Nature Search

De novo variants in the splicing factor gene SF3B1 are associated with neurodevelopmental disorders

This study reports that de novo germline missense variants in SF3B1, distinct from the somatic variants frequently observed in cancer, cause a neurodevelopmental disorder and disrupt global RNA splicing.

Kevin Uguen
Tiffany Bergot
Delphine G. Bernard
ResearchOpen Access23 Jan 2026
Nature Communications

P: 1-17
Porous titania glass as a photocatalyst for hydrogen production from water

Leonard Kruczynski
Hyman D. Gesser
Edward A. Speers
Research04 Jun 1981
Nature

Volume: 291, P: 399-401
CXCR4 induces memory formation over exhaustion in CAR-T cells to achieve durable leukemia targeting

CAR-T cell efficacy is often limited by the inability to maintain a memory T cell program. Here, the authors show that intrinsic CXCR4 expression enhances CAR-T cell persistence and memory differentiation in acute myeloid leukemia.

Ari Itoh-Nakadai
Minggao Liang
Fumihiko Ishikawa
ResearchOpen Access26 Jan 2026
Nature Communications

Volume: 17, P: 1-21
Identification of Chlamydia pneumoniae and NLRP3 inflammasome activation in Alzheimer’s disease retina

This study detects Chlamydia pneumoniae in human retina and brain, increasing with AD severity. Retinal pathogen load with Aβ₄₂ may predict AD stage. In models, infection drives Aβ deposition and NLRP3 activation, worsening pathology and cognition.

Bhakta Prasad Gaire
Yosef Koronyo
Maya Koronyo-Hamaoui
ResearchOpen Access22 Jan 2026
Nature Communications

Volume: 17, P: 1-24
Presence of Donor Specific Gamma-Globulins in Sera of Allogeneic Mouse Radiation Chimeras

LEONARD A. HERZENBERG
LEONARD J. COLE
Research25 Apr 1964
Nature

Volume: 202, P: 352-353
Nutritive Value of Elm Tree Bark

LEONARD HILL
Research24 May 1930
Nature

Volume: 125, P: 780
Fluorometric Analysis of Amidase and Alkaline Phosphatase in Neonatal Rat Thymocytes : Peak Activities at Two Days of Age

LEONARD J. GREENBERG
LEONARD J. COLE
Research07 Mar 1964
Nature

Volume: 201, P: 1001-1003
Inflatable porous organic crystals

Reversible and unidirectional expansion of an acicular porous molecular crystal is observed with gas uptake. Using in situ structural and photomicrographic techniques, a molecular-level insight is obtained that correlates macroscopic linear expansion of the crystal to the application of gas-specific pressure.

Alexios I. Vicatos
Leigh Loots
Leonard J. Barbour
ResearchOpen Access03 Nov 2025
Nature Materials

P: 1-6
Molecular cloning and expression of cDNAs for the human interleukin-2 receptor

Warren J. Leonard
Joel M. Depper
Warner C. Greene
Research18 Oct 1984
Nature

Volume: 311, P: 626-631
Effect of Mass Transfer on the Velocity of Rise of Bubbles in Water

J. H. LEONARD
G. HOUGHTON
Research20 May 1961
Nature

Volume: 190, P: 687-688
Examination of γ-irradiated Benzene for Optical Activity

LEONARD SPIALTER
JEAN H. FUTRELL
Research15 Oct 1960
Nature

Volume: 188, P: 225-226
TDP-43-dependent mis-splicing of KCNQ2 triggers intrinsic neuronal hyperexcitability in ALS/FTD

TDP-43 dysfunction in ALS/FTD causes faulty splicing of the KCNQ2 ion channel, leading to toxic protein buildup, neuron hyperactivity and a potential new biomarker and treatment target using RNA-based therapies.

Brian J. Joseph
Kelly A. Marshall
Evangelos Kiskinis
ResearchOpen Access31 Oct 2025
Nature Neuroscience

Volume: 28, P: 2476-2492
Super-cooled Water

LEONARD HAWKES
Research16 Feb 1929
Nature

Volume: 123, P: 244
Segré-Silberberg Annulus Formation : A Possible Explanation

R. V. REPETTI
E. F. LEONARD
Research26 Sept 1964
Nature

Volume: 203, P: 1346-1348
Improvements to the Melted Emulsion Technique of Autoradiography

LEONARD F. BÉLANGER
Research11 Oct 1952
Nature

Volume: 170, P: 625-626
Characterization of Nonmotile Neutrophil Subpopulations in Neonates and Adults

Peter J Krause
Donald L Kreutzer
Nadia Greca
Research01 May 1989
Pediatric Research

Volume: 25, P: 519-524
Surface interfacial analysis of simulant high level nuclear waste glass dissolved in synthetic cement solutions

Claire L. Corkhill
Colleen Mann
Eric M. Pierce
ResearchOpen Access18 Aug 2022
npj Materials Degradation

Volume: 6, P: 1-14
Genetically encoding multiple functionalities into extracellular vesicles for the targeted delivery of biologics to T cells

Biologics can be specifically delivered to T cells by genetically engineering cells to secrete extracellular vesicles that actively load protein cargo and that display high-affinity T-cell-targeting domains and fusogenic glycoproteins.

