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Showing 1–50 of 201 results

Advanced filters: Author: Tatsuya Chiba Clear advanced filters

Leveraging large scale deep learning models for diagnosis and visual outcome prediction in retinitis pigmentosa

Tatsuya Nagai
Koya Homma
Takayuki Baba
ResearchOpen Access08 Jan 2026
npj Digital Medicine

P: 1-11
Immune evasion through mitochondrial transfer in the tumour microenvironment

Mitochondria with mutations in their DNA from cancer cells can be transferred to T cells in the tumour microenvironment, which leads to T cell dysfunction and impaired antitumour immunity.

Hideki Ikeda
Katsushige Kawase
Yosuke Togashi
ResearchOpen Access22 Jan 2025
Nature

Volume: 638, P: 225-236
Author Correction: Immune evasion through mitochondrial transfer in the tumour microenvironment

Hideki Ikeda
Katsushige Kawase
Yosuke Togashi
Amendments and CorrectionsOpen Access25 Jul 2025
Nature

Volume: 644, P: E33
Spatial gene expression analysis reveals drivers of extremely early lymph node metastasis in breast cancer

Satoi Nagasawa
Keiko Kajiya
Yutaka Suzuki
ResearchOpen Access23 Jan 2026
npj Breast Cancer

P: 1-12
Publisher Correction: Immune evasion through mitochondrial transfer in the tumour microenvironment

Hideki Ikeda
Katsushige Kawase
Yosuke Togashi
Amendments and CorrectionsOpen Access13 Feb 2025
Nature

Volume: 639, P: E5
Blood DNA virome associates with autoimmune diseases and COVID-19

Analysis of the blood DNA virome in patients with COVID-19 and autoimmune disease associates endogenous HHV-6 (eHHV-6) and high anellovirus load with increased disease risk, most notably for systemic lupus erythematosus. eHHV-6 carriers show a distinct immune response.

Noah Sasa
Shohei Kojima
Yukinori Okada
ResearchOpen Access03 Jan 2025
Nature Genetics

Volume: 57, P: 65-79
Essential oil-derived decomposable polymers via cycloaddition polymerization of silyl ether-linked phenylpropanoids

Phenylpropanoids are an emerging class of bio-based aromatic monomers. Here, the authors report [2 + 2] cycloaddition polymerisations of silyl ether-linked phenylpropanoids to yield polymers capable of decomposing via Diels-Alder reactions or Si-O cleavage, enabling their chemical recycling.

Ryo Nagaya
Tatsuya Seko
Naoki Shida
ResearchOpen Access27 Nov 2025
Nature Communications

Volume: 16, P: 1-10
descSPIM: an affordable and easy-to-build light-sheet microscope optimized for tissue clearing techniques

Poor access to suitable light-sheet microscopes remains a big obstacle for many end-users in biomedical research. Here, the authors present descSPIM, a low-cost, low-expertise light-sheet microscope for routine 3D imaging of cleared samples.

Kohei Otomo
Takaki Omura
Etsuo A. Susaki
ResearchOpen Access12 Jun 2024
Nature Communications

Volume: 15, P: 1-19
Time-lapse monitoring of fertilized human oocytes focused on the incidence of 0PN embryos in conventional in vitro fertilization cycles

Tatsuya Kobayashi
Hiroshi Ishikawa
Makio Shozu
ResearchOpen Access22 Sept 2021
Scientific Reports

Volume: 11, P: 1-7
Functional reconstitution of purified muscarinic receptors and inhibitory guanine nucleotide regulatory protein

Kazuko Haga
Tatsuya Haga
Michio Ui
Research22 Aug 1985
Nature

Volume: 316, P: 731-733
Higher longitudinal brain white matter atrophy rate in aquaporin-4 IgG-positive NMOSD compared with healthy controls

Hiroki Masuda
Masahiro Mori
Satoshi Kuwabara
ResearchOpen Access03 Aug 2023
Scientific Reports

Volume: 13, P: 1-14
Isolation and characterization of mutations in the human holocarboxylase synthetase cDNA

Yoichi Suzuki
Yoko Aoki
Kuniaki Narisawa
Research01 Oct 1994
Nature Genetics

Volume: 8, P: 122-128
Electroporation enables the efficient mRNA delivery into the mouse zygotes and facilitates CRISPR/Cas9-based genome editing

Masakazu Hashimoto
Tatsuya Takemoto
ResearchOpen Access11 Jun 2015
Scientific Reports

Volume: 5, P: 1-8
Deciphering state-dependent immune features from multi-layer omics data at single-cell resolution

A single-cell multiomic immune cell atlas from 235 Japanese, including patients with COVID-19 and healthy individuals, linked with host genetics including germline and somatic mutation, plasma proteomics and metagenomics data reveals that immune cells are dynamically regulated in a cell state-dependent manner.

