Search

Relativistic jets launched from stellar-mass black holes (BHs) in our galaxy have been observed in less relativistic regime than those seen in the extra-galactic supermassive BHs named active galactic nucleus (AGN). Here, the authors show two relativistic jets from galactic BH X-ray binary 4U 1543−47, which are comparable to those seen in AGN.

LHAASO has detected γ-ray emission with a spectrum extending to 2 PeV from the pulsar wind nebula (PWN) powered by PSR J1849-0001, indicating an extreme particle acceleration efficiency and challenging the current particle acceleration theories.

Protein synthesis is tightly regulated by the integrated stress response, but therapeutic activation remains challenging. Here, the authors identify a drug‑like allosteric inhibitor, an ISRAC, that stabilises inactive eIF2B, mimicking stress‑induced eIF2α phosphorylation to activate the ISR, establishing eIF2B as a tractable target for ISR modulation.

Coherent ferrons (or polarization waves) driven by an ultrafast laser source in ferroelectric van der Waals materials generate narrow-band terahertz radiation and propagate uniaxially with long coherence times.

An electrochromic in-sensor computing architecture enables adaptive, pixel-level spectral compression before readout, reducing data transmission and supporting energy-efficient intelligent vision for edge-computing systems.

Understanding the charge transfer at microbe–semiconductor interfaces in biohybrids is valuable for advancing solar-to-chemical conversion. Now, the reverse electron transfer in Shewanella–haematite hybrids is quantified using multimodal single-particle imaging, revealing facet-dependent efficiency.

NUMTs record mitochondrial‑to‑nuclear DNA transfer, but their diversity is not well defined. Here, the authors create a pangenome‑based NUMT map, revealing hundreds of fixed and polymorphic events, regulatory activity, lineage‑specific dynamics and NUMT‑derived tandem repeats.

Multi-Embed is an interpretable framework that enables integrated analyses of histological images and multilayer molecular profiles.

NeAT is a computational framework that facilitates incorporating adaptive optics into custom or commercial two-photon microscopes. This allows correcting aberrations and conjugation errors in real time in the mouse brain during morphological or functional imaging.

A population genomic analysis of 1,854 Listeria soil isolates collected across the contiguous United States identifies geographically prevalent phylogroups with increased pangenome openness and recombination, as a result of adaptation to variable environments.

Multilayer capacitors comprising a solid solution of two electrocaloric materials PbSc_0.5Ta_0.5O₃ and PbMg_0.5W_0.5O₃ are shown to maintain high B-site order and latent heat without needing an energetically expensive anneal, enabling efficient refrigeration across room temperature.

DeepDrugDiscovery is an AI-powered screening platform incorporating ADMET and blood–brain barrier penetrability predictions to successfully identify mTOR-independent autophagy enhancers that can cross the blood–brain barrier for Alzheimer’s disease therapy.

Authors demonstrate layer-selective conductor–insulator transitions in twisted bilayer graphene driven by hydrogenation, realising an electrochemical interface with two decoupled 2D electron gases that enables configurable logic gates.

The CMS experiment at CERN reports one of the highest-precision measurements of the W boson mass, finding it in line with standard model predictions and at odds with recent anomalous measurements.

Electrically modulated metasurfaces manipulate light fields but suffer from high operating voltages, low tuning sensitivity, and a reliance on telecommunication bands. This work shows designs of electrically modulated plasmonic metasurfaces that enable continuous and reversible wavelength modulation with a tuning sensitivity up to ~ 1 nm/V at a CMOS-compatible voltage below 5 V in the visible and near-infrared light regime.

The creation of stable and isolated magnetic hopfions—three-dimensional topological solitons—has remained experimentally challenging. Now the laser-induced nucleation of hopfions has been achieved in a chiral magnet.

Understanding collective behaviour is an important aspect of managing the pandemic response. Here the authors show in a large global study that participants that reported identifying more strongly with their nation reported greater engagement in public health behaviours and support for public health policies in the context of the pandemic.

In-situ high-speed synchrotron X-ray imaging quantifies bubble explosion dynamics during electron beam melting, observing process sensitive melt pool instabilities and defect formation.

Reducing dissipation when generating spin currents remains a central challenge in spintronics. Now, an artificial ferrimagnet is shown to produce spin current output and simultaneously lower magnetic damping.

The authors from the ALICE collaboration identify multiple species of mesons and baryons and measure the anisotropic flow with non-flow removal techniques in pp and p-Pb collisions at the LHC, identifying the hallmark of quark flow associated with an expanding quark-gluon plasma.

Kancharla, Kelly et al. identify an acridone antimalarial potent across all major parasite life stages. Lead candidate T111 shows oral efficacy, low toxicity, and synergy with tafenoquine, providing a unique mechanism to overcome resistance.

The CMS Collaboration reports the measurement of the spin, parity, and charge conjugation properties of all-charm tetraquarks, exotic fleeting particles formed in proton–proton collisions at the Large Hadron Collider.

Complex coupled ion–electron interfacial processes are poorly understood but crucial to battery dynamics. Here an ion-localization optical nanoscopy that enables single-ion imaging at 50 nm spatial and 20-ms temporal resolution at the single-particle level is presented and used to observe metal stripping cooperativity on Zn anodes.

Understanding interfaces at sub-nanometer scales is vital for complex chemical reactions. Here, the authors advance Pattern-enhanced Resonant Soft X-ray Scattering, enabling efficient operando probing of chemical and structural dynamics at solid-liquid interfaces.

