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This study shows that WDR5 remodels NANOG condensates to control transcriptional programs. Disrupting their interaction compromises stem cell identity and suppresses leukemia stem cell expansion.

Bacteria can infect tumour cells which may affect the biological characteristics of the tumour or even the therapeutic outcome. Here authors show that Stenotrophomonas, upon entering tumour cells, trigger endoplasmic reticulum stress, leading to STING degradation and inhibition of MHC-II⁺ macrophages, which ultimately cause tumour progression and immunotherapy resistance.

Zhang et al. show that the activation of RIPK1 is suppressed by acetylhypusination in a spermidine-dependent manner. Disruption of this axis contributes to RIPK1-mediated vascular pathology to promote insulin resistance and diabetic kidney pathology.

Grain number per panicle (GNP) is a critical yield component trait of rice. Here, the authors clone a MAPKKK encoding gene GNP3 positively regulating grain yield and show its role in rice panicle development by interacting and destabilizing ethylene biosynthesis related enzyme SADENOSYLMETHIONINE SYNTHETASE 1.

This study shows that the wheat major QTL gene-encoded sugar metabolic enzyme HtL1/FBA10 undergoes vernalization-induced dynamic changes in O-GlcNAcylation and phosphorylation, enhancing its enzymatic activity and increasing VRN1 gene expression for flowering.

Sea cucumbers are predominant deposit feeders in benthic ecosystems. This study elucidates the mechanisms within the sea cucumber digestive system and their symbiotic microbiome which enable them to efficiently utilize nutrients from seabed sediments.

A hybrid cathode interfacial layer (AZnO-F3N) is developed, delivering 21.0% efficiency along with excellent stability, mechanical robustness and broad versatility, highlighting its potential to advance organic solar cells.

Photocatalytic disinfection is a known pollution-free water treatment strategy. However, its efficiency is limited due to the spin-forbidden feature of O₂, which hinders photocatalytic ·O₂⁻ formation and limits its disinfection efficiency. Here the authors produce a strained Mo_4/3B_2-xT_z MBene that can increase ·O₂⁻ photocatalytic production, which results in high levels of photocatalytic disinfection.

Traditional catalytic methods for recycling plastic often suffer from reduced efficiency and high energy demands. Here, the authors demonstrate a highly efficient and rapid process for depolymerizing plastic waste into valuable monomers and lubricant base oil precursors using microwave-assisted catalysis with Zn/b-ZnO under mild conditions.

Triplet exciton harvesting through thermally activated delayed fluorescence is shown to be effective also under X-ray excitation, increasing the efficiency and imaging quality of X-ray detectors based on organic scintillation.

Therapeutic options for myocardial infarction therapy remain limited. Here the authors report the application of an optimized liquid crystal substrate in the mass production and effective preconditioning of cardiospheres, which could generate cardiospheres with improved cell bioactivity and resistance to oxidative stress for myocardial infarction therapy.

Breeding of rice with ideal plant architecture has increased rice yield worldwide. Here Zhanget al. show that, in the super rice variety YY12, this ideal plant architecture trait arose from three distal tandem repeats that are associated with an open chromatin state and increased expression of the IPA1gene.

Large three-dimensional images are commonly generated through biological experimentation. Here the authors report software tools for exploration of three-dimensional images along with applications to assist in imaging, microsurgery, visualization and annotation of large image data sets.

Single-molecule diodes with rectification ratios over 200 at low voltages can be obtained with symmetric molecules by creating an environmental asymmetry using electric double-layers.

With the example of the paraspeckle protein PSPC1, Shao et al. demonstrated the synergistic interplay of promoter-associated RNA and its binding proteins in promoting transcription condensate formation and Pol II engagement and activity via phase separation.

During the activation and migration of T cells volume changes occur in response to osmolality cues which is not fully understood. Here the authors characterize the function of volume regulated ion channels in T cells and show that these channels regulate TCR sensitivity, thymic selection and TCR repertoire.

A novel ZrO₂-based photoresist enables an additive manufacturing printing speed of 7.77 m s^–1, with 38 nm resolution.

TET2 catalyses DNA demethylation and is mutated in various blood cancers; in particularTet2null mice develop haematological neoplasms. Here the authors show that this effect could be due to the increased frequency of mutation associated with TET2 loss in haematopoietic stem/progenitor cells.

Lithium dendrite and parasitic reactions are two major challenges for lithium metal anode. Here, the authors show suppression of lithium-dendrite and elimination of continuous parasitic reactions by tuning the reduction kinetics of lithium-ion through a uniform nano-porous separator.

Mutations that affect T_reg cell function can cause lethal autoimmunity, but whether correcting these mutations can reverse established disease is unclear. Here, the authors correct T_reg cell-specific Brg1 mutation in a minor fraction of T_reg cells, which supercharges these cells to rescue mice from otherwise fatal IPEX-like autoimmunity.

Nanofibrous networks are applied in environmental protection and electrical or bioengineering and experience a great demand, but the design of these functional materials is challenging. Here the authors demonstrate an electronetting technology for fabricating self-assembled nanonets from various materials.

Bacteria and other pathogens entering the blood stream can have serious consequences, which can even lead to death. Here, the authors developed a sieve containing nano-sized claws that capture and hold these intruders, thus aiding their removal from patient’s blood

Two diacylglycerol acyltransferases were shown to be differently regulated in large yellow croaker and rainbow trout. While DGAT1 is increased upon oleic acid treatment more in croaker than in trout, DGAT2 showed no significant expression difference.