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Here authors develop a focused ion beam-scanning electron microscopy tomography strategy that enables accurate 3D reconstruction of organic foulant accumulation within ceramic ultrafiltration membrane pores.

Therapeutic options for patients with renal medullary carcinoma (RMC) are limited. Here the authors report the results of a phase II clinical trial of anti-PD1 nivolumab plus anti-CTLA4 ipilimumab in RMC, associating the activation of a myeloid mimicry program in tumor cells to the rapid disease progression and hyper-progression observed in treated patients.

Organ metabolic crosstalk is vital but challenging to trace. Here, the authors present MSITracer, a computational tool for spatial isotope tracing that reveals inter-organ crosstalk, such as liver–heart fatty acid metabolism and lung-derived glutamine catabolism in tumors.

Diabetic kidney disease (DKD) is the leading cause of end-stage kidney failure. This study shows that prolonged glucagon exacerbates lipid accumulation, promoting renal injury in early DKD, rather than lipid oxidation. Targeting glucagon signaling significantly inhibits DKD progression.

Ligand-targeted nanocarriers are desirable for their potential to enhance precise drug delivery to targeted tissues, but their clinical translation faces challenges like protein corona formation. Here, Li et al. develop surface-galloylated liposomes that enable stable, non-covalent adsorption of antibodies while overcoming protein corona interference.

Intracellular α-ketoglutarate availability dictates energy sensing through regulation of TET–YBX1-dependent AMP-activated protein kinase synthesis, which prevents disulfide stress accumulation and cell death in cancer cells.

Topological polar textures in moiré ferroelectrics have been theoretically predicted but lacked experimental confirmation. Here, the authors observe alternating out-of-plane polarization in domain regions and vortex-like inplane polarization patterns at domain wall boundaries, indicative of a network of merons and antimerons.

The deficiency of MTAP, an enzyme of the adenine salvage pathway, occurs in some cancers. Here the authors perform a small cohort phase II clinical trial with metastatic MTAP-deficient urothelial cancer (UC) and show an increased overall response when comparing to MTAP-proficient UC patients.

Sonodynamic therapy is an emerging non-invasive antitumor strategy, but its efficiency is limited by the rapid electron and hole recombination of traditional semiconductor sonosensitizers under ultrasonic stimulation. Here, the authors address this issue by developing a Zn/Pt dual-site single-atom driven difunctional superimposition-augmented TiO₂-based sonosensitizer.

How obesity causes cardiac dysfunction is not fully understood. Here, the authors show that a high fat diet inhibits the activity of RabGAP AS160 in the heart, causing pathological metabolic remodeling and altering calcium signaling.

Mantle cell lymphoma can be refractory to treatment. Here, the authors used single cell sequencing to study the tumours of patients that were responsive and resistant to treatment and find gains of 17q in resistant tumours, which they attribute to increased expression of Birc5 and validate these findings in mouse models of the disease.

Organic luminophores emit a bright near-infrared afterglow after X-ray irradiation and outperform commercially available radio sensitizers by producing higher levels of singlet oxygen, having potential applications in precision cancer theranostics.

The neuroanatomical heterogeneity of depression is not well understood. Here, the authors identify four latent factors which characterise different patterns of gray matter morphology and are related to clinical symptoms.

Single-cell analysis of gastric cancer samples tracks the cell of origin of metastatic lesions and identifies an independent prognostic signature of the clinical outcome.

Single-cell transcriptomics reveals that the heterogeneity of anti-CD19 CAR T cell infusion products contributes to variability in clinical response, early molecular response and development of immune effector cell-associated neurotoxicity syndrome in patients with large B cell lymphomas.

Due to tumour microenvironment, Fenton reactions have low therapeutic efficiency. Here the authors report on the application of NIR-II hybrid semiconducting nanozymes for combined photothermal therapy and enhanced ferrotherapy with photoacoustic imaging and show application in vivo in tumour models.

The molecular mechanisms of resistance to immune checkpoint therapy remain elusive. Here, the authors perform immunogenomic analysis of TCGA data and data from clinical trials for antiPD-1/PD-L1 therapy and highlight the association of 9p21 loss with a cold tumor microenvironment and resistance to therapy.

Shared neuroanatomical differential factors explain heterogeneous gray matter volume variations in five common psychiatric disorders. These factors are characterized by dissociable cognitive processes, molecular signatures, and connectome-informed epicenters.

To improve the specificity of immunotherapy, here the authors report the design of a semiconducting polymer immunomodulatory nanoparticle with sonodynamic process to remotely release immune-modulators for deep-tissue precision cancer sono-immunotherapy.

Hollow UCNPs with tunable cavity size were synthesized, which can be used as ratiometric luminescent thermometers over a wide temperature range.

The response rate of relapsed/refractory acute myeloid leukemia patients to PD-1 checkpoint blockade is low and unpredictable. Authors here show by single cell RNA sequencing, T cell receptor profiling and genomic analysis that the phenotypes and repertoire of CD8 + T cells and loss of chromosome 7/7q are important determinants of response.

Stable free-standing two-dimensional Bi monolayer (Bismuthene) structures have been predicted theoretically, but never realized experimentally. Here, the authors show a large-scale synthesis of free-standing Bismuthene and its electrocatalytic activity for CO₂ reduction to formate.

A single-cell analysis of tumor-infiltrating T cells from 16 cancer types identifies new T cell subsets and a stress response cell state enriched in tumors resistant to immunotherapy.