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Unlike animals, plant possess mitochondria and chloroplasts and exhibit a unique defensive adaptation to stress. Here, the authors demonstrate the feasibility of restoring organelle interaction network homeostasis in animal cells by introducing plant-derived photosynthetic systems.

Neonatal sepsis caused by Escherichia coli is associated with reduced transfer of pathogen-specific maternal antibodies and, in a mouse model, can be prevented by maternal preconceptual colonization with probiotic E. coli.

Here proteomic chromatome analysis shows metabolic enzymes widely localize to chromatin in cancer in a tissue-specific manner. Nuclear enzymes affect DNA damage/repair and transcription, revealing non-canonical nuclear metabolic roles in cancer.

‘Populations residing near nuclear power plants may experience low-level chronic exposure to ionizing radiation through environmental release pathways. In here the authors find higher cancer mortality rates in U.S. counties closer to operational nuclear power plants, with the strongest relative risks observed in older adults.’

The authors present bioinspired solid-state proton diode membranes that achieve rectified proton transport by constructing an inherent water-content gradient and asymmetric transport pathways, enables efficient force-electric conversion.

A few anisotropic van der Waals materials have been shown to host hyperbolic polaritons in the visible and infrared ranges. Here, the authors characterize the complex dielectric function of hexagonal boron nitride in the deep-ultraviolet regime, supporting a natural hyperbolic dispersion and predicting hyperbolic exciton polaritons.

Most H₂ used in the chemical industry is derived from fossil fuels. Now it has been shown that coupling native microbial H₂ pathways with engineered alkene biosynthesis and membrane-bound Pd catalysis enables biocompatible hydrogenation of metabolic intermediates in living bacteria. This hybrid chemo-microbial platform supports the carbon-negative synthesis of industrial chemicals from waste-derived feedstocks.

Hepatitis C virus remains a health burden due to the lack of an effective vaccine, hindered by difficulties in replicating the native E1E2 antigen structure. Here, the authors engineer a stabilized E1E2 heterodimer using cryo-EM-guided modifications, enhancing immunogenicity and paving the way for future HCV vaccine development.

Protein N-terminal acetylation profoundly influences protein fate. Here, the authors establish NatB as a central regulator of the interplay between ubiquitin–proteasome system and autophagy, and highlight its role in maintaining proteome stability and enabling dynamic stress responses in plants.

Climate action could avoid over 1 million deaths globally from air pollution in 2040. However, it is suggested that cooperation is needed between developed and developing nations to ensure that disparities in air pollution are not perpetuated in the future.

High yield and wide adaptation rice are crucial for grain supply and food security. Here the authors report OsPI4Kγ7 which contributes to different “adaptability-yield” trade-offs in japonica and indica, and provides an alternative breeding strategy for raising grain yield in different latitudes.

N-terminal acetylation shapes protein fate during protein biosynthesis at the ribosome. Here the authors show that the NatA enzyme forms dynamic multi-factor complexes at the ribosome, acting as an interaction hub that coordinates cotranslational protein maturation.

Pseudogap states have previously been identified in moire systems. Here, the authors observe gate-tunable spontaneous symmetry breaking and shifting behavior of the pseudogap state in magic-angle twisted bilayer graphene using scanning tunneling microscopy.

How widespread brain areas flexibly interact to support behaviors is a fundamental challenge in neuroscience. Using direct brain recordings from humans, the authors show that spatiotemporally complex propagation patterns of traveling waves correlate with novel aspects of behavior.

The interplay between bulk oxygen diffusion and surface reactions in reducible metal oxides is key in heterogeneous catalysts, yet direct measurements of their coupling through transient kinetics and in situ spectroscopies have been lacking. Here, the authors uncover complex H₂-driven dynamics in ceria–zirconia using transient mass spectrometry along with in-situ Raman, near-ambient pressure X-ray photoelectron spectroscopy, machine learning potential-based molecular simulations, and multiscale kinetic modeling.

