Search

SARS-CoV-2 variants often exhibit immune evasion, necessitating antiviral strategies beyond vaccination. This study presents a papain-like protease (PLpro) inhibitor called YL1004, which exhibits potent, broad-spectrum antiviral activity against wild-type, Delta, and Omicron variants in vitro and in vivo.

This study presents a 3D large-range, boundary-identical, and open-cell microstructure datasets for the fast data-driven inverse design of bicontinuous multiscale structures with tunable elasticity and permeability for multifunctional applications.

Cardiometabolic disease and depression often co-occur, but their multi-organ basis was unclear. Here, the authors analyse UK Biobank imaging and genetics, identifying abdomen-heart-brain networks and 43 shared loci, improving multimorbidity prediction

Humanity’s Last Exam, a multi-modal benchmark at the frontier of human knowledge, is designed to be an expert-level closed-ended academic benchmark with broad subject coverage.

Aqueous zinc metal batteries often face performance decay under thermal environments, originating from side reactions caused by aqueous electrolytes. Here, authors report an organic-inorganic-H₂O multiphase aqueous soggy-sand electrolyte that reconstructs hydrogen-bond networks, eliminates parasitic reactions, and promotes uniform Zn deposition at elevated temperature (140 ^oC).

Genetic code expansion (GCE) has expanded protein functionality, but the cost of noncanonical amino acids (ncAAs) hinder large-scale use. Here, the authors coupled amino acid biosynthesis with GCE in E. coli for the production of ncAA-containing biomolecules.

This study characterizes the pan-centromere landscape and evolutionary dynamics in Brassica, generating and comparing telomere-to-telomere genome assemblies of multiple morphotypes and shedding light on centromere evolution during domestication.

Using channel-level decoupling to design independent photovoltage channels for each Stokes parameter with minimal crosstalk, a metaphotonic photodetector can be created that provides direct Stokes quantification.

GIANT, a genetically informed brain atlas, integrates genetic heritability with neuroanatomy. It shows strong neuroanatomical validity and surpasses traditional atlases in discovery power for brain imaging genomics.

By artificial superlattice design, the authors achieve stable polarization over wide frequency, temperature, and thickness ranges in epitaxial HfO₂/ZrO₂ superlattices, along with reduced coercive fields. This work offers a route to overcome polar phase metastability in HfO₂-based films.

Scavenger receptor class A member 3 (SR-A3) is implicated in metabolic diseases, but its relationship with MAFLD remains unclear. Here, the authors show that SR-A3 is an important modulator of hepatic energy metabolism and is a potential therapeutic target against MAFLD.

Chiral emission from collective guided modes is demonstrated within a photonic crystal slab, showing an example of collective oscillations in the momentum space.

HfO2-based ferroelectrics offer new options for memory but face reliability issues. By exploring device fatigue mechanisms, the authors develop an interface design strategy that regulates defect movement in films, improving its overall reliability performance.

Sea cucumbers are predominant deposit feeders in benthic ecosystems. This study elucidates the mechanisms within the sea cucumber digestive system and their symbiotic microbiome which enable them to efficiently utilize nutrients from seabed sediments.

The piezoelectricity of ferroelectric oxide films is limited by substrate clamping, and their rigidity hinders their applications in flexible electronics. Herein, authors report freestanding PbZr0.52Ti0.48O3 nanoscale membranes with both high piezoelectricity and high flexibility.

Horizontal and vertical expansions of urban commercial establishments are investigated in the digital era, revealing that across China, these expansions have increasingly moved away from reliance on street-facing and ground-floor locations.

Intra-cell line heterogeneity remains to be characterized. Here, the use of single multi-omics on a large panel of human cell lines identifies copy number variation, epigenetic variation and extrachromosomal DNA distribution as the main contributors to intra-cell line heterogeneity.

TAD hierarchy demonstrates cell-to-cell variability, leading to the development of numerous callers. Here, authors present a comprehensive benchmark of TAD hierarchy callers and introduce the ‘air conditioner’ model to illustrate TAD hierarchy’s role in transcription.

People in the USA who are incarcerated, or have a history of incarceration, face worse access to cancer care, leading to poorer outcomes. In this Comment, Zhao and colleagues highlight the need to address these inequities through coordinated action across research, healthcare, policy and correctional systems to ensure all individuals have access to high-quality cancer care.

This study generates and phases the complete genome assembly of a model plant Nicotiana benthamiana, revealing insights into the structure, epigenetic landscape and evolutionary dynamics of its centromeres following allotetraploidization.

