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Scientific Reports (39)
Hypertension Research (6)
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Showing 1–50 of 82 results

Advanced filters: Author: Tomoko Okada Clear advanced filters

Postpartum depression among women in Nagoya indirectly exposed to the Great East Japan Earthquake

Chika Kubota
Takashi Okada
Norio Ozaki
ResearchOpen Access02 Aug 2018
Scientific Reports

Volume: 8, P: 1-6
Presence of hematopoietic stem cells in the adult liver

Hideki Taniguchi
Tomoko Toyoshima
Hiromitsu Nakauchi
Research01 Feb 1996
Nature Medicine

Volume: 2, P: 198-203
A genome-wide association study identifies the GPM6A locus associated with age at onset in ALS

A genome-wide association study in Japanese patients with ALS identifies rs113161727 at the ADAM29-GPM6A locus as a modifier of age at onset and links it to GPM6A upregulation.

Ryoichi Nakamura
Genki Tohnai
Gen Sobue
ResearchOpen Access05 Dec 2025
Communications Biology

Volume: 8, P: 1-11
Genome-wide association study of long COVID

A genome-wide study by the Long COVID Host Genetics Initiative identifies an association between the FOXP4 locus and long COVID, implicating altered lung function in its pathophysiology.

Vilma Lammi
Tomoko Nakanishi
Hanna M. Ollila
ResearchOpen Access21 May 2025
Nature Genetics

Volume: 57, P: 1402-1417
Genome-wide association studies identify IL23R-IL12RB2 and IL10 as Behçet's disease susceptibility loci

Nobuhisa Mizuki and colleagues report a genome-wide association study for Behçet's disease, a chronic systemic inflammatory disorder, in a Japanese population. They identify variants at IL23R-IL12RB2 and IL10 associated with Behçet's disease.

Nobuhisa Mizuki
Akira Meguro
Hidetoshi Inoko
Research11 Jul 2010
Nature Genetics

Volume: 42, P: 703-706
Low-voltage-area ablation for persistent atrial fibrillation: a randomized controlled trial

In view of previous work suggesting that low-voltage areas may promote atrial fibrillation, a multicenter, randomized controlled trial tested the hypothesis that ablation of low-voltage areas in addition to pulmonary vein isolation might reduce the recurrence of atrial arrhythmic events, but found no significant benefit to the combined procedure.

Masaharu Masuda
Akihiro Sunaga
Takuya Ohashi
ResearchOpen Access30 Apr 2025
Nature Medicine

Volume: 31, P: 1661-1667
Helium penetrates into silica glass and reduces its compressibility

SiO₂ glass and helium are important in various fields of science and engineering. Sato et al. show SiO₂glass to be less compressible in helium under high pressure, which may be relevant for the interpretation of high-pressure experiments and in the design of new materials.

Tomoko Sato
Nobumasa Funamori
Takehiko Yagi
Research14 Jun 2011
Nature Communications

Volume: 2, P: 1-5
Staphylococcus aureus ST764-SCCmecII high-risk clone in bloodstream infections revealed through national genomic surveillance integrating clinical data

Authors present results from a national surveillance in Japan that found MRSA strains causing bloodstream infections are predominantly from three clonal lineages. They also identified the emergence of highest 30-day-mortality MRSA clone ST764-SCCmecII and traced its evolutionary path.

Junzo Hisatsune
Shoko Kutsuno
Motoyuki Sugai
ResearchOpen Access19 Mar 2025
Nature Communications

Volume: 16, P: 1-14
High-resolution imaging of living mammalian cells bound by nanobeads-connected antibodies in a medium using scanning electron-assisted dielectric microscopy

Tomoko Okada
Toshihiko Ogura
ResearchOpen Access23 Feb 2017
Scientific Reports

Volume: 7, P: 1-9
Nanoscale imaging of untreated mammalian cells in a medium with low radiation damage using scanning electron-assisted dielectric microscopy

Tomoko Okada
Toshihiko Ogura
ResearchOpen Access04 Jul 2016
Scientific Reports

Volume: 6, P: 1-8
Associations of family history of hypertension, genetic, and lifestyle risks with incident hypertension

Masato Takase
Takumi Hirata
Masayuki Yamamoto
ResearchOpen Access13 Aug 2025
Hypertension Research

Volume: 48, P: 2606-2617
Single-cell analysis reveals immune cell abnormalities underlying the clinical heterogeneity of patients with systemic sclerosis

Clinical manifestations in patients with systemic sclerosis (SSc) are highly heterogeneous, and identifying the root causes of clinical symptoms is challenging. Here, by performing single-cell profiling of peripheral blood from SSc patients, the authors identify distinct immune abnormalities associated with acute organ complications, including interstitial lung disease and scleroderma renal crisis.

