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Scientific Reports (36)
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Showing 1–50 of 68 results

Advanced filters: Author: Naoki Nagano Clear advanced filters

Subchondral bone strength of the metacarpal head and its related factors in patients with rheumatoid arthritis

Rika Kakutani
Hiroto Yoshida
Hajime Ishikawa
ResearchOpen Access12 Dec 2025
Scientific Reports

Volume: 16, P: 1-11
Staphylococcus aureus ST764-SCCmecII high-risk clone in bloodstream infections revealed through national genomic surveillance integrating clinical data

Authors present results from a national surveillance in Japan that found MRSA strains causing bloodstream infections are predominantly from three clonal lineages. They also identified the emergence of highest 30-day-mortality MRSA clone ST764-SCCmecII and traced its evolutionary path.

Junzo Hisatsune
Shoko Kutsuno
Motoyuki Sugai
ResearchOpen Access19 Mar 2025
Nature Communications

Volume: 16, P: 1-14
Clinical characteristics and treatment of elderly onset adult-onset Still’s disease

Dai Kishida
Takanori Ichikawa
Yoshiki Sekijima
ResearchOpen Access26 Apr 2022
Scientific Reports

Volume: 12, P: 1-7
Genetic polymorphisms in estrogen metabolism and breast cancer risk in case–control studies in Japanese, Japanese Brazilians and non-Japanese Brazilians

Naoki Shimada
Motoki Iwasaki
Shoichiro Tsugane
Research20 Feb 2009
Journal of Human Genetics

Volume: 54, P: 209-215
Prognostic model for pancreatic cancer based on machine learning of routine slides and transcriptomic tumor analysis

Manabu Takamatsu
Mariko Tanaka
Kengo Takeuchi
Research08 Jan 2026
British Journal of Cancer

P: 1-11
Pluripotent epigenetic regulator OBP-801 attenuates fibrosis and maintains lower intraocular pressure in a rabbit PRESERFLO MicroShunt surgery model

Yusuke Koga
Toru Ikushima
Chie Sotozono
ResearchOpen Access31 Dec 2025
Scientific Reports

Volume: 16, P: 1-13
Tumour-resident oncolytic bacteria trigger potent anticancer effects through selective intratumoural thrombosis and necrosis

A tumour-derived consortium of Proteus mirabilis and Rhodopseudomonas palustris eradicated diverse tumours in immunocompromised and immunocompetent animal models via thrombosis and necrosis, highlighting the therapeutic potential of tumour-resident bacteria.

Seigo Iwata
Taisei Nishiyama
Eijiro Miyako
ResearchOpen Access05 Aug 2025
Nature Biomedical Engineering

P: 1-16
Transfer learning from custom-tailored virtual molecular databases to real-world organic photosensitizers for catalytic activity prediction

The scarcity of experimental training data limits machine learning applications in catalysis research. Here, the authors demonstrate that graph convolutional network models pretrained on a molecular topological index significantly enhance the prediction of catalytic activity, showcasing a promising transfer-learning strategy that leverages self-generated virtual molecular databases.

Naoki Noto
Taiki Nagano
Susumu Saito
ResearchOpen Access01 Oct 2025
Communications Chemistry

Volume: 8, P: 1-8
Grafting of iPS cell-derived tenocytes promotes motor function recovery after Achilles tendon rupture

Tendon self-renewal occurs rarely and reconstructive surgery comes with significant limitations. Here the authors present an induced pluripotent stem cell-based method to generate tenocytes, analyze their developmental trajectory using scRNA-seq, and demonstrate their contribution to motor function recovery after Achilles tendon injury via engraftment and paracrine effects.

