In this study, we prepared a novel oil gel composed of poly(L-lactide) and a poly(trimethylene carbonate) derivative. We investigated the release of testosterone, an inexpensive therapeutic drug for the segmental defect of bones, from the gel. Dimethyl sulfoxide and dimethyl carbonate, which are organic solvents with relatively low toxicities, were used as dispersion media. The oil gel in dimethyl sulfoxide released testosterone faster than that in dimethyl carbonate. In addition, the dimethyl carbonate oil gel was vacuum-dried to reduce the gel porosity and resulted in slow testosterone release.
- Kazuya Takemura
- Hiroharu Ajiro
- Mitsuru Akashi
