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The mechanical properties of inorganic solid electrolytes for Li batteries are typically characterised by a high Young’s modulus above 15 GPa and hardness above 1 GPa. Here, authors develop a cost-effective and mechanically compliant inorganic solid electrolyte, with reduced Young’s modulus and hardness of 1.41 and 0.22 GPa, respectively, for practical all-solid-state Li batteries.

Aqueous two-phase systems have potential as biomimetic materials, but often lack stability and are prone to collapse. Here, the authors use interfacial assembly of chitin nanofibres and cellulose nanocrystals to prepare a biobased system with permeability and switchable motility.

Efficient Kr/Xe separation is crucial for high-tech industries, defense, and aerospace applications. While conventional adsorbents typically capture Xe, their application is hindered by high energy costs during desorption. Here authors present a MOF with synergistic structural dynamics and local flexibility that reverses conventional selectivity, enabling preferential adsorption of Kr at room temperature.

The development of advanced electrocatalysts with high efficiency and longevity is essential to alleviate the energy crisis. Here, the authors report an atomic editing strategy to access atomically dispersed, heteronuclear triatomic Fe and Co sites to endow improved activity and stability.

Zhuang, Zi et al. identify cyclin-dependent kinase 3 (CDK3) as a driver of neuron loss in Alzheimer’s disease that is associated with brain atrophy and memory decline in mice. Inhibition of CDK3 (BMX330) is shown to limit neuronal loss and improve cognition.

The coffee-ring effect has been a challenge for scalable fabrication and deployment of organic photovoltaics. Here, the authors employ a fluorinated rheology modifier to modulate the rheological properties and improve wettability, achieving an efficiency of 17.85% in green-printed solar modules.

Global air connectivity shapes where multinational firms locate subsidiaries, especially in knowledge-intensive sectors, by reducing coordination frictions. Eigenvector centrality emerges as the strongest predictor of a city’s attractiveness for foreign investment.

Solid-state sodium metal batteries with oxide solid-state electrolytes still face interfacial challenges. Here, authors report an electroinitiated polymerization strategy that heals interfaces, enhances stability, and enables long-life performance without external pressure.

Streptococcus equi subsp. zooepidemicus imports glucose via the bacterial mannose phosphotransferase system (PTS_man), which inhibits stringent response, supports growth in cerebrospinal fluid and promotes brain damage during meningitis.

Two groups of ammonia-oxidizing archaea drive marine nitrification. Stuehrenberg et al. reveal that their distribution reflects substrate use, with one relying on urea and the other on ammonia to maintain nitrification in open-ocean waters.

MedSegX is a vision foundation model for open-world medical image segmentation, and its accompanying dataset covers a large number of segmentation tasks across 39 organs and tissues.

The long-range genomic interactions present in different inbreeds and their hybrid offspring have not been assessed in maize. Here, the authors report conservation and variability of long-range interactions in structurally diverse maize genomes.

During SARS-CoV-2 infection caspase-8 fuels harmful inflammation independent of apoptosis. Genetic loss of caspase-8 reduces cytokine levels, lowers viral load and mitigates disease severity, revealing non-apoptotic caspase-8 as a key driver of severe COVID-19.

Pathogenic variants in UNC13A underlie a novel neurodevelopmental syndrome, with three subtypes defined by distinct genotypes with varying clinical and functional impacts characterized in cellular and animal models.

Integrated multi-omic analyses using samples from the TRACERx study highlight cross-talk between DNA hypermethylation and genomic lesions in non-small cell lung cancer.

The spatial and temporal control of material properties at a distance have been so far achieved with light, heat, or sound. Here, the authors control chemical reactions and further polymerization of composites with an electric field via inverse piezo-effect resulting in multi-stiffness gels.

Artificial neurons typically have functional parameters that are mismatched with their biological counterpart. Here, the authors develop artificial neurons that emulate biological neurons in functions and match their parameters such as signal amplitude, spiking energy, temporal features, and frequency response.

A screen for protein degraders discovers hits by imaging cell survival.

In this work, authors convert fallen leaves into energy harvesters using hygroscopic iron hydrogel, achieving continuous power generation from moisture. The device delivers high current density and power output with potential for lower environmental impact compared to alternative harvesters.

The use of a dimensionally graded 2D perovskite interface and passivation results in perovskite solar cells with very low photovoltage loss.

Lead halide perovskite quantum dots (PQDs) promise applications in optoelectronics but are limited by sensitivity to wet environments. Here the authors develop a Pb-S bonding approach to synthesize PQDs@silica nanodots that are capable of emitting and lasing in aqueous environments for long periods.