Taiki Nakajima
Akihiro Nakahata
Makoto Ikeya
ResearchOpen Access18 Aug 2021
Nature Communications

Volume: 12, P: 1-12
Diet-induced insulin resistance in mice lacking adiponectin/ACRP30

Norikazu Maeda
Iichiro Shimomura
Yuji Matsuzawa
Research17 Jun 2002
Nature Medicine

Volume: 8, P: 731-737
In vivo imaging of clock gene expression in multiple tissues of freely moving mice

The circadian rhythms of peripheral clocks are difficult to study. Here the authors demonstrate a technique to image clock gene expression simultaneously in various tissues of freely moving mice, and use it to show that a long duration light pulse resets the rhythms in the olfactory bulb faster than other tissues.

Toshiyuki Hamada
Kenneth Sutherland
Ken-ichi Honma
ResearchOpen Access10 Jun 2016
Nature Communications

Volume: 7, P: 1-13
Giant nanomechanical energy storage capacity in twisted single-walled carbon nanotube ropes

A single-walled carbon nanotube spring stores three times more mechanical energy than a lithium-ion battery, while offering wide temperature stability and posing no explosion risk.

Shigenori Utsumi
Sanjeev Kumar Ujjain
Katsumi Kaneko
ResearchOpen Access16 Apr 2024
Nature Nanotechnology

Volume: 19, P: 1007-1015
Mapping marine debris encountered by albatrosses tracked over oceanic waters

Bungo Nishizawa
Jean-Baptiste Thiebot
Yutaka Watanuki
ResearchOpen Access25 May 2021
Scientific Reports

Volume: 11, P: 1-7
Iminium catalysis meets Diels–Alderase

In the organocatalytic Diels–Alder (DA) reactions, a simple amine is used as a catalyst to form an iminium adduct as an electron-withdrawing group that speeds up reaction with the diene. Now iminium catalysis is identified in Diels–Alderase (DAase) reactions, enabling to substantially broaden the DAase platform.

Naoki Kato
Shingo Nagano
News & Views26 Mar 2025
Nature Catalysis

Volume: 8, P: 202-203
Influence of hospital capabilities and prehospital time on outcomes of thrombectomy for stroke in Japan from 2013 to 2016

Ai Kurogi
Daisuke Onozuka
Masayuki Yokota
ResearchOpen Access28 Feb 2022
Scientific Reports

Volume: 12, P: 1-17
A retrospective analysis of the relationship between anti-cyclic citrullinated peptide antibody and the effectiveness of abatacept in rheumatoid arthritis patients

Daihei Kida
Nobunori Takahashi
Toshihisa Kojima
ResearchOpen Access12 Nov 2020
Scientific Reports

Volume: 10, P: 1-9
Specific Light-Up System for Protein and Metabolite Targets Triggered by Initiation Complex Formation

Hiroto Fujita
Yuka Kataoka
Masayasu Kuwahara
ResearchOpen Access09 Nov 2017
Scientific Reports

Volume: 7, P: 1-8
Co-ordinated ocular development from human iPS cells and recovery of corneal function

A protocol has been developed to use human induced pluripotent stem cells to obtain a self-formed ectodermal autonomous multizone, which includes distinct cell lineages of the eye, including the ocular surface ectoderm, lens, neuro-retina, and retinal pigment epithelium that can be expanded to form a functional corneal epithelium when transplanted to an animal model of corneal visual impairment.

Ryuhei Hayashi
Yuki Ishikawa
Kohji Nishida
Research09 Mar 2016
Nature

Volume: 531, P: 376-380
Prepulse inhibition predicts subjective hearing in rats

Naoki Wake
Kotaro Ishizu
Hirokazu Takahashi
ResearchOpen Access23 Sept 2021
Scientific Reports

Volume: 11, P: 1-10
A molecular deletion study with southern hybridization on typical Prader-Willi syndrome (PWS) patients with various chromosome abnormalities involving 15q11–12 and on an atypical PWS patient with apparently normal karyotype

Tsutomu Kamei
Jun-ichi Hamabe
Norio Niikawa
Research01 Dec 1988
Japanese journal of human genetics

Volume: 33, P: 477-486
Blood pressure during long-term cilostazol-based dual antiplatelet therapy after stroke: a post hoc analysis of the CSPS.com trial

Kazunori Toyoda
Masatoshi Koga
Hiroaki Tanaka
ResearchOpen Access09 Jul 2024
Hypertension Research

Volume: 47, P: 2238-2249
How do β₃-adrenoceptor agonists work in the bladder?

