Hydrogen-Deuterium Exchange Mass-Spectrometry (HDX-MS) is a powerful method to study protein conformational dynamics, but peptide-level measurements obscure residue-level detail. The authors present ReX, a statistical approach that infers residue-level significance, outperforms existing methods on unseen data, and reveals distinct conformational signatures of ligand binding.
- Oliver M. Crook
- Nathan Gittens
- Charlotte M. Deane