The Einstein Probe has discovered a fast X-ray transient, EP240414a, associated with a broad-lined type Ic supernova. Its unusually soft spectrum and weak jet add to the diversity of stellar deaths and suggest a previously unknown Wolf–Rayet star explosion mechanism.

Identifying jets originating from heavy quarks plays a fundamental role in hadronic collider experiments. In this work, the ATLAS Collaboration describes and tests a transformer-based neural network architecture for jet flavour tagging based on low-level input and physics-inspired constraints.

Genomic data from snow carps reveal that the fusion of chromosomes initiates rediploidization following whole-genome duplication.

The death of massive stars has traditionally been discovered by explosive events in the gamma-ray band. Liu et al. show that the sensitive wide-field monitor on board Einstein Probe can reveal a weak soft-X-ray signal much earlier than gamma rays.

A large-scale study on the replicability of claims from social and behavioural science journals reports that about half of the results replicate in the same patterns as the original study.

Store-operated Ca²⁺ entry is essential for cellular signalling, yet excessive calcium influx drives disease. Here, authors develop genetically encoded CRAC channel inhibitory binders (CRABs) to precisely modulate Ca²⁺ signalling, with therapeutic potential in channelopathies and cancer immunotherapy.

Reducing China’s CO₂ emissions is crucial to achieving global carbon neutrality. This Perspective synthesizes bottom-up and top-down estimates to develop a regional CO₂ budget for China and evaluate pathways and uncertainties towards net zero.

Gene correction in the lung is achieved with inhalable mRNA lipid nanoparticles containing an amino acid-derived ionizable lipid identified from screening and structure–function optimization studies.

Conventional carbon synthesis is energy intensive. Here, the authors introduce an energy-autonomous pathway using polyaniline-HClO₄ composites. This rapid reaction yields carbon nanosheets with tunable active sites for electrocatalysis.

Protein motion in crowded environments governs cellular transport and reaction rates. Here, the authors use megahertz X-ray Photon Correlation Spectroscopy to reveal anomalous diffusion of ferritin, linking hydrodynamic and direct interactions to cage-trapping at microsecond time scales.

As an important class of open-shell molecules characterized by triangular nanographenic structures and interesting magnetic properties with high-spin ground states, triangulenes are attractive targets. Here, the authors report a highly stable aza-derivative of [4]triangulene triradical with a quartet ground state.

Room-temperature multiferroic materials are highly demanded for designing next-generation of spintronic devices. Here, the authors demonstrate an emergent room-temperature ferrimagnetism and polar phase in highly strained La₂CoRuO₆ epitaxial films through engineered 3d−4d cation ordering.

The authors study a topological insulator (TI) sandwiched between two magnetic TIs. By keeping one of the magnetic TIs insulating, while tuning the other one into a metallic regime, they find half quantized anomalous Hall conductance, a boundary signature consistent with a quantized axion field.

The interlayer π-π stacking primarily results in irreversible dispersibility of GO, providing supramolecular view for the regulation of graphene-based materials.

Wang et al. show that promyelocytic leukaemia protein (PML) reduces polyG inclusions via chaperone-mediated disaggregation and proteasome-dependent degradation. This suggests a possible role for PML in various neurodegenerative diseases.

Sphingolipids mediate inflammation, although the role of lipid aldehyde 2-HD is poorly understood. Here, the authors show ALDH3B1 detoxifies 2-HD to protect retinal vasculature, with 2HD accumulation causing vascular abnormalities.

While Bell inequalities have been violated several times—mostly in photonic systems—their violations within particle physics experiments are less explored. Here, the BESIII Collaboration showcases Bell-violating nonlocal correlations between entangled hyperon pairs.

Lithium-metal batteries promise high energy but dendrites limit life. Here, authors introduce a 90 wt.% lithium multicomponent solid solution alloy negative electrode that drives lithium into the bulk, enabling 3100 mAh g − 1 capacity and a 385 Wh kg−1 pouch cell that retains 82% capacity after 600 cycles.

Fracto-mechanoluminescence is the emission of light from fracturing solids. Here, the authors show that this emission in Mn halides arises from elastic stiffness, electromechanical coupling, and trap states that activate Mn²⁺ d−d transitions.

The authors present evidence for the coexistence and coupling of ferroelectricity and superconductivity at amorphous LaAlO3/KTaO3(111) interfaces. Furthermore, flipping ferroelectric polarization reduces interfacial conductivity by more than 1000 times, and simultaneously suppresses superconductivity

The authors introduce a deep learning pipeline integrating classification, ranking, and regression modules, in which each module is trained via a few-shot learning strategy involving pretraining and multiple fine-tuning steps, to identify potent AMPs against Acinetobacter baumannii.

A new artificial intelligence model, DeepSeek-R1, is introduced, demonstrating that the reasoning abilities of large language models can be incentivized through pure reinforcement learning, removing the need for human-annotated demonstrations.

The semileptonic decay channels of the Λc baryon can give important insights into weak interaction, but decay into a neutron, positron and electron neutrino has not been reported so far, due to difficulties in the final products’ identification. Here, the BESIII Collaboration reports its observation in e+e- collision data, exploiting machine-learning-based identification techniques.

The STAR experiment at the Relativistic Heavy Ion Collider at Brookhaven National Laboratory demonstrates evidence of spin correlations in \(\Lambda \bar{\Lambda }\) hyperon pairs inherited from virtual spin-correlated strange quark–antiquark pairs during QCD confinement.