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How GPCRs choose between different G proteins remains unclear. Here, authors show that the prototypical Gi-coupled melatonin receptor MT₁ also couples to G_s, resolve the MT₁-G_s structure, and identify ICL3 as a key determinant of this coupling.

Global analysis of obesity trends from 1980 to 2024 in 200 countries and territories using data from 4,050 population-based studies reveals that framing obesity as a single global epidemic masks the highly varied dynamics across countries and age groups.

Ferroptosis is a form of programmed immunogenic cell death (ICD) that has gained increasing attention in cancer immunotherapy. In this study, we present dendritic cell vaccines loaded with ferroptotic tumor lysates to enhance antitumoral immune response in glioma models.

Are hiring managers asking too much of job-seeking researchers? A comparison between two job ads, posted 30 years apart, offers some clues.

Two lab leaders discuss what they look for in candidates, and how their own values and cultural backgrounds influence their approach.

Funding crises, bereavement and a supervisor’s relocation can derail your career path, but you can overcome them.

Julie Gould explores some of the theories and frameworks to help identify future work goals and achieve them.

Start with pen and paper, keep things simple, do your coding at the end, say data visualization specialists.

A study examines the effects of mutations that occur naturally in T cell cancers, reporting that such mutations can potentially be exploited to increase the potency of T cell therapies.

How do you have a full and meaningful retirement? Late-career researchers and retired colleagues discuss the many options available.

Learning how to code brings career benefits and helps science by aiding reproducibility, Julie Gould discovers.

Widespread volcanic eruptions caused rapid warming during the Early Jurassic. Rhenium isotopes reveal that this led to positive climate feedbacks as higher temperatures increased weathering of organic matter, releasing further greenhouse gases.

Julie Gould asks two mid-career researchers to reflect on how closely their professional paths have followed their original goals and ambitions.

APE1 co-evolved with Photosystem II as an ancestral enzyme that contributed to the Great Oxidation Event. This thylakoid-bound copper protein detoxifies O₂^•⁻, playing an essential role in photosynthetic acclimation to high light in oxic environments.

Authors reveal symmetry-protected topological phonons and strong phonon interactions in the thermoelectric Mg₃Bi_2-xSb_x family, explaining its low thermal conductivity and offering a strategy to engineer heat flow in thermoelectric materials.

Julie Gould learns of a career-planning framework that can help pinpoint what you love about your current role, and how that can influence future job moves.

Should you book a session with a careers advisor or go solo with an individual development plan? Here are the pros and cons of each approach.

Chris Woolston and Julie Gould discuss the findings of Nature's 2018 salary and job satisfaction survey

Precipitation distribution shows distinct spatial changes, with intensifications in Northern Europe and strong decrease in the Mediterranean, revealed by high-resolution climate model simulations.

How do scientists define themselves when they leave paid employment after an all-consuming career in academic research?

Acute rheumatic fever (ARF) is a serious sequela of Strep A infection, for which a diagnostic biomarker is still lacking. Here, the authors demonstrate that CXCR3 directs T cells to heart valves in patients with ARF, linking inflammation to tissue damage.

Industry has long courted physicists for their data science expertise, but will this change as more undergraduates acquire these skills?

Trying to achieve a perfect work–life balance is a misguided strategy at the mid-career stage, Julie Gould discovers.

Julie Gould looks at some of the schemes develped by universities to prepare staff for life in retirement.

Different approaches to achieving Target 3 affect distinct and socially diverse populations. These contrasting socioeconomic contexts imply varying challenges and opportunities, underscoring the importance of context-specific, equitable implementation.

In this study, Luo and colleagues identify previously unknown viruses that actively infect highly productive chemoautotrophs. These findings provide new insights into key trophic interactions and virus-host dynamics that impact microbial carbon cycling in aphotic environments.

A large-scale proteomics analysis of the dark proteome by the TransCODE Consortium reveals many translated non-canonical open reading frames to encode microproteins and peptideins.

Mona Nemer tells Julie Gould about her role as Canada's chief scientific adviser and how she aims to strengthen science in the country.

Fragile X-related protein 1 (FXR1) is a potential therapeutic target for ovarian cancer. Here, the authors show that RNA interference of FXR1 using a locked nucleic acid (LNA) form enables efficient inhibition of ovarian cancer growth and metastasis; single-cell RNA sequencing reveals the impacts on tumour proliferation pathways and the immune microenvironment.

Seasoned negotiators share tips on how to handle conversations around pay, bonuses, benefits and contract length.

Media interest in particle physics and the Large Hadron Collider boosted Jon Butterworth's interest in public engagement, reports Julie Gould.

Snyder et al. analyze two population-based birth cohorts to test associations of newborn metabolite concentrations and childhood respiratory outcomes. C4, C10:1, C18:2, and citrulline are associated with early-life wheezing and asthma, with C18:2 specifically associated with increased non-allergic asthma risk.

It can be daunting to see the final chapter of your career approaching. Planning ahead can help.

Artists love working with scientists, and when they do it can unlock new perspectives for research.

The effects of global biodiversity loss on local plant communities have been equivocal. Across 57,398 European time series, covering > 100 years, local plant diversity gains are often associated with rises in generalist and non-native plants.

Why is recruitment often speedier in industry? Julie Gould investigates what the two sectors can learn from each other in the race to source top talent.

Eindhoven University of Technology was set up to partner with local companies. Mutual trust and a respect for academic freedom are key, Julie Gould discovers.

Many scientists switch sectors mid-career and often face life-changing challenges at the same time. These include illness, divorce and caring responsibilities. How do they cope?

Brazilian biologist Fernanda Staniscuaski saw career opportunities diminish after returning from parental leave, prompting her to take action.

Using an evolutionary optimization approach, the authors report a culture medium that matures stem cell-derived heart cells, improving their structure, metabolism and electrical activity to advance highly functional models for in vitro testing.

A philosopher and a behavioural economist suggest some remedies to tackle the “muddle of the middle”.

If academic research isn’t for you, when is the best time to switch sectors? Industry insiders offer their advice.

A stint at CERN exposed María Teresa Dova to longstanding collaborators and mentors, culminating in a successful bid to join a landmark project.

Julie Gould learns that age is no barrier to enjoying interesting work and life opportunities in retirement.

A misleading image in a medical textbook could have life and death implications, but some disciplines can deploy myth and metaphor to convey their science through art.

The M1636 trial evaluated a peptide vaccine targeting IDO and PD-L1 in combination with nivolumab in patients with advanced melanoma. Here, the authors present 5-year survival data confirming durable clinical benefit from an IDO/PD-L1 immune modulatory vaccine combined with αPD-1 in metastatic melanoma, and they identify serum CCL3, CCL4, and TNFα as biologic markers of response