Nature Search

Changes in phenology mediate vertebrate population responses to temperature globally

Climate change can alter when and how animals grow, breed, and migrate, but it is unclear whether this allows populations to persist. This global study shows that shifts in seasonal timing are key to helping vertebrate species maintain population growth under global warming.

Viktoriia Radchuk
Carys V. Jones
Martijn van de Pol
ResearchOpen Access12 Jan 2026
Nature Communications

Volume: 17, P: 1-14
NLRP3-induced systemic inflammation controls the development of JAK2V617F mutant myeloproliferative neoplasms

In JAK2V617F mutant myeloproliferative neoplasms (MPN), inflammation impacts clinical outcomes. This study uncovers that the NLRP3 inflammasome drives thrombocytosis, granulocytosis, HSPC expansion, splenomegaly, and bone marrow fibrosis in MPN

Ruth-Miriam Koerber
Calvin Krollmann
Lino L. Teichmann
ResearchOpen Access26 Nov 2025
Nature Communications

Volume: 16, P: 1-16
Toxoplasma effector TgROP1 establishes membrane contact sites with the endoplasmic reticulum during infection

The Toxoplasma gondii effector TgROP1 mimics host factors to bind VAPA/B, thereby establishing parasite–host ER contact sites.

Chahat Mehra
Jesús Alvarado Valverde
Lena Pernas
ResearchOpen Access25 Nov 2025
Nature Microbiology

Volume: 10, P: 3331-3345
Nano-second pulsed laser ablation of inconel 718 and MMPCD for simultaneous optimal ablation rate and surface quality

Ahmed Elkaseer
Islam H. Abdelgaliel
Mohamed F. Aly
ResearchOpen Access30 Dec 2024
Scientific Reports

Volume: 14, P: 1-18
H&E-based MSI/MMR testing with AI in colorectal cancer: a multi-centred blinded evaluation

Cher Bass
Foivos Ntelemis
Salim Arslan
ResearchOpen Access15 Dec 2025
npj Digital Medicine

Volume: 9, P: 1-11
Defective mitochondrial COX1 translation due to loss of COX14 function triggers ROS-induced inflammation in mouse liver

Dysfunctions of the mitochondrial OXPHOS system lead to severe human disorders. Here, the authors analyzed a mouse mutant that mimics a mitochondrial disorder patient and find that reactive oxygen species trigger RNA release and inflammatory pathway in liver.

Abhishek Aich
Angela Boshnakovska
Peter Rehling
ResearchOpen Access12 Aug 2024
Nature Communications

Volume: 15, P: 1-20
Defining the landscape of circular RNAs in neuroblastoma unveils a global suppressive function of MYCN

The role of circular RNAs (circRNAs) in modulating gene expression in cancer remains to be investigated. Here, the authors perform whole transcriptome sequencing in 104 primary neuroblastomas and reveal the involvement of MYCN in regulating circRNAs.

Steffen Fuchs
Clara Danßmann
Johannes H. Schulte
ResearchOpen Access04 Jul 2023
Nature Communications

Volume: 14, P: 1-21
Through bonds or contacts? Mapping protein vibrational energy transfer using non-canonical amino acids

Vibrational energy transfer (VET) is essential for protein function as it is responsible for efficient energy dissipation in reaction sites and is linked to pathways of allosteric communication. Here authors equipped a tryptophan zipper with a VET injector and a VET sensor for femtosecond pump probe experiments to map the VET.

Erhan Deniz
Luis Valiño-Borau
Jens Bredenbeck
ResearchOpen Access02 Jun 2021
Nature Communications

Volume: 12, P: 1-8
Threat expectancies in a VR fear conditioning paradigm follow non-linear extinction patterns but are not influenced by intolerance of uncertainty

Markus Grill
Matthias Kloft
Anke Haberkamp
ResearchOpen Access16 Oct 2025
Scientific Reports

Volume: 15, P: 1-13
Stalled developmental programs at the root of pediatric brain tumors

A single-cell transcriptomic atlas from embryonal pons and forebrain provides insights into the developmental origins of pediatric brain tumors. The study identifies impaired differentiation of specific neural progenitors as a common mechanism underlying these cancers.

Selin Jessa
Alexis Blanchet-Cohen
Claudia L. Kleinman
Research25 Nov 2019
Nature Genetics

Volume: 51, P: 1702-1713
Multisecond ligand dissociation dynamics from atomistic simulations

Protein-ligand unbinding processes are out of reach for atomistic simulations due to time-scale involved. Here the authors demonstrate an approach relying on dissipation-corrected targeted molecular dynamics that enables to provide binding and unbinding rates with a speed-up of several orders of magnitude.

