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Cryogenic Li | |Cl₂ batteries face severe interfacial instability. Here, authors demonstrate a solvation reconfiguration strategy to build a robust interphase, enabling stable cycling of Li | |Cl₂ batteries for over 1100 cycles at –40 °C.

A computational ‘information co-evolution’ framework is developed for the discovery of covalent organic frameworks (COFs) for hydrogen peroxide photosynthesis. By integrating cross-level feature fusion with data augmentation and ensemble modelling, this strategy overcomes challenges in structural representation and data limitations, enabling the identification of high-performance COF candidates and the discovery of important structural motifs.

Nanodiamonds are promising components for quantum technologies, but their heterogeneous size, shape, and surface chemistry hinder large‑scale deterministic placement. Here the authors report a simple electrostatic‑trapping method that rapidly and reliably patterns single nanodiamond arrays on arbitrary substrates.

Epithelial organoids share a common central lumen with various shapes and dynamics. Here, authors show that epithelial cysts formed from three different cell types obey the same physical laws and end up with a single lumen following conserved rules depending on their luminal pressure.

Humanity’s Last Exam, a multi-modal benchmark at the frontier of human knowledge, is designed to be an expert-level closed-ended academic benchmark with broad subject coverage.

While CDK4/6 inhibitors (CDK4/6i) are often initially successful in many breast cancer subtypes, often resistance develops and other subtypes like triple-negative breast cancer (TNBC) fail to respond. Here, the authors demonstrate that the CDK2 inhibitor BLU-222, alone or with CDK4/6i, restores cell-cycle control via p21/p27 induction overcoming resistance in preclinical models of breast cancer, including TNBC.

Inspired by the human eye’s dynamic focusing, this work demonstrates an integrated bionic LiDAR that achieves energy-efficient, adaptive 4D imaging, offering a compact and scalable path toward intelligent machine vision.

Human embryonic stem cells are simultaneously capable of self-renewal and poised for differentiation. Here, the authors show a role for the ZNF263 transcription factor promotes primed pluripotency and facilitates differentiation into primary germ layer lineages.

C10, a potent non-nucleoside inhibitor targeting NSP14’s SAM-binding pocket, suppresses viral translation, exhibits immunostimulatory effects, and reverses NSP14-induced transcriptome alterations, offering promise for broader coronavirus treatment.

A broad new class of commercially available multiphoton photoinitiators is identified, the properties of which result in the inverse scaling of photolithographic feature size with exposure time, rather than the usual proportional scaling. On combination with a conventional initiator, photoresists can be created for which the feature size is independent of exposure.

A-kinase anchoring protein 1 (AKAP1) promotes the assembly of signalosomes on the mitochondrial outer membrane and act as a central hub for mitochondrial signalling. Here, the authors show that AKAP1 protects against MASLD progression by inhibiting mitochondrial GPAT1 activity and subsequent lysophosphatidic acid production.

To turn on and obtain emission from lanthanide-doped insulating nanoparticles, an electrical excitation pathway coupling them to organic optical molecules to form nanohybrids is described, enabling tunable electroluminescence properties of LEDs fabricated from such materials.

Reducing non-radiative recombination at the perovskite/electron transport layer interface remains a critical challenge for achieving efficient perovskite/TOPCon silicon tandem solar cells. Here, authors employ bilayer passivation using AlOx/PDAI2 treatment, achieving device efficiency of 31.6%.

The extracellular matrix (ECM) is assembled through liquid–liquid phase separation and directed phase transition. Now—inspired by tropoelastin—a designer minimalistic model incorporating alternating hydrophobic moieties and crosslinking domains can template the assembly of a biomimetic matrix that mimics the ECM, promoting the mechanosensing of stem cells.

Fan et al. describe DF-003, an alpha-kinase 1 (ALPK1) inhibitor that targets the root cause of the rare genetic disease ROSAH syndrome, demonstrating the ability of DF-003 to inhibit ocular inflammatory pathology in ROSAH model mice.

Stabilizing silicon without sacrificing other device parameters is essential for practical use in lithium and post lithium battery anodes. Here, the authors show the skin-like two-dimensional covalent encapsulation furnishing a remarkable level of integrated lithium storage performances of silicon.

The excessive porous space in carbon anodes for lithium-ion batteries has to be utilized for high volumetric performance. Here the authors show an adaptable sulfur template strategy to yield graphene-caged noncarbon materials with a precisely controlled amount of void, enabling ultrahigh volumetric lithium storage.

An integrated photonic 3D tensor processing engine enables 3D tensor computation, caching, and synchronization with tunable clock frequencies, experimentally achieving operation from 10 GHz to 30 GHz and 97.06% LiDAR point-cloud classification accuracy.

Phosphoantigen-mediated BTN2A1 association drives BTN3A1 intracellular fluctuations outwards in a thermodynamically favourable manner, thereby enabling BTN3A1 to push off from the BTN2A1 ectodomain to initiate T cell receptor–mediated γδ T cell activation.