Hiroshi Shimagami
Kei Nishimura
Masayuki Nishide
ResearchOpen Access17 Jun 2025
Nature Communications

Volume: 16, P: 1-18
Dissection of the polygenic architecture of neuronal Aβ production using a large sample of individual iPSC lines derived from Alzheimer’s disease patients

Using more than 100 independent iPSC lines derived from patients with Alzheimer’s disease, the authors discovered loci associated with the neuronal production of amyloid β and confirmed their influence using RNA interference.

Takayuki Kondo
Norikazu Hara
Haruhisa Inoue
Research17 Feb 2022
Nature Aging

Volume: 2, P: 125-139
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
Development and validation of a nomogram incorporating YpT stage for predicting ypN0 using multicenter data in clinically node-positive breast cancer

Hideo Shigematsu
Shinsuke Sasada
Morihito Okada
ResearchOpen Access10 Dec 2025
Scientific Reports

Volume: 16, P: 1-9
Lower mortality in calcimimetic users compared to non-users in dialysis patients with serum parathyroid hormone levels within the target range

Kazuyoshi Okada
Manabu Tashiro
Jun Minakuchi
ResearchOpen Access30 Nov 2025
Scientific Reports

Volume: 16, P: 1-9
Association study of BCL9 gene polymorphism rs583583 with schizophrenia and negative symptoms in Japanese population

Hiroki Kimura
Satoshi Tanaka
Norio Ozaki
ResearchOpen Access23 Oct 2015
Scientific Reports

Volume: 5, P: 1-6
Social support helps protect against perinatal bonding failure and depression among mothers: a prospective cohort study

Masako Ohara
Takashi Okada
Norio Ozaki
ResearchOpen Access25 Aug 2017
Scientific Reports

Volume: 7, P: 1-8
Dietary intake of folate, vitamin B6, vitamin B12, and riboflavin and the risk of incident dementia

Rie Kishida
Kazumasa Yamagishi
Hiroyasu Iso
Research25 Sept 2025
European Journal of Clinical Nutrition

Volume: 79, P: 1099-1105
Complementation of placental defects and embryonic lethality by trophoblast-specific lentiviral gene transfer

Yuka Okada
Yuko Ueshin
Masahito Ikawa
Research14 Jan 2007
Nature Biotechnology

Volume: 25, P: 233-237
Drosophila endogenous small RNAs bind to Argonaute 2 in somatic cells

The identification of esiRNAs, a class of small RNAs, many of which are expressed from (and repress) retrotransposons, but in somatic cells. esiRNAs and piRNAs interact with different subfamilies of Argonaute proteins involved in RNAi.

Yoshinori Kawamura
Kuniaki Saito
Haruhiko Siomi
Research07 May 2008
Nature

Volume: 453, P: 793-797
Gilteritinib overcomes lorlatinib resistance in ALK-rearranged cancer

Resistance to ALK inhibitors such as lorlatinib often arise due to on-target mutations. Here, the authors show the multi-kinase inhibitor gilteritinib is effective against different mutations that arise during lorlatinib in ALK fusion positive lung cancer to cause resistance.

Hayato Mizuta
Koutaroh Okada
Ryohei Katayama
ResearchOpen Access24 Feb 2021
Nature Communications

Volume: 12, P: 1-16
LC3 lipidation is essential for TFEB activation during the lysosomal damage response to kidney injury

Nakamura et al. find that the master transcriptional regulator of lysosomal biogenesis and autophagy TFEB is activated following LC3 lipidation during lysosomal damage and show the importance of this mechanism during kidney injury.

