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Showing 1–50 of 55 results

Advanced filters: Author: Masatoshi Murakami Clear advanced filters

Disruption of intracellular iron homeostasis through mitochondrial dysfunction associated with suppression of ATP 13A2 expression

Takanori Murakami
Kazuki Ohuchi
Masatoshi Inden
ResearchOpen Access10 Jan 2026
Scientific Reports

P: 1-18
DOCK2 is involved in the host genetics and biology of severe COVID-19

A genome-wide association study highlights a variant in DOCK2, which is common in East Asian populations but rare in Europeans, as a host genetic risk factor for severe COVID-19.

Ho Namkoong
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access08 Aug 2022
Nature

Volume: 609, P: 754-760
Genetic structure of human populations I. Local differentiation of blood group gene frequencies in Japan

Masatoshi Nei
Yoko Imaizumi
Research01 Feb 1966
Heredity

Volume: 21, P: 9-35
Clinical characteristics of EYS-associated retinal dystrophy in 291 Japanese patients

Yoshito Koyanagi
Yusuke Murakami
Yasuhiro Ikeda
ResearchOpen Access06 Dec 2025
npj Genomic Medicine

Volume: 11, P: 1-9
The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force

Genetic mechanisms influencing COVID-19 susceptibility are not well understood. Here, the authors analyzed whole blood RNA-seq data of 465 Japanese individuals with COVID-19, highlighting thousands of fine-mapped variants affecting expression and splicing of genes, as well as the presence of COVID-19 severity-interaction eQTLs.

Qingbo S. Wang
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access22 Aug 2022
Nature Communications

Volume: 13, P: 1-19
Deciphering state-dependent immune features from multi-layer omics data at single-cell resolution

A single-cell multiomic immune cell atlas from 235 Japanese, including patients with COVID-19 and healthy individuals, linked with host genetics including germline and somatic mutation, plasma proteomics and metagenomics data reveals that immune cells are dynamically regulated in a cell state-dependent manner.

Ryuya Edahiro
Go Sato
Yukinori Okada
ResearchOpen Access28 Jul 2025
Nature Genetics

Volume: 57, P: 1905-1921
Strain-Induced Crystallization of Crosslinked Natural Rubber As Revealed by X-ray Diffraction Using Synchrotron Radiation

Masatoshi Tosaka
Reviews23 Oct 2007
Polymer Journal

Volume: 39, P: 1207-1220
Blood DNA virome associates with autoimmune diseases and COVID-19

Analysis of the blood DNA virome in patients with COVID-19 and autoimmune disease associates endogenous HHV-6 (eHHV-6) and high anellovirus load with increased disease risk, most notably for systemic lupus erythematosus. eHHV-6 carriers show a distinct immune response.

Noah Sasa
Shohei Kojima
Yukinori Okada
ResearchOpen Access03 Jan 2025
Nature Genetics

Volume: 57, P: 65-79
Solid-State ¹³C NMR Analysis of the Crystalline–Noncrystalline Structure and Chain Conformation of Thermotropic Liquid Crystalline Polyester

Miwa Murakami
Hiroyuki Ishida
Junji Watanabe
Research14 Oct 2004
Polymer Journal

Volume: 36, P: 830-840
Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity

Peripheral blood mononuclear cells from 73 Japanese patients with coronavirus disease 2019 (COVID-19) and 75 healthy controls were analyzed using single-cell transcriptomics. Combining these data with genotyping data highlights the interplay between host genetics and the immune response in modulating disease severity.

Ryuya Edahiro
Yuya Shirai
Yukinori Okada
ResearchOpen Access24 Apr 2023
Nature Genetics

Volume: 55, P: 753-767
A-102395, a New Inhibitor of Bacterial Translocase I, Produced by Amycolatopsis sp. SANK 60206

Ryo Murakami
Yoko Fujita
Masatoshi Inukai
Research01 Nov 2007
The Journal of Antibiotics

Volume: 60, P: 690-695
A-94964, a Novel Inhibitor of Bacterial Translocase I, Produced by Streptomyces sp. SANK 60404

Ryo Murakami
Yoko Fujita
Masatoshi Inukai
Research01 Sept 2008
The Journal of Antibiotics

Volume: 61, P: 537-544
Anti-tumor activity of antizyme which targets the ornithine decarboxylase (ODC) required for cell growth and transformation