Steffen Wolf
Benjamin Lickert
Gerhard Stock
ResearchOpen Access10 Jun 2020
Nature Communications

Volume: 11, P: 1-8
On-tissue dataset-dependent MALDI-TIMS-MS² bioimaging

There is a need for dataset-dependent MS² acquisition in trapped ion mobility spectrometry imaging. Here the authors report spatial ion mobility-scheduled exhaustive fragmentation (SIMSEF) which enables on-tissue metabolite and lipid annotation in mass spectrometry bioimaging studies, and use this to visualise the chemical space in rat brains.

Steffen Heuckeroth
Arne Behrens
Robin Schmid
ResearchOpen Access18 Nov 2023
Nature Communications

Volume: 14, P: 1-9
Complex archaea that bridge the gap between prokaryotes and eukaryotes

This study identifies a clade of archaea that is the immediate sister group of eukaryotes in phylogenetic analyses, and that also has a repertoire of proteins otherwise characteristic of eukaryotes—proteins that would have provided the first eukaryotes with a ‘starter kit’ for the genomic and cellular complexity characteristic of the eukaryotic cell.

Anja Spang
Jimmy H. Saw
Thijs J. G. Ettema
Research06 May 2015
Nature

Volume: 521, P: 173-179
scEpiAge: an age predictor highlighting single-cell ageing heterogeneity in mouse blood

Here, the authors generate a single-cell DNA methylation and transcriptome dataset from mouse peripheral blood samples, spanning a broad range of ages. They next develop scEpiAge, a single-cell DNA methylation age predictor.

Marc Jan Bonder
Stephen J. Clark
Ferdinand von Meyenn
ResearchOpen Access31 Aug 2024
Nature Communications

Volume: 15, P: 1-15
Targeting tumoral heterogeneity in lung cancer: a novel, CT-texture-guided targeted biopsy approach with exome sequencing

Alexander Hertel
Alexander Streuer
Matthias F. Froelich
ResearchOpen Access07 Nov 2025
npj Precision Oncology

Volume: 9, P: 1-11
Rigid tumours contain soft cancer cells

Cervix and breast carcinomas are highly heterogeneous in their mechanical properties across scales. This heterogeneity provides the tumour with stability and room for cell motility.

Thomas Fuhs
Franziska Wetzel
Josef A. Käs
Research29 Sept 2022
Nature Physics

Volume: 18, P: 1510-1519
Serum β-synuclein, neurofilament light chain and glial fibrillary acidic protein as prognostic biomarkers in moderate-to-severe acute ischemic stroke

Lorenzo Barba
Christoph Vollmuth
Markus Otto
ResearchOpen Access28 Nov 2023
Scientific Reports

Volume: 13, P: 1-7
Gene-diet interactions associated with complex trait variation in an advanced intercross outbred mouse line

Complex traits associate with genetic variation and environment and their interaction. Here, the authors study the influence of different diets on trait variability in 1154 outbred mice from an advanced intercross line and find gene-diet interactions associated with spontaneous autoimmunity development in these animals.

Artem Vorobyev
Yask Gupta
Ralf J. Ludwig
ResearchOpen Access10 Sept 2019
Nature Communications

Volume: 10, P: 1-15
Brown-adipose-tissue macrophages control tissue innervation and homeostatic energy expenditure

Macrophages serve important functions in defense and tissue homeostasis. Jung and colleagues demonstrate that a resident population of macrophages controls the innervation of brown adipose tissue and thereby regulates energy use.

Yochai Wolf
Sigalit Boura-Halfon
Steffen Jung
Research01 May 2017
Nature Immunology

Volume: 18, P: 665-674
A new type of microglia gene targeting shows TAK1 to be pivotal in CNS autoimmune inflammation

In this study, the authors generate a new mouse model that allows selective genetic targeting of microglial cells. Using this model, they show that elimination of TGF-β-activated kinase 1 (TAK1) specifically in microglial cells reduces pathology in a mouse model of multiple sclerosis by inhibiting NF-κB, ERK and JNK signaling pathways.

Tobias Goldmann
Peter Wieghofer
Marco Prinz
Research29 Sept 2013
Nature Neuroscience

Volume: 16, P: 1618-1626
Remodeling oncogenic transcriptomes by small molecules targeting NONO

Integrated phenotypic screening and activity-based protein profiling identifies small molecules that decrease the expression of oncogenic transcription factors and suppress cancer cell growth by covalently targeting the RNA-binding protein NONO.