Devin M. Stranford
Lacy M. Simons
Joshua N. Leonard
Research27 Nov 2023
Nature Biomedical Engineering

Volume: 8, P: 397-414
Effect of Capacitor Arrangement on the Symmetry of Linear Pinch Discharges

DONALD P. DUCLOS
LEONARD ARONOWITZ
FREDERIC P. FESSENDEN
Research05 Oct 1963
Nature

Volume: 200, P: 59
Locusts in Sunlight

LEONARD HILL
H. J. TAYLOR
Research19 Aug 1933
Nature

Volume: 132, P: 276
The Specific Action of Ultra Short Wireless Waves

LEONARD HILL
H. J. TAYLOR
Research03 Oct 1936
Nature

Volume: 138, P: 591
Metallosupramolecular self-assembly of a universal 3-ravel

There has been recent progress in the synthesis of complex intertwined supramolecular topologies. In this study, Liet al.report the self-assembly of an intertwined structure based on a universal 3-ravel.

Feng Li
Jack K. Clegg
George V. Meehan
Research22 Feb 2011
Nature Communications

Volume: 2, P: 1-5
Sialic Acid as a Structural Component of Some Mammalian Tissue Cell Surfaces

LEONARD WEISS
Research09 Sept 1961
Nature

Volume: 191, P: 1108-1109
Methane formation driven by light and heat prior to the origin of life and beyond

Abiotic methane and ethane formation routes in aqueous environments driven by light and heat are identified. The released hydrocarbons may have contributed to the chemical evolution of the atmosphere from prior to the origin of life until today.

Leonard Ernst
Uladzimir Barayeu
Johannes G. Rebelein
ResearchOpen Access01 Aug 2023
Nature Communications

Volume: 14, P: 1-10
Traction proteins in the extracellular matrix of Dictyostelium discoideum slugs

Phil H. Vardy
Leonard R. Fisher
Keith L. Williams
Research10 Apr 1986
Nature

Volume: 320, P: 526-529
Microglial REV-ERBα regulates inflammation and lipid droplet formation to drive tauopathy in male mice

The circadian clock protein REV-ERBα has been implicated in neuroinflammation but mechanisms are poorly understood. Here, the authors show that microglial REV-ERBα regulates inflammatory signaling and lipid droplet formation to exert sex-specific effects on tau pathology in mice.

Jiyeon Lee
Julie M. Dimitry
Erik S. Musiek
ResearchOpen Access25 Aug 2023
Nature Communications

Volume: 14, P: 1-17
Methane formation driven by reactive oxygen species across all living organisms

Methane formation by a ROS-mediated process is linked to metabolic activity and is identified as a conserved feature across living systems.

Leonard Ernst
Benedikt Steinfeld
Frank Keppler
Research09 Mar 2022
Nature

Volume: 603, P: 482-487
Trophic niche partitioning in giant clams

Isotopic analysis of six giant clam species reveals trophic niche partitioning along a heterotrophy-autotrophy continuum. The most autotrophic species had the fastest growth rates, but may be more susceptible to environmental disturbances.

Isis Guibert
Inga Elizabeth Conti-Jerpe
David Michael Baker
ResearchOpen Access06 Dec 2025
Communications Biology

Volume: 9, P: 1-10
Enhancing extracellular vesicle cargo loading and functional delivery by engineering protein-lipid interactions

Understanding principles that govern protein association with extracellular vesicles should expand their potential as a therapeutic modality. Here, the authors show that by localizing proteins to the plasma membrane and lipid rafts, a variety of proteins can be preferentially loaded into extracellular vesicles.

Justin A. Peruzzi
Taylor F. Gunnels
Neha P. Kamat
ResearchOpen Access04 Jul 2024
Nature Communications

Volume: 15, P: 1-18
MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis

Exercise has beneficial effects on metabolism and overall physiologic fitness in aged organisms. Here the authors show that MOTS-c is a mitochondrial-encoded exercise-induced peptide that regulates skeletal muscle metabolism and improves healthspan of older mice.

Joseph C. Reynolds
Rochelle W. Lai
Changhan Lee
ResearchOpen Access20 Jan 2021
Nature Communications

Volume: 12, P: 1-11
Super-cooled Water

LEONARD HAWKES
Research10 Aug 1929
Nature

Volume: 124, P: 225-226
Isoamylases of Human Parotid Saliva

ROBERT O. WOLF
LEONARD L. TAYLOR
Research01 Mar 1967
Nature

Volume: 213, P: 1128-1129
The Arctic Mid-Oceanic Ridge

G. LEONARD JOHNSON
BRUCE C. HEEZEN
Research01 Aug 1967
Nature

Volume: 215, P: 724-725
Letter from Charles Darwin to Lord Farrer

LEONARD DARWIN
Research03 Jan 1931
Nature

Volume: 127, P: 15
Room Comfort

LEONARD HILL
Research24 Dec 1932
Nature

Volume: 130, P: 967
A Fruit-setting Hormone from Apple Seeds

LEONARD C. LUCKWIL
Research09 Nov 1946
Nature

Volume: 158, P: 663
Radium Treatment

LEONARD HILL
Research27 Jan 1940
Nature

Volume: 145, P: 151
Autoradiographic Detection of Sulphur-35 Synthesis by the Mucous Neck Cells of the Rat's Stomach