Ryuya Edahiro
Go Sato
Yukinori Okada
ResearchOpen Access28 Jul 2025
Nature Genetics

Volume: 57, P: 1905-1921
Germline variants of the POLH and RAD51 genes are candidate variants associated with risk of hormone receptor-negative young-onset breast cancer

Shu Yazaki
Rui Kitadai
Kouya Shiraishi
ResearchOpen Access28 Nov 2025
npj Breast Cancer

Volume: 11, P: 1-11
Magnified endoscopy with texture and color enhanced imaging with indigo carmine for superficial nonampullary duodenal tumor: a pilot study

Kenichiro Okimoto
Tomoaki Matsumura
Naoya Kato
ResearchOpen Access20 Jun 2022
Scientific Reports

Volume: 12, P: 1-7
White matter dissection and structural connectivity of the human vertical occipital fasciculus to link vision-associated brain cortex

Tatsuya Jitsuishi
Seiichiro Hirono
Atsushi Yamaguchi
ResearchOpen Access21 Jan 2020
Scientific Reports

Volume: 10, P: 1-14
The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force

Genetic mechanisms influencing COVID-19 susceptibility are not well understood. Here, the authors analyzed whole blood RNA-seq data of 465 Japanese individuals with COVID-19, highlighting thousands of fine-mapped variants affecting expression and splicing of genes, as well as the presence of COVID-19 severity-interaction eQTLs.

Qingbo S. Wang
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access22 Aug 2022
Nature Communications

Volume: 13, P: 1-19
DOCK2 is involved in the host genetics and biology of severe COVID-19

A genome-wide association study highlights a variant in DOCK2, which is common in East Asian populations but rare in Europeans, as a host genetic risk factor for severe COVID-19.

Ho Namkoong
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access08 Aug 2022
Nature

Volume: 609, P: 754-760
Efficacy of Texture and Color Enhancement Imaging in visualizing gastric mucosal atrophy and gastric neoplasms

Tsubasa Ishikawa
Tomoaki Matsumura
Naoya Kato
ResearchOpen Access25 Mar 2021
Scientific Reports

Volume: 11, P: 1-8
Linked color imaging can improve the visibility of superficial non-ampullary duodenal epithelial tumors

Kenichiro Okimoto
Daisuke Maruoka
Naoya Kato
ResearchOpen Access26 Nov 2020
Scientific Reports

Volume: 10, P: 1-8
Clinical and brain functional correlates of instrumental rigidity measurement in Parkinson’s disease

Yoshikazu Nakano
Shigeki Hirano
Satoshi Kuwabara
ResearchOpen Access07 Mar 2025
Scientific Reports

Volume: 15, P: 1-9
Mitochondrial protein C15ORF48 is a stress-independent inducer of autophagy that regulates oxidative stress and autoimmunity

Stress-independent autophagy is less understood than stress-induced autophagy and is important for thymic self-tolerance. Here the authors show that a mitochondrial protein C15ORF48 is important for stress-independent autophagy and alters glutathione metabolism and C15orf48 knockout mice develop autoimmunity and changes to thymic epithelial cells.

Yuki Takakura
Moeka Machida
Noritaka Yamaguchi
ResearchOpen Access01 Feb 2024
Nature Communications

Volume: 15, P: 1-19
Anatomical integration of the sacral–hindlimb unit coordinated by GDF11 underlies variation in hindlimb positioning in tetrapods

The position of limbs varies across vertebrates. Here, the authors show that GDF11 is a key factor in the integration of sacral vertebrae and hindlimb positioning and underlies diversification of the hindlimb position in vertebrates.

Yoshiyuki Matsubara
Tatsuya Hirasawa
Takayuki Suzuki
Research31 Jul 2017
Nature Ecology & Evolution

Volume: 1, P: 1392-1399
Understanding of HLA-conferred susceptibility to chronic hepatitis B infection requires HLA genotyping-based association analysis

Nao Nishida
Jun Ohashi
Masashi Mizokami
ResearchOpen Access19 Apr 2016
Scientific Reports

Volume: 6, P: 1-7
Treatment strategy changes for inflammatory bowel diseases in biologic era: results from a multicenter cohort in Japan, Far East 1000

Takashi Taida
Yuki Ohta
Naoya Kato
ResearchOpen Access21 Aug 2023
Scientific Reports

Volume: 13, P: 1-11
¹³C NMR Assignments of the Methine Carbons in Polypropylene Using Two-Dimensional ¹³C-¹³C INADEQUATE NMR Spectroscopy

