Search

Inducible base editors enhance cancer genomic screens in vivo.

Exposome analyses across 34 countries showed that social exposures were associated with faster functional brain aging and physical exposures with faster structural brain aging.

Assessment of how 16 taxonomic groups in a lowland tropical forest resist and recover from anthropogenic disturbance shows the potential of protecting naturally regenerating secondary forests to reverse biodiversity losses.

Salladay-Perez and colleagues explore senescence induction in human and mouse macrophages using multiomic profiling. They characterize a p21⁺TREM2⁺ senescent macrophage population, which they functionally implicate in inflammaging and liver disease.

Tumours with alterations in SWI/SNF complex have elevated EZH2 activity, which is associated with poor prognosis and tumour progression. Here, the authors report a phase 2 basket study investigating the safety and efficacy of oral tazemetostat (EZH2 inhibitor) in patients with solid tumours harbouring SWI/SNF driver mutations.

Liu, Gad et al. develop an approach to purify the endoplasmic reticulum and integrate genetic, structural, molecular and cell biological analyses to identify SLC33A1 as an endoplasmic reticulum oxidized glutathione (GSSG) exporter in mammalian cells.

Sialic acid O-acetylation occurs in the Golgi apparatus and is catalyzed by CASD1, a multi-pass transmembrane protein. Here, the authors reveal that SLC33A1 delivers acetyl-CoA to the luminal catalytic domain of CASD1, while a catalytic transmembrane tunnel enables SLC33A1-independent O-acetylation.

The genomewide meta-analysis of lumbar spinal stenosis LSS identifies 73 previously unreported loci in addition to 15 known loci and highlights spinal degeneration as a key pathogenic mechanism. Overall, the findings expand knowledge of the genetic background of LSS.

In this phase 1/2 trial, patients with Ewing sarcoma received trabectedin and low-dose irinotecan at concentrations known to inhibit the activity of the transcription factor EWS::FLI1, leading to encouraging clinical response rates.

Here authors show in a human stem cell–derived model, neural cultures from children with MPSIIIA exhibit hyperactive excitatory synapses associated with excitation–inhibition imbalance, altered network dynamics, and broad dysregulation of genes involved in synaptic homeostasis.

Here, Wulczynski et al. find fewer small-intestinal fiber-degrading bacteria in CeD patients, independent of the gluten-free diet, while inulin-supplemented diet in gluten-sensitized mice facilitates microbial saccharolytic function and SCFAs, accelerating mucosal healing in the small intestine.

Natural genetic variation of photosynthesis is an underexplored resource for plant genetic improvement. Here, the authors find allelic variations of YS1 affect Arabidopsis photosynthesis acclimation using genome-wide association study, reverse genetics, and quantitative complementation approaches.

The microtubule–kinesin system is a well-known active matter system. Now it is shown that a microtubule-based active fluid can assemble adhesive non-thermal fibres into a membrane-like structure.

The authors demonstrate a method for the manipulation of the motion of chiral nanoparticles, which involves utilising circularly polarised light in an ultrathin optical fibre. The evanescent field of this fibre can both trap and propel particles near the fibre surface, with the direction of the particle motion depending on the circular polarisation state of the light.

Magnetic resonance control of spin-correlated radical pairs alters red fluorescent protein emission in transgenic Caenorhabditis elegans, demonstrating in vivo magnetic field modulation of biomolecular processes.

Analyses of snRNA genes in a French cohort of people with rare disorders, with validation through international collaboration, identify monoallelic and biallelic variants in RNU2-2 as frequent causes of neurodevelopmental disorders with epilepsy.

Printed MoS₂ memristive networks yield spiking neurons with multi-order complexity. Thermally activated snap-back produces physiological waveforms that stimulate mouse Purkinje neurons, offering a scalable platform for bio-realistic neuromorphic hardware and brain–machine interfaces.

HIV-1 integrase forms an RNA-binding module on the luminal side of the mature capsid lattice.

Connectome-seq allows access to connectomic and transcriptomic information in high throughput, using an RNA barcoding strategy and isolation of synaptosomes, followed by single-nucleus and single-synaptosome RNA sequencing.

Understanding collective behaviour is an important aspect of managing the pandemic response. Here the authors show in a large global study that participants that reported identifying more strongly with their nation reported greater engagement in public health behaviours and support for public health policies in the context of the pandemic.

Robustness checks and reproduction of analyses with existing and updated data based on 110 articles in economics and political science journals with data and code-sharing requirements found high levels of robustness and reproducibility and determined that robustness was not dependent on author characteristics or data availability.

Here, the authors develop Q4ddPCR, a high-throughput assay to quantify genetically intact HIV reservoirs by targeting four regions, and demonstrate that it reduces assay dropout to 5%, tracks reservoir decay, and closely correlates with viral outgrowth.

Arterial development is critical for proper blood flow, but the mechanisms mediating this process at the organ level remain unclear. Here, they show that a subpopulation of endothelial cells is important for formation of arterial endothelium in the intestine.

