Nature Search

The bacterial toxin colibactin triggers prophage induction

The bacterial genotoxin colibactin triggers prophage-mediated lysis of neighbouring bacteria, a finding that provides insight into the dynamics of microbial communities and relationships between bacterial metabolite production and phage behaviour.

Justin E. Silpe
Joel W. H. Wong
Emily P. Balskus
ResearchOpen Access23 Feb 2022
Nature

Volume: 603, P: 315-320
Preventing dysbiosis of the neonatal mouse intestinal microbiome protects against late-onset sepsis

Disrupting the normal maturation of the infant gut microbiota induced late-onset sepsis in mice, which could be prevented by administering specific bacteria.

Jeffrey R. Singer
Emily G. Blosser
Casey T. Weaver
Research07 Nov 2019
Nature Medicine

Volume: 25, P: 1772-1782
Human organoid biofilm model for assessing antibiofilm activity of novel agents

Bing (Catherine) Wu
Evan F. Haney
Robert E. W. Hancock
ResearchOpen Access25 Jan 2021
npj Biofilms and Microbiomes

Volume: 7, P: 1-13
Light adaptation does not prevent early retinal abnormalities in diabetic rats

Joanna Kur
Michael A. Burian
Eric A. Newman
ResearchOpen Access08 Feb 2016
Scientific Reports

Volume: 6, P: 1-8
A benchmark of expert-level academic questions to assess AI capabilities

Humanity’s Last Exam, a multi-modal benchmark at the frontier of human knowledge, is designed to be an expert-level closed-ended academic benchmark with broad subject coverage.

Long Phan
Alice Gatti
Davide Scaramuzza
ResearchOpen Access28 Jan 2026
Nature

Volume: 649, P: 1139-1146
Dye-sensitized solar cells for efficient power generation under ambient lighting

A dye-sensitized solar cell that has been designed for efficient operation under indoor lighting could offer a convenient means for powering the Internet of Things.

Marina Freitag
Joël Teuscher
Anders Hagfeldt
Research01 May 2017
Nature Photonics

Volume: 11, P: 372-378
Staphylococcus saprophyticus prevents skin damage by inhibiting Staphylococcus aureus quorum sensing

Liuying Song
Xiaobao Bai
Masanori Matsumoto
ResearchOpen Access16 Apr 2025
Scientific Reports

Volume: 15, P: 1-13
SuFEx-based antitubercular compound irreversibly inhibits Pks13

A preclinical covalent compound, CMX410, contains a aryl fluorosulfate warhead that targets the acyltransferase domain of Mtb Pks13, an essential enzyme in cell-wall biosynthesis, making it a promising candidate for tuberculosis treatment regimens.

Inna V. Krieger
Paridhi Sukheja
Case W. McNamara
Research30 Jul 2025
Nature

Volume: 645, P: 755-763
Beyond the spore, the exosporium sugar anthrose impacts vegetative Bacillus anthracis gene regulation in cis and trans

Michael H. Norris
Andrew P. Bluhm
Jason K. Blackburn
ResearchOpen Access28 Mar 2023
Scientific Reports

Volume: 13, P: 1-19
A molecular photosensitizer achieves a V_oc of 1.24 V enabling highly efficient and stable dye-sensitized solar cells with copper(II/I)-based electrolyte

Designing photo-sensitisers with high open-circuit voltage (V_oc) is desirable to enhance the power conversion efficiency (PCE) of co-sensitized solar cells. Here, the authors employ a judiciously tailored organic sensitiser MS5 with copper electrolyte to achieve a V_oc of 1.24 V, and recorded PCE of 34.5% under ambient light.

Dan Zhang
Marko Stojanovic
Michael Grätzel
ResearchOpen Access19 Mar 2021
Nature Communications

Volume: 12, P: 1-10
Pathogenic variants in SMARCA1 cause an X-linked neurodevelopmental disorder modulated by NURF complex composition

The authors identify pathogenic variants in the SMARCA1 gene as the cause of a variable neurodevelopmental disorder. Mouse studies suggest diverse genetic mechanisms related to NURF complex composition mediate the phenotype.

