Amyloid fibril formation from amyloid-beta peptides is a key feature of Alzheimer’s disease, yet the mechanisms of its spatial and temporal spread remain unclear. Here, the authors reveal that amyloid-beta 42 aggregation propagates via diffusion of oligomers in solution, highlighting these species as key drivers of the spatial spreading of aggregation.
- Quentin Peter
- Chris Taylor
- Tuomas P. J. Knowles