Data from an immunohistochemical study reveal abundant expression of β₃-adrenoceptors on cholinergic nerves of the human urinary bladder. This finding suggests that the effects of β₃-adrenoceptor agonists on overactive bladder are not mediated simply through direct inhibition of bladder smooth muscle cell excitability, but might involve a more complex mechanism, including an inhibitory effect on cholinergic nerve terminals.

Yasuhiko Igawa
Naoki Aizawa
News & Views21 Mar 2017
Nature Reviews Urology

Volume: 14, P: 330-332
Circulating thrombospondin 2 as a predictor of hepatocellular carcinoma in hepatitis B patients undergoing nucleos(t)ide analog therapy

Taiki Okumura
Takefumi Kimura
Takeji Umemura
ResearchOpen Access26 Oct 2024
Scientific Reports

Volume: 14, P: 1-9
A small-molecule inhibitor of SOD1-Derlin-1 interaction ameliorates pathology in an ALS mouse model

Amyotrophic lateral sclerosis (ALS) is a neurological disease that leads to loss of voluntary muscle movement. Here, the authors screen for molecules that disrupt interaction between SOD1, a protein linked to ALS, and Derlin-1, and find an inhibitor that reduces pathology in an ALS mouse model.

Naomi Tsuburaya
Kengo Homma
Hidenori Ichijo
ResearchOpen Access10 Jul 2018
Nature Communications

Volume: 9, P: 1-12
Arf6 regulates tumour angiogenesis and growth through HGF-induced endothelial β1 integrin recycling

Targetting tumour angiogenesis is a useful strategy to reduce tumour burden; however, the clinical benefits of anti-angiogenetic drugs are modest. Here, the authors show that HGFR signalling, which contributes to tumour angiogenesis, requires Arf6 and that blocking Arf6 can lead to reduced tumour growth in mice.

Tsunaki Hongu
Yuji Funakoshi
Yasunori Kanaho
Research04 Aug 2015
Nature Communications

Volume: 6, P: 1-12
Sarcomere gene variants did not improve cardiac function in pediatric patients with dilated cardiomyopathy from Japanese cohorts

Keiichi Hirono
Yukiko Hata
Fukiko Ichida
ResearchOpen Access16 Dec 2024
Scientific Reports

Volume: 14, P: 1-14
Dichloroacetate reduces cisplatin-induced apoptosis by inhibiting the JNK/14-3-3/Bax/caspase-9 pathway and suppressing caspase-8 activation via cFLIP in murine tubular cells

Hideki Kimura
Kazuko Kamiyama
Masayuki Iwano
ResearchOpen Access16 Oct 2024
Scientific Reports

Volume: 14, P: 1-19
Intensive or standard blood pressure control in patients with a history of ischemic stroke: RESPECT post hoc analysis

A total of 1074 patients with a history of ischemic stroke enrolled in The Recurrent Stroke Prevention Clinical Outcome (RESPECT) Study were assigned to intensive blood pressure (BP) control group (blood pressure < 120/80 mmHg) or standard blood pressure control group (blood pressure < 140/90 mmHg) and were followed up for a mean of 3.9 years. Seventy-eight first recurrent strokes occurred, including 70 ischemic stroke and 8 intracerebral hemorrhage. Intensive treatment did not change annual risk of ischemic stroke (1.74% vs. 1.75%, P = 0.999), but markedly reduced risk of hemorrhagic stroke (0.00% vs. 0.39%, P = 0.005). Beneficial effect of intensive BP control were observed for risk of hemorrhagic stroke in the patients with a history of ischemic stroke.

