Search

Li–S batteries typically rely on static internal modifications. Here, authors apply dynamic external acoustic modulation to create a non-equilibrium entropy-driven electrolyte, enhancing mass transfer and Li-ion desolvation to accelerate sulfur conversion and stabilize lithium negative electrode.

Fast-charging black phosphorus electrodes are limited by slow multiphase redox reactions. Here, authors engineer P–N bonds in the phosphorus bulk to accelerate lithium insertion and boost performance. Pouch cells can hit 80% charge in 10 min, delivering 282 Wh/kg and lasting over 3,400 cycles.

Liquid crystal elastomers are promising for actuators in soft robotics, but 3Dprinting methods often restrict responsive properties. Here the authors design by tuning the printing angle, affording a coiled fiber, for programmable actuation.

High endothelial venules (HEVs) are an underexplored metastatic route. The authors show that breast cancer cells spreading via HEVs are less immunogenic due to ALOX12-driven immune evasion.

Authors develop a general paradigm combining fluorescence resonance energy transfer imaging, gel electrophoresis and mass spectrometric analysis to identify and quantify intracellular N-acetylglucosamine modified glycoRNAs.

All-solid-state batteries have attracted widespread attention due to their potential for high specific energy and safety, but they struggle to operate stably under low pressure. Here, the authors reveal that fluorine atoms can spontaneously form stable bulk and interfacial structures through rapid diffusion kinetics, thereby improving the ability of all-solid-state batteries to operate stably under low pressure.

Mucosal melanoma is a rare and aggressive subtype which, unlike cutaneous melanoma, shows limited response to immune checkpoint inhibition. Here, the authors report the safety and efficacy of neoadjuvant pembrolizumab (anti-PD-1) and lenvatinib (multi tyrosine kinase inhibition) in patients with resectable mucosal melanoma, along with exploratory biomarker analysis.

A Spectral Contrastive-Aware Network decodes Zhurong, OMEGA, and CRISM SWIR data, revealing altitude-dependent manganese (hydr)oxide enrichments forming shoreline ‘bathtub rings’ tracing 0.8–1.5-million-year ocean evolution in Utopia Planitia, Mars.

SUCCEED is a supervised multi-task DNA foundation model pretrained on 6,389 ENCODE tracks. It integrates CNN and Transformer architectures to model local motifs and long-range dependencies, enabling prediction of genomic regulatory features across tasks and cell types.

A chip-integrated metasurface wavefront sensor operating without external optics uses orientation and lobe-spacing encoding of double-helix point spread functions, enabling a ± 9.4° dynamic range and doubled sampling.

Perovskite/silicon tandem solar cells degrade under reverse bias. Wang et al. introduce graded dielectric layers that smooth the electric field and reduce tunnelling and interfacial reactions, improving reverse-bias tolerance.

A randomised trial in metformin-treated type 2 diabetes found once-weekly efsubaglutide improved HbA1c and fasting glucose, reduced weight, and enhanced meal-stimulated insulin secretion with mainly mild GI side effects.

The high demand of soft strain sensors requires solutions to reduce resource waste. Here, the authors propose a machine learning framework that corrects unstable signals in soft strain sensors, making them more accurate, reliable and longer-lasting, and extending their usable lifetime by more than 3,000 times.

After deep-space flight, rice seeds show increase in mutations and alteration in DNA and RNA modifications. Multi-omics and single-cell analyses suggest a transcription factor named SVT1 suppresses the differentiation of mutation-carrying cells via the MAPK pathway.

Perovskite solar modules suffer from reverse-bias instability. To address this, Wang et al. promote the assembly of self-assembled monolayers through hydrogen-bonding interactions with a polycarbazole template.

Soft tactile chips embed in-situ sensing in pneumatic actuators, improving teleoperation via adaptive haptic feedback. Liquid-metal pressure and pectin temperature sensors enable precise manipulation and better human-robot interaction.

How co-invading species facilitate one another remains largely unknown. This study shows that facilitation is often asymmetric and increases when co-invading plants differ in competitiveness and their ability to shape microbial communities.

