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The authors report ambient-pressure, polarization-resolved electronic Raman scattering measurements on single crystals of nickelate La₃Ni₂O₇, which becomes superconducting under pressure. Quantitative analysis reveals momentum-selective spin density wave (SDW) gap amplitudes, indicating an unconventional SDW driven by anisotropic electronic correlations.

Climate change is altering the timing—not just the volume—of meltwater from the Asian Water Tower. Although meltwater has historically buffered dry‑season urban water scarcity, future increases are concentrated in the monsoon season, weakening its effectiveness just as urban water demand rises.

Btg2 suppresses UFMylation of Fmo1, promoting its k48-linked ubiquitination and degradation, thereby restricting taurine synthesis and exacerbating ferroptosis and apoptosis in hepatic ischemia-reperfusion injury.

Reversible-deactivation radical polymerisations are highly sensitive to oxygen and inhibitors, hindering their industrial application. Here, the authors report a heterogeneous phenanthroline-based conjugated hypercrosslinked polymer photocatalyst for photoinduced copper-catalysed atom transfer radical polymerisations, achieving high oxygen and inhibitor tolerance.

Early detection of nasopharyngeal carcinoma through Epstein–Barr virus serology is hindered by a low positive predictive value. Here this group introduces a hierarchical dynamic model for stratification refinement within serologically defined risk individuals thereby yielding cost savings for current serological screening strategy.

Most atmospheric water harvesters suffer from slow sorption and intermittent solar-driven desorption. Here, the authors develop a hybrid wood composite with a phase change material that stores solar heat. It rapidly captures water across a wide humidity range and releases it continuously, even in darkness, achieving a daily yield of 0.96–1.72 L kg⁻¹.

This study achieves ultrafast all-electrical perpendicular magnetization switching with a pulse width of 16 ps and an energy consumption of 41 fJ/bit in a CoTb/Ti/CoFeB/MgO heterostructure, enabled by combining the in-plane and out-of-plane spin current.

Idiopathic pulmonary fibrosis is a fatal lung disease driven by aberrant fibroblast activation, but the underlying metabolic changes remain unclear. Here, the authors show that dysregulated branched chain amino acid metabolism promotes lung fibrosis and can be therapeutically targeted.

RNA-binding proteins (RBPs) regulate gene expression, but predicting RBP–RNA interactions across species is challenging. Here, the authors introduce MuSIC, a deep learning framework leveraging label smoothing and evolutionary conservation across 11 species to predict cross-species RBP–RNA interactions.

Photodetectors for aerospace exploration require high temperature and radiation tolerance. Here, the authors report the realization of Au-intercalated potassium niobate ultraviolet photodetectors with stable operation in a wide temperature range (from −263.15 °C to 300 °C) and under γ-ray radiation doses up to 200 kGy.

Low-dose IL-2 therapy has been evaluated for the treatment of numerous autoimmune conditions. This study reports the outcomes of a phase 2, randomised, placebo-controlled trial evaluating the efficacy and safety of low-dose IL-2 for the treatment of systemic lupus erythematosus (SLE).

This study found COVID-19 vaccination offers added protection against reinfection in children and adolescents with prior infection but variable effectiveness across variants. Findings support vaccination benefits beyond infection-acquired immunity.

Natural variation in the promoter of OsTPS8 contributes to differences in grain chalkiness and seed vigor between indica and japonica rice subspecies by altering trehalose-6-phosphate biosynthesis and α-amylase levels.

A macrolide resistant Bordetella pertussis lineage (MT28) carrying a high-virulence allele (ptxP3) has been reported as a predominant lineage in China. Here, the authors show that MT28 has enhanced colonization and inflammatory characteristics.

Converting carbon dioxide into useful chemicals needs catalysts that are fast, selective and long-lasting. This study creates nickel–tungsten carbide nano-islands that efficiently make carbon monoxide and stay stable for 100 hours.

Researchers have found that extreme hot-wet weather in 2024 triggered a spike in ecosystem respiration, mainly in tropical non-forests, significantly reducing the year’s land carbon sink and pushing the atmospheric CO2 growth rate to a record high.

Susceptibility of Nasopharyngeal carcinoma (NPC), associated with Epstein-Barr virus infection, is linked with HLA gene region with mechanisms unclear. The authors here show that the high-risk EBV subtype BALF2 upregulates HLA-DP, leading to CD8⁺ T cell exhaustion, and combined anti-LAG-3 and anti-PD-1 therapy improves anti-cancer efficacy.

A sequential deposition method combined with a multifunctional organic additive enables sky-blue all-thermally evaporated perovskite light-emitting diodes with a peak external quantum efficiency of 20.15%, as well as their integration into an active-matrix display prototype.

