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Circularized polarized luminescence is promising for photonics, though balancing material and photophysical properties is challenging. Here the authors use a liquid crystal system for chiroptical applications.

Preeclampsia is a serious pregnancy complication, but early identification of women at risk remains difficult due to limited biomarkers. Here, the authors show that cell-free DNA fragmentomics from maternal blood can predict preeclampsia risk early in pregnancy.

The authors revealed that defective sulfation of a cholesterol-derived metabolite drives harmful lipid buildup in cartilage cells, while the sulfated form protects against osteoarthritis.

All-inorganic perovskite solar cells promise strong stability but still suffer from moisture-driven surface damage and limited efficiency. Zhang et al. form a one-dimensional/three-dimensional interface using a tailored salt to stabilize the material and boost performance.

The authors conducted two trials to evaluate the efficacy and safety of NH600001, an etomidate derivative, in gastrointestinal endoscopy. The results showed NH600001 has a sedative effect while reducing the risk of adrenocortical depression.

The arrestin-mediated regulation of signaling through the metabotropic glutamate receptors (mGlus) is fundamental for synapse function. Here, authors report multiple subtype-dependent arrestin binding modes of the mGlus that account for their differential signaling profiles.

Global Burden of Disease analysis found that in 2023, suboptimal diet was estimated to be responsible for 4 million deaths and 97 million morbidity burdens from ischemic heart disease.

Although ketenes are important intermediates in chemical synthesis, the high reactivity of difluoroketene has impeded its controlled generation and practical application. Here, the authors report a transition-metal-free strategy for its mild, in situ production from difluorobromoacetylsilane, enabling cycloadditions, rearrangements and difluoroacetylations.

This study shows that the EBF2 activates brown fat through biomolecular condensation. Disrupting EBF2 condensates impairs thermogenic gene expression, while small molecules that modulate condensate dynamics improve thermogenic programming.

A mesoscopic fluorescence imaging platform incorporating a double-helix phase mask enables realtime 3D mapping of cerebrovascular networks and blood flow dynamics in the living mouse brain under healthy conditions and in glioma.

CRISPR–Cas tools enable genome regulation but are often too large for efficient AAV delivery. Here, authors engineer a compact enhanced TnpB–ωRNA system (enTnpB) as a versatile genome regulation platform and develop a single-AAV regimen, ImmunAct, to activate endogenous cytokines and enhance cancer immunotherapy.

The authors discover a “Yin-Yang” vortex on the (011) surface of UTe₂ under a perpendicular magnetic field by scanning tunneling microscopy/spectroscopy. Via theoretical modeling, they conclude that the observation of this vortex confirms the spin-triplet pairing of UTe₂ and imposes constraints on the d-vector.

The DAMPE satellite observed a universal charge-dependent spectral softening in primary cosmic rays, and ruled out mass-dependent softening with >99.999% confidence.

This study highlights a strategy to additively manufacture lightweight, strong, and ductile heat-resistant aluminum alloys. The partial solid-state amorphization of the nanoprecipitates during high-temperature tension offers an additional toughening mechanism.

The manuscript describes two pathogenic mutations in GTPBP3 that cause defects in mitochondrial tRNA taurine modification, mitochondrial translation, structure and function. Mutant mice reproduce certain clinical features seen in patients and this can be reversed by virus-mediated exogenous expression of Gtpbp3.

Integrating optical properties and conical structural design constructs a radiative cooling textile with self-sustaining spectral selectivity, enabling efficient directional sweat transport that mitigates sweat’s impact on its spectral performance.

Topological phase transitions between two distinct Weyl topological states have thus far proven difficult to find. Here, using a combination of neutron diffraction, transport measurement and first principles calculations, Yang et al show that a magneto-structural transition in the kagome magnet Mn₃Ga exhibits such a topological phase transition.

You, Wang, Xu, Zhao, Peng and colleagues identify endothelial cell-derived extracellular vesicles (c-BEEVs) in the cerebrospinal fluid as a potential biomarker for brain vascular pathology and highlight their role in neurovascular dysfunction.

