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During meiosis the MRX complex is required for DSB formation in budding yeast. Here, the authors show the Mre11 forms DNA-dependent condensates via its C-terminal disordered tail, which further interacts with Mer2 and Smt3, enabling MRX recruitment to chromatin and programmed DSB formation during meiosis.

A first-in-human phase 1 trial shows that intravitreal photoswitch therapy can be administered safely in advanced retinitis pigmentosa, with exploratory signals compatible with light responsiveness following treatment.

BRCA2 mutations are well known to increase cancer risk, however, the significance of many variants remains unknown. Here, the authors combine data from two saturation genome editing studies to classify a total of 5926 variants as pathogenic or benign.

Extracellular vesicles from lung epithelial cells deliver ACE2 and TMPRSS2 to recipient cells, enabling SARS-CoV-2 infection beyond receptor-expressing cells and expanding viral tropism.

The functional impact of most missense variants remains unknown. Here the authors perform deep mutational scanning of the tumor suppressor SMARCB1 and find missense mutations that retain detectable protein expression but disrupt function similar to protein-null mutations

The total sediment flux from land to the ocean across the pan-Arctic has risen by 15% since 1980, driven by greater river discharge, intensified thermokarst disturbances and wildfire activity, according to machine learning and satellite-based reconstructions of suspended sediment dynamics in 4,331 river reaches.

Antibody mediated prevention (AMP) trials with the broadly neutralizing antibody VRC01 showed protection against VRC01-sensitive viruses. Here, by deep sequencing plasma samples from 172 participants of the AMP trials, the authors show a high frequency of multilineage HIV infections (38%), including coinfection with both sensitive and resistant viruses, and demonstrate that VRC01 doesn’t alter the transmission bottleneck.

Benralizumab (an anti-IL-5 receptor α antibody), compared to placebo, significantly reduced the risk of first flare in patients with hypereosinophilic syndrome.

In this phase 1, open-label dose-escalation study in healthy adults found that the mRNA vaccine (mRNA-1215), encoding the Nipah virus Malaysian strain chimeric pre-fusion F protein linked to glycoprotein G, was safe and induced elevated immune responses at 1 year of follow-up, indicating that this is a promising vaccine candidate for further development.

A prespecified analysis from the SELECT trial showed that semaglutide reduces major adverse cardiovascular events by 20% compared with placebo, particularly in patients at high risk of fibrosis, as indicated by the Fibrosis-4 index.

Millisecond pulsar PSR J0435+3233, with a spin-down rate that is 100 times higher than those of other millisecond pulsars, occupies a unique position on the P–Ṗ diagram. This pulsar challenges classical recycling models and constrains spin-up theories.

Recovery of 48 bat and 9 horse HeV genomes from Australia (2016–2020) identified four Hendra virus clades, offering insights into evolutionary dynamics.

Two individuals with KCNT1-related epileptic encephalopathy were treated with a KCNT1-targeting antisense oligonucleotide, leading to significant reductions in seizure frequency and intensity, but also the development of hydrocephalus.

N-desethyl-fluornitrazene is a µ-opioid receptor agonist derived from nitazenes that has supramaximal intrinsic efficacy that produces analgesia with minimal adverse effects in rodent models.

Glioblastoma (GBM) invasion into brain parenchyma presents significant challenges for treatment. Here, the authors employ multi-omics analysis of orthotopic GBM xenograft mouse models to show that GBM cellular states are correlated both to the propensity to invade by distinct anatomical routes and to the programs that GBM cells activate during invasion.

The Mouse Cancer Cell line Atlas (MCCA) provides major advances towards a mechanistic understanding of cancer genomes.

In a randomized trial enrolling Black adults residing in food deserts in Boston, Massachusetts, who were undergoing treatment for hypertension, home-delivery for 3 months of groceries designed to provide a low-sodium diet, together with dietician counseling, reduced blood pressure beyond a monetary stipend, an effect that was maintained for an additional 3 months after the intervention ended.

LHAASO has detected γ-ray emission with a spectrum extending to 2 PeV from the pulsar wind nebula (PWN) powered by PSR J1849-0001, indicating an extreme particle acceleration efficiency and challenging the current particle acceleration theories.

In a double-blind, cluster-randomized, placebo-controlled trial in Niger that examined azithromycin mass drug distribution in different age groups of children, there was evidence of selection of macrolide resistance determinants in the gut in children 1 to 59 months old, but resistance to other classes of antibiotics were not observed in the gut or nasopharynx.

This study introduces SimuScan, a synthetic data-driven deep learning framework that enables autonomous atomic force microscopy without manual annotation, accelerating AI-based nanoscale characterization.

The excitatory neuron diversity and specialized connectivity of complex, multilayered mammalian neocortex are driven by mammalian-specific cis-regulatory elements bound by ZBTB18, deletion of which disrupts gene expression and results in projection patterns resembling those of non-mammalian brains.

Longitudinal metatranscriptomics in a prospective cohort of 1,164 adults hospitalized for COVID-19 reveals that azithromycin offered no apparent anti-inflammatory benefit but enriched the respiratory microbiome with potential pathogens and antimicrobial resistance genes.

Climate models overestimate greenhouse gas effects on the temperature difference between Earth’s hemispheres, with this bias strongest in high climate sensitivity models, suggesting future tropical rainfall shifts may be less severe than projected.

