Search

Introducing and stabilizing oxygen vacancies within oxide supports remains a significant challenge for enhancing catalytic activity in redox reactions. Here, the authors fabricate centimeter-scale porous single-crystalline Nb₂O₅ monoliths and deposit Pt clusters on their surfaces, creating an interfacial system that markedly improves catalytic CO oxidation.

Li-metal batteries suffer from sluggish kinetics at low temperatures. Here, authors propose a guideline for rational electrolyte solvent screening and design a class of asymmetric ethers, which bestows the Li metal pouch cell with a high specific energy of 345.3 Wh kg⁻¹ over 40 cycles at −40 °C.

HOXA2 expression was inhibited by aberrant hypermethylation, leading to decreased SIRT1 levels, which could increase ATF6 acetylation and activation as well as subsequent ER stress, resulting in renal damage in CKD-related fibrosis.

Integrative analyses of transcriptome and whole-genome sequencing data for 1,188 tumours across 27 types of cancer are used to provide a comprehensive catalogue of RNA-level alterations in cancer.

The authors report the synthesis of (La_0.9Y_0.1)H₁₀ superhydrides and their characterization using synchrotron-based, spatially resolved x-ray diffraction and electrical transport imaging. They reveal μm-scale structural inhomogeneity with coexisting cubic and hexagonal clathrate phases exhibiting distinct superconducting transition temperatures.

The stabilization of perovskites in both solution and solid phases is critical to the fabrication of solution-processed perovskite solar cells. Here, 4-(trifluoromethyl)phenylhydrazine is introduced to enhance storage stability, achieving consistent high efficiency of 26.0% in stable devices.

How resistance to different classes of AKT inhibitors can emerge is unclear. Here, the authors show that resistance to allosteric inhibitors is mainly due to mutation of AKT1 while the ATP competitive resistance is driven by activation of PIM kinases in prostate cancer models.

Data from two large longitudinal cohorts in China, in which the participants were clustered into five groups based on their metabolic characteristics, show that a signature of microbiome age modulates the risk of cardiovascular disease in metabolically unhealthy individuals.

Polygenic scores for body mass index and obesity constructed using data from 5 million people with different ancestries were associated with distinct weight gain trajectories from early childhood to adulthood.

Molecular doping is essential for optimizing carrier concentration, charge mobility, and energy levels of organic semiconductors, but efficient n(electron)-type doping remains challenging. Here, the authors present a catalysed n-doping strategy using air-stable, cost-effective, and commercially available soluble organometallic complexes.

Haplotype-resolved, gap-free genome assemblies for a representative Asian pear (Pyrus bretschneideri, ‘Dangshansuli’) and a European pear (Pyrus communis, ‘Max Red Bartlett’) provide insights into genome evolution and interspecies variation in Pyrus species.

A radical-mediated dynamic remedial strategy based on bio-inspired disulfide metathesis has been developed to construct metal–organic frameworks with crystalline dynamicity. The disulfide exchange-based crystal dynamics of the metal–organic frameworks allows for sustained gas separation.

A layer-by-layer thermal evaporation strategy enables thermally evaporated inverted perovskite solar cells with a power conversion efficiency of 25.19%, maintaining about 95% of their initial efficiency after 1,000 h of operation.

In this study the authors consider the structural variants (SVs) present within cancer cases of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium. They report hundreds of genes, including known cancer-associated genes for which the nearby presence of a SV breakpoint is associated with altered expression.

The benchmark fullerene-based electron-transporting materials (ETMs) for inverted perovskite solar cells are often limited by thermal evaporation or stability issues. Here the authors report solution-processable non-fullerene ETMs with improved device stability and efficiency.

The operational lifetimes of n-i-p perovskite solar cells have been limited by the layer-to layer ion diffusion in the perovskite/hole-transport layer heterojunction. Here, the authors introduce an ultrathin p-type polymeric interlayer and achieve a certified efficiency of 26.17% in stable devices.

The flagship paper of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium describes the generation of the integrative analyses of 2,658 cancer whole genomes and their matching normal tissues across 38 tumour types, the structures for international data sharing and standardized analyses, and the main scientific findings from across the consortium studies.

In this study, authors evaluate mass tuberculosis (TB) screening data from 183,808 elderly individuals in China, finding that abnormal chest X-rays significantly increase TB risk.

Here the authors report the synthesis of defect-rich boron nitride by flux reconstruction method, which exhibited good reactivity for semihydrogenation of low concentration acetylene in ethylene-abundant gas stream.

Donor exciton delocalization and its impact on photovoltaic performance of organic solar cells remains less explored. Here, the authors found that delocalized excitons are formed in aggregates of the donor polymer D18, and that these delocalized excitons mediate charge generation in solar cells.

Analyses of 2,658 whole genomes across 38 types of cancer identify the contribution of non-coding point mutations and structural variants to driving cancer.

A large genome-wide association study of more than 5 million individuals reveals that 12,111 single-nucleotide polymorphisms account for nearly all the heritability of height attributable to common genetic variants.

In this large-scale study, the authors used multimodal neuroimaging and cognitive data from UK Biobank participants to examine the relationship between regional adiposity and brain health.

Well-defined metastable phase nanostructures are a core issue for catalyst design. Here, the authors report metastable monoclinic phase IrO2 nanoribbons obtained via a molten-alkali mechanochemical method, which exhibit intrinsic high performance towards the acidic oxygen evolution reaction.

The random orientation of spontaneously formed 2D phase atop 3D perovskites limits the performance of solar cells. Here, authors introduce a meta-amidinopyridine ligand with solvent post dripping to generate highly ordered 2D perovskites, achieving maximum efficiency of 26.05% for stable devices.

