Search

Metabolite signatures were identified for subtypes of dietary carbohydrate, including added sugar, whole grain and refined grain, and showed different associations with type 2 diabetes, providing an objective measure of dietary risk.

Fast panoramic rotational ultrasound tomography and photoacoustic tomography are integrated for hybrid rotational ultrasound and photoacoustic tomography, for three-dimensional dual-contrast imaging of soft tissue and vasculature across the human body.

A study reports on the antigenic characterization of SARS-CoV-2 BA.1, BA.1.1 and BA.2 and the neutralizing activity of different monoclonal antibodies and sera against them.

A severe acute respiratory syndrome coronavirus 2 Omicron subvariant, BA.2.86, was found to be no more resistant to human sera than the currently dominant XBB.1.5 and EG.5.1, but it had a remarkably higher receptor affinity.

Synthesis of urea through the electrochemical co-reduction of abundant CO₂ and nitrates offers an eco-friendly alternative to existing technologies. The authors use ionic liquids to construct molecular bridges between the catalyst’s active sites and the reactants, thereby enhancing urea production.

This study introduces 3D-PanoPACT, a panoramic photoacoustic imaging system enabling high spatiotemporal-resolution visualization of whole-body dynamics and metabolism, overcoming limitations in speed and field of view for advanced 3D tomography.

Catalyst-free conversion of methane and carbon dioxide using light of various wavelengths under ambient conditions is reported.

The extent to which SARS-CoV-2 serum neutralising antibodies are informative as correlates of protection for Omicron strains is uncertain. Here, the authors use data from a household-based prospective cohort study in Nicaragua to investigate correlates of protection against infection and symptomatic infection for Omicron BA.1 and BA.2.

The B.1.1.529/Omicron variant of SARS-CoV-2 is resistant to neutralization by serum not only from patients who recovered from COVID-19, but also from individuals vaccinated with one of the four widely used COVID-19 vaccines.

The electrosynthesis of amino acids is hindered by inefficient oxime intermediate conversion. Here, a relayed electron transfer mechanism is proposed using an ionic-liquid@Bi catalyst. Electrons are accepted by the ionic liquid to generate related radicals, which then transfer electrons to oxime, enabling efficient amino acid production.

A class of core–shell nanoparticles self-assembled from amphiphilic peptides can kill a range of bacteria, yeast and fungus. They are more potent than their unassembled peptide counterparts and can suppress bacterial growth in the brains of rabbits infected with meningitis. These particles, which carry a high number of positive charges, are promising antimicrobial agents.

Photoacoustic microscopy allows for label-free 3D in vivo imaging by detecting the acoustic response of a photoexcited material. Here, Yang et. al use a digital-micromirror-device based structured illumination scheme to both improve resolution and greatly increase the depth of field, enabling 3D volumetric imaging.

Pumpkin rootstock delivers CmoKARI1 mRNA to cucumber scion under chilling stress, enhancing tolerance by activating JA-Ile signaling. This mobile mRNA acts as a key chilling-responsive signal, redefining the understanding of rootstock–scion communication.

The SARS-CoV-2 variant B.1.1.7 can be neutralized by convalescent sera or sera from vaccinated individuals, whereas the B.1.351 variant is resistant to neutralization by these sera and by several monoclonal antibodies that are in clinical use.

Antibodies against SARS-CoV-2 provide protection against infection, but the virus has evolved to evade them. Here, the authors characterize a human antibody with incomplete neutralization of SARS-CoV-2 variants and engineer it to enhance potency and expand coverage to all tested variants by increasing conformational flexibility.

A mechanical exfoliation method for producing freestanding metal oxide ultrathin flakes is reported. The flakes can be transferred and integrated with 2D materials, providing a platform to investigate the fundamental properties of ultrathin metal oxides.

Sea cucumbers are predominant deposit feeders in benthic ecosystems. This study elucidates the mechanisms within the sea cucumber digestive system and their symbiotic microbiome which enable them to efficiently utilize nutrients from seabed sediments.

Drones and online rescue forms lead to broad flood recovery, while navigation apps and drainage target traffic and buildings, according to text-mining modeling of millions of posts revealing sector-specific technology impacts and adaptation pathways.

