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Autophagosome-lysosome fusion is crucial to mitigate nonalcoholic fatty liver disease (NAFLD). Here, the authors demonstrate that CHIP mediates non-degradative ubiquitination of STX17, which enhances SNRAE complex formation, which alleviates NAFLD.

Eom, Peak, Park, Ahn and colleagues reveal and provide a comprehensive resource of 8-oxoguanine modifications in tumour microRNAs and show how they differentially influence malignancy progression in gliomas and hepatocellular carcinoma.

Conventional platforms for electrophysiological recording of organoids have limited recording site density. Here, the authors present the magnetically reshapable 3D liquid metal-based electrode array for high-resolution analysis on neural activities of brain organoids.

A single-metasurface-based holographic light projection covering the whole 360° field of view is realized by optimizing the metasurface design through a neural network and applying 360° structured light for holographic light projection and three-dimensional imaging.

The mechanisms underlying the impact of probiotic supplementation on health remain largely elusive. Here, the authors explore the mechanisms through which living Lactiplantibacillus enhance the healthspan of Caenorhabditis elegans (C. elegans).

Guanidinium doping is shown to enhance the operation of perovskite nanocrystal light-emitting diodes.

The catalytic performance of dilute Pd-in-Au alloys depends on the Pd ensemble size on the bimetallic nanoparticle surface. Here the authors reveal how Pd ensemble formation on Au nanoparticles depends on the deposition sequence and nanoparticle–support wetting interactions, consequently affecting reactivity.

Soft electronic patches worn on the skin of infants or children in intensive-care units have a wide range of capabilities in aiding critical care, including monitoring of hemodynamic parameters, cardiac activity, movement and crying.

Analyses of genome and exome sequencing data identify rare coding and structural variants associated with atrial fibrillation and highlight genetic links between atrial fibrillation and cardiomyopathies.

Artificial ion channels are in demand for ionotronic devices. Here, the authors use layered MXene membranes modified with plasmonic gold nanostars and cellulose nanofibers to convert a thermal gradient into an ion current for photosensitive ion channeling.

Yeom et al. demonstrate that tumour cell-secreted Dilp8/INSL3 activates Lgr3 signalling and modulates expression of distinct feeding hormones such as NUCB1 and sNPF, thereby inducing anorexia in cancer.

A millimetre-scale bioresorbable optoelectronic system with an onboard power supply and a wireless, optical control mechanism is developed for general applications in electrotherapy and specific uses in temporary cardiac pacing.

The impact of obesity on cancer remains insufficiently explored. Here the authors show that in mouse models, dysfunctional adipocytes exhibit low levels of BECN1 which induce YAP/TAZ activity to promote breast and colorectal tumor progression.

Despite significant efforts to improve the thermoelectric properties of polycrystalline SnSe, precise control of texturing and doping is a challenge. Here, the authors report hole doped and highly textured SnSe thin films prepared by low cost, scalable solution processing.

Self-propelling micro/nanomotors represent a therapeutic option for drug delivery. Here the authors report the design and characterization of a biodegradable urease-powered nanomotor containing STING agonist, promoting anti-tumor immune responses in bladder cancer models.

Hepatocellular carcinoma is the most common type of primary liver cancer. Here the authors show an oxygen gradient chip that separates aggressive hepatocellular carcinoma cells from a heterogeneous tumor mass, mirroring the conditions of the portal vein, hepatic artery, and liver.

Alterations of the mTOR signalling pathway are associated with neurodevelopmental defects. Regulators of the mTOR kinase activity are not fully described. Here, the authors show that Tanc2, a scaffolding protein, acts as a direct inhibitor of mTOR kinase activity in the developing mouse brain and cultured human neurons.

Electrochemical pumps can effectively purify and compress hydrogen for subsequent use in energy and industrial applications but struggle with low hydrogen concentrations. Here the authors present an electrochemical pump based on an ion-pair membrane that can produce high-purity hydrogen from a 10% blend in methane.

Adipose tissue has an important role in metabolic homeostasis and undergoes age-related changes contributing to metabolic decline, via mechanisms that remain incompletely explored. Here the authors show that Crtc2 deficiency in adipocytes protects against age-related hyperactivation of the BCAA–mTORC1 axis and metabolic alterations.