Although river protection is core to social and environmental well-being, the extent to which river conservation policies are effective is difficult to assess. This study reveals that, under all relevant protection mechanisms in the contiguous USA, only 12% of rivers are adequately protected.

The authors report that Ta-doped PbTiO₃ films with a p-i-n structure can generate a high photovoltaic current, offering the opportunity to advanced optoelectronic and imaging devices.

This study uses machine learning and ground data from the Arctic to constrain land albedo feedback. The projected feedback is reduced by 0.29–0.52 W m⁻² K⁻¹ and uncertainty by 45–55%, suggesting that climate models overestimate this key warming amplifier.

This study reveals migrating zebrafish primordial germ cells use migrasomes as mobile carriers to transport growth signals between neighbours, coupling cell migration with proliferation to ensure robust population expansion during their journey.

Conventional spin-orbit torques are limited by symmetry. Here, the ferroelectric domain structure of multiferroic bismuth ferrite is engineered to manipulate the orientation of magnon spin current, enabling field-free type-x magnetic switching.

A combination of DFT calculations, comprehensive structural searches and high-resolution photoelectron spectra unveils a broad variety of often highly symmetric structural motifs of gold cluster anions with a few tens of atoms.

Conventional genome mapping overlooks genetic variation, especially in regions that substantially differ from the reference. Here, the authors reveal hidden variation in South Asian populations by assembling unmapped sequencing reads.

Spatial representations in the hippocampus can rapidly form through behavioral timescale synaptic plasticity. Here authors show rapid formation of non-spatial olfactory representations in CA1, consistent with behavioral timescale synaptic plasticity, and describe modulation by medial and lateral entorhinal cortices.

The genomes of Asgard archaea, the closest prokaryotic relatives to eukaryotes, are larger than those of other archaea and contain multiple genes seemingly acquired from bacteria. Here, Manzano-Morales and Gabaldón quantify gene duplication, loss, and transfer events in Asgard genomes, showing that gene duplications, rather than horizontal gene transfers, are the primary drivers behind the increased genome sizes.

Here the authors report that WNT10B, a ligand of the Wnt family, mediates renal inflammation and fibrosis. Mechanistic work in male mice with induced chronic kidney disease shows that the WNT10B/FOXO6 axis controls tubular senescence fate transition and pro-inflammatory microenviroment formation through metabolic reprogramming.

The authors show that the leucine metabolic enzyme AUH promotes fat burn and protects against obesity. AUH drives thermogenesis via Ucp1 mRNA stabilization and PPARγ modification via metabolite HMG-CoA, linking amino acid metabolism to weight regulation.

Zhan et al. report a fully vapor-deposited graded perovskite photodiode for visible-to-IR imaging with 230 dB linear dynamic range and 33 ns response time. Wafer-scale reconfigurable imaging processor is developed for edge detection, adaptive background suppression under dim light, and noise-immune high-speed dynamic imaging.

Spatial transcriptomics analyses often lose a substantial fraction of molecular signals because standard cell segmentation and deconvolution methods fail to capture expression from fragile cell types, subcellular structures, or extracellular regions. This study introduces RESCUE, a computational approach that recovers these unattributed spatial expression patterns, revealing biologically meaningful signals across diverse datasets and enabling more complete and accurate tissue interpretation.

Current strategies for regulating enzyme activity are often enzyme-specific. Here, the authors report a spintronic approach that uses chiral gold nanohelices as electron spin polarizers to enantiospecifically modulate cyclooxygenase-2 activity for rheumatoid arthritis intervention, and explore electron spin polarization as an orthogonal mechanism for enzymatic regulation.

An intrinsic hub that integrates the OsRALF4-THE3-RbohB pathway with the binding of OsRALF4-demethylesterified pectin modulates meristem homeostasis by balancing O₂⁻ and promotes cell expansion by pectin demethylesterification and condensation.