Using a framework based on optoelectronic polarization eigenvectors and optoelectronic conversion matrixes, an on-chip full-Stokes polarimeter can be created that offers a root mean square error of less than 1% for each Stokes parameter over the entire range of polarization states at arbitrary light intensities.

Sparse immune-binding data for emerging pathogens limits the ability of existing in silico antigenicity prediction methods to aid vaccine design. Here, the authors introduce a computational method that estimates antigenic pathogen similarity based on epitope structure.

Circularly polarised room temperature materials have promising applications, but colour control is still challenging. Here, the authors report the development of these materials with full colour based on anionic cellulose derivatives and achiral luminophores.

Room temperature phosphorescent materials have potential in a range of applications, but it is challenging to achieve multiple emission and excitation modes. Here, the authors report the development of RTP materials with different emission modes by regulating the aggregation state.

High-throughput cytometry generates complex single-cell data with challenging manual gating process. Here, authors introduce UNITO, a framework that transforms cell classification into image segmentation, outperforming existing methods in identifying cytometric subpopulations across diverse datasets.

The authors reveal hyperbolic-to-hyperbolic transitions where two nearby Reststrahlen bands just touch each other. Such phenomena are prevalent in isostructural rare-earth oxyorthosilicates and unfolds vast opportunities for broadband on-chip light control.

Plant microbiome confers fitness benefits upon drought. By integrating plant genetic, microbial genetic and multi-omics approaches, this work reveals the critical role of root hair developmental regulators in shaping drought alleviating microbiome.

Heterologous vaccination with Convidecia, a recombinant adenovirus type 5-vectored COVID-19 vaccine, after one or two doses of CoronaVac, an inactivated SARS-CoV-2 vaccine, is more reactogenic but elicits significantly higher levels of neutralizing antibodies than homologous vaccination.

Superionic materials are of interest for solid-state batteries or thermoelectrics, yet a clear understanding of the atomistic mechanisms is lacking. Here it is shown that transverse acoustic phonons persist above the superionic transition in argyrodite Ag₈SnSe₆, and that the free-Se sublattice controls fast Ag cation diffusion.

Here the authors show that lithium carbonate can revitalize tumor-reactive CD8⁺T cells by shunting cytosolic lactic acid into the mitochondria for oxidation, indicating that lithium ions might be applied as a cancer immunotherapy.

Ferroelectric HfO₂ is faced with an oxygen vacancy dilemma, which favors the polar phase but harm to switching behaviors. Here, the authors propose a donor-acceptor co-doping method to enhance polarization switching characteristics of the HfO₂ films.

Mechanisms underlying the connection between autophagy decline and vascular endothelial cell (VEC) ageing remain unclear. Here, the authors identify a key role for CD44 in controlling autophagy and ageing in VECs, and this function is conserved in nematodes.

Osteoclast over-activation leads to bone loss and chloride homeostasis is important for osteoclast function. Here, the authors show that Anoctamin 1 controls bone resorption by coupling Cl⁻ channel activation with RANKL-RANK signaling transduction.

A photodetector responding to only circularly polarized light is developed. It has a ring-shaped form, consisting of plasmonic nanostructures on a graphene sheet. Its zero-bias responsivity and detectivity of ellipticity in the mid-infrared at room temperature are 392 V W⁻¹ and 0.03° Hz^−1/2, respectively.

Functional features in the spatiotemporal regulation of blood chemistry are not much explored. Here authors show vascular network-inspired fluidics, functionalizable for different region-specific trans-wall transport to regulate fluids over space and time.

While heterogeneous catalysts can act as tangible, efficient materials for energy conversion, understanding the active catalytic sites is challenging. Here, authors engineer specific catalytic sites into molybdenum sulfide to improve and elucidate hydrogen evolution electrocatalysis.

Modules of foldable crystalline silicon solar cells retain their power-conversion efficiency after being subjected to bending stress or exposure to air-flow simulations of a violent storm.

Many diseases can display distinct brain imaging phenotypes across individuals, potentially reflecting disease subtypes. However, biological interpretability is limited if the derived subtypes are not associated with genetic drivers or susceptibility factors. Here, the authors describe a deep-learning method that links imaging phenotypes with genetic factors, thereby conferring genetic correlations to the disease subtypes.

Apple is one of the most important fruit crops. Here, the authors perform deep genome resequencing of 117 diverse accessions and reveal comprehensive models of apple origin, speciation, domestication, and fruit size evolution as well as candidate genes associated with important agronomic traits.