Stowell et al. show that the intrinsically disordered region (IDR) of Puf3 binds the Ccr4–Not deadenylase complex using an extended interface. Phosphorylation of the IDR regulates the interaction to tune exonucleolytic activity in a graded manner.
- James A. W. Stowell
- Conny W. H. Yu
- Lori A. Passmore