Shuhei Nakamura
Saki Shigeyama
Tamotsu Yoshimori
Research28 Sept 2020
Nature Cell Biology

Volume: 22, P: 1252-1263
Identification and replication of sex-dimorphic protein quantitative trait loci across multiple ancestries and their associations with diseases

Youngjune Bhak
Vasilis Raptis
Albert Tenesa
ResearchOpen Access28 Aug 2025
Scientific Reports

Volume: 15, P: 1-16
STING expression is an independent prognostic factor in patients with mycosis fungoides

Reiko Takayanagi-Hara
Yu Sawada
Etsuko Okada
ResearchOpen Access26 Jul 2022
Scientific Reports

Volume: 12, P: 1-7
Intravenous nicardipine for Japanese patients with acute intracerebral hemorrhage: an individual participant data analysis

Kazunori Toyoda
Sohei Yoshimura
Kazuo Minematsu
ResearchOpen Access13 Oct 2022
Hypertension Research

Volume: 46, P: 75-83
Simulating metabolic pathways to enhance interpretations of metabolome genome-wide association studies

Shun Kodate
Mitsuharu Sato
Kengo Kinoshita
ResearchOpen Access16 May 2025
Scientific Reports

Volume: 15, P: 1-11
Effect of extramedullary disease on allogeneic hematopoietic cell transplantation for pediatric acute myeloid leukemia: a nationwide retrospective study

Hirotoshi Sakaguchi
Takako Miyamura
Yoshiko Atsuta
Research10 Mar 2021
Bone Marrow Transplantation

Volume: 56, P: 1859-1865
Trans-ancestry mutational landscape of hepatocellular carcinoma genomes

Tatsuhiro Shibata, David Wheeler, Hiroyuki Aburatani and colleagues report the genomic, exomic and oncoviral sequencing of hundreds of liver cancers from the United States and Japan. The authors analyzed mutation patterns and identified signatures unique to the Asian cases.

Yasushi Totoki
Kenji Tatsuno
Tatsuhiro Shibata
Research02 Nov 2014
Nature Genetics

Volume: 46, P: 1267-1273
Evolution of Shh endoderm enhancers during morphological transition from ventral lungs to dorsal gas bladder

Endoderm enhancer MACS1 of Sonic Hedgehog is conserved in animals with lungs. Here, the authors show that mouse without MACS1 has defective laryngeal development, and use phylogenetic analyses to show association of evolutionary lung-gas bladder transition with change of the enhancer.

Tomoko Sagai
Takanori Amano
Toshihiko Shiroishi
ResearchOpen Access03 Feb 2017
Nature Communications

Volume: 8, P: 1-12
Stable factor structure of the Edinburgh Postnatal Depression Scale during the whole peripartum period: Results from a Japanese prospective cohort study

Chika Kubota
Toshiya Inada
Norio Ozaki
ResearchOpen Access05 Dec 2018
Scientific Reports

Volume: 8, P: 1-7
Developmental Changes of Optical Properties in Neonates Determined by Near-Infrared Time-Resolved Spectroscopy

Sonoko Ijichi
Takashi Kusaka
Susumu Itoh
Research01 Sept 2005
Pediatric Research

Volume: 58, P: 568-573
Mutation screening of GRIN2B in schizophrenia and autism spectrum disorder in a Japanese population

Yuto Takasaki
Takayoshi Koide
Norio Ozaki
ResearchOpen Access12 Sept 2016
Scientific Reports

Volume: 6, P: 1-7
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
Serum uric acid and risk of stroke and its types: the Circulatory Risk in Communities Study (CIRCS)

Jiaqi Li
Isao Muraki
Tetsuya Ohira
Research27 Jan 2020
Hypertension Research

Volume: 43, P: 313-321
Author Correction: LC3 lipidation is essential for TFEB activation during the lysosomal damage response to kidney injury

Shuhei Nakamura
Saki Shigeyama
Tamotsu Yoshimori
Amendments and Corrections04 Oct 2022
Nature Cell Biology

Volume: 24, P: 1677-1679
Improved survival with high albumin leakage in patients with protein-energy wasting and inflammation on hemodialysis and online hemodiafiltration

Kazuyoshi Okada
Manabu Tashiro
Jun Minakuchi
ResearchOpen Access01 Aug 2025
Scientific Reports

Volume: 15, P: 1-13
Suppression of induced pluripotent stem cell generation by the p53–p21 pathway

Induced pluripotent stem (iPS) cells are generated from mouse and human somatic cells by the introduction of four genes, but with low efficiency. Here it is reported that 10% of transduced mouse embryonic fibroblasts lacking p53 became iPS cells, even without the Myc retrovirus, and iPS cells were also generated from terminally differentiated T lymphocytes in the p53-null background.