Ghayda M. Mirzaa
Keqin Yan
David J. Picketts
ResearchOpen Access10 Nov 2025
Nature Communications

Volume: 16, P: 1-21
Identification of a stress-sensitive endogenous opioid-containing neuronal population in the paranigral ventral tegmental area

Carrie Stine
Amanda L. Pasqualini
Michael R. Bruchas
ResearchOpen Access20 Dec 2025
Neuropsychopharmacology

P: 1-9
High-throughput fitness screening and transcriptomics identify a role for a type IV secretion system in the pathogenesis of Crohn’s disease-associated Escherichia coli

Adherent-invasive E. coli (AIEC) are frequently isolated from Crohn’s disease (CD) patients. Here, Elhenawy et al. conduct a genome-wide screen to identify AIEC genes required for in vivo intestinal colonization, and show that a type IV secretion system contributes to AIEC persistence in the gut and is enriched in CD patients’ isolates.

Wael Elhenawy
Sarah Hordienko
Brian K. Coombes
ResearchOpen Access01 Apr 2021
Nature Communications

Volume: 12, P: 1-13
Hybridization and low-light adaptability in California eelgrass (Zostera spp.)

Seagrass genomes of the deep-water Zostera pacifica and shallow-water Z. marina from the Eastern Pacific Ocean provide evidence for low-light adaptation exemplified in the wild hybrid Z. marina × pacifica subjected to low-light stress in aquaria.

Malia L. Moore
Nicholas Allsing
Todd P. Michael
ResearchOpen Access29 Oct 2025
Nature Plants

Volume: 11, P: 2409-2422
TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal

Xaralabos Varelas
Rui Sakuma
Jeffrey L. Wrana
Research22 Jun 2008
Nature Cell Biology

Volume: 10, P: 837-848
Identifying reliable traits across laboratory mouse exploration arenas: A meta-analysis

Michael Galsworthy
Rime Madani
Hans-Peter Lipp
ResearchOpen Access12 Mar 2012
Nature Precedings

P: 1
Reversible labeling of native and fusion-protein motifs

Removing phosphopantetheine-tagged labels from acyl carrier proteins (ACPs) and ACP fusion proteins contributes to a versatile labeling method in which tags can be iteratively swapped.

Nicolas M Kosa
Robert W Haushalter
Michael D Burkart
Research16 Sept 2012
Nature Methods

Volume: 9, P: 981-984
Identification of a common ketohexokinase-dependent link driving alcohol intake and alcohol-associated liver disease in mice

Ethanol-induced fructose metabolism, mediated by KHK-A/C, drives excessive alcohol consumption and pathogenesis of alcoholic liver disease.

Ana Andres-Hernando
David J. Orlicky
Miguel A. Lanaspa
ResearchOpen Access10 Nov 2025
Nature Metabolism

Volume: 7, P: 2250-2267
Chronic social defeat stress induces meningeal neutrophilia via type I interferon signaling in male mice

Chronic stress is a risk factor for depression, yet the mechanisms are unclear. Here, the authors show in mice that stress drives interferon-mediated neutrophil recruitment from the skull to the brain’s outer membranes, contributing to depressive behaviors.

Stacey L. Kigar
Mary-Ellen Lynall
Miles Herkenham
ResearchOpen Access01 Sept 2025
Nature Communications

Volume: 16, P: 1-19
A spatial atlas of the complement system uncovers unique expression patterns in postnatal brain development in mice

The complement cascade is increasingly recognized in the brain. Here, with MERFISH, the authors showed developmentally regulated brain endogenous expression of complement genes and a potential role of the alternative pathway in brain development.

Yingying Zhang
Brianna Watson
Michael C. Carroll
ResearchOpen Access02 Dec 2025
Nature Communications

Volume: 16, P: 1-15
BrainPhys neuronal medium optimized for imaging and optogenetics in vitro

Current media for neuronal cell and organoid cultures are suboptimal for functional imaging and optogenetics experiments, owing to phototoxicity and unphysiological performance. Here the authors formulate an optimised neuronal medium to support live cell imaging and electrophysiological activity.

Michael Zabolocki
Kasandra McCormack
Cedric Bardy
ResearchOpen Access03 Nov 2020
Nature Communications

Volume: 11, P: 1-19
Luminance contrast and colour contrast related errors in pseudoisochromatic plate identification

Michael Wall
Paul B Donzis
Research01 Sept 1997
Eye

Volume: 11, P: 713-716
Heterogeneous pericoerulear neurons tune arousal and exploratory behaviours

A set of neurons in the peri-locus coeruleus region controls arousal and avoidance states, providing an understanding of the neurobiological basis of arousal and exploratory behaviours.