Kazuo Kitagawa
Hisatomi Arima
Seigo Nakada
Research04 Mar 2022
Hypertension Research

Volume: 45, P: 591-601
DMY is a Y-specific DM-domain gene required for male development in the medaka fish

Masaru Matsuda
Yoshitaka Nagahama
Mitsuru Sakaizumi
Research12 May 2002
Nature

Volume: 417, P: 559-563
An integrated screening system for the selection of exemplary substrates for natural and engineered cytochrome P450s

Naoki Kanoh
Ayano Kawamata-Asano
Shunji Takahashi
ResearchOpen Access02 Dec 2019
Scientific Reports

Volume: 9, P: 1-13
A prospective cohort study of periostin as a serum biomarker in patients with idiopathic pulmonary fibrosis treated with nintedanib

Masaki Okamoto
Kiminori Fujimoto
Tomoaki Hoshino
ResearchOpen Access27 Dec 2023
Scientific Reports

Volume: 13, P: 1-15
Pathophysiological changes of the lower urinary tract behind voiding dysfunction in streptozotocin-induced long-term diabetic rats

Kazuki Masuda
Naoki Aizawa
Hiroshi Fukuhara
ResearchOpen Access06 Mar 2020
Scientific Reports

Volume: 10, P: 1-9
A multi-ethnic meta-analysis identifies novel genes, including ACSL5, associated with amyotrophic lateral sclerosis

Gen Sobue, Masao Nagasaki and colleagues report a genome-wide association study for amyotrophic lateral sclerosis (ALS) in a large, multi-ethnic cohort comprising Japanese, Chinese, and European ancestry populations. They find a significant association to variants within the ACSL5 gene and identify novel associations with 4 additional genes using a gene-based approach.

Ryoichi Nakamura
Kazuharu Misawa
Gen Sobue
ResearchOpen Access23 Sept 2020
Communications Biology

Volume: 3, P: 1-9
Evaluation of the collagen-binding properties and virulence of killed Streptococcus mutans in a silkworm model

Yuto Suehiro
Ryota Nomura
Kazuhiko Nakano
ResearchOpen Access18 Feb 2022
Scientific Reports

Volume: 12, P: 1-12
Postischemic administration of angiotensin II type 1 receptor blocker reduces cerebral infarction size in hypertensive rats

Emi Omura-Matsuoka
Yoshiki Yagita
Kazuo Kitagawa
Research08 May 2009
Hypertension Research

Volume: 32, P: 548-553
Comparative analysis of necrotizing enterocolitis in preterm infants born in Japan and born to mothers of Japanese ethnicity in California

Satoshi Kusuda
Mihoko V. Bennett
Asao Yara
ResearchOpen Access22 Mar 2025
Scientific Reports

Volume: 15, P: 1-11
The effects of phytochrome-mediated light signals on the developmental acquisition of photoperiod sensitivity in rice

Yoshihiro Yoshitake
Takayuki Yokoo
Takatoshi Tanisaka
ResearchOpen Access09 Jan 2015
Scientific Reports

Volume: 5, P: 1-11
An ENU-induced splice site mutation of mouse Col1a1 causing recessive osteogenesis imperfecta and revealing a novel splicing rescue

Koichi Tabeta
Xin Du
Bruce Beutler
ResearchOpen Access15 Sept 2017
Scientific Reports

Volume: 7, P: 1-13
Age-specific assessment of initial hemoglobin levels and shock index for predicting life-saving interventions in pediatric blunt liver and spleen injuries

Tetsuya Yumoto
Takafumi Obara
Tamotsu Gotou
ResearchOpen Access12 Mar 2025
Scientific Reports

Volume: 15, P: 1-10
Relationship between the lower limit of systolic blood pressure target and kidney function decline in advanced chronic kidney disease: an instrumental variable analysis from the REACH-J CKD cohort study

Shimon Kurasawa
Yoshinari Yasuda
Kiyoyuki Tokuyama
Research18 Jul 2023
Hypertension Research

Volume: 46, P: 2478-2487
New reference values for ultrasound fetal biometry in Japanese population and comparison with other studies

Sumito Nagasaki
Keisuke Ishii
Hirokazu Yorioka
ResearchOpen Access20 Aug 2025
Scientific Reports