The mammalian gut undergoes a dramatic transformation during mid-gestation to create intestinal villi. Zhu and colleagues show that the transcription factor Foxl1 impacts key events during the epithelial transition of the fetal mammalian gut.

The existing ENCODE registry of candidate human and mouse cis-regulatory elements is expanded with the addition of new ENCODE data, integrating new functional data as well as new cell and tissue types.

Decreased brain volumes and increased NfL levels can be observed earlier than disease diagnosis in short-tandem-repeat-associated neurological diseases.

Eukaryotic 20S proteasomes assemble from 14 distinct subunits. Here, the authors use cryo-EM to analyze multiple intermediates showing that biogenesis involves alternative routes, rather than one fixed pathway. They also reveal roles of Ump1 and Pba1-Pba2 chaperones in orchestrating maturation.

Longitudinal metatranscriptomics in a prospective cohort of 1,164 adults hospitalized for COVID-19 reveals that azithromycin offered no apparent anti-inflammatory benefit but enriched the respiratory microbiome with potential pathogens and antimicrobial resistance genes.

Endothelial-to-mesenchymal transition contributes to plaque progression in atherosclerosis. Here, Ayllon et al. show that the protein TWIST1 drives endothelial cell plasticity in atherosclerosis, promoting plaque growth and stability while reducing features linked to rupture, challenging the view that these cell changes always worsen disease.

Pouget et al. identified distinct CA1 neuron ensembles active during specific moments of fear learning and uncovered the core engram essential for memory formation.

Cosgun et al. show that, in B cell leukemia, β-catenin expression is maintained at low levels through glycogen synthase kinase 3B (GSK3β)-mediated phosphorylation. Inhibition of GSK3β results in β-catenin–Ikaros–NuRD complex formation, leading to B-ALL cell death through MYC repression.

In mice, a circuit between the spinal cord and various regions of the brain, centring on spinal-cord-projecting neurons in the rostral ventromedial medulla, has a key role in driving chronic pain.

This study reveals a non-canonical immunomodulatory function for the enzyme iNOS, based on the direct interaction in mitochondria with the itaconate-producing protein IRG1, which limits itaconate production in mouse and human macrophages

The authors consider risks to global biodiversity from wildfire under climate change. They show increased risk to 83.9% of species pre-identified as wildfire vulnerable, with high risks for species with small ranges, high conservation concern and those in South America, Australia and South Asia.

Impure glycerol is obtained as a significant by-product of biodiesel production. Now it is shown that this crude glycerol can be reacted with water over very simple basic or redox oxide catalysts to produce methanol in high yields, together with other useful chemicals, in a one-step low pressure process.

The authors use data on the entire Finnish population to develop a machine learning model for predicting COVID-19 vaccination uptake. Important predictors are proxies of socio-economic status, and those at high risk for COVID-19 consequences are less likely to get vaccinated.

Barrett et al. identify a key Rubisco phase-separating protein in the CO₂-fixing pyrenoid of Chlorella algae. This protein’s broad promiscuity for green lineage Rubiscos may aid in engineering CO₂-supercharging pyrenoids in plants to boost yields.

The mitochondrial pathway of apoptosis requires coordinated protein–lipid signals. Here, Gelles et al. show that a BAX lipid-binding cavity for 2-trans-hexadecenal cooperates with BIM to allosterically activate BAX prior to membrane insertion.

Lee et al. report a mechanism regulating mRNP export mediated by N⁶-adenosine methylation, METTL3 and NUP93 with potential implications for nephrotic syndrome and other human diseases.

Genetic analyses in more than 15,000 individuals from across the Americas, including individuals with autism and family members, define the genetic landscape of autism in Latin American populations and identify significant overlap with other ancestries.

Li and colleagues show that the transcription factor ZFP148 restrains the differentiation of antigen-specific CD8⁺ T cells toward cytolytic effector cells by repressing the expression of KLF2.

Retrogressive thaw slumps are a key disturbance resulting from permafrost thaw that impact both vegetation and soil carbon. This study assesses surface greenness recovery times following thaw and shows that recovery can be predicted based on annual ecosystem gross primary productivity.

Analysis of nuclear and mitochondrial genomes from archaeological canid remains found across Europe and Anatolia shows that a genetically homogeneous dog population was already widely distributed across the region by 15,000 years ago.

The choanoflagellate Choanoeca flexa forms motile and contractile cell monolayers purely clonally, purely aggregatively or through a combination of both processes depending on environmental conditions.

Here the authors present NCATS-SM0225, a small molecule that inhibits ERAD and selectively kills cancer cells by binding VDACs, disrupting calcium homeostasis, and triggering the PERK-STIM1 pathway to degrade ERAD regulators.

Hodgson, Huang, Lang et al. show that TDP-43 limits ribonucleoprotein particle condensation into paraspeckles in a concentration- and polymerization-dependent manner. They also link paraspeckle condensation to stress response and neuroprotection.

Donahue et al. show that ageing is associated with changes in ER morphology. ER-phagy drives age-associated ER remodelling through tissue-specific factors.

Johnson et al. discuss the role of dietary and endogenous fructose as a calorie source and modulator of metabolic health and disease.