Nature Search

Author Correction: Hepatorenal syndrome

Pere Ginès
Elsa Solà
Patrick S. Kamath
Amendments and Corrections15 Oct 2018
Nature Reviews Disease Primers

Volume: 4, P: 1
Global burden of amphetamine, cannabis, cocaine and opioid use in 204 countries, 1990–2023: a Global Burden of Disease Study

Global Burden of Disease estimates show that between 1990 and 2023, the prevalence and burden of drug use disorders, inclusive of amphetamine, cannabis, cocaine and opioid use, have been increasing in high-income countries, particularly in the USA.

Jiseung Kang
Hyeon Jin Kim
Dong Keon Yon
Research16 Jan 2026
Nature Medicine

P: 1-18
Global, regional, and national burden of chronic respiratory diseases and impact of the COVID-19 pandemic, 1990–2023: a Global Burden of Disease study

Estimates from the Global Burden of Disease study reveal declines in chronic respiratory disease mortality between 1990 and 2023—especially during the COVID-19 pandemic—but the burdens on people affected remain substantial.

Jiyeon Oh
Soeun Kim
Dong Keon Yon
Research06 Jan 2026
Nature Medicine

Volume: 32, P: 197-223
Detection of undiagnosed liver cirrhosis via AI-enabled electrocardiogram: a pragmatic, cluster-randomized clinical trial

In a trial involving 45 clinics and 15,596 visits, the use of an AI-based screening tool applied to ECG for opportunistic detection of advanced chronic liver disease led to a significant increase in new diagnoses compared to the standard workflow.

Douglas A. Simonetto
David Rushlow
Vijay H. Shah
Research17 Dec 2025
Nature Medicine

Volume: 32, P: 160-167
Characterising acute and chronic care needs: insights from the Global Burden of Disease Study 2019

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

Cecilia Anza-Ramirez
J. Jaime Miranda
Yves Miel H. Zuniga
ResearchOpen Access07 May 2025
Nature Communications

Volume: 16, P: 1-36
Genomics reveals historic and contemporary transmission dynamics of a bacterial disease among wildlife and livestock

The role of wild elk in the spread and persistence of bovine brucellosis in the Great Yellowstone area is unclear. Here, Kamath et al. analyse the genomic sequences of 245 Brucella abortusisolates from elk, bison and cattle, supporting the idea that elk is an important reservoir and source of livestock infections.

Pauline L. Kamath
Jeffrey T. Foster
Paul C. Cross
ResearchOpen Access11 May 2016
Nature Communications

Volume: 7, P: 1-10
GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie
ResearchOpen Access17 May 2023
Nature

Volume: 617, P: 764-768
Does nadolol improve the efficacy of endoscopic variceal ligation in the treatment of variceal bleeding?

Patrick S Kamath
Vijay Shah
Comments & Opinion01 Jun 2005
Nature Clinical Practice Gastroenterology & Hepatology

Volume: 2, P: 254-255
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
Hematological malignancy manifesting as ascites

Konstantinos N Lazaridis
Susan C Abraham
Patrick S Kamath
Reviews01 Feb 2005
Nature Clinical Practice Gastroenterology & Hepatology

Volume: 2, P: 112-116
Clinical trial design, biomarkers and end points in metabolic and alcohol-related liver disease

Metabolic and alcohol-related liver disease presents challenges in clinical trials due to complex pathophysiology. This Review discusses noninvasive imaging, serum biomarkers and adaptive designs as modalities to enhance patient-centric end points, aiming to refine diagnostics and improve drug development.

Luis Antonio Diaz
Maja Thiele
Rohit Loomba
Reviews26 Sept 2025
Nature Reviews Gastroenterology & Hepatology

Volume: 22, P: 866-884
Mutations in SEC63 cause autosomal dominant polycystic liver disease

Sonia Davila
Laszlo Furu
Stefan Somlo
Research09 May 2004
Nature Genetics

Volume: 36, P: 575-577
Control of osteocyte dendrite formation by Sp7 and its target gene osteocrin

The molecular circuitry that drives dendrite formation during osteocytogenesis remains poorly understood. Here the authors show that deletion of Sp7, a gene linked to rare and common skeletal disease, in mature osteoblasts and osteocytes causes severe defects in osteocyte dendrites.