Stefan G. Kathman
Seong Joo Koo
Benjamin F. Cravatt
Research02 Mar 2023
Nature Chemical Biology

Volume: 19, P: 825-836
Alternatively activated macrophages do not synthesize catecholamines or contribute to adipose tissue adaptive thermogenesis

In contrast to previously reported findings, M2-like polarized macrophages are not a source of catecholamines and do not contribute to browning of the fat.

Katrin Fischer
Henry H Ruiz
Christoph Buettner
Research17 Apr 2017
Nature Medicine

Volume: 23, P: 623-630
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
Unanticipated Side Effects of Stratospheric Albedo Modification Proposals Due to Aerosol Composition and Phase

Daniel J. Cziczo
Martin J. Wolf
Ulrike Lohmann
ResearchOpen Access11 Dec 2019
Scientific Reports

Volume: 9, P: 1-7
Cell–cell adhesion and 3D matrix confinement determine jamming transitions in breast cancer invasion

Ilina et al. investigate the balance between cell adhesion and matrix density on patterns of collective breast cancer cell invasion using three-dimensional models of the extracellular matrix, in vivo imaging and in silico modelling

Olga Ilina
Pavlo G. Gritsenko
Peter Friedl
Research24 Aug 2020
Nature Cell Biology

Volume: 22, P: 1103-1115
Expression of the transcription factor ΔFosB in the brain controls sensitivity to cocaine

Max B. Kelz
Jingshan Chen
Eric J. Nestler
Research16 Sept 1999
Nature

Volume: 401, P: 272-276
Correction: Evaluation of p16^INK4a expression as a single marker to select patients with HPV-driven oropharyngeal cancers for treatment de-escalation

Steffen Wagner
Elena-Sophie Prigge
Jens Peter Klussmann
Amendments and CorrectionsOpen Access10 Jun 2021
British Journal of Cancer

Volume: 125, P: 307
Dynamical Binding Modes Determine Agonistic and Antagonistic Ligand Effects in the Prostate-Specific G-Protein Coupled Receptor (PSGR)

Steffen Wolf
Nikolina Jovancevic
Klaus Gerwert
ResearchOpen Access22 Nov 2017
Scientific Reports

Volume: 7, P: 1-15
Galar - a large multi-label video capsule endoscopy dataset

Maxime Le Floch
Fabian Wolf
Franz Brinkmann
ResearchOpen Access20 May 2025
Scientific Data

Volume: 12, P: 1-7
In vivo genome editing and organoid transplantation models of colorectal cancer and metastasis

Metastatic progression of colorectal cancer is modeled in mice using in vivo genome editing and transplantation of engineered organoids.

Jatin Roper
Tuomas Tammela
Ömer H Yilmaz
Research01 May 2017
Nature Biotechnology

Volume: 35, P: 569-576
Ellipsoid zone reflectivity as a functional imaging biomarker for age-related macular degeneration: a MACUSTAR study report

Yannick N. Liermann
Charlotte Behning
N. Zakaria
ResearchOpen Access20 Jun 2025
Scientific Reports

Volume: 15, P: 1-12
An objective comparison of cell-tracking algorithms

This analysis describes the results of three Cell Tracking Challenge editions for examining the performance of cell segmentation and tracking algorithms and provides practical feedback for users and developers.

Vladimír Ulman
Martin Maška
Carlos Ortiz-de-Solorzano
Research30 Oct 2017
Nature Methods

Volume: 14, P: 1141-1152
Mapping of subthalamic nucleus using microelectrode recordings during deep brain stimulation

Nabin Koirala
Lucas Serrano
Muthuraman Muthuraman
ResearchOpen Access06 Nov 2020
Scientific Reports

Volume: 10, P: 1-12
X-linked mental retardation: a comprehensive molecular screen of 47 candidate genes from a 7.4 Mb interval in Xp11

Lars Riff Jensen
Steffen Lenzner
Andreas Walter Kuss
Research13 Sept 2006
European Journal of Human Genetics

Volume: 15, P: 68-75
Active turnover of DNA methylation during cell fate decisions

Recent studies have demonstrated that concomitant activity of de novo methylation and demethylation machineries results in rapid turnover of DNA methylation in certain contexts. The authors review this phenomenon and propose that DNA methylation turnover may facilitate key lineage decisions.

