The widespread use of biaryl monophosphines is frequently hampered by the challenges associated with their modular preparation. Here, the authors report a protocol that appends arenes to arylphosphines to access a series of these compounds via rhodium-catalysed P(III)- directed ortho C–H activation, enabling one-fold, two-fold, and threefold direct arylation.
- Dingyi Wang
- Mingjie Li
- Zhuangzhi Shi