Andrew T. Luskin
Li Li
Michael R. Bruchas
Research07 May 2025
Nature

Volume: 643, P: 437-447
A small-molecule nitroimidazopyran drug candidate for the treatment of tuberculosis

C. Kendall Stover
Paul Warrener
William R. Baker
Research22 Jun 2000
Nature

Volume: 405, P: 962-966
Metastasis-associated protein 1 is an integral component of the circadian molecular machinery

Mammalian circadian clocks modulate the daily cycles of many cellular processes. Here the authors find that metastasis-associated protein 1, which is upregulated in human cancers, is an intrinsic regulator of the mammalian molecular clock.

Da-Qiang Li
Suresh B. Pakala
Rakesh Kumar
Research03 Oct 2013
Nature Communications

Volume: 4, P: 1-13
Systems Biology Markup Language (SBML) Level 2: Structures and Facilities for Model Definitions

Michael Hucka
Andrew Finney
Nicolas Le Novere
ResearchOpen Access18 Jun 2007
Nature Precedings

P: 1
Systems Biology Markup Language (SBML) Level 2: Structures and Facilities for Model Definitions

Michael Hucka
Stefan Hoops
Darren Wilkinson
ResearchOpen Access24 Dec 2008
Nature Precedings

P: 1
Systems Biology Markup Language (SBML) Level 2: Structures and Facilities for Model Definitions

Michael Hucka
Andrew Finney
Nicolas Le Novere
ResearchOpen Access05 Nov 2007
Nature Precedings

P: 1
Propyl-5-hydroxy-3-methyl-1-phenyl-1H-pyrazole-4-carbodithioate (HMPC): a new bacteriostatic agent against methicillin—resistant Staphylococcus aureus

Tatiana Johnston
Daria Van Tyne
Eleftherios Mylonakis
ResearchOpen Access04 May 2018
Scientific Reports

Volume: 8, P: 1-12
Engineered autonomous dynamic regulation of metabolic flux

Metabolic engineering allows the design of microorganisms for the bioproduction of specific metabolites, such as value-added chemicals. This Review discusses autonomous dynamic regulation approaches, including metabolite-specific transcriptional regulation and non-specific systems using environmental factors, quorum sensing and growth-phase regulation.

Michael Ream
Kristala L. J. Prather
Reviews21 Dec 2023
Nature Reviews Bioengineering

Volume: 2, P: 233-243
Downregulation of integrin α3 in ADHD mirrored in mutant mouse model by dopamine-dependent hippocampal AMPAR expression

Xiaojuan Yao
Ruiying Chen
Xiao Xiao
Research15 Dec 2025
Molecular Psychiatry

P: 1-19
Diminishing benefits of urban living for children and adolescents’ growth and development

The advantage of living in cities compared with rural areas with respect to height and BMI in children and adolescents has generally become smaller globally from 1990 to 2020, except in sub-Saharan Africa.

Anu Mishra
Bin Zhou
Majid Ezzati
ResearchOpen Access29 Mar 2023
Nature

Volume: 615, P: 874-883
RO4938581, a GABA_A-α5 negative allosteric modulator rescued behavioral and EEG phenotypes of a mouse model of Dup15q syndrome

Ryoko Nakagawa
Francesca Nani
Maria-Clemencia Hernandez
ResearchOpen Access05 Jan 2026
Molecular Psychiatry

P: 1-10
Inducible cell-to-cell signaling for tunable dynamics in microbial communities

Biotechnology innovations require the precise control over microbial dynamics. Here the authors engineer an inducible quorum sensing system to fine tune population and community level behaviour.

Arianna Miano
Michael J. Liao
Jeff Hasty
ResearchOpen Access04 Mar 2020
Nature Communications

Volume: 11, P: 1-8
Genetic suppression features ABHD18 as a Barth syndrome therapeutic target

The enzyme ABHD18 is shown to have a key role in cardiolipin metabolism in mitochondria, offering a potential route for a small-molecule treatment of the rare genetic disease Barth syndrome.

Sanna N. Masud
Anchal Srivastava
Jason Moffat
Research03 Sept 2025
Nature

Volume: 645, P: 1029-1038
Selective inhibition of TGF-β responsive genes by Smad-interacting peptide aptamers from FoxH1, Lef1 and CBP

Qiqi Cui
Sang Kyun Lim
Francis Michael Hoffmann
Research07 Mar 2005
Oncogene

Volume: 24, P: 3864-3874
Independent mechanisms of inflammation and myeloid bias in VEXAS syndrome

UBA1-mutant macrophages exposed to inflammatory stimuli undergo aberrant apoptotic and necroptotic cell death mediated by CASP8 and RIPK3–MLKL, offering insights into the mechanisms underlying VEXAS syndrome.