Aled Parry
Steffen Rulands
Wolf Reik
Reviews06 Oct 2020
Nature Reviews Genetics

Volume: 22, P: 59-66
Evaluation of p16^INK4a expression as a single marker to select patients with HPV-driven oropharyngeal cancers for treatment de-escalation

Steffen Wagner
Elena-Sophie Prigge
Jens Peter Klussmann
ResearchOpen Access06 Jul 2020
British Journal of Cancer

Volume: 123, P: 1114-1122
Impact of BMI on patient outcome in acute myeloid leukaemia patients receiving intensive induction therapy: a real-world registry experience

Julius C. Enßle
Sebastian Wolf
Björn Steffen
ResearchOpen Access04 Aug 2023
British Journal of Cancer

Volume: 129, P: 1126-1133
Cytokine-responsive T- and NK-cells portray SARS-CoV-2 vaccine-responders and infection in multiple myeloma patients

Julius C. Enssle
Julia Campe
Evelyn Ullrich
ResearchOpen Access04 Dec 2023
Leukemia

Volume: 38, P: 168-180
Animal models of arrhythmia: classic electrophysiology to genetically modified large animals

Various models of cardiac arrhythmia have been developed in several different animal species to study the mechanisms of disease. In this Review, Clauss and colleagues summarize the advantages and disadvantages of the models and species used in arrhythmia research and provide guidance to investigators planning experiments in this field.

Sebastian Clauss
Christina Bleyer
Stefan Kääb
Reviews20 Mar 2019
Nature Reviews Cardiology

Volume: 16, P: 457-475
Retest variability and patient reliability indices of quantitative fundus autofluorescence in age-related macular degeneration: a MACUSTAR study report

Leon von der Emde
Merten Mallwitz
Thomas Ach
ResearchOpen Access13 Oct 2023
Scientific Reports

Volume: 13, P: 1-12
Individual shear rate therapy (ISRT)—further development of external counterpulsation for decreasing blood pressure in patients with symptomatic coronary artery disease (CAD)

Frauke Picard
Petroula Panagiotidou
Rolf Michael Klein
Research23 Dec 2019
Hypertension Research

Volume: 43, P: 186-196
Bone marrow dendritic cells support the survival of chronic lymphocytic leukemia cells in a CD84 dependent manner

Avital F. Barak
Hadas Lewinsky
Idit Shachar
Research26 Nov 2019
Oncogene

Volume: 39, P: 1997-2008
Relative ellipsoid zone reflectivity and its association with disease severity in age-related macular degeneration: a MACUSTAR study report

Marlene Saßmannshausen
Charlotte Behning
Sarah Thiele
ResearchOpen Access02 Sept 2022
Scientific Reports

Volume: 12, P: 1-12
Comparability of automated drusen volume measurements in age-related macular degeneration: a MACUSTAR study report

Davide Garzone
Jan Henrik Terheyden
N. Zakaria
ResearchOpen Access19 Dec 2022
Scientific Reports

Volume: 12, P: 1-10
Mineralocorticoid Receptor Stimulation Improves Cognitive Function and Decreases Cortisol Secretion in Depressed Patients and Healthy Individuals

Christian Otte
Katja Wingenfeld
Kim Hinkelmann
Research18 Jul 2014
Neuropsychopharmacology

Volume: 40, P: 386-393
Multidimensional differences of right- and left-sided colorectal cancer and their impact on targeted therapies

Marwa Abdel Hamid
Lorenz M. Pammer
Andreas Seeber
ReviewsOpen Access22 Apr 2025
npj Precision Oncology

Volume: 9, P: 1-13
Validating candidate endpoints for intermediate age-related macular degeneration trials in a multi-centre setting—lessons from the MACUSTAR study

Jan Henrik Terheyden
Hannah M. P. Dunbar
N. Zakaria
ReviewsOpen Access05 Feb 2025
Eye

Volume: 39, P: 1031-1039
Author Correction: Comparability of automated drusen volume measurements in age-related macular degeneration: a MACUSTAR study report

Davide Garzone
Jan Henrik Terheyden
N. Zakaria
Amendments and CorrectionsOpen Access07 Mar 2023
Scientific Reports

Volume: 13, P: 1-2
Cystic transformation of focal lesions after therapy is associated with remission but adverse outcome in myeloma

Maximilian Merz
Thomas Hielscher
Jens Hillengass
CorrespondenceOpen Access27 Aug 2019
Blood Cancer Journal

Volume: 9, P: 1-5

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