A programmable photonic quantum processor, Jiuzhang 4.0, incorporates 1,024 high-efficiency squeezed states into a hybrid spatial–temporal encoded 8,176-mode circuit.

A MoSe₂ piezocatalyst with lattice strain upcycles wastewater pollutants into value-added chemicals, offering an environmental and energy solution by accelerating carbon reduction and lowering reaction energy barriers.

By developing frequency locking and time synchronization between independent ultrastable lasers and atomic clocks, twin-field quantum key distribution is demonstrated over 14.2-km turbulent free-space channels, with a secure key rate exceeding the repeaterless capacity bound.

Orbital-selective correlations are crucial in understanding Fe-based superconductors, yet their origins remain debated. Here, the authors propose a band-theory-based mechanism for orbital-selective physics in monolayer FeSe, revealing that antiferromagnetic fluctuations selectively couple to x² − y² orbitals, offering broader insights for orbital-selective systems with four-fold and six-fold symmetry axes.

fMRI-based speaker–listener and speech–brain synchronization analyses reveal a contralateral neural mechanism by which spatial attention shapes selective speech processing in cocktail party listening.

Large-scale atmospheric circulation patterns modulate surface meteorology, enhancing isoprene production and transfer from the sea-surface microlayer to the atmosphere, according to combined emissions and cruise observations.

Selective C–F functionalization of polyfluoroarenes remains a considerable challenge, particularly for controlled and sequential substitution. Now it has been shown that reactivity-tunable pyridine-boryl radicals enable sequential and versatile C–F transformations through a link-and-lose pathway, allowing hydro- and deuterodefluorination, defluorinative arylation and alkylation with spectroscopic observation of key radical intermediates.

Re–Co–Ta–B bulk metallic glasses have high strength, fracture toughness and thermal stability, combining traditionally exclusive properties of metals and ceramics.

Ding et al. present a scaffold-aware foundation model for small-molecule natural products leveraging masked objectives and contrastive learning to enhance taxonomy classification, genome mining and virtual screening in drug discovery.

Cardiovascular surgery and haemodialysis urgently need durable vascular grafts. Here, authors develop a decellularized polymer skeleton-reinforced biotube as a readily-available vascular graft and demonstrate utility in vivo across multiple large animal preclinical models.

A miR-318/FolDH regulatory axis upstream of juvenile hormone controls ovarian development and female fertility in Bactrocera dorsalis.

Single-cell transcriptomics of HPV-related HNSCC identifies cellular states with spatial correlation within ecotypes and distinguishes therapeutic vulnerability of HNSCC.

In this Perspective, members of the Aging Biomarker Consortium outline the X-Age Project, an Aging Biomarker Consortium plan for building standardized aging clocks in China. The authors discuss the project roadmap and its aims of decoding aging heterogeneity, detecting accelerated aging early and evaluating geroprotective interventions.

Rhizoctonia solani delivers its own small RNAs into rice cells to silence the plant’s defense genes. In response, rice employs a long non-coding RNA to counteract this attack, thereby preventing the fungus from silencing the host’s immune genes.

PLA–Pb co-contamination disrupts soil–plant-microbiome interactions and suppresses plant growth, while enriching viral AMGs, including carbohydrate esterases, that may facilitate bioplastic degradation and reshape rhizosphere microbial functions.

Zhang, Han, Tan, Lu, Ma et al. report that kynurenine derived from peritumoural adipose tissue is hijacked by cancer cells to mediate ferroptosis resistance, a process that could potentially be targeted with immunotherapy to inhibit tumour growth.

The human LRP8 protein is a receptor for yellow fever viruses (YFVs). Knockdown of the mosquito orthologue reduces YFV infection in mosquitoes, whereas overexpression of human LRP8 aggravates YFV infection in mice. Purified LRP8 protein blocks YFV infection.

ERAST speeds up homology search and provides a vector database for 1 billion biological sequences.

Measurement-based quantum computing implements quantum algorithms by performing sequences of measurements on special classes of entangled states, such as cluster states. This approach has now been demonstrated on a superconducting quantum processor.