High-energy-density lithium metal batteries suffer from limited cycle life. Here the authors develop a homogeneous and mechanically stable solid–electrolyte interphase by using a trioxane-modulated electrolyte, thereby expanding battery cyclability.

Understanding deregulation of biological pathways in cancer can provide insight into disease etiology and potential therapies. Here, as part of the PanCancer Analysis of Whole Genomes (PCAWG) consortium, the authors present pathway and network analysis of 2583 whole cancer genomes from 27 tumour types.

Whole-genome sequencing data from more than 2,500 cancers of 38 tumour types reveal 16 signatures that can be used to classify somatic structural variants, highlighting the diversity of genomic rearrangements in cancer.

Analysis of cancer genome sequencing data has enabled the discovery of driver mutations. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium the authors present DriverPower, a software package that identifies coding and non-coding driver mutations within cancer whole genomes via consideration of mutational burden and functional impact evidence.

A pan-cancer genomic analysis reports the effects of structural variations on chromatin domains (TADs). Most TAD disruptions do not result in appreciable changes in expression of nearby genes.

An analysis of 2,954 genomes from 38 cancer subtypes identified 19,166 retrotransposition events in 35% of samples. Aberrant LINE-1 retrotranspositions can lead to the deletion of tumor-suppressor genes as well as the amplification of oncogenes.

Multi-omics datasets pose major challenges to data interpretation and hypothesis generation owing to their high-dimensional molecular profiles. Here, the authors develop ActivePathways method, which uses data fusion techniques for integrative pathway analysis of multi-omics data and candidate gene discovery.

The development of dendrite-free, Zn-free anodes is challenging. Here, the authors design a two-dimensional antimony/antimony-zinc alloy heterostructured interface to achieve dendrite-free Zn deposition with areal capacity of 200 mAh cm⁻², and energy density of around 270 Wh kg⁻¹ for anode-free zinc-bromine battery.

There’s an emerging body of evidence to show how biological sex impacts cancer incidence, treatment and underlying biology. Here, using a large pan-cancer dataset, the authors further highlight how sex differences shape the cancer genome.

In somatic cells the mechanisms maintaining the chromosome ends are normally inactivated; however, cancer cells can re-activate these pathways to support continuous growth. Here, the authors characterize the telomeric landscapes across tumour types and identify genomic alterations associated with different telomere maintenance mechanisms.

With the generation of large pan-cancer whole-exome and whole-genome sequencing projects, a question remains about how comparable these datasets are. Here, using The Cancer Genome Atlas samples analysed as part of the Pan-Cancer Analysis of Whole Genomes project, the authors explore the concordance of mutations called by whole exome sequencing and whole genome sequencing techniques.

Viral pathogen load in cancer genomes is estimated through analysis of sequencing data from 2,656 tumors across 35 cancer types using multiple pathogen-detection pipelines, identifying viruses in 382 genomic and 68 transcriptome datasets.

Whole-genome sequencing data for 2,778 cancer samples from 2,658 unique donors across 38 cancer types is used to reconstruct the evolutionary history of cancer, revealing that driver mutations can precede diagnosis by several years to decades.

Some cancer patients first present with metastases where the location of the primary is unidentified; these are difficult to treat. In this study, using machine learning, the authors develop a method to determine the tissue of origin of a cancer based on whole sequencing data.

The authors present SVclone, a computational method for inferring the cancer cell fraction of structural variants from whole-genome sequencing data.

The authors introduce a structural design with a well-ordered local structure for barium titanate-based ceramics, which decreases Curie temperature while preserves a sharp phase transition, enabling tunable polarization, large dielectric constant and intrinsic electrocaloric effect near room temperature.

The characterization of 4,645 whole-genome and 19,184 exome sequences, covering most types of cancer, identifies 81 single-base substitution, doublet-base substitution and small-insertion-and-deletion mutational signatures, providing a systematic overview of the mutational processes that contribute to cancer development.

Cancers evolve as they progress under differing selective pressures. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, the authors present the method TrackSig the estimates evolutionary trajectories of somatic mutational processes from single bulk tumour data.

Metal-organic frameworks (MOFs) are so sensitive to electron beams that it is challenging to atomically image their structures by electron microscopy. Here, the authors use the integrated differential phase contrast technique in STEM to achieve the low-dose imaging of a beam-sensitive MOF, revealing its detailed local structure.

Electrochemical oxygen reduction is a promising method for H₂O₂ production but suffers from poor activity and low yield. In this work, the authors present Ni single atom catalyst for efficient H₂O₂ production which is further coupled with organic oxidation reaction to enhance the economic feasibility of the system.

Many tumours exhibit hypoxia (low oxygen) and hypoxic tumours often respond poorly to therapy. Here, the authors quantify hypoxia in 1188 tumours from 27 cancer types, showing elevated hypoxia links to increased mutational load, directing evolutionary trajectories.

Sulfur utilization in high-mass-loading positive electrodes is crucial for developing practical all-solid-state lithium-sulfur batteries. Here, authors propose a low-density inorganic solid-state electrolyte to improve the sulfur utilization in lab-scale Li-In||S all-solid-state cells.

While electrochemical conversion of nitrate to ammonia offers a renewable means to remediate waste compounds, it is challenging to achieve selective catalysis. Here, authors demonstrate a strategy to improve electrocatalytic ammonia production using cobalt phosphide on carbon nanosheet arrays.

The construction of well-ordered nanoarrays, particularly invoking metastable material phases, remains a challenge. Here, authors prepared a well-ordered, rhodium nanoarray on two-dimensional, metastable rhodium oxide to enhance hydrogen evolution electrocatalysis.