A plug-and-play system fine-tunes multiple targets simultaneously for secondary metabolite production in Streptomyces.

Forming and steering a tight optical focus noninvasively in scattering media is a pivotal challenge in biomedical optics. The authors present an iterative time-reversal mechanism using nonlinearity to achieve this without a point-like guide star.

A diverse collection of potent neutralizing antibodies against the SARS-CoV-2 spike protein have been isolated from five patients with severe COVID-19 and high serum neutralization titres.

Spermine is a polyamine dysregulated in different cancers. This group shows that Serpinb9 prevents spermine synthase degradation, raising spermine levels and impairing the tumor immune microenvironment, and identifying Serpinb9 as a potential therapeutic target for pancreatic cancer immunotherapy.

Alphaviruses are enveloped RNA viruses that contain several human pathogens. Here, the authors use block-based reconstruction method and provide a 3.5 Å cryo-EM structure of sindbis virus that identifies a conserved hydrophobic pocket near the viral membrane that is stabilized by an unknown pocket factor.

The authors present Compressed Ultrafast Planar Polarization Anisotropy Imaging, capturing real-time, wide-field, non-invasive measurements of molecular size in liquids and gases. The method could enable scientists to visualize dynamic processes like drug binding and nanoparticle formation.

Disruption of CREB/CRTC2, a key gluconeogenic transcriptional complex, has been shown to ameliorate insulin resistance in mice. Here, the authors show that the inhibitor artipllin C and the synthetic compound A57, which presents with higher inhibitory activity, improve insulin sensitivity in obese mice by inhibiting CREB-CRTC2 interaction.

LncRNAs modulate diverse physiological cellular processes, however, their involvement in heme-dependent processes are not yet clear. Here the authors reveal the role of lncRNA UCA1 in erythroid cell development.

A clinical study of women with abnormal breast mammograms establishes a workflow to evaluate the capability of breast photoacoustic computed tomography in the classification, monitoring and segmentation of lesions.

Seed dormancy is the preferred trait in rice production as it can prevent preharvest sprouting. Here, the authors report that MODD (mediator of OsbZIP46 deactivation and degradation) negatively regulates seed dormancy by inhibiting the transcriptional activity of ABSCISIC ACID INSENSITIVES (ABIs).

Root-knot nematodes (RKNs) are global soil-borne parasites that damage most plants. Here, the authors show that native root-associated bacterial consortium exhibit general suppression of RKN infections by offering protective functions.

CO₂ reduction (CO₂R) to C₂₊ alcohols has low selectivity and current density due to competing C₂+ pathways that produce ethylene. Defect-rich Pr–Cu oxide heterointerfaces are developed to induce asymmetric carbon–carbon coupling and selective hydrodeoxygenation of CO₂R intermediates, accelerating the production of C₂₊ alcohols.

Decoding the pathogenic genes of the inherited anemia could provide us with novel regulators of pathological and physiological erythropoiesis. Here, the authors show TLR8 is expressed by erythroid cells and regulates erythropoiesis through interacting with EPO signaling.

Rare earth elements are widely used in agriculture to promote plant growth. Here the authors show that aerial application of a rare earth element to the leaves triggers a graft-transmissible, RbohD- and jasmonic acid-dependent systemic signal that triggers endocytosis and mineral nutrient uptake in roots.

Using more than 300 serum samples from individuals with an age range of 1-88 years old, the authors here show that older adults possess higher breadth of antibody reactivity to avian influenza virus (AIV) neuraminidases, potentially explaining the age-specific risks of AIV human infections.

Human Treg cells are central to immune tolerance, yet their heterogeneity and differentiation remain incompletely understood. Here the authors perform single-cell RNA and T cell receptor sequencing to resolve Treg cells from healthy individuals and patients with or without acute graft-versus-host disease revealing Treg complexity in health and disease.

Wang et al show that microglial NF-κB activation is essential for tau spreading and tau-mediated spatial learning and memory deficits in tauopathy mice. Inactivation of NF-κB reversed tau associated microglial states and rescued autophagy deficits.