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Liu, Chen, Yang et al. investigate the effect of GLP-1 receptor activation on ovarian cancer risk across different subtypes. They show that it specifically lowers the risk of one subtype, endometrioid ovarian cancer, mediated in part by specific metabolic factors.

Selective catalytic reduction of NOx to N₂ using methanol as the reductant (Methanol-SCR) offers a promising route for eliminating NOx emissions from methanol engines and coal-fired power plants, but its performance at low temperatures remains limited. Here, the authors identify a strategy to enhance low-temperature Methanol-SCR activity through the cooperation between zeolitic acid sites and single iron redox sites.

Insulin resistance contributes to cardiometabolic disease, but its genetic basis remains incompletely defined. Here, the authors identify 217 associated loci and highlight potential therapeutic targets, linking insulin resistance to multiple diseases and aging traits.

Stem cell therapy for stroke is limited by poor survival and integration. Here, the authors present an injectable microgel-matrix scaffold combining microporous microgels for cell delivery with interstitial spaces for vascular growth, improving neurological recovery in stroke models.

Magnetoelectric composites of magnetic and ferroelectric components are promising for their use in applications such as information storage. Here, the authors find that magnetic quasiparticles embedded in a ferroelectric film matrix show promising properties compared to the usual thin-film architectures.

Kerr microcombs promise the miniaturization of frequency comb sources, but many applications require additional second-order nonlinearities. Here, Wang et al. demonstrate that comb generation and second-order functionalities can be monolithically integrated on a single lithium niobate chip.

Efficient electro-optic conversion is central to photonic computing, and thin-film lithium niobate (TFLN) offers this capability. Here, the authors demonstrate computing circuits on the TFLN platform, enabling the next generation of photonic computing systems featuring both high-speed and low-power.

A method to synthesize non-van der Waals MAX phases and van der Waals layered early transition metal Xide chalcogenides (TMXCs) is developed through editing of covalent M–A/M–X sublayers. Exfoliated monolayer TMXCs resemble MXenes but feature tunable oxidation states, making the materials promising for applications in energy storage and catalysis.

Toripalimab with definitive chemoradiotherapy is a promising treatment strategy for esophageal squamous cell carcinoma. Here, the authors show that ctDNA positivity and bTMB are predictive of response in patients within the EC-CRT-001 phase II trial.

Accurately genotyping structural variations (SVs) from short-read sequencing data is challenging. Here, the authors introduce SVLearn for precise genotyping of bi-allelic SVs, demonstrating robust cross-species generalizability across multiple coverage levels.

Fu et al. describe a pathogen effector, HaRxL10 that suppresses plant immunity and interferes with plant development by hijacking the clock component CHE to perturb its function in transcriptional regulation.

Ultrawideband beamforming is essential for next generation radar and communication. Here, authors demonstrate a photonic beamforming approach using frequency combs that enables beamforming and continuous beam-steering of LFM waveforms, supporting high-performance integrated sensing and communication.

Data from two large longitudinal cohorts in China, in which the participants were clustered into five groups based on their metabolic characteristics, show that a signature of microbiome age modulates the risk of cardiovascular disease in metabolically unhealthy individuals.

Here, the authors identify genes and drug targets that show immune cell-specific and activation time point-specific effects on type 2 diabetes and coronary heart disease and find strong immune-to-metabolic disease connections.

Within plate interiors, assessments of earthquake hazards rely heavily on the assumption that the locations of the few recorded small earthquakes reflect continuing deformation that will cause future large earthquakes. Here, however, a simple model shows that many of these recent earthquakes are probably aftershocks of large earthquakes that occurred hundreds of years ago, causing earthquake prediction to overestimate hazard in presently active areas, and underestimate it elsewhere.

Ye et al. find a positive causal effect of mental well-being on healthy aging, independent of socioeconomic status. This work underscores the imperative to prioritize mental well-being in health policies geared to fostering healthy aging.

The authors used Mendelian randomization to investigate how various dimensions of socio-economic status causally affect longevity. They found a positive independent causal effect of education on longevity but no evidence for independent effects from income or occupation.