Volume: 15, P: 1-12
Identifying transcription factors that reduce wood recalcitrance and improve enzymatic degradation of xylem cell wall in Populus

Chiaki Hori
Naoki Takata
Dan Cullen
ResearchOpen Access16 Dec 2020
Scientific Reports

Volume: 10, P: 1-13
Predictors for clinical effectiveness of baricitinib in rheumatoid arthritis patients in routine clinical practice: data from a Japanese multicenter registry

Nobunori Takahashi
Shuji Asai
Toshihisa Kojima
ResearchOpen Access14 Dec 2020
Scientific Reports

Volume: 10, P: 1-10
Home blood pressure-lowering effect of esaxerenone vs trichlormethiazide for uncontrolled hypertension: a prespecified subanalysis of the EXCITE-HT randomized controlled study by age subgroup

A subgroup analysis of the EXCITE-HT study according to age (<65 and ≥65 years) showed that esaxerenone achieved the pre-defined non-inferiority margin to trichlormethiazide in its BP-lowering effect regardless of age. In patients aged ≥65 years, esaxerenone achieved the superiority margin to trichlormethiazide in lowering SBP.

Kazuomi Kario
Hiroyuki Ohbayashi
Mitsuru Ohishi
ResearchOpen Access28 Mar 2025
Hypertension Research

Volume: 48, P: 1586-1598
Serum autotaxin is a prognostic indicator of liver-related events in patients with non-alcoholic fatty liver disease

Iwadare et al. investigate the value of serum autotaxin levels in predicting liver-related events within a retrospective cohort of 309 biopsy-proven NAFLD patients. Multivariate Cox proportional hazards models identify autotaxin levels and advanced fibrosis as independent predictive factors.

Takanobu Iwadare
Takefumi Kimura
Takeji Umemura
ResearchOpen Access16 Apr 2024
Communications Medicine

Volume: 4, P: 1-9
Development of a chub mackerel with less-aggressive fry stage by genome editing of arginine vasotocin receptor V1a2

Hirofumi Ohga
Koki Shibata
Michiya Matsuyama
ResearchOpen Access23 Feb 2023
Scientific Reports

Volume: 13, P: 1-13
1,3a,6a-Triazapentalene derivatives as photo-induced cytotoxic small fluorescent dyes

Photoactive dyes can show promising cytotoxicity via reactive oxygen species generated by photoirradiation, however, the cytotoxicity of small molecule dyes is typically weak. Here, the authors develop 1,3a,6a-triazapentalene derivatives exhibiting selective and efficient photo-induced cytotoxicity.

Daisuke Tsuji
Atsushi Nakayama
Kosuke Namba
ResearchOpen Access22 Feb 2023
Communications Chemistry

Volume: 6, P: 1-11
Correction: “The 5th edition of The World Health Organization Classification of Haematolymphoid Tumours: Lymphoid Neoplasms” Leukemia. 2022 Jul;36(7):1720–1748

Rita Alaggio
Catalina Amador
Wei-Li Zhao
Amendments and CorrectionsOpen Access19 Jul 2023
Leukemia

Volume: 37, P: 1944-1951
Does surgery improve neurological outcomes in older individuals with cervical spinal cord injury without bone injury? A multicenter study

Satoshi Nori
Kota Watanabe
Satoshi Kato
Research11 Jun 2022
Spinal Cord

Volume: 60, P: 895-902
Prevalence and treatment of LUTS in patients with Parkinson disease or multiple system atrophy

Lower urinary tract symptoms (LUTS) are common comorbidities in patients with Parkinson disease, or multiple system atrophy, and these can have considerable negative effects on patients' quality of life. In this Review, the authors describe the prevalence, diagnosis and management of LUTS in patients with PD or MSA, including the key differences in LUTS between patients with these disorders, which can, in some patients, enable a differential diagnosis.

Teruyuki Ogawa
Ryuji Sakakibara
Naoki Yoshimura
Reviews13 Dec 2016
Nature Reviews Urology

Volume: 14, P: 79-89

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