Satoshi Iwata
Yuya Sato
Shuki Mizutani
Research19 Jan 1999
Oncogene

Volume: 18, P: 165-172
Role of a transmembrane protein, epithelial membrane protein 1, in the pathogenesis of pancreatic ductal adenocarcinoma

Akihisa Ohno
Nao Fujimori
Yoshihiro Ogawa
Research10 Dec 2025
Oncogene

Volume: 45, P: 307-321
Identification and replication of sex-dimorphic protein quantitative trait loci across multiple ancestries and their associations with diseases

Youngjune Bhak
Vasilis Raptis
Albert Tenesa
ResearchOpen Access28 Aug 2025
Scientific Reports

Volume: 15, P: 1-16
Comparison of the associations between office and home BP with placenta-mediated pregnancy complications: the BOSHI study

Noriyuki Iwama
Seiya Izumi
Hirohito Metoki
ResearchOpen Access20 Nov 2025
Hypertension Research

P: 1-12
Characterization of intracellular signals via tyrosine 1062 in RET activated by glial cell line-derived neurotrophic factor

Hironori Hayashi
Masatoshi Ichihara
Masahide Takahashi
Research14 Sept 2000
Oncogene

Volume: 19, P: 4469-4475
Associations of Brachial-Ankle Pulse Wave Velocity and Carotid Atherosclerotic Lesions with Silent Cerebral Lesions

Masatoshi Matsumoto
Kazuo Inoue
Akihito Moriki
Research01 Sept 2007
Hypertension Research

Volume: 30, P: 767-773
Genome-wide association studies for pelvic organ prolapse in the Japanese population

The authors performed a GWAS for pelvic organ prolapse (POP) in Japanese women, and identified WT1 as a susceptibility locus for POP in Japanese women. Transethnic GWAS meta-analysis further identified FGFR2 as an additional susceptibility locus for POP.

Masatoshi Matsunami
Minako Imamura
Shiro Maeda
ResearchOpen Access30 Sept 2024
Communications Biology

Volume: 7, P: 1-9
The Glasgow Prognostic Score and stricture site can predict prognosis after endoscopic duodenal stent placement for malignant gastric outlet obstruction

Yu Takamatsu
Nao Fujimori
Yoshihiro Ogawa
ResearchOpen Access13 Jun 2022
Scientific Reports

Volume: 12, P: 1-10
Synthetic biology based construction of biological activity-related library of fungal decalin-containing diterpenoid pyrones

Combining genome mining and heterologous expression in a genetically tractable host can lead to bioactive natural products discovery and production. Here, the authors employ this strategy for new decalin-containing diterpenoid pyrenes production by expressing native, extended, and shunt pathways in Aspergillus oryzae.

Kento Tsukada
Shono Shinki
Teigo Asai
ResearchOpen Access14 Apr 2020
Nature Communications

Volume: 11, P: 1-12
Volume-wise destruction of the antiferromagnetic Mott insulating state through quantum tuning

Knowing whether a quantum phase transition is first- or second-order is crucial for understanding any associated exotic phenomena, but direct experimental evidence has been scarce. Here, Frandsen et al. report first-order magnetic quantum phase transitions in archetypal Mott systems, providing insight into the underlying quantum fluctuations.

Benjamin A. Frandsen
Lian Liu
Yasutomo J. Uemura
ResearchOpen Access17 Aug 2016
Nature Communications

Volume: 7, P: 1-8
Clinical characteristics of human herpesvirus-6 myelitis after allogeneic hematopoietic stem cell transplantation and its favorable outcome by early intervention

Kohei Shiroshita
Takehiko Mori
Shinichiro Okamoto
Research21 Nov 2019
Bone Marrow Transplantation

Volume: 55, P: 939-945
Diagnostic accuracy of deep-learning with anomaly detection for a small amount of imbalanced data: discriminating malignant parotid tumors in MRI

Hidetoshi Matsuo
Mizuho Nishio
Takamichi Murakami
ResearchOpen Access09 Nov 2020
Scientific Reports

Volume: 10, P: 1-9
Higher prevalence of hypertensive disorders of pregnancy in women who smoke: the Japan environment and children’s study

Kosuke Tanaka
Hidekazu Nishigori
Hirohito Metoki
Research21 Jan 2019
Hypertension Research

Volume: 42, P: 558-566
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
Wormlike Chain Parameters of Cellulose and Cellulose Derivatives

Masatoshi Saito
Research01 Mar 1983
Polymer Journal

Volume: 15, P: 213-223
Double Isomerization Polymerization of Optically Active Cyclic Pseudoureas

Masatoshi Miyamoto
Takashi Umezawa
Research01 May 1996
Polymer Journal

Volume: 28, P: 432-439
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
Dissection of the polygenic architecture of neuronal Aβ production using a large sample of individual iPSC lines derived from Alzheimer’s disease patients

Using more than 100 independent iPSC lines derived from patients with Alzheimer’s disease, the authors discovered loci associated with the neuronal production of amyloid β and confirmed their influence using RNA interference.