Tatsuya Miyatake
Yoshio Kawai
Kunio Hikichi
Research01 Oct 1989
Polymer Journal

Volume: 21, P: 809-814
The long-term effect of biologics in patients with ulcerative colitis emerging from a large Japanese cohort

Yuya Yokoyama
Yuki Ohta
Naoya Kato
ResearchOpen Access06 Dec 2022
Scientific Reports

Volume: 12, P: 1-11
Drawing boundaries between feasible and unfeasible zeolite intergrowths using high-throughput computational screening with synthesis validation

Determining the feasibility of intergrowths between zeolites is investigated using high-throughput atomistic simulations and experimental verification. Interfacial energy is an effective descriptor for identifying the feasibility of zeolite intergrowths and a zincosilicate zeolite intergrowth with three and nine rings is realized by hydrothermal syntheses.

Kota Oishi
Koki Muraoka
Akira Nakayama
Research20 Oct 2025
Nature Materials

Volume: 24, P: 1978-1984
d-Alanine content in the marine edible bivalve Panopea japonica and evaluation of its associated enzyme activities

Mayu Onozato
Tomoya Takaura
Takeshi Fukushima
ResearchOpen Access14 Jul 2025
Scientific Reports

Volume: 15, P: 1-10
The significance of electrical signals in maturing spermatozoa for phosphoinositide regulation through voltage-sensing phosphatase

Membrane potentials in living cells can function as electrical signals. Here, the authors report that spermatozoa utilize their electrical signals during the maturing stage to create appropriate membrane lipids environment that is important for sperm motility.

Takafumi Kawai
Shin Morioka
Yasushi Okamura
ResearchOpen Access24 Aug 2024
Nature Communications

Volume: 15, P: 1-14
EZH1/2 inhibition augments the anti-tumor effects of sorafenib in hepatocellular carcinoma

Yuko Kusakabe
Tetsuhiro Chiba
Naoya Kato
ResearchOpen Access01 Nov 2021
Scientific Reports

Volume: 11, P: 1-14
Hepatic SerpinA1 improves energy and glucose metabolism through regulation of preadipocyte proliferation and UCP1 expression

Lipodystrophy and obesity are associated with insulin resistance and metabolic syndrome accompanied by fat tissue dysregulation. Here, the authors show that SerpinA1, secreted from the liver, activates mitochondrial UCP1 expression through interaction with EphB2 in adipocytes, contributing to increased energy expenditure, improved glucose metabolism and reduced obesity.

Shota Okagawa
Masaji Sakaguchi
Eiichi Araki
ResearchOpen Access12 Nov 2024
Nature Communications

Volume: 15, P: 1-19
Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity

Peripheral blood mononuclear cells from 73 Japanese patients with coronavirus disease 2019 (COVID-19) and 75 healthy controls were analyzed using single-cell transcriptomics. Combining these data with genotyping data highlights the interplay between host genetics and the immune response in modulating disease severity.

Ryuya Edahiro
Yuya Shirai
Yukinori Okada
ResearchOpen Access24 Apr 2023
Nature Genetics

Volume: 55, P: 753-767
Machine learning interatomic potential reveals hydrogen embrittlement origins at general grain boundaries in α-iron

Hydrogen embrittlement is an issue that alloys used in the energy sector must overcome. Here, a machine learning interatomic potential for iron-hydrogen is reported, with large-scale molecular dynamics simulations revealing that hydrogen can suppress >111 < /2 dislocation emission at grain boundaries.

Kazuma Ito
Takashi Otaki
Hideki Mori
ResearchOpen Access26 Dec 2025
Communications Materials

Volume: 7, P: 1-16
Genetic profiles of Barrett’s esophagus and esophageal adenocarcinoma in Japanese patients

Mamoru Tokunaga
Kenichiro Okimoto
Naoya Kato
ResearchOpen Access03 Sept 2021
Scientific Reports

Volume: 11, P: 1-11
TMS-EEG signatures of the effects of transcranial static magnetic field stimulation (tSMS) on cortical excitability

Sumiya Shibata
Hideaki Onishi
Tatsuya Mima
ResearchOpen Access27 Sept 2024
Scientific Reports

Volume: 14, P: 1-10
Investigation of risk factors for metachronous recurrence in patients with early gastric adenocarcinoma by miRNA–mRNA integral profiling

Ariki Nagashima
Kenichiro Okimoto
Naoya Kato
ResearchOpen Access11 Nov 2023
Scientific Reports

Volume: 13, P: 1-13
The clinical outcomes of combination chemotherapy in elderly patients with advanced biliary tract cancer: an exploratory analysis of JCOG1113

Ikuhiro Yamada
Chigusa Morizane
Junji Furuse
ResearchOpen Access19 Jan 2022
Scientific Reports

Volume: 12, P: 1-9
Genome sequencing reveals the genetic architecture of heterostyly and domestication history of common buckwheat

Genome sequencing and analyses of common buckwheat, Fagopyrum esculentum, reveal the genetic architecture of heterostyly, show that southeast Tibet played a key role in the domestication and provide new genetic materials for buckwheat breeding.