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Soft tissue fabrication using digital light processing remains challenging. Here the authors present a molecular cleavage approach to achieve high-performance bioprinting of constructs with tissue-matching mechanical properties and structural complexity.

Yang et al. reported the development of nongenetically engineered artificial mechanoreceptors capable of reprogramming non-mechanoresponsive receptors to sense user-defined force cues, enabling de novo-designed mechanotransduction.

Functional oxides with coexisting states of comparable energy typically exhibit extraordinary responses to external stimuli. Here, the authors demonstrate that coexisting phase structures provide large electric field-triggered volume change.

Allelopathy—the chemical competition between neighbouring plants—has been observed for centuries. This study identifies a sensor of phenolic allelochemicals and reveals translational control as a key mechanism.

This study reveals that phosphorus and nitrogen deficiency alters the abundance and profiles of extrachromosomal circular DNA in rice, underscoring its crucial role in genome plasticity and stress adaptation, which has implications for agricultural performance.

The proapoptotic protein Siva1 has been shown to inhibit the tumour suppressor p53, however, it remains unclear how this activity is mediated. Here the authors show that Siva1 is an E3 ubiquitin ligase which inhibits p53 by promoting the degradation of ARF.

Chen et al. demonstrate the use of multi-angular polarimetric remote sensing to pinpoint global aerosol absorption and direct radiative forcing.

How aging induces aortic aneurysm and dissection (AAD) remains unclear. Here, the authors show that aging induces miR-1204 to inhibit MYLK, promoting vascular smooth muscle cells to acquire senescence-associated secretory phenotype, resulting in vascular inflammation, and the aggravation of AAD formation.

Aurora-A kinase is frequently over-expressed in tumours. Here, the authors show that it modulates the activity of lactate dehydrogenase B, resulting in enhanced glycolysis, bio-synthesis and tumour growth.

Stroke is a multifactorial disease influenced by genetic and environmental factors. Here, the authors apply exome-wide association analysis to find rare coding variants associated with stroke in a Pakistani cohort, finding a significant association of a variant in NOTCH3 that is highly enriched in South Asians.

The second messenger cAMP modulates a wide range of important biological processes. Here, the authors developed a fluorescent indicator termed G-Flamp1, which can accurately report levels of cAMP in living cells.

Fungal cell walls release β-1,3-glucan fragments that trigger plant immunity. Here, the authors show that a glucanase (Ebg1) of the blast fungus Magnaporthe oryzae suppresses plant immunity by hydrolyzing β-1,3-glucan. At the same time, Ebg1 induces plant immune responses that are dampened by a fungal protein that interacts with Ebg1.

Realizing ultra-high work functions (UHWFs) in hole-doped polymer semiconductors remains a challenge due to water-oxidation reactions. Here, the authors determine the role of water-anion complexes in limiting the work function and develop a design strategy for realizing UHWF polymers.

The authors present DeepMod2, a deep-learning based computational method that allows fast and accurate detection of DNA methylation and epihaplotypes from Oxford Nanopore sequencing data.

Cellular stress results in the release of damage-associated molecular pattern (DAMP) molecules that promote inflammatory responses. Here Ping Wang and colleagues show that cold-inducible RNA-binding protein (CIRP) is a DAMP that is released into the circulation in response to hemorrhagic shock and sepsis. It promotes proinflammatory cytokine release by binding to the TLR4-MD2 complex. Blockade of CIRP reduces inflammation, organ injury and mortality in animal models of hemorrhage and sepsis, suggesting that CIRP may be targeted therapeutically in these conditions.

TR3 is an orphan nuclear receptor with roles in apoptosis. A TR3-binding compound induces mitochondrial translocation of TR3 and autophagy via the Nix–Toms–ANT1/VDAC1 pathway, providing a mechanism for cell death in melanoma cells that are resistant to spontaneous and drug-induced apoptosis.

The FarmGTEx Project aims to understand genetic control of gene activity under diverse biological and environmental contexts in domestic animals, providing a foundation for improving animal precision breeding, adaptation and human health.

Coupled lithium niobate ring resonators enable control of a ‘photonic molecule’ by programmed microwave signals. An on-demand optical storage and retrieval system is demonstrated.