Hyenjong Hong
Kazutoshi Takahashi
Shinya Yamanaka
Research09 Aug 2009
Nature

Volume: 460, P: 1132-1135
Direct reprogramming of somatic cells is promoted by maternal transcription factor Glis1

Momoko Maekawa
Kei Yamaguchi
Shinya Yamanaka
Research08 Jun 2011
Nature

Volume: 474, P: 225-229
Profiling of runs of homozygosity from whole-genome sequence data in Japanese biobank

Aye Ko Ko Minn
Motomichi Matsuzaki
Gen Tamiya
ResearchOpen Access03 Apr 2025
Journal of Human Genetics

Volume: 70, P: 287-296
Blood pressure during long-term cilostazol-based dual antiplatelet therapy after stroke: a post hoc analysis of the CSPS.com trial

Kazunori Toyoda
Masatoshi Koga
Hiroaki Tanaka
ResearchOpen Access09 Jul 2024
Hypertension Research

Volume: 47, P: 2238-2249
Upregulated expression of FGF13/FHF2 mediates resistance to platinum drugs in cervical cancer cells

Tomoko Okada
Kazuhiro Murata
Toru Imamura
ResearchOpen Access11 Oct 2013
Scientific Reports

Volume: 3, P: 1-8
Relationship between social support during pregnancy and postpartum depressive state: a prospective cohort study

Mako Morikawa
Takashi Okada
Norio Ozaki
ResearchOpen Access29 May 2015
Scientific Reports

Volume: 5, P: 1-9
Mesenchymal properties of iPSC-derived neural progenitors that generate undesired grafts after transplantation

A single cell-based approach to characterize human induced pluripotent stem cells resistant to differentiation finds cellular properties of neural and mesenchymal origins, pointing at underlying causes for undesired grafts after transplantation.

Miho Isoda
Tsukasa Sanosaka
Jun Kohyama
ResearchOpen Access07 Jun 2023
Communications Biology

Volume: 6, P: 1-15
Different cholinergic cell groups in the basal forebrain regulate social interaction and social recognition memory

Kana Okada
Kayo Nishizawa
Kazuto Kobayashi
ResearchOpen Access30 Jun 2021
Scientific Reports

Volume: 11, P: 1-12
Higher longitudinal brain white matter atrophy rate in aquaporin-4 IgG-positive NMOSD compared with healthy controls

Hiroki Masuda
Masahiro Mori
Satoshi Kuwabara
ResearchOpen Access03 Aug 2023
Scientific Reports

Volume: 13, P: 1-14
“KAIZEN” method realizing implementation of deep-learning models for COVID-19 CT diagnosis in real world hospitals

Naoki Okada
Yutaka Umemura
Satoshi Fujimi
ResearchOpen Access19 Jan 2024
Scientific Reports

Volume: 14, P: 1-15
Distinct roles of basal forebrain cholinergic neurons in spatial and object recognition memory

Kana Okada
Kayo Nishizawa
Kazuto Kobayashi
ResearchOpen Access06 Aug 2015
Scientific Reports

Volume: 5, P: 1-13
Rare loss of function mutations in N-methyl-d-aspartate glutamate receptors and their contributions to schizophrenia susceptibility

Yanjie Yu
Yingni Lin
Norio Ozaki
ResearchOpen Access10 Jan 2018
Translational Psychiatry

Volume: 8, P: 1-9
Resequencing and Association Analysis of Six PSD-95-Related Genes as Possible Susceptibility Genes for Schizophrenia and Autism Spectrum Disorders

Jingrui Xing
Hiroki Kimura
Norio Ozaki
ResearchOpen Access07 Jun 2016
Scientific Reports

Volume: 6, P: 1-8

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