The contribution of maternal antibodies to the postnatal establishment of oral and salivary mucosal immunity in the offspring is underexplored. Using an experimental mouse model, here the authors show that maternal IgG (transferred in utero or via breastfeeding) shapes oral immune homeostasis in neonates and adults, regulating microbial colonization, adaptive immune responses, and epithelial maturation and integrity. The lack of in-utero-derived IgG increases immune activation, bacterial load, and susceptibility to experimental periodontitis in adulthood.

Treatment options for patients with advanced neuroendocrine tumors (NETs) are limited. Here this group reports a single-arm, phase 2 trial assessing the safety and efficacy of cabozantinib and metronomic temozolomide in patients with advanced, progressive, well-differentiated NETs of gastroenteropancreatic, pulmonary or unknown origin.

A solidification strategy enables stable ceramic nanoparticle dispersion in molten Mg via an atomically bonded interface, ensuring exceptional wetting and uniform incorporation in casting, overcoming long-standing barriers in metal–ceramic systems.

Replicating enzyme function with minimal components is a major challenge in abiotic mimicry. Here, the authors show that liquid gallium droplets act as tunable artificial nucleases, cleaving DNA with nucleotide bias via oxide-mediated adsorption and hydroxyl radical-assisted hydrolysis.

Modulating CADM1-AS1 expression can restore proper histone acetylation patterns and mitigate the damaging effects observed in OA joints.

The selective photocatalytic reduction of CO₂ to CH₄ remains a big challenge. Here, the authors report dual-functional IrCu/TiO₂ effectively reconstructs the hydrogen bond network for H-down configuration, facilitating *H transfer and *CO reduction, which significantly improves CH₄ selectivity.

Hydrolytic polyethylene terephthalate (PET) depolymerization typically employs harsh acid or alkali conditions. Here, the authors develop a high efficiency defect-zinc oxide nanosheet catalyst for the hydrolytic depolymerisation of PET to terephthalic acid in water under neutral conditions.

During stress, cells profoundly reduce translation and simultaneously generate a large number of autophagosomes de novo. Here, the authors find that cells resolve this apparent contradiction with local translation at the site of autophagosome formation.

In this work, authors show that the loss of the carbapenem porin OprD in Pseudomonas aeruginosa reduces mucus entrapment and enhances airway epithelial barrier crossing, illustrating how antibiotic resistance mutations can reshape infection dynamics beyond drug resistance.

Temperature sensing is crucial for biological responses. Here, authors show that membrane lipids tune SthK cold sensitivity by modulating an intersubunit salt bridge, revealing thermosensitivity arising from cooperative protein–membrane interactions.

Most alternative splicing preserves the reading frame, leaving the role of non‑triplet events unclear. Here, the authors identify hundreds of non‑triplet splicing events in C. elegans and humans, showing they generate NMD‑sensitive, C‑terminal‑altered, and dual‑coding isoforms with regulated and functional roles.

How behavioural states influence binocular visual processing remains unclear. Here, the authors show that arousal rapidly alters binocularity and binocular integration via the differential modulation of visual inputs arriving to cortex from each eye.

Synthetic macrocycles are promising therapeutics; however, most high-throughput discovery platforms rely on genetically encoded libraries of large peptide macrocycles, which are typically not optimized for drug-like properties. Here, the authors report CycloSEL (Cyclic Self-Encoded Libraries), an end-to-end workflow that screens synthetic macrocycle libraries enriched in drug-like ‘beyond rule of five’ features, based on affinity selections and hit identification by tandem mass spectrometry.

With rapid progress in quantum error correction, clear performance benchmarks are needed to assess readiness for fault tolerant operation. Here the authors report benchmarking and noise characterization in a superconducting quantum processor, identifying key factors that impact error-corrected logic.

Forestation creates a climate trade-off between carbon uptake and wind energy. This study reveals forestation has high carbon sequestration potential with lower wind energy loss in tropical regions but has high wind energy loss in Europe and the US.