Takayuki Kondo
Norikazu Hara
Haruhisa Inoue
Research17 Feb 2022
Nature Aging

Volume: 2, P: 125-139
Gut microbiota–mediated lipid accumulation as a driver of evolutionary adaptation to blue light toxicity in Drosophila

Laboratory selection for tolerance to blue light toxicity in Drosophila revealed that gut microbiota–mediated obesity, marked by midgut elongation and increased beneficial bacteria, is a key evolutionary adaptation.

Yuta Takada
Toshiharu Ichinose
Masatoshi Hori
ResearchOpen Access07 Jul 2025
Communications Biology

Volume: 8, P: 1-21
Flory Enthalpy Parameter at Infinite Dilution of Polymer Solutions Determined by Various Methods

Kenji Kamide
Shigenobu Matsuda
Masatoshi Saito
Research01 Jan 1988
Polymer Journal

Volume: 20, P: 31-43
Improving mechanical properties of cardanol-bonded cellulose diacetate composites by adding polyester resins and glass fiber

We developed advanced cellulose-based resin composites consisting of cardanol-bonded cellulose diacetate (CDA), polyester resins and glass fiber, which have high impact strength and bending strength suitable for durable products. By testing the addition of various polyester resins to the PAA-bonded CDA, we found that poly(butylene succinate adipate) (PBSA), which has flexibility and high compatibility with the PAA-bonded CDA, greatly increased its impact strength. Furthermore, adding glass fiber to the PAA-bonded CDA composites with PBSA enhanced its bending strength and impact strength.

Makoto Soyama
Masatoshi Iji
Research22 Feb 2017
Polymer Journal

Volume: 49, P: 503-509
A novel assay of bacterial peptidoglycan synthesis for natural product screening

Ryo Murakami
Yasunori Muramatsu
Fujio Isono
Research20 Feb 2009
The Journal of Antibiotics

Volume: 62, P: 153-158
Characterization of H7N9 influenza A viruses isolated from humans

Here, biological attributes of two early human isolates of the newly emerged H7N9 influenza viruses are characterized: the potential of these viruses to infect and/or transmit within various animal models is discussed, as is their relative sensitivity to neuraminidase inhibitors and experimental polymerase inhibitors compared to an H1N1 pandemic strain.

Tokiko Watanabe
Maki Kiso
Yoshihiro Kawaoka
Research10 Jul 2013
Nature

Volume: 501, P: 551-555
In vitro and in vivo characterization of new swine-origin H1N1 influenza viruses

On 11 June 2009 the World Health Organization declared that the infections caused by a new strain of influenza A virus closely related to swine viruses had reached pandemic levels. Here, one of the first US isolates of the new swine-origin H1N1 influenza virus (S-OIV) is characterized, as well as several other S-OIV isolates, both in vitro and in vivo.

Yasushi Itoh
Kyoko Shinya
Yoshihiro Kawaoka
Research13 Jul 2009
Nature

Volume: 460, P: 1021-1025
Left atrial single-cell transcriptomics reveals amphiregulin as a surrogate marker for atrial fibrillation

Left atrial scRNA-seq from patients with atrial fibrillation (AF) reveals macrophage heterogeneity and identifies monocytes and IL1B⁺ macrophages as key sources of EGF signals to fibroblasts, with serum AREG emerging as a biomarker for persistent AF.

Yuya Suzuki
Takuo Emoto
Koji Fukuzawa
ResearchOpen Access02 Dec 2024
Communications Biology

Volume: 7, P: 1-13
A deep learning approach to predict differentiation outcomes in hypothalamic-pituitary organoids

A deep learning model predicts gene expression and subsequent adrenocorticotropic hormone secretory function in the differentiation process of hypothalamic–pituitary organoids.