Maternal obesity is a risk factor for developing chronic kidney disease in the offspring later in life. Here the authors study male offspring in a mouse model of maternal obesity and identify dysregulated metabolism due to disrupted crosstalk between proximal tubules and macrophages as an important mechanism.

A multiphase-flow-guided solar evaporator integrates water replenishment, vapor dissipation, salt reflux, and heat management, enabling ultrahigh-efficiency solar desalination with stable operation in ~15 wt.% saline water and high daily freshwater production under natural sunlight.

This study presents ECG-LFM, an AI model trained on more than 10 million electrocardiograms to predict cardiovascular diseases and uncover novel genetic markers for heart health.

Chemical warfare agents (CWAs) are highly toxic compounds capable of causing mass casualties on the battlefield. Current analytical methods for detecting blister, nerve, and blood agents suffer from several inherent limitations, including false-positive results, high costs, susceptibility to environmental interferences and cross-contamination, and relatively cumbersome sample pretreatment and operational procedures. In this work, the authors report the design and synthesis of TrioAlert, a fluorescent sensor capable of simultaneously detecting the blister agent sulfur mustard, the G-type nerve agent sarin, and the blood agent cyanide within 90 s.

This study utilizing data from the UK biobank suggests that plasma proteomics profiles significantly improve prediction of the incidence of 17 diseases, for example some types of cancer and cardiometabolic diseases, over standard clinical predictors and metabolomics profiles.

Valine metabolism disruption is linked to heart disease, but the mechanisms are unclear. Here, the authors show that ACAD8 deficiency drives isobutyryl-CoA accumulation and histone isobutyrylation, increasing chromatin accessibility and gene expression to promote cardiac hypertrophy, while ACAD8 overexpression reverses these effects.

Patients with hepatocellular carcinoma (HCC) with Vp4 portal vein tumour thrombus (PVTT) have poor prognosis and are underrepresented in clinical trials. Here, the authors report a phase 2 clinical trial evaluating first-line durvalumab (anti-PD-L1) plus HAIC-FOLFOX (hepatic arterial infusion chemotherapy) in patients with HCC with Vp4 PVTT, along with biomolecular and preclinical analysis.

Nasopharyngeal carcinoma (NPC) screening in southern China uses EBV serology, but its positive predictive value is low. Here, the authors introduce a swab-based E-CpMQ method in high-risk individuals, achieving better specificity.

Treatment failure exists in Induction chemotherapy followed by concurrent chemoradiotherapy (CCRT) for locoregionally advanced nasopharyngeal carcinoma (LA-NPC) patients. Here this group reports a phase 2 randomized trial evaluating the efficacy and safety of adding nimotuzumab, to CCRT on 246 patients with untreated, non-keratinising, stage II–IVA LA-NPC.

Sun et al. show that a synergistic coupling in soil mineral-Hg(II)-organic matter ternary systems markedly promotes Hg(II) dark reduction, thereby liberating ~6.3% of terrestrial surface Hg and potentially impacting global Hg cycling.

Despite recent progresses, scintillating detectors still have limited detection specificity. Here, the authors demonstrate hybrid organic-inorganic scintillating glasses with superior α-particle detection performance, useful for mixed radiation fields and γ-interference scenarios.

Seawater lithium extraction represents an innovative transformative solution that could alleviate future lithium supply concerns. In response, we propose an Albizia julibrissin-inspired adsorption-responsive photothermal ion pump for enhanced and reversible Li+ extraction from seawater.

PANoptosis, a lytic cell death pathway, is promising for cancer immunotherapy, yet its therapeutic exploitation is underdeveloped. Here, the authors report a tumor-targeting nanozyme, Hemin-His-Mn, that concurrently activates retinoic acid-inducible gene I (RIG-I)–mediated PANoptosome assembly and catalyzes reactive oxygen species amplification to achieve PANoptosis induction.

Designing efficient high entropy catalysts is highly desired but remains challenging. Here, the authors report the spin state engineering to develop high-entropy Ruddlesden Popper perovskite oxides for efficient seawater splitting, with the strategy applicable to other high entropy catalysts.