Olivine iron phosphate (FePO₄) is widely proposed for electrochemical lithium extraction, but particles with different physical attributes demonstrate varying Li preferences. Here, the authors characterize the electrochemical lithiation and sodiation behavior of a series of FePO₄ particles with different morphology to identify critical features that enhance Li selectivity.

The combination of electrochemistry and photochemistry in the context of organic synthesis is in its infancy. Here, the authors report selective C(sp3)–H arylation/alkylation of alkanes, using Earth-abundant bimetallic transition metal catalysis, under photo- and electrochemical conditions.

The authors fabricate a thermoelectric cooling device based on n-type PbS based material, which exhibits a remarkable cooling temperature difference of 36.9 K at room temperature, and the single-leg power generation efficiency of 8%.

Protein homologs in large databases are rapidly identified with an alignment-free pipeline.

A consensus cell type atlas for the fly brain provides both an intellectual framework and open-source toolchains for brain-scale comparative connectomics.

The efficiency of antibody-based immune checkpoint blockades could be compromised by the intracellular accumulation of checkpoint proteins. Here authors show that a pH-responsive artificial protein that targets PD-L1 to lysosomal degradation could achieve superior therapeutic effect compared to anti-PD-L1 treatment in mouse models of high microsatellite instability colon adenocarcinoma.

Viral tracers play a crucial role in studying neural circuits, but current options are limited in areas like retrograde transduction and astrocytic tropism. Here, the authors demonstrate that AAV11 function as a powerful retrograde viral tracer allowing for analyzing circuit connectivity and shows superior astrocytic tropism compared to the commonly used AAV vectors.

Pectin, as a major component of plant cell walls, has essential roles in various biological processes. Here the authors show that gibberellins signal via DELLA proteins to regulate pectin biosynthesis by attenuating the activity of the TTG2 and MBW complexes.

RhoFold+ is an end-to-end language model-based deep learning method to predict RNA three-dimensional structures of single-chain RNAs from sequences.

Water electrolysis is considered a key reaction for future sustainable fuel generation. Here, authors report a three-dimensional RuIrOx nano-netcage catalyst that shows high activities and efficiencies for pH-universal overall water splitting.

Synthetic microbial communities are suitable for mixed substrates fermentation and long metabolic pathway engineering. Here, the authors combine fermentation experiments with mathematical modeling to reveal the effect of compositional and temporal changes on division of labor in cellulosic ethanol production using two yeast strains.

The authors experimentally realize the control of the topological charge of magnetic skyrmionic structures at room temperature in a Dzyaloshinskii-Moriya interaction (DMI) platform with spatially alternating signs. By modifying the DMI energy landscape through chemisorbed oxygen, a magnetic topological transition is realized.

This study explores how the activity and selectivity of Cu electrodes for CO₂ reduction can be tuned with organic films of different porosity and thickness. As a result, the films increase the local CO partial pressures and surface coverages.

The Crabtree effect affects yeast-based bioproduction. Here, the authors report the development of a Crabtree-negative yeast through introducing the sucrose phosphorolysis pathway, deletion of the phosphoglucose isomerase gene PGI1, and engineering a synthetic energy system to regulate NADH/NAD⁺ ratio.

An increasing number of preclinical and clinical studies have investigated the antitumor efficacy of combined radiotherapy and immunotherapy. Here the authors report that low-dose radiotherapy enhances the antitumor effect of dual VEGFA and PD-L1 blockade in preclinical models of hepatocellular carcinoma.

The m6A reader IGF2BP3 is upregulated in various cancer, including glioblastoma. Here the authors report that IGF2BP3 facilitates NETosis and glioma survival as well as resistance to oncolytic herpes simplex virotherapy.

The authors report a wet-chemical selenization-based anisotropy optimization to control the orientation of the Ag₂Se thin film, achieving a power factor of 30.8 μW cm⁻¹ K⁻² in the thin film and a normalized power density of 1.8 μW cm⁻² K⁻² in the device.

Artificial ion channels have potential in a range of applications, but achieving performance comparable to biological channels has been challenging. Here, the authors report an artificial, light-driven chloride pump, inspired by halorhodopsin, with a helical porphyrin channel array.

Eye tracking techniques enable high-efficient, natural, and effortless human-machine interaction. Here, Zhu et al. proposed a contact lens to track eye movement for wireless eye-machine interaction

Simultaneous electrochemical reduction of CO₂ and H⁺/H₂O is an attractive renewable route to produce syngas mixtures. Here, the authors introduce a ternary Co₃O₄-CDots-C₃N₄ electrocatalyst that couples hydrogen evolution and CO₂ reduction catalysts and achieves cheap, stable and tunable production of syngas.