consumes 20 times less energy than GPUs.

Rechargeable lithium batteries featuring 5 V cathodes offer high energy density yet struggle with stability. Here, the authors formulate an electrolyte incorporating dimethyl 2,5-dioxahexanedioate solvent, which facilitates stable lithium plating and stripping while offering an extended cycle life.

The combination of dynamic, energy driven folding and growth with structural stiffness and length control is difficult to achieve in synthetic polymer self-assembly. Here the authors show that highly charged, monodisperse DNA oligomers assemble via seeded growth into length-controlled supramolecular fibers during heating.

The authors demonstrate integration of a single-slit diffraction method into linear-array transducers for advancing 3D photoacoustic and ultrasound imaging in biological tissues. The method enhances spatial resolution and signal-to-noise ratio while maintaining low-cost and practicality.

The roles of liver-specific genes in hepatocellular carcinoma (HCC) remain to be explored. Here the authors report that PGRMC1, localized to the endoplasmic reticulum (ER) membrane, functions as a tumor suppressor in HCC by inhibiting c-Myc protein translation via activation of PERK independent of ER stress.

Hrd1 is an E3 ubiquitin ligase involved in ER-associated degradation and MHC I turnover. Here the authors use T-cell-specific ko mice and a mouse model of multiple sclerosis to show that Hrd1 also drives pro-inflammatory T helper cell responses and contributes to pathogenesis of autoimmune disease.

Nanoindentation of the microscale honeybee comb reveals a stiffness gradient that spans two orders of magnitude, which amplifies the catapult effect and facilitates solid particle repellency. By leveraging this, the study presents the fabrication of scaled-up, bioinspired stiffness-gradient elastomeric catapult-like soft actuators.

The high solar reflectance needed by radiative cooling is easily dampened by environmental aging. Here, authors describe durable cooling performance against heavy soiling and long-term ultraviolet exposure of paint-based coatings, enhancing the potential of radiative cooling for real-world applications.

Haematopoietic stem cells (HSCs) are metabolically quiescent, with balanced myeloid and lymphoid potential. Here the authors show that MAEA is required in HSCs for ubiquitination and downregulation of surface cytokine receptors via autophagy; MAEA loss leads to impaired HSC quiescence and a myeloproliferative disorder.

Capacitive coupling between tissue and flexible integrated electronics through a sealing dielectric layer facilitates long-term electrophysiology measurements, as demonstrated in ex vivo Langendorff heart models.

Combining long-term atmospheric CO₂ records with satellite observations of vegetation activities across the Northern Hemisphere, the authors identify a weakening trend of the link between spring and summer productivity over the past 40 years.

Chromodomains mainly function as histone methyl-lysine readers to regulate gene expression. Here the authors delineate a functional map of chromodomain proteins and identify an H3K9me1/2 writer, MET-2, and reader, CEC-5, that are required for the normal lifespan of C. elegans.

Single-crystal graphene can be grown on a copper foil at a rate of 60 μm s^-1 by using an adjacent oxide substrate that continuously supplies oxygen to the surface of the copper catalyst.

Phage combination therapies reduce bacterial wilt disease incidence in tomato by up to 80%.

Experimental determination of how the post-garnet phase transition pressure varies with temperature suggests a downward-convex phase boundary with potential implications for mantle dynamics.

Hypocrystalline ceramic aerogels with a zig-zag architecture show high thermal stability under thermal shock and exposure to high temperature, providing a reliable material system for thermal insulation at extreme conditions.

Loss of sympathetic nerve innervention of the bone marrow contributes to the aging of hematopoietic stem cells, which can be rejuvenated using an adrenergic receptor agonist.

A subset of renal cell carcinomas have uncertain histology and are aggressive in nature. Here, the authors examine this group of unclassified renal cancers using genomics techniques and identify further subclasses of the tumours that have differing prognoses.

Reconfigurable electronic devices that can be shaped in two or more stable geometries modifying their functionalities have been realized by engineering the sequence in which the elastomeric substrates are mechanically buckled.