The interface between perovskite and tin dioxide in perovskite solar cells suffers from interfacial defects and energy level mismatch that limit efficiency. Zhang et al. add a polymerized dimethyldiallylammonium chloride interlayer to passivate defects, tune band bending, and enhance charge extraction.

Designing high performance elastomers are promising for multifunctional materials, though existing materials have unfavorable mechanical properties. Here the others design a cellulose based liquid crystal elastomer system affording a biodegradable material with mechanochromic properties.

High yield and wide adaptation rice are crucial for grain supply and food security. Here the authors report OsPI4Kγ7 which contributes to different “adaptability-yield” trade-offs in japonica and indica, and provides an alternative breeding strategy for raising grain yield in different latitudes.

UCl₃-type electrolytes show promise for all-solid-state batteries, yet their structure and Li⁺ transport remain debated. Here, authors reveal foreign cations reside in the amorphous phase, which serve as the dominant Li⁺ pathway yielding enhanced conductivity and low-temperature battery performance.

Neuraminidase activity of NEU1 regulates insulin resistance and glucose tolerance. Here the authors report that NEU1 also inhibits hepatic gluconeogenesis in a non-enzymatic manner by binding SAM68, thereby activating GCN5 transcription.

Lithium||sulfur batteries are limited by sluggish solid-state sulfur conversion. Here, authors investigate spin-state transitions as a key kinetic barrier and design a spin-regulated catalyst that accelerates sulfur conversion, suppresses polysulfide shuttling, and enables high-capacity pouch cells.

CNS injury disrupts neural circuits, with poor regeneration due to HDAC retention and hostile environments. Here, the authors show a nanosystem with LMK-235 that forms electroactive scaffolds and promotes regeneration and enhances synaptic reconnection

Electrochromic windows provide an energy-efficient pathway to manage thermal efficiency. This work describes a glazing design that is scalable, stable over cycling and functional for a wide solar spectrum.

Yang et al. report a molecular confinement strategy that regulates self-assembled monolayer packing and stabilizes buried interfaces in inverted perovskite solar cells, enabling a power conversion efficiency of 26.84% with an 86.6% fill factor.

Li et al. conduct a multi-omics analysis of nasopharyngeal carcinoma and identify three molecular subtypes with distinct immune profiles and responses to induction chemotherapy.

Tang, Dai, Qing, Zhang and colleagues describe a role for N-glycosylation in the nucleus: N-glycans modify inner nuclear membrane proteins, and the modification is implicated in the maintenance of H3K9me3 heterochromatin and genome stability.

Conversion-type batteries involving solid–solid transformations can store more energy than intercalation materials; however, their rates and cyclability have been limited by kinetics and incomplete conversion. This study introduces homonuclear dual-atom catalysts that increase the conductivity of insulating solid intermediates to enhance lithium–sulfur (and lithium–air) battery performance.

Global analysis of obesity trends from 1980 to 2024 in 200 countries and territories using data from 4,050 population-based studies reveals that framing obesity as a single global epidemic masks the highly varied dynamics across countries and age groups.

In this study, the authors find that the perirhinal cortex controls hippocampal seizures in male mice via multiple downstream circuits that arise from distinct neuronal subpopulations, including projections to the fasciola cinerea, highlighting it as a promising therapeutic target.

Here, the authors show that uridine enhances oocyte quality in aged mice by binding to PCBP1 to suppress ferroptosis and preserve mitochondrial function, suggesting a potential strategy to delay female reproductive aging.

This work presents a scalable and flexible mixed-matrix membrane to overcome mass-transport limitations in sorption-based atmospheric water harvesting, enabling ultrafast sorption–desorption kinetics and high-productivity water harvesting prototypes driven by sunlight or electricity.

The authors conducted two trials to evaluate the efficacy and safety of NH600001, an etomidate derivative, in gastrointestinal endoscopy. The results showed NH600001 has a sedative effect while reducing the risk of adrenocortical depression.

Authors created a new evaluation framework called GPBench that compares large language models (LLMs) against general practitioners. They found that current LLMs are not suitable for autonomous deployment and still require human oversight.

Here the authors reveal a large-scale multi-ancestry genome-wide association study (GWAS) that identifies 11 new risk loci for kidney cancer, including one specific to Chinese populations.