Varun K. Narendra
Tandrila Das
Alexander D. Gitlin
ResearchOpen Access03 Nov 2025
Nature

Volume: 649, P: 1273-1281
Circadian oscillations of cytosolic free calcium regulate the Arabidopsis circadian clock

The circadian clock involves daily variations in transcription of a set of core genes. Here, the authors show that oscillations in free calcium concentration, read by calmodulin-like proteins, regulate the clock and are part of this complex mechanism.

María Carmen Martí Ruiz
Katharine E. Hubbard
Alex A. R. Webb
Research20 Aug 2018
Nature Plants

Volume: 4, P: 690-698
FERONIA restricts Pseudomonas in the rhizosphere microbiome via regulation of reactive oxygen species

A genetic screen identifies the versatile membrane receptor protein FERONIA as a key modulator of rhizosphere Pseudomonas and microbiome composition in Arabidopsis, through the control of basal levels of reactive oxygen species production.

Yi Song
Andrew J. Wilson
Cara H. Haney
Research10 May 2021
Nature Plants

Volume: 7, P: 644-654
Melatonin’s role in the timing of sleep onset is conserved in nocturnal mice

Pureum Kim
Nicholas Garner
Oliver Rawashdeh
ResearchOpen Access01 Nov 2024
npj Biological Timing and Sleep

Volume: 1, P: 1-13
FKBP51 in glutamatergic forebrain neurons promotes early life stress inoculation in female mice

Early life stress can induce lasting changes in brain function and behavior. Here, authors show that glutamatergic FKBP51 specifically in females mediates adaptive stress effects on anxiety and cognition via TCF4.

Lotte van Doeselaar
Alexandra Abromeit
Mathias V. Schmidt
ResearchOpen Access14 Mar 2025
Nature Communications

Volume: 16, P: 1-16
Development of Circadian Sleep-Wake Rhythms in Preterm and Full-Term Infants

I Caroline McMillen
Joyce S M Kok
Rachel Nowak
Research01 Apr 1991
Pediatric Research

Volume: 29, P: 381-384
Deletion of Crhr2 reveals an anxiolytic role for corticotropin-releasing hormone receptor-2

Toshimitsu Kishimoto
Jelena Radulovic
Joachim Spiess
Research01 Apr 2000
Nature Genetics

Volume: 24, P: 415-419
Just-in-time transcription program in metabolic pathways

Alon Zaslaver
Avi E Mayo
Uri Alon
Research25 Apr 2004
Nature Genetics

Volume: 36, P: 486-491
Preventing light-induced toxicity in a new mouse model of sector retinitis pigmentosa caused by Rhodopsin M39R variant

Rosellina Guarascio
Kalliopi Ziaka
Michael E. Cheetham
ResearchOpen Access21 Oct 2025
Cell Death Discovery

Volume: 11, P: 1-14
Cryptic species Chrysoperla lucasina and C. carnea differ in predation of early Nezara viridula instars

Raghavendra Reddy Manda
Radjeshry Raghoedat Panday
Gerben J. Messelink
ResearchOpen Access09 Jan 2026
Scientific Reports

Volume: 16, P: 1-18
Towards fair decentralized benchmarking of healthcare AI algorithms with the Federated Tumor Segmentation (FeTS) challenge

Federated learning (FL) algorithms have emerged as a promising solution to train models for healthcare imaging across institutions while preserving privacy. Here, the authors describe the Federated Tumor Segmentation (FeTS) challenge for the decentralised benchmarking of FL algorithms and evaluation of Healthcare AI algorithm generalizability in real-world cancer imaging datasets.

Maximilian Zenk
Ujjwal Baid
Spyridon Bakas
ResearchOpen Access08 Jul 2025
Nature Communications

Volume: 16, P: 1-20
The Systems Biology Markup Language (SBML): Language Specification for Level 3 Version 1 Core

Lucian Smith
Darren Wilkinson
James Schaff
ResearchOpen Access06 Oct 2010
Nature Precedings

P: 1
The Systems Biology Markup Language (SBML): Language Specification for Level 3 Version 1 Core (Release 1 Candidate)

Michael Hucka
Frank Bergmann
Darren Wilkinson
ResearchOpen Access02 Jan 2010
Nature Precedings

P: 1
Protection of Rpe65-deficient mice identifies rhodopsin as a mediator of light-induced retinal degeneration

Christian Grimm
Andreas Wenzel
Charlotte E. Remé
Research01 May 2000
Nature Genetics

Volume: 25, P: 63-66

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