Jeffrey A. Fawcett
Ryoma Takeshima
Yasuo Yasui
Research10 Aug 2023
Nature Plants

Volume: 9, P: 1236-1251
Molecular Weight Distribution of Polyphenylene Sulfide by High Temperature Gel Permeation Chromatography

Tatsuya Housaki
Kazuo Satoh
Research01 Dec 1988
Polymer Journal

Volume: 20, P: 1163-1166
PIM kinases facilitate lentiviral evasion from SAMHD1 restriction via Vpx phosphorylation

The accessory lentiviral protein X (Vpx) of the SIV_smm/mac and HIV-2 lineage targets the host-restriction factor SAMHD1 for proteasomal degradation. Here, the authors show that host PIM kinase-mediated phosphorylation of Vpx stabilizes its interaction with SAMHD1, suggesting PIM as potential antiviral targets.

Kei Miyakawa
Satoko Matsunaga
Akihide Ryo
ResearchOpen Access23 Apr 2019
Nature Communications

Volume: 10, P: 1-12
Dissection of the polygenic architecture of neuronal Aβ production using a large sample of individual iPSC lines derived from Alzheimer’s disease patients

Using more than 100 independent iPSC lines derived from patients with Alzheimer’s disease, the authors discovered loci associated with the neuronal production of amyloid β and confirmed their influence using RNA interference.

Takayuki Kondo
Norikazu Hara
Haruhisa Inoue
Research17 Feb 2022
Nature Aging

Volume: 2, P: 125-139
Nucleotide-sugar transporter SLC35D1 is critical to chondroitin sulfate synthesis in cartilage and skeletal development in mouse and human

Shuichi Hiraoka
Tatsuya Furuichi
Shiro Ikegawa
Research21 Oct 2007
Nature Medicine

Volume: 13, P: 1363-1367
Effects of transcranial static magnetic stimulation over the primary motor cortex on local and network spontaneous electroencephalogram oscillations

Sumiya Shibata
Tatsunori Watanabe
Tatsuya Mima
ResearchOpen Access15 Apr 2021
Scientific Reports

Volume: 11, P: 1-7
Endoscopic resection is a suitable initial treatment strategy for oxyntic gland adenoma or gastric adenocarcinoma of the fundic gland type

Masaya Iwamuro
Chiaki Kusumoto
Hiroyuki Okada
ResearchOpen Access01 Apr 2021
Scientific Reports

Volume: 11, P: 1-9
Transcranial static magnetic stimulation over the motor cortex can facilitate the contralateral cortical excitability in human

Yasuyuki Takamatsu
Satoko Koganemaru
Tatsuya Mima
ResearchOpen Access08 Mar 2021
Scientific Reports

Volume: 11, P: 1-8
Influence of hospital capabilities and prehospital time on outcomes of thrombectomy for stroke in Japan from 2013 to 2016

Ai Kurogi
Daisuke Onozuka
Masayuki Yokota
ResearchOpen Access28 Feb 2022
Scientific Reports

Volume: 12, P: 1-17
eIF2B-capturing viral protein NSs suppresses the integrated stress response

Here the authors show that a viral protein interferes with the binding of phosphorylated eIF2 to eIF2B, thereby suppressing the host integrated stress response (ISR). This suppression of the ISR abrogates translational changes of the host and ameliorates neurite degradation under stress.

Kazuhiro Kashiwagi
Yuichi Shichino
Takuhiro Ito
ResearchOpen Access07 Dec 2021
Nature Communications

Volume: 12, P: 1-12
Egg white-based strong hydrogel via ordered protein condensation

High mechanical strength hydrogel material was fabricated from egg white proteins. Egg white proteins were condensed at a regular interval with ionic surfactants and gelled by heating. The maximum compressive fracture strength was 34.5 MPa, which is 150-fold higher than that of boiled egg white. The high strength is due to the synergic effects of both covalent and non-covalent networks.

Tatsuya Nojima
Tomokazu Iyoda
ResearchOpen Access05 Jan 2018
NPG Asia Materials

Volume: 10, P: e460

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