Post-translational redox modification of protein cysteine residues has emerged as a mode of immune cell regulation. Now, a deep redox proteomics study identifies redox-regulated and druggable cysteines in immunological proteins.

Analysis of sequencing data from rare disease cohorts identifies biallelic variants in RNU2-2 underlying a developmental and epileptic encephalopathy associated with reduced U2-2 abundance and clinically distinct from the dominant RNU2-2 disorder.

As presented at the 2026 ASCO Genitourinary Cancers Symposium, in the phase 2 INDIBLADE trial, induction therapy with ipilimumab and nivolumab followed by consolidating chemoradiotherapy in stage II/III muscle-invasive bladder cancer led to encouraging bladder-intact event-free survival outcomes that were associated with ctDNA clearance.

Emerging fungal pathogens have detrimental impacts on crops, animals, and humans, however little is known about their transition to a pathogenic lifestyle. This study demonstrates that the transition from saprotroph to opportunistic human pathogen is likely facilitated by adaptive translation.

An online experiment compared 12 brief online interventions for depression. Most improved mental health immediately, but these gains decreased over time, with only two interventions significantly reducing depression 4 weeks later.

Women of reproductive age may have specific concerns relating to perceived impacts on fertility and menstrual cycles that make them hesitant to receive COVID-19 vaccination. In this study, the authors explore COVID-19 vaccine uptake rates in women of reproductive age using linked data for ~13 million women in England.

Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) have been associated with adverse effects affecting both the cardiovascular and gastrointestinal systems. Here the authors show that NSAIDs lower plasma tryptophan concentrations in humans and mice and that replacement of tryptophan in mice treated with naproxen leads to decreased adverse effects.

Ongoing chikungunya virus replication leads to the accumulation of inflammatory macrophages and CD4⁺ T cells in joint-associated tissues. Inhibition of chikungunya virus replication during chronic disease reduced viral RNA and joint inflammation in mice.

Despite high morbidity and mortality, there are currently no approved vaccines for protection against Middle East respiratory syndrome (MERS) coronavirus. Here the authors develop a ferritin nanoparticle-based MERS-CoV vaccine that elicits high levels of neutralizing antibodies in mice, non-human primates, and alpacas and prevents infection in an alpaca challenge model.

Selecting for varieties of commercial crops with enhanced nutritional quality is important in agriculture. Here, the authors identify alleles of a gene in tomatoes that give rise to increased levels of vitamin E and find that the promoter of the gene is differentially methylated.

In a randomized, double-blind, placebo-controlled trial comparing autologous mRNA-engineered BCMA-targeting CAR T cell therapy versus placebo in patients with generalized myasthenia gravis, a significantly higher percentage of patients exhibited a reduction in disease activity in the treatment arm than in the placebo arm.

Most advanced triple-negative breast cancers remain resistant to immunotherapy. Here, the authors discover that RIPK1-driven necroptosis in both tumor and stromal compartments is essential for effective immunogenic cell death-based therapy and immune checkpoint blockade.

Elite and viremic controllers of HIV can spontaneously regulate viral replication, but some lose this ability over time. In this longitudinal cohort study, 31% of viremic and 3% of elite HIV controllers lost viral control over 17 years. Specific T-cell– related proteins distinguish controller types and predict loss years in advance.

Increasing dietary carbohydrate-to-fat ratio in a randomized controlled feeding study altered circulating small molecules (metabolites), including ones associated with diabetes risk, underscoring important metabolic effects of dietary composition.

Mucosal administration of a multivalent, adjuvanted vaccine against Clostridioides difficile promoted bacterial clearance and protected against morbidity, mortality, tissue damage and recurrence in mice.

Vassy, Dornisch and colleagues developed a genomics-based prostate cancer risk model to support a randomized clinical trial of precision screening in a national healthcare system.

Zhang et al. examine associations between wildfire-specific PM_2.5 and emergency department visits for mental disorders in children across 845 communities in Australia, Brazil and Canada over a 15-year period.

This study utilized a longitudinal cohort of adolescents to identify distinct brain signatures linked to ADHD symptom trajectories, revealing that specific cortical and subcortical changes correlate with symptom persistence, remission and emergence, enhancing predictive capabilities for ADHD outcomes.

Neuromodulation via epidural electrical stimulation both below and above the lesion in three participants with complete spinal cord injury could enable respectively motor activation and sensory perception.

A purpose-built implantable system based on biomimetic epidural electrical stimulation of the spinal cord reduces the severity of hypotensive complications in people with spinal cord injury and improves quality of life.

Genome-wide analysis coupled with long-read sequencing identifies a repeat expansion in GOLGA8A associated with high risk for atypical frontotemporal lobar degeneration with ubiquitin-positive inclusions.

Whether orientation-selectivity is discernable via fMRI remains unclear. Here, by analyzing a public dataset of responses to natural scenes using neurally-inspired image-computable models, the authors isolate and characterize a coarse-scale orientation map and demonstrate that orientation-selective BOLD responses reflect multiple distinct computations at a range of spatial scales.

In a phase 1 trial, personalized mRNA vaccines tailored to individual tumour mutations in triple-negative breast cancer induced robust, long-lasting T cell responses and improved prognosis.

In this work, Wilson et al., examined sharing of Salmonella between humans, animals and the environment using household samples from Malawi. They revealed an interconnected web of Salmonella circulation, underscoring the importance of the One Health concept.