Jialiang S. Wang
Tushar Kamath
Marc N. Wein
ResearchOpen Access01 Nov 2021
Nature Communications

Volume: 12, P: 1-20
Author Correction: Tau molecular diversity contributes to clinical heterogeneity in Alzheimer’s disease

Simon Dujardin
Caitlin Commins
Bradley T. Hyman
Amendments and Corrections29 Jan 2021
Nature Medicine

Volume: 27, P: 356
Evidence for 28 genetic disorders discovered by combining healthcare and research data

By integrating healthcare and exome-sequencing data from parent–offspring trios of patients with developmental disorders, 28 genes that had not previously been associated with developmental disorders were identified.

Joanna Kaplanis
Kaitlin E. Samocha
Kyle Retterer
Research14 Oct 2020
Nature

Volume: 586, P: 757-762
Hepatorenal syndrome

Hepatorenal syndrome (HRS) is defined as severe kidney functional impairment that occurs in patients with liver cirrhosis. This Primer discusses new diagnostic criteria of acute kidney injury in the context of HRS and also covers pathophysiology and management of this serious disorder.

Pere Ginès
Elsa Solà
Patrick S. Kamath
Reviews13 Sept 2018
Nature Reviews Disease Primers

Volume: 4, P: 1-17
The contribution of X-linked coding variation to severe developmental disorders

Developmental disorders (DDs) are more prevalent in males, thought to be due to X-linked genetic variation. Here, the authors investigate the burden of X-linked coding variants in 11,044 DD patients, showing that this contributes to ~6% of both male and female cases and therefore does not solely explain male bias in DDs.

Hilary C. Martin
Eugene J. Gardner
Matthew E. Hurles
ResearchOpen Access27 Jan 2021
Nature Communications

Volume: 12, P: 1-13
High-resolution epitope mapping and characterization of SARS-CoV-2 antibodies in large cohorts of subjects with COVID-19

Using a high throughput, random bacterial peptide display approach applied to patient serum samples, Haynes, Kamath, Bozekowski et al identify the antigens and epitopes that elicit a SARS-CoV-2 humoral response. They identify differences depending on disease severity and further in silico analysis suggests decreased epitope signal for Q677P but not for D614G mutant SARSCoV-2 strains.

Winston A. Haynes
Kathy Kamath
John C. Shon
ResearchOpen Access22 Nov 2021
Communications Biology

Volume: 4, P: 1-14
Author Correction: GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie
Amendments and CorrectionsOpen Access11 Jul 2023
Nature

Volume: 619, P: E61
Screening for fibrosis to diagnose liver diseases early: the LIVERSCREEN project

Pere Ginès
Maja Thiele
Aleksander Krag
Correspondence31 Mar 2023
Nature Medicine

Volume: 29, P: 774-775
Predicting opioid consumption after surgical discharge: a multinational derivation and validation study using a foundation model

Chris Varghese
Luke Peters
Caroline Reinke
ResearchOpen Access26 Aug 2025
npj Digital Medicine

Volume: 8, P: 1-16
Designing clinical trials to address alcohol use and alcohol-associated liver disease: an expert panel Consensus Statement

Alcohol-associated liver disease is the main cause of liver-related morbidity and mortality globally. This Consensus Statement makes recommendations for the design, best practice and conduct of clinical trials to evaluate the effects of alcohol use in alcohol-associated liver disease and alcohol use disorder.

Brian P. Lee
Katie Witkiewitz
Mack C. Mitchell
Reviews07 Jun 2024
Nature Reviews Gastroenterology & Hepatology

Volume: 21, P: 626-645
Tau molecular diversity contributes to clinical heterogeneity in Alzheimer’s disease

A molecular analysis of tau from patients with sporadic Alzheimer’s disease reveals striking diversity in biochemical properties between patients, which influences seeding activity and correlates with the aggressiveness of the disease.

Simon Dujardin
Caitlin Commins
Bradley T. Hyman
Research22 Jun 2020
Nature Medicine

Volume: 26, P: 1256-1263
Screening for liver fibrosis: lessons from colorectal and lung cancer screening

In this Perspective, Ginès and colleagues discuss liver fibrosis screening programmes using insights from colorectal and lung cancer screening.

Maja Thiele
Patrick S. Kamath
Pere Ginès
Reviews13 Mar 2024
Nature Reviews Gastroenterology & Hepatology

Volume: 21, P: 517-527
Metrics reloaded: recommendations for image analysis validation

Metrics Reloaded is a comprehensive framework for guiding researchers in the problem-aware selection of metrics for common tasks in biomedical image analysis.