LEONARD F. BÉLANGER
Research19 Dec 1953
Nature

Volume: 172, P: 1150
Suggestion Relating to the Kew Standard Thermometers

LEONARD WALDO
Research02 Jun 1881
Nature

Volume: 24, P: 100-101
The Philippine cynomolgus monkey (Macaca fasicularis) provides a new nonhuman primate model of tuberculosis that resembles human disease

Gerald P. Walsh
Esterlina V. Tan
Marcus A. Horwitz
Research01 Apr 1996
Nature Medicine

Volume: 2, P: 430-436
Dual interfacial H-bonding-enhanced deep-blue hybrid copper–iodide LEDs

A dual interfacial hydrogen-bond passivation strategy and a hybrid copper–iodide are used to fabricate deep-blue light-emitting diodes with excellent external quantum efficiency and lifetime.

Kun Zhu
Obadiah Reid
Jing Li
Research16 Jul 2025
Nature

Volume: 643, P: 1246-1254
A c-myc antisense oligodeoxynucleotide inhibits entry into S phase but not progress from G₀ to G₁

Reino Heikkila
Gisela Schwab
Leonard M. Neckers
Research30 Jul 1987
Nature

Volume: 328, P: 445-449
Production of constrained L-cyclo-tetrapeptides by epimerization-resistant direct aminolysis

The synthesis of constrained 12-membered peptide rings is challenging due to constraints during the linear peptide cyclization. Here the authors present a β-thiolactone framework that enables the synthesis of cyclo-tetrapeptides via direct aminolysis while preventing commonly observed C-terminus epimerization.

Huan Chen
Yuchen Zhang
Qiang Zhang
ResearchOpen Access25 Jun 2024
Nature Communications

Volume: 15, P: 1-11
Measuring the burden of hundreds of BioBricks defines an evolutionary limit on constructability in synthetic biology

Engineered DNA will slow the growth of a host cell if it redirects limiting resources or otherwise interferes with homeostasis. Here the authors measure how 301 BioBrick plasmids affected Escherichia coli growth and found that 19.6% were burdensome, primarily because they depleted the limited gene expression resources of host cells.

Noor Radde
Genevieve A. Mortensen
Jeffrey E. Barrick
ResearchOpen Access24 Jul 2024
Nature Communications

Volume: 15, P: 1-17
Cyclic AMP induces functional presynaptic boutons in hippocampal CA3–CA1 neuronal cultures

Li Ma
Leonard Zablow
Steven A. Siegelbaum
Research01 Jan 1999
Nature Neuroscience

Volume: 2, P: 24-30
Stable restoration of the sarcoglycan complex in dystrophic muscle perfused with histamine and a recombinant adeno-associated viral vector

James P. Greelish
Leonard T. Su
Hansell H. Stedman
Research01 Apr 1999
Nature Medicine

Volume: 5, P: 439-443
Sulphostin-inspired N-phosphonopiperidones as selective covalent DPP8 and DPP9 inhibitors

The targeted development of proteome-wide selective covalent probes remains a challenge. Here, the authors show the exploration of the natural product Sulphostin as a starting point for dipeptidyl peptidase 8 and 9 inhibitor development.

Leonard Sewald
Werner W. A. Tabak
Markus Kaiser
ResearchOpen Access03 Apr 2025
Nature Communications

Volume: 16, P: 1-15
Investigational eIF2B activator DNL343 modulates the integrated stress response in preclinical models of TDP-43 pathology and individuals with ALS in a randomized clinical trial

Flores et al. show that brain-penetrant eIF2B agonists suppress ISR activation in cellular and mouse models of ALS and reduce ISR biomarkers in humans, enabling further clinical studies of ISR inhibition in individuals with neurological diseases

Brittany N. Flores
Seungyoon B. Yu
Joseph W. Lewcock
ResearchOpen Access18 Aug 2025
Nature Communications

Volume: 16, P: 1-23
Retinol induces density-dependent growth inhibition and changes in glycolipids and LETS

LEONARD M. PATT
KOICHI ITAYA
SEN-ITIROH HAKOMORI
Research01 Jun 1978
Nature

Volume: 273, P: 379-381
Dual-targeting CRISPR-CasRx reduces C9orf72 ALS/FTD sense and antisense repeat RNAs in vitro and in vivo

CRISPR-CasRx effectively reduces ALS- and FTD-causing C9orf72 sense and antisense repeat derived RNAs and proteins in cell lines, patient iPSC-neurons and two independent mouse models of C9orf72 repeat expansion.

Liam Kempthorne
Deniz Vaizoglu
Adrian M. Isaacs
ResearchOpen Access08 Jan 2025
Nature Communications

Volume: 16, P: 1-15

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