Tomoyoshi Asano
Hidetaka Suga
Hiroshi Arima
ResearchOpen Access06 Dec 2024
Communications Biology

Volume: 7, P: 1-10
A variant in HMMR/HMMR-AS1 is associated with serum alanine aminotransferase levels in the Ryukyu population

Noriko Ohyama
Masatoshi Matsunami
Shiro Maeda
ResearchOpen Access22 Feb 2025
Scientific Reports

Volume: 15, P: 1-10
Author Correction: Left atrial single-cell transcriptomics reveals amphiregulin as a surrogate marker for atrial fibrillation

Yuya Suzuki
Takuo Emoto
Koji Fukuzawa
Amendments and CorrectionsOpen Access26 May 2025
Communications Biology

Volume: 8, P: 1
The neuroprotective effects of FG-4592, a hypoxia-inducible factor-prolyl hydroxylase inhibitor, against oxidative stress induced by alpha-synuclein in N2a cells

Ayaka Fujimaki
Kazuki Ohuchi
Masatoshi Inden
ResearchOpen Access20 Sept 2023
Scientific Reports

Volume: 13, P: 1-10
Secondhand smoke exposure is associated with the risk of hypertensive disorders of pregnancy: the Japan Environment and Children’s Study

The association between second-hand smoking exposure and hypertensive disorders of pregnancy risk was analyzed using the JECS data. The relative risks in 4–7 days/week and ≥2 h/day of SHS exposures were 1.18 and 1.27, respectively. The PAFs due to SHS exposure and maternal smoking were 3.80% and 1.81%, respectively.

Kosuke Tanaka
Hidekazu Nishigori
Hirohito Metoki
ResearchOpen Access03 Feb 2023
Hypertension Research

Volume: 46, P: 834-844
Risk scores for predicting small for gestational age infants in Japan: The TMM birthree cohort study

Noriyuki Iwama
Taku Obara
Shinichi Kuriyama
ResearchOpen Access26 May 2022
Scientific Reports

Volume: 12, P: 1-14
Maternal personality and postpartum mental disorders in Japan: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study

Keiko Murakami
Mami Ishikuro
Shinichi Kuriyama
ResearchOpen Access16 Apr 2022
Scientific Reports

Volume: 12, P: 1-8
Tumor necroptosis is correlated with a favorable immune cell signature and programmed death-ligand 1 expression in cholangiocarcinoma

Thanpisit Lomphithak
Perawatt Akara-amornthum
Siriporn Jitkaew
ResearchOpen Access03 Jun 2021
Scientific Reports

Volume: 11, P: 1-18
The antioxidative stress regulator Nrf2 potentiates radioresistance of oral squamous cell carcinoma accompanied with metabolic modulation

Yuichiro Matsuoka
Ryoji Yoshida
Hideki Nakayama
ResearchOpen Access12 Apr 2022
Laboratory Investigation

Volume: 102, P: 896-907
Adipophilin expression in cutaneous malignant melanoma is associated with high proliferation and poor clinical prognosis

The pathological significance of adipophilin (ADP), a primary protein component of lipid droplets, in cancer remains unclear. Here the authors show that high ADP expression in malignant melanoma is significantly associated with high proliferation and poor clinical prognosis. Cell-based assays supported the importance of ADP in tumor proliferation. They propose that ADP is a marker of aggressive melanoma with a lipogenic phenotype.

Masakazu Fujimoto
Ibu Matsuzaki
Shin-ichi Murata
Research19 Dec 2019
Laboratory Investigation

Volume: 100, P: 727-737
Association of maternal home blood pressure trajectory during pregnancy with infant birth weight: the BOSHI study

Noriyuki Iwama
Mari S. Oba
Hirohito Metoki
Research10 Mar 2020
Hypertension Research

Volume: 43, P: 550-559
Reconstitution of the embryonic kidney identifies a donor cell contribution to the renal vasculature upon transplantation

Yoichi Murakami
Hidekazu Naganuma
Ryuichi Nishinakamura
ResearchOpen Access04 Feb 2019
Scientific Reports

Volume: 9, P: 1-10
Upregulation of ANGPTL6 in mouse keratinocytes enhances susceptibility to psoriasis

Hiroki Tanigawa
Keishi Miyata
Yuichi Oike
ResearchOpen Access04 Oct 2016
Scientific Reports

Volume: 6, P: 1-12

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