Lena Maier-Hein
Annika Reinke
Paul F. Jäger
Reviews12 Feb 2024
Nature Methods

Volume: 21, P: 195-212
Disparities in steatosis prevalence in the United States by Race or Ethnicity according to the 2023 criteria

Díaz et al. estimate the prevalence of steatotic liver disease (SLD) in adults in the United States. Increased waist circumference, excess weight, abnormal glucose metabolism, and hypertension are associated with a higher risk of advanced fibrosis in SLD, with sex, hispanic ethnicity and lack of health insurance associated with certain types.

Luis Antonio Díaz
Jeffrey V. Lazarus
Juan Pablo Arab
ResearchOpen Access29 Oct 2024
Communications Medicine

Volume: 4, P: 1-11
Acute-on-chronic liver failure in cirrhosis

Patients with cirrhosis can develop acute-on-chronic liver failure, a syndrome characterized by acute decompensation, organ failure and high short-term mortality. Arroyo et al. discuss the mechanisms, diagnosis and management of this evolving concept in the field of liver disease.

Vicente Arroyo
Richard Moreau
Bernd Schnabl
Reviews09 Jun 2016
Nature Reviews Disease Primers

Volume: 2, P: 1-18
Antibody epitope repertoire analysis enables rapid antigen discovery and multiplex serology

Kathy Kamath
Jack Reifert
Patrick S. Daugherty
ResearchOpen Access24 Mar 2020
Scientific Reports

Volume: 10, P: 1-9
Altered Treg and cytokine responses in RSV-infected infants

Allison F. Christiaansen
Muhammad A. Syed
Steven M. Varga
Research21 Jun 2016
Pediatric Research

Volume: 80, P: 702-709
Clinical and molecular correlates from a predominantly adult cohort of patients with short telomere lengths

Abhishek A. Mangaonkar
Alejandro Ferrer
Mrinal M. Patnaik
CorrespondenceOpen Access22 Oct 2021
Blood Cancer Journal

Volume: 11, P: 1-4
Functional validation of TERT and TERC variants of uncertain significance in patients with short telomere syndromes

Alejandro Ferrer
Abhishek A. Mangaonkar
Mrinal M. Patnaik
CorrespondenceOpen Access17 Nov 2020
Blood Cancer Journal

Volume: 10, P: 1-5

Search

Author Correction: Hepatorenal syndrome

Global burden of amphetamine, cannabis, cocaine and opioid use in 204 countries, 1990–2023: a Global Burden of Disease Study

Global, regional, and national burden of chronic respiratory diseases and impact of the COVID-19 pandemic, 1990–2023: a Global Burden of Disease study

Detection of undiagnosed liver cirrhosis via AI-enabled electrocardiogram: a pragmatic, cluster-randomized clinical trial

Characterising acute and chronic care needs: insights from the Global Burden of Disease Study 2019

Genomics reveals historic and contemporary transmission dynamics of a bacterial disease among wildlife and livestock

GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

Does nadolol improve the efficacy of endoscopic variceal ligation in the treatment of variceal bleeding?

A second update on mapping the human genetic architecture of COVID-19

Hematological malignancy manifesting as ascites

Clinical trial design, biomarkers and end points in metabolic and alcohol-related liver disease

Mutations in SEC63 cause autosomal dominant polycystic liver disease

Control of osteocyte dendrite formation by Sp7 and its target gene osteocrin

Author Correction: Tau molecular diversity contributes to clinical heterogeneity in Alzheimer’s disease

Evidence for 28 genetic disorders discovered by combining healthcare and research data

Hepatorenal syndrome

The contribution of X-linked coding variation to severe developmental disorders

High-resolution epitope mapping and characterization of SARS-CoV-2 antibodies in large cohorts of subjects with COVID-19

Author Correction: GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

Screening for fibrosis to diagnose liver diseases early: the LIVERSCREEN project

Predicting opioid consumption after surgical discharge: a multinational derivation and validation study using a foundation model

Designing clinical trials to address alcohol use and alcohol-associated liver disease: an expert panel Consensus Statement

Tau molecular diversity contributes to clinical heterogeneity in Alzheimer’s disease

Screening for liver fibrosis: lessons from colorectal and lung cancer screening

Metrics reloaded: recommendations for image analysis validation

Disparities in steatosis prevalence in the United States by Race or Ethnicity according to the 2023 criteria

Acute-on-chronic liver failure in cirrhosis

Antibody epitope repertoire analysis enables rapid antigen discovery and multiplex serology

Altered Treg and cytokine responses in RSV-infected infants

Clinical and molecular correlates from a predominantly adult cohort of patients with short telomere lengths

Functional validation of TERT and TERC variants of uncertain significance in patients with short telomere syndromes

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