Idiopathic pulmonary fibrosis (IPF) is a fatal adult lung disease. Here the authors investigate the functional significance of PDCD5 in club cells as a mediator of lung fibrosis and potential therapeutic target for IPF.

As perovskite-based solar cells are reaching high efficiency, issues of stability and end-of-life become predominant. Here, Kim et al. selectively dissolve the perovskite layer and reuse the electron transport layer to fabricate devices with efficiency and stability comparable to those of the original solar cells.

Aminoacyl-tRNA synthetases possess unique domains. In this study the structure of the vertebrate IARS1 and EARS1 complex reveals that vertebrate IARS1 protects the DNA repair factor BRCA1 from proteolytic degradation via its UBX-fold domain.

Bahn et al explore the role of the lipid raft protein Prominin-1 in liver regeneration. They show that Prominin-1 promotes hepatocyte proliferation after acute liver injury by interacting with the signal transducer GP130, confining it to lipid rafts and activating IL-6 signaling pathway and eventual activation of STAT3.

Schizophrenia is associated with brain ventricular enlargement. Here, the authors show in mice that 22q11 deletion, which is associated with schizophrenia, causes ventricular enlargement and motility abnormalities in cilia lining ventricle walls via a microRNA mechanism.

This study finds the key neurons that respond to 3D objects in the medial preoptic area (MPA). Their photostimulation induces hunting-like behaviors towards toys and prey, showing how the brain organizes behaviors to acquire useful resources.

Agonism of microglial glucagon-like peptide-1 receptor (GLP1R) using a brain-penetrant peptide prevents the generation of neurotoxic astrocytes and ameliorates disease progression in two rodent models of Parkinson’s disease.

A purely quantum electronic liquid on the surface of an electride crystal is reported.

Neural basis of multisensory decision-making is not fully understood. Here authors show that locomotion shifts multisensory decisions in mice from auditory to visual dominance by activating the motor cortex that inhibits auditory output to the parietal cortex. This reveals how state-dependent auditory gating shapes multisensory perception.

Lack of local phase patterning in liquid crystal elastomers has hindered their broad implementation. The authors report a laser-induced dynamic crosslinking approach with allyl sulfide groups to achieve reconfigurable high-resolution patterning of multiple liquid crystalline phases in a single film.

Reactive species of oxygen promote the development of hepatic steatosis. Here, Kim et al. demonstrate that palmitate stimulates macrophage infiltration and increases oxidative stress during steatosis by binding to the TLR4–MD2 complex, which results in the activation of NOX2.

Touch technology holds potential for the development of smartphones and touchscreens, yet the conventional devices are usually built on separate pressure and location sensing units. Kim et al. show a flexible and transparent touch sensor capable of mapping the position and pressure at the same time.

The authors use a nanogap structure in capacitive pressure sensors to suppress fringe fields, the cause of interference. This enables interference-free operation while achieving high resolution and bending insensitivity for human-machine interface applications.

Real-time monitoring human motions normally demands connecting a large number of sensors in a complicated network. To make it simpler, Kim et al. decode the motion of fingers using a flexible sensor attached on wrist that measures skin deformation with the help of a deep-learning architecture.

The presynaptic LAR-RPTPs interact with postsynaptic Slitrks and this contributes to regulating synapse formation. Here, the authors identified the minimal binding regions and determined the crystal structure of the resulting complex and performed functional analysis in cells to determine LAR-RPTP/Slitrk complex-mediated synapse formation.

Osteoclasts are involved in arthritis, and their differentiation depends on RANKL signaling. The author show that the ROS-scavenging protein DJ-1 negatively regulates RANKL signaling and that its ablation increases osteoclast numbers and exacerbates bone damage in mouse models of arthritis.

Mitochondrial function has been linked to immunity but the role of the Krebs’s cycle in regards the immune response is not well characterised. Here the authors show that Krebs’s cycle enzyme ACO2 suppresses immunity via modulation of oxaloacetate and the mitochondrial unfolded protein response.