Induction of hypothermia during hibernation/torpor enables certain mammals to survive under extreme conditions. Here, the authors show that the natural product P57 induces hypothermia by targeting pyridoxal kinase and has a potential application in therapeutic hypothermia.

Thermogenic adipocytes are a potential therapy to combat obesity, although the process underlying their activation remains unclear. Here, the authors use epigenetic profiling to demonstrate RUNX1 and RUNX2 inhibit thermogenesis by distinct mechanisms.

Here, the authors show that the Saccharibacteria Nanosynbacter lyticus strain TM7x elicits limited immune activation in the oral cavity, and binds to gingival epithelial cells via a T4P-dependent mechanism, leading to clustering of TLR2 receptors and subsequent caveolin-mediated endocytosis.

Two types of signal folding—for input signals and for weight conductance—can be implemented in molybdenum disulfide-based one-transistor–one-resistor arrays to decrease power consumption and improve weight precision in vector–matrix multiplication.

The DAMPE satellite observed a universal charge-dependent spectral softening in primary cosmic rays, and ruled out mass-dependent softening with >99.999% confidence.

A new series of narrow-bandgap acceptors exploiting the heavy-atom effect enables organic solar cells with a power conversion efficiency of 20.7% and 1-cm² perovskite–organic tandem devices with a certified power conversion efficiency of 27.5%.

Global Burden of Disease analysis found that in 2023, suboptimal diet was estimated to be responsible for 4 million deaths and 97 million morbidity burdens from ischemic heart disease.

Emerging evidence suggests that organs age at different rates. This study identifies a mechanism by which the naturally hypoxic intervertebral disc ages relatively slowly, via selective autophagy of HIF-1α, and designs a small molecule to export this mechanism across tissues.

Treatment data for triple-negative breast cancer show the importance of macrophage subtypes and cancer-cell metaprograms for interferon signalling, HLA expression and cell cycle activity that are associated with a good response to neoadjuvant chemotherapy.

A programmable photonic quantum processor, Jiuzhang 4.0, incorporates 1,024 high-efficiency squeezed states into a hybrid spatial–temporal encoded 8,176-mode circuit.

Li et al. conduct a multi-omics analysis of nasopharyngeal carcinoma and identify three molecular subtypes with distinct immune profiles and responses to induction chemotherapy.

Colorectal cancer has high recurrence and metastasis rates making treatment difficult. Here, the authors report on peptide modified cell membrane coated cobalt based metal-organic frameworks which degrades and forms, in situ, photothermal materials with H₂S, allowing for immune-photothermal therapy.

The positive electrode/electrolyte interface is crucial for the performance of all-solid-state lithium batteries. Here, authors use a sintering technique to form a conformal interface between high-entropy disordered rock salt electrodes and garnet-type electrolytes to reduce interfacial resistance.

Acute sinusitis, exacerbated by environmental pollutants and poor medication adherence, poses significant health challenges due to increased drug resistance. Here, the authors develop a QACS/SA@Py@Ta₄C₃ injectable hydrogel, integrating phillyrin from traditional chinese medicine with Ta₄C₃ quantum dots and natural polymers (quaternary chitosan and sodium alginate), demonstrating potent antibacterial, anti-inflammatory, and antioxidant effects against sinusitis.

BioMedAgent is a self-evolving LLM multi-agent framework that learns to use various bioinformatics tools and chain them into executable workflows for autonomously carrying out diverse biomedical data tasks initiated by natural-language prompts.

Self-assembled monolayers are efficient hole-selective contacts but suffer from aggregation and adhesion issues. To address these, Wang et al. introduce a dimeric molecular design that forms a hydrogen-bond network, enabling 28.4% certified efficiency in all-perovskite tandem solar cells.

Stacking XA48-mediated effector-triggered immunity with XA21-mediated pattern-triggered immunity in Oryza sativa japonica reconstitutes the broad-spectrum resistance from wild rice.

Perovskite–organic-based solar cells typically show poor reverse-bias stability. By modulating the deep trap state in the bulk-heterojunction region, organic and perovskite–organic tandem solar cells show largely improved stability under reverse biases up to –40 V.

Alternative targets are required for tumor therapy. The authors here show that transmembrane protein 175 (TMEM175) knock out in macrophages improves aPD-1 treatment prognosis with the mechanism of enhanced NLRP3 expression and antigen cross-presentation of macrophages.

The immune mechanism of radioresistance in cancer patients remains to be explored. The authors here show that CXCL13 is upregulated in tumor regions upon radiation, which recruits immune suppressive CXCR5⁺ monocytes. Blocking CXCR5/CXCL13 interactions facilitate tumor control following radiation.