Methane can be converted into other useful chemicals and fuels via photocatalytic oxidative coupling, yet producing molecules with more than two carbon atoms remains difficult. Here the authors show that highly strained Au confined within the nanopores of TiO₂ can convert methane to propane with high selectivity.

SARS-CoV-2 Omicron variant evolves into multiple sub-variants. Here, authors evaluate the binding capacity of these sub-variants to human and animal ACE2s and reveal molecular bases for their receptor binding and broader interspecies recognition.

Semiconductor quantum dots that simultaneously support blue and yellow emission offer a route to realizing efficient white light-emitting diodes.

An iodine-induced self-depassivation strategy extends Na-Cl₂ battery life to 2000 cycles by forming high-reactivity NaCl and lowering the chlorine conversion polarization, which successfully solves a key failure mechanism for superior reversibility.

The authors demonstrate a high-speed silicon photonic transmitter employing on-chip adaptive dispersion compensation through integrating Mach-Zehnder modulators with tunable chirp control, enabling energy-efficient, high-capacity optical interconnects.

IL-33-ST2 activation upregulates CCL2 to drive inflammatory pain via activation of TRPV1 and TRPM8 in hindpaw skin and enhancement of LTP in spinal cord.

Functional differentiation of homologous genes are usually followed by polyploidization in plants, which may contribute to adaptation. Here, the authors report the negative and positive synergistic regulation of GhCBL1A1-GhCIPK6D1 and GhCBL2A1-GhCIPK6D3, respectively, on drought resistance in cotton.

Integrated single-cell RNA and immune repertoire analysis of PBMCs identifies key circulating immune perturbations in lupus nephritis, highlighting non-invasive biomarkers and CD74 as a potential therapeutic target.

The molecular mechanisms underlying the function of different cellular states in glioblastoma stem cells (GSCs) remain poorly understood. Here, the authors perform integrated single cell and bulk analysis of GSCs and identify potential therapeutic targets.

The photooxidation of CH₄ to CH₃OH is limited by the availability of reactants at flooded interfaces. Now the authors report a modified metal organic framework nanoreactor to promote the direct photooxidation of CH4 to CH₃OH at the gas-solid interface.

High-quality micron-thick perovskite films with high-Miller-index-oriented grains can be used to achieve high-performance solar cells and modules.

Rich and colleagues identify that lymphatic endothelial-like cells in glioblastoma drive the growth of cancer stem cells via CCL21–CCR7 signaling, inducing KAT5 to acetylate HMGSC1, which enhances its protein stability and cholesterol synthesis.

The heterogeneous and compartmentalized environments within living cells make it difficult to deploy theranostic agents with precise spatiotemporal accuracy. Zhao et al. demonstrate a DNA framework state machine that can switch among multiple structural states according to the temporal sequence of molecular cues, enabling temporally controlled CRISPR–Cas9 targeting in living mammalian cells.

Amorphous phases of self-assembling molecules employed as a hole-transporting layer in inverted perovskite solar cells contribute to homogeneous perovskite film growth, resulting in a power conversion efficiency of 25.20% (certified 24.35%) for one-square-centimetre area cells.

Edge-exposed exfoliation using sticky tape is shown to be a simple and reliable method for scaling up the production of ultrathin, ultraflat and ultraflexible polycrystalline diamond membranes for diverse electrical, optical, mechanical, thermal, acoustic and quantum applications.

Non-viral CAR-T cells with gene-specific targeted integration are safe and effective in patients with lymphoma.

Inflammatory conditions often affect colorectal cancer patients, and their effect on their ongoing treatment is a pressing medical question. Here authors show that inflammation interferes with local anti-tumour immune response and inhibits response to immune checkpoint blockade therapy via immunosuppressive neutrophil leukocytes.

Lattice mismatches are a difficult obstacle in the formation of core-shell heterostructures. Here, the authors develop a strategy to overcome the lattice mismatch and grow α-phase lead halide perovskites onto β-phase lanthanide-doped nanoparticles.

Tailoring the composition of organic cations enables manipulating the recombination rates of perovskites. Optimized solution-processed perovskite emitters fabricated on silicon exhibit up to 42.6-MHz modulation bandwidth and 50-Mbps data rate.

Chen et al. report a large-area white LED with sunlight-like emission by regulating the heterophase γ/σ-CsPb(I/Cl)₃ at nanoscale, in which a fraction of carriers recombines in γ-CsPbI₃ for deep-red emission, while other carriers diffuse to the heterophase interface for broadband emission.

Understanding degradation mechanisms in perovskite solar cells is key to their development. Now, Guo et al. show a greater degradation of the perovskite structure and morphology for devices operated under vacuum than under nitrogen.

Lu et al. demonstrate that allergens induce the formation of eosinophil extracellular traps, which activate pulmonary neuroendocrine cells to secrete neuropeptides and neurotransmitters as well as amplify allergic immune responses.

Interlayer decoupling plays an essential role in realizing unprecedented properties. Here, authors construct a superlattice consisting of alternating layers of NbSe2 and highly porous hydroxide, realizing interlayer decoupling and thus realizing exotic monolayer behaviors in bulk materials.